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Clinical Chemistry

Image: The new ClinSpec Diagnostics’ test can diagnose brain cancer from a blood sample (Photo courtesy of University of Strathclyde).

Chemical Analysis of Blood Samples Diagnoses Brain Tumors

 Brain tumors tend to have ambiguous symptoms, such as headache or memory problems, and a brain scan is currently the only reliable way of diagnosing them. In recent years, the use of infrared (IR) spectroscopy to analyze disease state in biofluids has been largely employed with promising results. More...
21 Nov 2019
Image: The nano-plasmonic exosome (nPLEX) sensor (Photo courtesy of Massachusetts General Hospital).

Novel Nanosensing Technologies Developed for Exosome Detection and Profiling

Exosomes are extracellular vesicles (EVs) that are produced in the endosomal compartment of most eukaryotic cells. Liquid biopsy technologies have been developed to do high-throughput exosome protein profiling and point-of-care (POC) exosome analysis. More...
20 Nov 2019
Image: Photomicrograph of a hematoxylin-eosin-stained human lung tissue specimen, harvested from a pulmonary aspergillosis patient. The histopathologic changes indicate the presence of Aspergillus sp. fungal organisms. Note the branching hyphae amongst the lung tissue (Photo courtesy of the Armed Forces Institute of Pathology).

Routine Blood Parameters Predict Invasive Aspergillosis Prognosis

Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems, e.g. those undergoing bone marrow transplantation. Symptoms include fever, chills, shock, delirium, seizures, and blood clots. More...
19 Nov 2019
Image: A blood film showing neutrophils and lymphocytes and other white and red blood cells, and a platelet (Photo courtesy of University of Minnesota).

Hematological Ratios Associated with Mortality in Pediatric Trauma Patients

Trauma-related injury as a potential cause of death affects millions of people worldwide, especially in less developed countries and furthermore, it is the leading cause of mortality in pediatric trauma patients. More...
14 Nov 2019
Image: Diabetes and higher HbA1c levels are independently associated with adverse renal outcomes in inpatients following multiple hospital admissions (Photo courtesy of Anitha Anchan).

Increased HbA1c Identifies Rapid Kidney Function Deterioration in Diabetics

Among adults with multiple hospital admissions, those with type 2 diabetes were more likely to have worsening renal function compared with those without diabetes. The association between glycemic status prior to the first hospital presentation with developing adverse renal outcomes overtime in patients with multiple hospital re-admissions has been assessed. More...
13 Nov 2019
Image: The Elecsys Troponin T-high sensitive (TnT-hs) assay can reduce the time needed to rule-in or rule-out non-ST segment elevation myocardial infarction (NSTEMI) to as little as just one hour (Photo courtesy of Roche).

Cardiac Biomarkers Identify High-Risk Kidney Disease Patients

Cardiovascular disease (CVD) claims more lives in people with chronic kidney disease (CKD) than complications of kidney disease and this can be explained in part by shared common risk factors including hypertension, diabetes, hyperlipidemia, smoking, and obesity. More...
12 Nov 2019
Image: Histopathology of prostate cancer: crystalloids (bright eosinophilic rhomboid to prismatic structures, seen in ~40% cancer) and amorphous eosinophilic secretions (Photo courtesy the American Urological Association).

High Levels of Blood Hormones Raise Prostate Cancer Risk

Men with higher levels of 'free' testosterone and a growth hormone in their blood are more likely to be diagnosed with prostate cancer. Other factors such as older age, ethnicity and a family history of the disease are already known to increase a man's risk of developing prostate cancer. More...
11 Nov 2019


The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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