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Clinical Chem.

Image: The STANDARD G6PD Test is a low-cost, simple device developed to guide treatment of patients with malaria and support malaria elimination programs (Photo courtesy of SD BIOSENSOR/PATH)

Repeatability and Reproducibility of a Handheld Quantitative G6PD Diagnostic

Novel treatment regimens for the radical cure of P. vivax malaria are more effective than current options but require prior quantitative G6PD testing. The reference method for quantitative G6PD measurement is spectrophotometry but, due to its operational characteristics, is not suitable for routine use. Furthermore, poor inter-laboratory reproducibility of spectrophotometry has prevented quantitative global definitions of G6PD deficiency. SD Biosensor (ROK) have developed a novel handheld “Biosensor” device (G6PD STANDARD), which measures G6PD activity within two minutes and has operational characteristics suited to point of care diagnosis. More...
03 Mar 2022
Image: The Vantera Clinical Analyzer combines nuclear magnetic resonance (NMR) spectroscopic detection and proprietary signal processing algorithms to identify and quantify concentrations of lipoproteins and, potentially, small molecule metabolites (Photo courtesy of Association for Advancing Automation)

Essential Amino Acids Associated With Complications in Liver Transplant Recipients

End stage liver disease is a major cause of morbidity and mortality worldwide and orthotopic liver transplantation (OLTx) is the only curative treatment. However, OLTx leads to its own risks and adverse sequelae. More...
02 Mar 2022
Image: Electroanalytical technique uses gold-containing ternary nanocomposites (Photo courtesy of Unsplash)

Gold Nanoparticle-Based Electrode Marks Breakthrough in Urinalysis Disease Detection Methodology

Using gold-containing ternary nanocomposites, researchers have developed a novel electroanalytical technique with key diagnostic implications. More...
25 Feb 2022
Image: The Orbitrap Fusion Lumos Tribrid Mass Spectrometer is an advanced performance mass spectrometry system that can be upgraded to even higher resolution (1M), additional dissociation capabilities (UVPD and ETD), and a unique internal calibration (IC) (Photo courtesy of Thermo Fisher Scientific)

Biomarker Panel For Risk of Early Respiratory Failure Following Hematopoietic Cell Transplantation

This study identified and validated ST2, WFDC2, IL6 and TNFR1 as risk biomarkers for respiratory failure and related mortality post-HCT. More...
23 Feb 2022
Image: The LIAISON XL is a fully automated chemiluminescence analyzer, performing complete sample processing as well as measurement and evaluation (Photo courtesy of Medical Laboratory Observer)

Calprotectin Fecal Assay Adapted for Serum Samples

Calprotectin is a calcium-binding protein that can be measured in serum, plasma, and feces. Increased serum and plasma calprotectin concentrations have been found in chronic inflammatory rheumatic disorders. An analytical and clinical evaluation of the DiaSorin Liaison® fecal Calprotectin assay using LIAISON® XL was performed. More...
16 Feb 2022
Image: Serum Glucose Identifies Hospitalized Stroke Patients At Greatest Risk For Recurrence (Photo courtesy of Blood Tests London)

Serum Glucose Identifies Hospitalized Stroke Patients at Greatest Risk for Recurrence

Presence of hyperglycemia at hospital admission for stroke was linked with elevated risk for subsequent stroke by 90 days, an increase that dual antiplatelet therapy seemingly failed to curtail. More...
14 Feb 2022
Image: The Simoa HD-1 Analyzer was used for measuring plasma biomarkers of dementia (Photo courtesy of Quanterix)

Blood Biomarkers May Distinguish Dementia Disorders

Clinical diagnostics and clinical trials will benefit from scalable non-invasive biomarkers moving beyond positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) analysis to blood based assays. More...
09 Feb 2022

The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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