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Pathology

Image: A color hereditary cancer risk screening kit (Photo courtesy of Color Genomics).

Pathogenic Variant Carriers Missed by Current Genetic Testing

Current guidelines recommend genetic testing for people who have a personal or family history of cancer that indicates they might be at an increased risk of harboring a pathogenic familial variant, but this approach could miss people who lack any personal or family history. More...
27 Jun 2019
Image: Identifying a metastatic colorectal cancer patient’s Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment (Photo courtesy of University of Southern California).

Identifying Colorectal Cancer Subtypes Improves Treatment Decisions

Colorectal cancer is the second leading cause of cancer death in the USA, and is expected to cause about 51,000 deaths in 2019, but until now, it was unclear which drugs were most effective for which patients. More...
25 Jun 2019
The handheld MasSpec Pen device which can be connected to a Mass Spectrometer for diagnosing ovarian and other cancers (Photo courtesy of the University of Texas at Austin).

Masspec Pen Evaluated for Rapid Diagnosis of Cancer

 Ovarian cancer is a highly lethal disease and the fifth leading cause of all cancer-related deaths in women. Accurate diagnosis and stratification of ovarian cancer is important to develop personalized treatment approaches. More...
20 Jun 2019
A histopathology of pancreatic ductal adenocarcinoma, a gland-forming cancer. In this example, the adenocarcinoma has wrapped around a nerve (center of the image) (Photo courtesy of JHM).

Novel Methylated DNA Markers Assay Detects Cancer

 An estimated 56,770 people will be diagnosed with pancreatic cancer in the U.S. in 2019, and more than 45,750 will die from the disease. Pancreatic cancer is the third leading cause of cancer-related deaths in the U.S. and is expected to become the second leading cause by 2020. More...
20 Jun 2019
Breast cancer cells invading through a layer of fibroblasts. Hormone receptor-positive breast cancer has been found to spread faster when the microbiome is disrupted (Photo courtesy of Institute of Cancer Research).

Unhealthy Gut Promotes Spread of Breast Cancer

 Most breast cancers, 65% or more, are hormone receptor positive. That means their growth is fueled by a hormone, either estrogen or progesterone. The good news is that these types of cancers are likely to respond well to hormone therapy. More...
18 Jun 2019
The Fecal Swab Collection and Preservation System fecal collection kit (Photo courtesy of Norgen Biotek).

Rare Gut Bacteria Linked to Restless Legs Syndrome

 One common sleep disorder in which the microbiome may play a role is restless legs syndrome (RLS). While the pathogenesis of RLS is not fully understood, a relative state of brain iron deficiency has been described in patients with RLS and appears to induce changes in several pathways known to be involved in the disease. More...
18 Jun 2019
Image: The nCounter Max analysis system (Photo courtesy of NanoString Technologies).

Custom NanoString Assay Detects Bowel Cancer Subtypes

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. The median overall survival of metastatic (m)CRC patients with unresectable disease remains around 24 months with standard chemotherapies. More...
13 Jun 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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