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Direct Effect Media/Illumina

Pathology

Image: A scanning electron micrograph (SEM) of a prostate cancer cell captured on frosted slide with silica nanowires (Photo courtesy of the American Chemical Society).

Biochip Developed to Detect Prostate Cancer Cells

In men with prostate cancer, some tumor cells exit the prostate gland and circulate in the blood. Detecting these cells could enable diagnosis at an earlier stage or help doctors assess whether treatment is effective. More...
20 Jun 2018
Image: Mycobacterium chimaera colonies growing on agar; the infections can cause serious injury, including pneumonia and death. Of particular concern is that patients infected with M. chimaera may not develop symptoms and signs of infection for months to years after initial exposure, making the infections difficult to detect and diagnose (Photo courtesy of the CDC).

Post-Cardiac Surgery Infection Associated with Different Diseases

Mycobacterium chimaera infection following cardiac surgery, due to contaminated cardiopulmonary bypass heater-cooler units (HCUs), has been reported worldwide. However, the spectrum of clinical disease remains poorly understood. More...
19 Jun 2018
Image: An endometrial carcinoma showing loss of nuclear expression of MSH2. The lymphocytes and stromal cells should stain positive and represent an internal positive control (Photo courtesy of Memorial Sloan Kettering Cancer Center).

MSI Tumor Analysis Implicates Lynch Syndrome in Cancer Types

A new pan-cancer analysis suggests that there may be a benefit to doing germline testing for Lynch syndrome in advanced cancer patients who have high microsatellite instability (MSI) in their tumors. More...
19 Jun 2018
Image: Testosterone/estradiol ratio and the risk of cardiovascular disease, coronary heart disease and heart failure (HF) in post-menopausal women (Photo courtesy of Johns Hopkins Medicine).

Hormone Levels Alter CVD Risk in Older Women

Higher androgen and lower estrogen levels are associated with cardiovascular disease (CVD) risk factors in women; however, studies on sex hormones and incident CVD events in women have yielded conflicting results. More...
13 Jun 2018
Image: A photomicrograph of breast cancer cells in purple surrounded by healthy tissue in pink (Photo courtesy of US National Institute of Health).

Hereditary Breast Cancer Tests Double Detection Rate

Germline genetic testing in patients newly diagnosed with cancer has the potential to reduce disease burden through secondary prevention and targeted therapies. There is a prerequisite to understand how genetic testing is being integrated into practice for patients newly diagnosed with cancer and the impact of results on treatment decisions. More...
23 May 2018
Image: Six genes have been identified that predispose carriers to develop the brain tumor medulloblastoma (Photo courtesy of St. Jude Children\'s Research Hospital).

Genetic Predisposition Validated in Medulloblastoma

Medulloblastoma is a rare malignant tumor of the brain and occurs predominantly in children and is associated with rare hereditary cancer predisposition syndromes. It is believed that in many cases hereditary gene defects trigger the development of this malignant disease. More...
22 May 2018
Image: The MSI Analysis System, Version 1.2, is a fluorescent multiplex PCR-based method to detect microsatellite instability (MSI), a form of genomic instability (Photo courtesy of Promega).

Molecular Subtype Identified for CRCs Metastasized to Liver

Metastases are the leading cause of cancer-related deaths and frequently are widely disseminated, which has led to the prevailing view that metastases are always widespread. More...
17 May 2018

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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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