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ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
16 Aug 2021 - 26 Aug 2021
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Clinical Chem.

Image: Altered Perivascular Fibroblast Activity Precedes Amyotrophic Lateral Sclerosis Onset (Photo courtesy of Karolinska Institutet)

Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor neurons that eventually causes muscular atrophy, paralysis and death. There is currently no cure. The cause of ALS is only understood in the 5% to 10% of patients who have an inherited form of the disease. More...
28 Apr 2021
Image: The Simoa HD-1 Analyzer (Photo courtesy of Quanterix)

Blood-Based Markers Tied to Brain Cell and Memory Loss

Previous studies have linked elevated levels of plasma total tau and neurofilament light chain (NfL) with worse cognition and neuroimaging measures of cortical thickness, cortical atrophy, white matter hyperintensity, or white matter integrity. More...
27 Apr 2021
Image: The cobas c 701 module is a high throughput clinical chemistry module that performs photometric assay tests for a wide range of analytes (Photo courtesy of Roche Diagnostics)

Serum α-L-Fucosidase Activity Measured for COVID-19 Infection

An unusual fucosylated LacdiNAc in the receptor-binding domains of the spike protein of COVID-19 has been observed. Reduced fucosylation was also found in a specific Fc domain of IgG antibodies in COVID-19 patients that enhanced the interactions with the activating FcγR, FcγRIIIa. More...
22 Apr 2021
Image: The Rayto RT‐6500 microplate reader (Photo courtesy of Rayto Life and Analytical Sciences)

Urinary Heat Shock Protein 70 Evaluated in Chronic Prostatitis

Chronic prostatitis (CP) is a common, but a confusing urological disease that seriously affects men's lives and health and cannot be ignored. The incidence rate is increasing, and the disease is affecting younger men and long‐term prostatitis affects male sexual function. More...
21 Apr 2021
Image: The BreathID Exalenz device (Photo courtesy of Meridian Bioscience)

Breath Test Determines Severity of Methylmalonic Acidemia Disease

Methylmalonic acidemia is a disorder in which the body cannot break down certain proteins and fats. The result is a buildup of a substance called methylmalonic acid in the blood. This condition is passed down through families and is one of several conditions called an "inborn error of metabolism." More...
20 Apr 2021
Image: Lower vitamin D levels are associated with metabolic syndrome and insulin resistance in systemic lupus (Photo courtesy of Nikki Yelton, RD)

Vitamin D Deficiency Linked to Metabolic Changes in Lupus Patients

Systemic lupus erythematosus (SLE), is the most common type of lupus. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. More...
15 Apr 2021
Image: The Phadia 200 instrument is small enough to fit on a benchtop, and yet capable of running the complete menu of more than 700 different ImmunoCAP and EliA tests to aid in the diagnosis of allergy and autoimmune diseases (Photo courtesy of Thermo Fisher Scientific)

Circulating Calprotectin as Biomarker in Neutrophil-Related Inflammation

Calprotectin (CLP) acts as an endogenous ligand of different cell-surface proteins like Toll-like receptor 4 and receptor of advanced glycation end-products facilitating a local proinflammatory effect. CLP is mostly secreted through an active, calcium-dependent Protein Kinase C (PKC) pathway, next to the passive leakage from necrotic cells and release in neutrophil extracellular traps (NET). More...
15 Apr 2021

The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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