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Clinical Chemistry

Image: The High Mobility Group Box protein 1 (HMGB1) quantitative enzyme-linked immunosorbent assay kit (Photo courtesy of Shino-Test Corporation).

Serum HMGB1 Levels Reflect Clinical Features of HLH

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome. Hypercytokinemia secreted from dysregulated hyperactivated monocytes, macrophages, T cells and NK cells has been reported to play a major role in HLH. More...
17 Sep 2019
Image: Men who are obese may be at increased risk for developing hypoandrogenemia or low free testosterone, especially if they have more severe obesity (Photo courtesy of iStock).

Increased Risk of Hypoandrogenemia Found in Obese Young Men

Hyperandrogenism is a medical condition characterized by high levels of androgens in females, but men with obesity may be at increased risk for developing hypoandrogenemia or low free testosterone, especially if they have more severe obesity. More...
12 Sep 2019
Image: The i-STAT Alinity system integrates with-patient testing directly into the patient-care pathway, accelerating time to treatment, improving quality and increasing access to care (Photo courtesy of Abbott).

New Blood Test Helps Detect Brain Injury in Minutes

After traumatic brain injury (TBI), plasma concentration of glial fibrillary acidic protein (GFAP) correlates with intracranial injury visible on computerized axial tomography (CT) scan. Some patients with suspected TBI with normal CT findings show pathology on magnetic resonance imaging (MRI). More...
11 Sep 2019
Image: A new study suggests patients with gout are at elevated risk for chronic kidney disease (Photo courtesy of Shutterstock).

Gout Increases Risk of Advanced Chronic Kidney Disease

Chronic kidney disease (CKD) is a major public health epidemic, with at least 1 in 10 individuals having some degree of kidney impairment, contributing substantially to adverse clinical and economic outcomes. More...
11 Sep 2019
Image: A major new study on the association between blood glucose levels, including HbA1c, and risks of organ impairment in people with type 1 diabetes can make a vital contribution to diabetes care (Photo courtesy of HealthEngine).

Blood Sugar Levels Affect Risks in Type 1 Diabetes

Type 1 diabetes is the predominant form of diabetes diagnosed in childhood and is characterized by increased blood glucose levels resulting from insulin deficiency. More...
11 Sep 2019
Image: Preeclampsia is a condition that occurs only during pregnancy and some symptoms may include high blood pressure and protein in the urine. A specific phenotype narrows the risk of preeclampsia (Photo courtesy of the American Pregnancy Association).

Specific Phenotype Narrows Risk of Preeclampsia

Preeclampsia can lead to a baby being born early and can put the mother at risk of a seizure or stroke during delivery. It can also lead to damage in the kidneys, liver, lungs, heart or eyes and can increase a patient's risk for cardiovascular disease in the future. More...
10 Sep 2019
Image: The Elecsys Troponin T Gen 5 STAT assay (Photo courtesy of Roche Diagnostics).

Analytical Performance Evaluated for Troponin T Gen 5 Assay

Increased blood concentrations of cardiac troponin (cTn) I and T are indicative of myocardial injury and are the preferred biomarkers for diagnosing acute myocardial infarction (AMI). The diagnosis of AMI requires a rise and/or fall in serial cTn measurements, in addition to other clinical features. More...
05 Sep 2019


The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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