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Image: Photomicrograph of histology of pancreatic neuroendocrine tumor (Photo courtesy of Nephron)

Novel Surrogate Marker Described for Pancreatic Neuroendocrine Tumors

Tumors of the endocrine pancreas are a collection of tumor cell types collectively referred to as PanNETs. These tumors originate in islet cells. Although they may be similar or identical in histologic appearance to carcinoid tumors of the gastrointestinal tract, differences in their underlying biology and likely differences in response to therapeutic agents suggest that they should be treated and investigated as a distinct entity. More...
19 May 2022
Image: a) Schematic of Tear Collection using Schirmer strip before being analyzed by LC-MS/MS and validated by ELISA. b) Functional classification of 301 mapped proteins in tear samples using PANTHER classification system (Photograph courtesy of Namida Lab)

Tear-Based Method Detects Breast Cancer

With advances in screening techniques, and adjustment of recommended screening guidelines, mortality rates due to breast cancer continue to decline. Despite the estimated waning in mortality rates, breast cancer still remains the highest cancer diagnosis of women globally. More...
11 May 2022
Image: The Vectra 3 System for Quantitative Pathology Imaging (Photo courtesy of PerkinElmer)

Immunohistochemistry Biomarkers Used to Subtype Gastric Intestinal Metaplasia

Gastric cancer (GC) is the fifth most common and third most lethal cancer globally. Patients with GC are often asymptomatic, with presentation occurring at advanced stage, and a low 5-year survival rate in most countries. Intestinal metaplasia is considered a key pivot point in the Correa model of GC. More...
04 May 2022
Image: HistoCore PEGASUS Plus Tissue Processor (Photo courtesy of Leica Biosystems)

Leica Biosystems Launches HistoCore PEGASUS Plus Dual-Retort Tissue Processor in Europe

Leica Biosystems (Nussloch, Germany) has launched a compact, dual-retort tissue processor, the HistoCore PEGASUS Plus. For the first time, the technology will now be available to medium-sized laboratories, enabling them to optimize histopathology workflows. More...
04 May 2022
Image: MinION sequencing device was used on three novel species for hybrid assembly (Photo courtesy of Oxford Nanopore Technologies)

Urinary Microbiome Linked to Prostate Cancer Risk

Prostate cancer is the most common non-skin malignancy in men in developed countries, with over 250,000 deaths annually worldwide. The clinical course of prostate cancer is highly heterogeneous, and critical decisions are made about the likelihood of aggressive disease based on information obtained at presentation. More...
02 May 2022
Image: Lunit SCOPE PD-L1 (Photo courtesy of Lunit)

Lunit AI-Powered Pathology Solution Aids Highly Accurate Cancer Diagnosis

Programmed death ligand 1 (PD-L1) expression is the standard biomarker in advanced non-small cell lung cancer (NSCLC). However, manual evaluation of PD-L1 tumor proportion score (TPS) by pathologists has practical limitations of interobserver bias, variation in subjectivity on the area of interest, and intensive labor. Now, a new artificial intelligence (AI)-powered TPS analyzer could reduce the human discrepancy. More...
28 Apr 2022
Image: PathScan Enabler IV Histology/Pathology Digital Slide Scanner (Photo courtesy of Meyer Instruments)

Immunohistochemistry-Guided Sequencing Finds Mutations in Most Cortisol-Producing Adenomas

Cushing syndrome (CS) represents a constellation of signs and symptoms associated with chronic and excessive exposure to glucocorticoids, from either endogenous endocrinopathies or, more commonly, from exogenous pharmacologic sources. More...
27 Apr 2022

The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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