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Clinical Chemistry

Image: Higher levels of the inflammatory biomarker soluble tumor necrosis factor receptor-1 (sTNFR-1) are tied to kidney decline in healthy adults (Photo courtesy of Enbrel).

Kidney Function Decline Linked with Inflammatory Marker Levels

Tumor necrosis factor receptor-1 (TNFR-1), which plays a causative role in endothelial cell dysfunction and inflammation, is expressed on the cell surface in glomerular and peritubular capillary endothelium of the kidneys. More...
15 Oct 2018
Image: An albumin immunoturbidimetric assay urine or serum plasma; standard microalbumin range is 0.4-500mg/L (Photo courtesy of Sentinel Diagnostics).

Kidney Disease Biomarker May Indicate Lung Problems

Chronic lower respiratory diseases (CLRD) are the fourth leading cause-of-death and a major source of health care costs. CLRD includes chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, and asthma, airflow limitation as a physiologic correlate, and acute exacerbations as the major clinical manifestation. More...
09 Oct 2018
Image: The QTRAP 6500 Q-Trap mass spectrometer (MS) (Photo courtesy of Sciex).

Collection Tubes Influence Targeted Metabolomics Studies

Plasma and serum are the most widely used matrices in clinical studies. However, some variability in absolute concentrations of metabolites are likely to be observed in these collection tubes matrices. More...
08 Oct 2018
Image: An illustration of early cardiac troponin kinetics in patients after acute myocardial injury including acute myocardial infarction (Photo courtesy of ESC Scientific Document Group).

Blood Tests Differentiate Myocardial Injury from Infarction

Myocardial infarction represents the death of myocardial cells and is characterized by acute myocardial ischemia. Nonischemic myocardial injury by comparison is often associated with other conditions such as renal failure or heart conditions like myocarditis. More...
03 Oct 2018
Image: A pregnant woman undergoing a blood test for gestational diabetes (Photo courtesy of US National Institute of Diabetes and Digestive and Kidney Diseases).

High Blood Sugar During Pregnancy Increases Risk of Diabetes

Mothers with elevated blood glucose during pregnancy, even if not high enough to meet the traditional definition of gestational diabetes, were significantly more likely to have developed type 2 diabetes a decade after pregnancy than their counterparts without high blood glucose. More...
02 Oct 2018
Image: CT45, a biomarker marker found in some ovarian cancer cells, is associated with extended disease-free survival for women with advanced ovarian cancer (Photo courtesy of University of Chicago Medical Center).

Ovarian Cancer Biomarker Predicts Therapy Response

Despite months of aggressive treatment involving surgery and chemotherapy, about 85% of women with high-grade widespread ovarian cancer will have a recurrence of their disease. This leads to further treatment, but never to a cure. About 15% of patients, however, do not have a recurrence and most of those women remain disease free for years. More...
01 Oct 2018
Image: The Aperio Scanscope XT slide scanner (Photo courtesy of University of New South Wales).

Nano-LCMS Differentiates Liver Diseases

Non-alcoholic steatohepatitis (NASH) is among the leading causes of liver disease worldwide. It is increasingly recognized that the phenotype of NASH may involve a number of different pathways, of which each could become important therapeutic targets. More...
24 Sep 2018


The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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