We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Blood Test Distinguishes between Forms of Inflammatory Bowel Disease

By LabMedica International staff writers
Posted on 13 May 2019
A recently developed blood test distinguishes between mild and severe forms of inflammatory bowel disease and is potentially a step towards realizing personalized therapy for the syndrome.

Crohn's disease and ulcerative colitis, collectively referred to as inflammatory bowel disease (IBD), are chronic conditions that involve inflammation of the gut. More...
Investigators at the University of Cambridge (United Kingdom) had previously described a prognostic transcriptional signature in CD8 T-cells that separated patients with IBD into two phenotypically distinct subgroups, termed IBD1 and IBD2. The IBD1 subgroup experienced significantly more aggressive disease and demonstrated poorer prognosis than IBD2 patients.

In the current study, the investigators sought to develop a blood-based test that could identify these subgroups without cell separation and be suitable for clinical use. To this end, they used a combination of machine learning and the qPCR (quantitative polymerase chain reaction) whole blood assay to identify genetic signatures in a cohort of 69 Crohn's disease patients that re-created the two subgroups from their previous study. The signatures were then validated in 123 IBD patients. Results indicated that the new test was 90-100% accurate in correctly identifying patients with the milder IBD2 form of the disease.

"IBD can be a very debilitating disease, but this new test could help us transform treatment options, moving away from a "one size fits all" approach to a personalized approach to treating patients," said senior author Dr. Kenneth G. C. Smith, professor of medicine at the University of Cambridge.

Further development of the test is being carried out by the spinout company PredictImmune (Cambridge, United Kingdom).

The IBD blood test was described in the April 27, 2019, online edition of the journal Gut.

Related Links:
University of Cambridge
PredictImmune


New
Gold Member
Latex Test
SLE-Latex Test
Serological Pipet Controller
PIPETBOY GENIUS
New
Gold Member
Quality Control Material
iPLEX Pro Exome QC Panel
New
Silver Member
Quality Control Material
Multichem ID-B
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.