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Pathology

Image: Photomicrograph of histopathology of Barrett`s esophagus showing the characteristic goblet cells (Alcian blue stain) (Photo courtesy of Nephron).

Genomic Copy Number Predicts Esophageal Cancer Years Before Transformation

Barrett’s esophagus is a condition in which the lining of the esophagus changes, becoming more like the lining of the small intestine rather than the esophagus. This occurs in the area where the esophagus is joined to the stomach. More...
23 Sep 2020
Image: The Guardant360 tests 74 genes in a blood sample to identify the presence of spot tumor mutations, reordering, insertions and deletions (indels), as well as microsatellite instability (Photo courtesy of MygeneLab).

Circulating Tumor DNA Analysis Directs Therapy in Breast Cancer

Multiple tumor mutations are potentially targetable for advanced breast cancer treatment. Some of these mutations are common, such as activating PIK3CA mutations that are targetable with PI3K inhibitors. More...
22 Sep 2020
Image: Gut Microbiome Data Helps Routine Screening of Cardiovascular Disease (Photo courtesy of Nishant Mehta PhD).

Gut Microbiome Data Helps Routine Screening of Cardiovascular Disease

Besides genetics and environmental factors, gut microbiota has emerged as a new factor influencing cardiovascular disease (CVD). Although cause-effect relationships are not clearly established, the reported associations between alterations in gut microbiota and CVD are prominent. More...
22 Sep 2020
Image: Histopathology of the coronary artery demonstrating an intramural hematoma compressing the vessel lumen from outside from a patient with spontaneous coronary artery dissection (Photo courtesy of Professor Mary N Sheppard, MBBCh FRCPath).

Genetics Influence Risk for Spontaneous Coronary Artery Dissection

Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of myocardial infarction (MI) in young and otherwise healthy women, for which the etiology is incompletely understood. More...
14 Sep 2020
Image: Newborn Exome Sequencing Could Augment Other Newborn Screening Approaches (Photo courtesy of Sushytska).

Sequencing Could Augment Other Newborn Screening Methods

Newborn screening (NBS) was established as a public health program in the 1960s and is crucial for facilitating detection of certain medical conditions in which early intervention can prevent serious, life-threatening health problems. More...
14 Sep 2020
Image: Schematic diagram of fetal and maternal DNA as studied in the detection and characterization of jagged ends of double-stranded DNA in plasma (Photo courtesy of Ariosa Diagnostics).

Jagged Ends of Double-Stranded DNA Characterized

Cell-free DNA in plasma has been used for noninvasive prenatal testing and cancer liquid biopsy. The physical properties of cell-free DNA fragments in plasma, such as fragment sizes and ends, have attracted considerable recent interest. More...
10 Sep 2020
Image: The Bio-Plex Luminex 200 instrument is a suspension array system which offers protein and nucleic acid scientists a reliable multiplex assay solution that permits analysis of up to 100 biomolecules in a single sample (Photo courtesy of Bio-Rad Laboratories).

Diabetes Blood Markers Linked to Alzheimer’s Disease Pathology

Alzheimer's is a progressive disease, where dementia symptoms gradually worsen over a number of years. In its early stages, memory loss is mild, but late-stage Alzheimer's, individuals lose the ability to carry on a conversation and respond to their environment. More...
09 Sep 2020


The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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