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Pathology

Image: The FLUOstar Omega multi-mode microplate reader. A newly developed prion seeding assay called Real-Time Quaking Induced Conversion assay (RT-QuIC), scientists can now measure prion seeding at lower levels and in less than a few days in standard 96-well microplates (Photo courtesy of BMG Labtech).

Prion Protein Found in Skin of CJD Patients

Creutzfeldt-Jakob disease (CJD) is an incurable, and ultimately fatal, transmissible, neurodegenerative disorder in the family of prion diseases. Prion diseases originate when normally harmless prion protein molecules become abnormal and gather in clusters and filaments in the human body and brain. More...
07 Dec 2017
Image: A confocal fluorescent microscopy of living nasospheroids developed from a cystic fibrosis patient\'s nasal tissue (Photo courtesy of the University of North Carolina).

Simple Test Helps CF Patients Find Best Treatment

Individuals with cystic fibrosis (CF) suffer from abnormal secretions in multiple tissues, including the lungs, pancreas, liver, and intestine, leading to mucus stasis and obstruction. Several cutting-edge treatments have become available in recent years to correct the debilitating chronic lung congestion associated with CF. More...
06 Dec 2017
Image: A histological section showing a obstructed extrahepatic bile duct. It exhibits residual expression of the enzyme called MMP-7 (shown in brown) (Photo courtesy of Cincinnati Children\'s Hospital Medical Center).

Diagnostic Test Identified for Pediatric Biliary Atresia

Biliary atresia is a rare disease of the liver and bile ducts that occurs in infants. Liver cells produce bile, which helps digest fat and carries waste products from the liver to the intestines. When an infant has biliary atresia, this flow is blocked and bile becomes trapped inside the liver, quickly causing liver damage and eventually liver failure. More...
05 Dec 2017
Image: A histopathology of a brain showing metastatic lesions from a patient with non-small cell lung cancer (Photo courtesy of Peter Anderson).

CSF Analyzed in Lung Cancer with Brain Metastases

The analysis of mutations in cerebrospinal fluid of lung cancer patients with brain metastases has been explored. Tumor tissue from brain metastasis is difficult to obtain and therefore less invasive methods are needed to identify and monitor the presence of known actionable mutations. More...
29 Nov 2017
Image: Diagram of DiviTum sTK1 assay: BrdUTP is subsequently incorporated into a solid-phase DNA-strand. Incorporated BrdU is detected using an anti-BrdU monoclonal antibody conjugated to the signal generating enzyme alkaline phosphatase. The level of BrdU incorporated over time is proportional to the level of thymidine kinase activity in the sample (Photo courtesy of Biovica).

Blood Test Reduces Interim for Evaluating Cancer Treatment

Although prognosis and treatment of metastatic breast cancer (MBC) have improved over the last years, there is still an unmet clinical need for more precise prognostic and treatment monitoring tools. More...
27 Nov 2017
Image: A scanning electron photomicrograph (SEM) of prostate cancer cells (Photo courtesy of Prostate Cancer UK).

Low Testosterone Men Less Likely to Have Prostate Cancer

Prostate cancer affects more than 170,000 men each year in the USA, of who almost 30,000 die from the disease. While it is not yet known what causes the condition, a number of risk factors have been identified, such as age, ethnicity, and genetic mutations. More...
24 Nov 2017
Image: The TK210 ELISA kit for the measurement of Thymidine Kinase by immunoassay (Photo courtesy of AroCell AB).

Immunoassay Quantifies Cancer Cell Loss During Treatment

The quantification of cell loss in breast cancer during neoadjuvant treatment (NACT) can be assessed by serum thymidine kinase protein concentrations (sTK1). TK1 has a key function in DNA synthesis and repair responsible for maintaining the nucleoid pool balance by salvage and recycle thymidine from extracellular sources. More...
21 Nov 2017


The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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