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Image: A histopathology micrograph of a liver biopsy showing of steatohepatitis showing balloon degeneration of hepatocytes, a form of apoptosis (Photo courtesy of Nephron).

Image Analysis System Quantifies NASH Disease Activity

Non-alcoholic steatohepatitis (NASH) is the progressive form of non-alcoholic fatty liver disease (NAFLD), in which excessive fat accumulates in the liver of individuals who do not have a history of alcohol abuse. More...
25 Apr 2018
Image: A diagram of a normal heart compared to hypertrophic cardiomyopathy (Photo courtesy of the Mayo Clinic).

Genetic Variant Identified As Better Marker for CV Disease

A newly identified subset of a known genetic variant found primarily in individuals of South Asian descent may be a better marker for carriers of heart dysfunction in this population and that individuals with this genetic variant are more likely to develop early signs of hypertrophic cardiomyopathy. More...
24 Apr 2018
Image: Determination of the amyloid‐beta (Aβ) secondary structure distribution in blood plasma by an immuno‐IR‐sensor correlates with PET scanning and CSF markers in Alzheimer\'s disease (AD) patients, with potentials to be an accurate, simple, and minimally invasive biomarker for early AD detection (Photo courtesy of Ruhr University Bochum).

Amyloid Blood Biomarker Detects Alzheimer's Disease

There is, as yet, no cure for Alzheimer's disease. It is often argued that progress in drug research has been hampered by the fact that the disease can only be diagnosed when it is too late for an effective intervention. Alzheimer's disease is thought to begin long before patients show typical symptoms like memory loss. More...
17 Apr 2018
Image: The Vivascope 2500 confocal scanning microscopic view of lymph node metastases from thyroid carcinoma are papillary structures made up of scanty bright spots floating in a dark background (left) (Photo courtesy of IRCSS Santa Maria Nuova Hospital).

Confocal Fluorescence Microscopy Used for Rapid Tissue Evaluation

Optical imaging techniques are currently available for imaging tissues without the need for any type of extensive tissue preparation. There are several applications for their potential use in surgical pathology practice. More...
16 Apr 2018
Image: The use of the WATS3D biopsy is an adjunct to forceps biopsy, identified a patient with abnormality in the esophagus (Photo courtesy of CDx Diagnostics).

Sampling Device Increases Detection of Barrett’s Esophagus

Esophageal adenocarcinoma, one of the most fatal and fastest growing cancers in the USA, can be prevented if detected at a precancerous stage. In Barrett’s esophagus (BE), esophageal squamous mucosa is replaced by metaplastic columnar mucosa predisposed to developing esophageal adenocarcinoma (EAC). More...
12 Apr 2018
Image: The GloMax Discover multimode microplate reader (Photo courtesy of Promega).

Aggressive Meningioma Linked to Transcription Factor Activity

Meningioma, a cancer of the cerebral and spinal meninges, is the most common primary CNS tumor in the USA. Meningioma is the most common primary intracranial tumor, but the molecular drivers of aggressive meningioma are incompletely understood. More...
12 Apr 2018
Image: The Ion Personal Genome Machine (PGM) System combines semiconductor sequencing technology with natural biochemistry to directly translate chemical information into digital data (Photo courtesy of Thermo Fisher Scientific).

Gut Microbiome Analysis Predicts Hospitalizations in Cirrhosis

Cirrhosis is a leading cause of mortality and healthcare expenditure due to hospitalizations worldwide. Bacterial products such as endotoxin play a key role in the development of a proinflammatory milieu and disease progression in cirrhosis. More...
11 Apr 2018

The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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