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Clinical Chemistry

Image: The Minicare I-20 handheld diagnostics platform is designed to detect multiple target molecules at very low concentrations in a single ‘finger-prick’ blood sample, and display the results on a handheld analyzer within minutes (Photo courtesy of Philips Healthcare).

B-Type Natriuretic Peptide Sandwich Immunoassay Evaluated

The measurement of circulating natriuretic peptides (NP) is considered to be a useful marker of myocardial function, and international guidelines recommend its use for the diagnosis of patients with heart failure (HF), and in particular ruling out the presence of HF. More...
23 Apr 2019
Image: A blood test for high‐density lipoprotein that may indicate adverse renal outcomes for patients with chronic kidney disease (Photo courtesy of Drs. Wolfson).

HDL‐C Levels Associated with Harmful CKD Progression

Serum high‐density lipoprotein (HDL) has traditionally been considered to be protective against cardiovascular disease in the general population. HDL exerts an antiatherogenic effect through reverse cholesterol transport, a multiorgan process that removes excess cholesterol from lipid‐laden macrophages and peripheral tissue. More...
17 Apr 2019
Image: The Automatic QC RAPID Systems RAPIDPoint 500 blood gas analyzer (Photo courtesy of Siemens Healthcare).

Capillary and Venous Lactate Compared in ED Patients

Elevated lactate levels are a common finding in acutely unwell patients. Blood lactate level is a good predictor of patient outcome and high lactate levels are associated with high morbidity and mortality. Lactate may be detected and measured in all blood samples: arterial, venous and capillary. More...
16 Apr 2019
Image: The AfinionHbA1c assay cartridge is used to test for quantitative determination of glycated hemoglobin (HbA1c) in human whole blood, which is used to monitor metabolic control in patients with diabetes (Photo courtesy of Alere).

HbA1c Point-of-Care Test Reliably Diagnoses Diabetes

Glycated hemoglobin is a form of hemoglobin that is covalently bound to glucose. It is formed in a non-enzymatic glycation pathway by hemoglobin's exposure to plasma glucose. More...
11 Apr 2019
Image: The DS2 ELISA Automation System (Photo courtesy of Dynex Technologies).

Storage Conditions Affect Urinary Albumin and Creatinine

Moderately increased urinary albumin excretion, formerly known as microalbuminuria, has been established as a risk factor for diabetic kidney disease. Increasing albumin to creatinine ratio (ACR) within the normal range is a risk factor for cardiovascular disease in the general population. More...
09 Apr 2019
Image: The diagram shows how sPLA2-IIA binding to anionic phospholipids leads to its activation and promotes inflammation. The oxidation of the phospholipids produces stress, which causes the anionic phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) to be transported to the outer leaflet. This reaction activates cationic sPLA2-IIA. The higher activity of sPLA2-IIA promotes the hydrolysis of the outer leaflet phospholipids into arachidonic acid and lysophospholipids. Through the cyclooxygenase and 5-lipoxygenase enzymes, arachidonic acid is converted into prostaglandins, leukotrienes, and other inflammatory eicosanoids (Photo courtesy of Randox).

New Automated Assay Measures Levels of sPLA2-IIA

Phospholipase A2 (PLA2s) are a family of enzymes that cleave the fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glycerol molecule. More...
08 Apr 2019
Image: The Architect I2000sr immunoassay (Photo courtesy of Abbott).

C-Peptide Test Essential after Type 1 Diabetes Diagnosis

C-peptide testing a few years after a diagnosis of type 1 diabetes should be a routine procedure as it can help pinpoint occasional patients who have been misdiagnosed and actually have type 2 diabetes or a monogenic form of the disease. More...
03 Apr 2019

The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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