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Clinical Chemistry

Image: Photomicrograph of a hematoxylin-eosin-stained human lung tissue specimen, harvested from a pulmonary aspergillosis patient. The histopathologic changes indicate the presence of Aspergillus sp. fungal organisms. Note the branching hyphae amongst the lung tissue (Photo courtesy of the Armed Forces Institute of Pathology).

Routine Blood Parameters Predict Invasive Aspergillosis Prognosis

Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems, e.g. those undergoing bone marrow transplantation. Symptoms include fever, chills, shock, delirium, seizures, and blood clots. More...
19 Nov 2019
Image: A blood film showing neutrophils and lymphocytes and other white and red blood cells, and a platelet (Photo courtesy of University of Minnesota).

Hematological Ratios Associated with Mortality in Pediatric Trauma Patients

Trauma-related injury as a potential cause of death affects millions of people worldwide, especially in less developed countries and furthermore, it is the leading cause of mortality in pediatric trauma patients. More...
14 Nov 2019
Image: Diabetes and higher HbA1c levels are independently associated with adverse renal outcomes in inpatients following multiple hospital admissions (Photo courtesy of Anitha Anchan).

Increased HbA1c Identifies Rapid Kidney Function Deterioration in Diabetics

Among adults with multiple hospital admissions, those with type 2 diabetes were more likely to have worsening renal function compared with those without diabetes. The association between glycemic status prior to the first hospital presentation with developing adverse renal outcomes overtime in patients with multiple hospital re-admissions has been assessed. More...
13 Nov 2019
Image: The Elecsys Troponin T-high sensitive (TnT-hs) assay can reduce the time needed to rule-in or rule-out non-ST segment elevation myocardial infarction (NSTEMI) to as little as just one hour (Photo courtesy of Roche).

Cardiac Biomarkers Identify High-Risk Kidney Disease Patients

Cardiovascular disease (CVD) claims more lives in people with chronic kidney disease (CKD) than complications of kidney disease and this can be explained in part by shared common risk factors including hypertension, diabetes, hyperlipidemia, smoking, and obesity. More...
12 Nov 2019
Image: Histopathology of prostate cancer: crystalloids (bright eosinophilic rhomboid to prismatic structures, seen in ~40% cancer) and amorphous eosinophilic secretions (Photo courtesy the American Urological Association).

High Levels of Blood Hormones Raise Prostate Cancer Risk

Men with higher levels of 'free' testosterone and a growth hormone in their blood are more likely to be diagnosed with prostate cancer. Other factors such as older age, ethnicity and a family history of the disease are already known to increase a man's risk of developing prostate cancer. More...
11 Nov 2019
Image: Preeclampsia is a pregnancy complication marked primarily by high blood pressure and organ damage. The diagnostic values of STAT4 and sEng in preeclampsia have been analyzed (Photo courtesy of Johns Hopkins University).

Diagnostic Values of Serum STAT4 and sEng Analyzed in Preeclampsia

Preeclampsia is a pregnancy complication characterized by high blood pressure and signs of damage to another organ system, most often the liver and kidneys. Preeclampsia usually begins after 20 weeks of pregnancy in women whose blood pressure had been normal. More...
06 Nov 2019
Image: The LIAISON 25 OH Vitamin D TOTAL Assay is a fully automated assay measuring both D2 and D3 for a total result (Photo courtesy of Diasorin).

Vitamin D Deficiency Associated with Impaired Muscle Strength

Maintaining muscle mass and function throughout life is a crucial component of successful ageing. The progressive loss of skeletal muscle mass, accompanied by a loss of muscle strength or performance, in aging, is a feature of primary sarcopenia. More...
05 Nov 2019


The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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