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Clinical Chemistry

Image: The BC-5390CRP blood cell analyzer (Photo courtesy of Mindray).

Potential Biomarkers Found for Acute Aortic Dissection

An aortic dissection is a serious condition in which the inner layer of the aorta, the large blood vessel branching off the heart, tears. Blood surges through the tear, causing the inner and middle layers of the aorta to separate (dissect). More...
10 Dec 2018
Image: Neuropathy is the damage of peripheral nerves; pain and loss of sensation in the extremities and can be caused by diabetes (Photo courtesy of Alnoor Ladhani).

Routine Vitamin B12 Screening May Prevent Irreversible Nerve Damage

The increasing incidence of type-2 diabetes is a serious health issue worldwide. Its prevalence is associated with poor diet and unhealthy lifestyle choices, and it is characterized by high blood glucose levels that need to be controlled by medication. More...
05 Dec 2018
Image: The ARCHITECT B.R.A.H.M.S PCT assay, which is a two-step immunoassay using chemiluminescent microparticle immunoassay (CMIA) technology (Photo courtesy of Abbott Laboratories).

Commercial Fully Automated Procalcitonin Immunoassay Compared

Procalcitonin (PCT), a 13-kDa peptide precursor of calcitonin, has gained widespread acceptance as an early and specific biomarker for the presence of systemic bacterial infection. In particular, PCT monitoring has demonstrated value in guiding antibiotic use for bacterial infections. More...
04 Dec 2018
Image: The FLEXMAP 3D instrument is an advanced and versatile multiplexing platform. The platform uses both magnetic and non-magnetic microspheres and is capable of simultaneously measuring up to 500 genes or proteins from a small sample (Photo courtesy of Luminex).

Plasma Human Proteins Associated with Acute Pediatric Malaria

Severe malaria caused by Plasmodium falciparum continues to be one of the leading infectious causes of morbidity and mortality in children worldwide. The intimate interaction between the pathophysiology of the human host and the biology of the P. falciparum parasite results in a wide spectrum of disease outcomes in malaria. More...
27 Nov 2018
Image: Q Exactive hybrid quadrupole-Orbitrap mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Proteins Used for Diagnosing ALS

Proteins have been identified that may be useful in both earlier diagnosis of Amyotrophic Lateral Sclerosis (ALS) and in more accurate disease prognosis. ALS, often referred to as Lou Gehrig's disease, is a progressive, neurodegenerative disease that affects the brain and spinal cord. Currently, there is no effective treatment or cure. More...
20 Nov 2018
Image: The AB Sciex QTRAP 5500 triple quadrupole mass spectrometer (Photo courtesy of Sciex).

Chromaffin Cell Tumors Diagnosed by Plasma Panel

Pheochromocytomas and paragangliomas include adrenal and extraadrenal chromaffin cell tumors as well as head and neck paragangliomas and measurements of plasma or urinary metanephrines are recommended for diagnosis of pheochromocytoma and paraganglioma (PPGL). More...
19 Nov 2018
Image: The automatic immunoassay analyzer / chemiluminescence ARCHITECT i1000SR (Photo courtesy of Abbott Diagnostics).

Cardiac Troponin Assays Compared in Large Cohort

High-sensitivity (hs) assays for the measurement of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are now used widely for the diagnosis of myocardial infarction. The universal definition of myocardial infarction recommends the 99th centile derived from a normal reference population be used to define myocardial necrosis. More...
19 Nov 2018

The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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