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Image: Methods of extracting features from label-free immune cell analysis. Multivariate label-free data, composed of both morphological and spectral parameters, are used to identify high-level features at the single-cell level such as cellular type, response to drugs, as well as response differences between specimens (Photo courtesy of Osaka University)

Non-Invasive Microscopy Detects Activation and Distinguishes Cell Types

Measurement techniques that allow the global analysis of cellular responses while retaining single-cell sensitivity are increasingly needed in order to understand complex and dynamic biological processes. Read more
04 Dec 2019 | Lab Tech.
Image: A new type of microscope has been developed that uses a bowl studded with LED lights of various colors and lighting schemes produced by machine learning (Photo courtesy of Duke University)

Optimized Microscope Hardware Developed for Accurate Image Classification

Despite the widespread automation enabled by new post-processing software, the physical layout of the standard microscope has still changed relatively little as it is, for the most part, still optimized for a human viewer to peer through and inspect what is placed beneath. Read more
03 Dec 2019 | Lab Tech.
Image: The Luminex 100/200 System is a clinical diagnostics instrument that allows multiplexing of up to 100 analytes in a single well of a microtiter plate (Photo courtesy of Luminex Corporation)

New Blood Test Marks Progress in Battle Against Sepsis

Sepsis is a serious condition in which the immune system launches an overwhelming response to infection. Read more
03 Dec 2019 | Pathology
Image: Researchers introduced the first electrochemical CRISPR-based biosensor to help improve disease diagnostics (Photo courtesy of Richard Bruch, University of Freiburg)

CRISPR-based Electrochemical Biosensor Detects Disease-related MicroRNAs

A microfluidic chip containing a CRISPR/Cas-based electrochemical biosensor has been introduced as a device for the rapid and precise analysis of the microRNAs involved in various disease states. Read more
03 Dec 2019 | Molecular Diagnostics
Image: False color SEM (scanning electron microscope) micrograph of a Leishmania promastigote. The cell body is shown in orange and the flagellum is in red (Photo courtesy of Wikimedia Commons)

Gene Panel Predicts Failure of Cutaneous Leishmaniasis Treatment

Patients infected with the protozoan parasite Leishmania braziliensis develop chronic skin lesions that often fail to respond to treatment with anti-parasitic drugs. Read more
03 Dec 2019 | Molecular Diagnostics
Image: Immunohistochemistry showing expression of mutated IDH1 protein in glioblastoma using a monoclonal antibody targeting the IDH1 R132H mutation (Photo courtesy of Marvin 101)

Longitudinal Molecular Trajectories of Adult Diffuse Glioma Examined

Until relatively recently, cancer was viewed as a single disease with sub-types based on where in the body it arose. Read more
02 Dec 2019 | Pathology
Image: Structure of the AP2A2 protein (Photo courtesy of Wikimedia Commons)

Genetic Locus with Unique Tandem Repeats Linked to Development of Late-onset Alzheimer’s Disease

Researchers have discovered evidence of a novel genetic variation linked to the development of late-onset Alzheimer’s disease (AD). Read more
02 Dec 2019 | Molecular Diagnostics
Image: Simulations showing cancerous multiple myeloma cells, also known as cCPCs, getting stuck between micropillars in the new filter device. Blue outline is the cCPC and fluid is flowing is from top to bottom (Photo courtesy of Lidan You, University of Toronto)

Liquid Biopsy Filter Facilitates Multiple Myeloma Diagnosis

A newly developed filtering device that collects circulating cancer cells from blood liquid biopsy samples demonstrated strong potential for facilitating diagnosis of multiple myeloma. Read more
02 Dec 2019 | Lab Tech.
Image: A cancer cell amongst normal cells. A new biomarker, plectin, has been discovered in cancer stem cells that governs cancer survival and spread (Photo courtesy of Laurie Fickman/ University of Houston).

New Biomarker Discovered for Cancer Stem Cells

Tumors often contain a small subset of drug-resisting, self-renewing, and highly metastatic cells called tumor initiating cells or cancer stem cells (CSCs). Read more
28 Nov 2019 | Pathology
Image: The QuantStudio 7 Pro Real-Time PCR System is one of several platforms that the new ChromaCode multi-drug resistant (MDR) panel can be assayed (Photo courtesy of Thermo Fisher Scientific)

Multiplex Panel Debuts for Multi-Drug Resistant Infection Screening

A multi-drug resistant (MDR) panel detects genetic signatures of resistance to specific antibiotics in pathogens that are commonly thought of as hospital acquired, and is designed to be used as a screening test for infection control and isolation of asymptomatic carriers. Read more
28 Nov 2019 | Molecular Diagnostics
Image: Immunofluorescence image of microglial cells stained red with antibody. DNA shown in blue (Photo courtesy of Wikimedia Commons)

Non-coding Regions of the Genome in Microglia Linked to Alzheimer’s Disease Risk

A recently published paper linked risk of developing Alzheimer’s disease (AD) to enhancers - non-coding DNA regions of the genome - that were present in microglia but not in other types of brain cells such as neurons or astrocytes. Read more
28 Nov 2019 | Molecular Diagnostics
Image: Photomicrograph of a blood smear that revealed the presence of numerous Plasmodium falciparum ring-form parasites. Note that some red blood cells (RBCs) contain multiple parasites. Anemia is a common and sometimes deadly complication of malaria infections (Photo courtesy of Centers of Disease Control and Prevention/Dr. Greene).

Immune Cells Linked to Malaria-Induced Anemia Through Autoantibody Production

Malaria is still a major global health threat with over 200 million new infections and around 400,000 deaths per year. Read more
28 Nov 2019 | Immunology

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Clinical Chemistry

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Next Generation Glycated Hemoglobin Assay Evaluated
Effect of Lipoprotein(A) on the Diagnosis of Familial Hypercholesterolemia
Chemical Analysis of Blood Samples Diagnoses Brain Tumors
Image: The Hepcidin-25 (bioactive) HS ELISA RUO is a highly sensitive enzyme immunoassay for the quantitative measurement of Hepcidin-25 in serum or plasma. Hepcidin is elevated in Parkinson’s disease patients (Photo courtesy of DRG Instruments)

Uremic Toxins Level Measured in Parkinson’s Disease Patients

Uremic-retention solutes are the compounds whose concentration in an organism increases with decreasing kidney function. At uremic concentrations, they play a crucial role in the progression of chronic... Read more

Molecular Diagnostics

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LDL Subclasses Ratio Predicts Cardiovascular Disease Risk More Accurately than L...
MicroRNA Panel Distinguishes Benign Moles from Melanoma in the Eye
Novel, High-Accuracy Blood Test Can Screen for Multiple Cancers
Image: Human sperm stained for semen quality testing in the clinical laboratory (Photo courtesy of Wikimedia Commons)

Epigenetic DNA Biomarkers Pinpoint Infertile Men and Predict Potential Success of Treatment

A molecular analysis method was developed that identifies infertility in men through evaluation of genome wide alterations in sperm DNA methylation. Male infertility is increasing and has been recognized... Read more

Hematology

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Second Malignancy Risk Higher for Some Leukemia Survivors
Hematological Ratios Associated with Mortality in Pediatric Trauma Patients
Reference Intervals Established for Serum Ferritin in Chinese Adults
Image: Schematic diagram of how the deep learning algorithm classifies leukocytes in a blood smear in an automated and standardized way (Photo courtesy of Helmholtz Zentrum München / Dr. Carsten Marr)

Acute Myeloid Leukemia Diagnosed by Convolutional Neural Networks

Every day, millions of single blood cells are evaluated for disease diagnostics in medical laboratories and clinics. Most of this repetitive task is still done manually by trained cytologists who inspect... Read more

Immunology

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Innovative Blood Test Aids Early Detection of Breast Cancer
Automated Immunoassay Systems Evaluated for KL‐6 Antigen Quantification
Systematic Serological Screening Programme Used for Strongyloidiasis
Image: Colored scanning electron micrograph (SEM) of a B lymphocyte white blood cell (Photo courtesy of the US National Institute of Allergy and Infectious Diseases)

Measles Virus Infection Impacts Immune Cells

Measles is a disease caused by the highly infectious measles virus (MeV) that results in both viremia and lymphopenia. Measles virus is a highly infectious lymphotropic virus associated with an extended... Read more

Microbiology

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Crohn's Disease-Associated Bacteria Tolerate Antibiotics
Routine Blood Parameters Predict Invasive Aspergillosis Prognosis
Phoenix CPO Test Evaluated for Detection of Carbapenemase Producers
Image: Growth characteristics of rough and smooth phenotypes of Mycobacterium abscessus on 7H11 agar cultured at 37 °C: representative single rough (left) and smooth (right) colonies (Photo courtesy of Hannover Medical School)

Mycobacterium Infection Found in Gastric Patients’ Stomachs

Development of gastric diseases such as gastritis, peptic ulcer and gastric cancer is often associated with several biotic and abiotic factors. Helicobacter pylori infection is such a well-known biotic factor.... Read more

Pathology

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Lynch Syndrome Screening by IHC Leads to Mutation Studies
Methylation Signature Identified for Brain Metastases of Lung Cancer
Multigene Testing for Breast Cancer Patients Proves Cost-Effective
Image: Retinoblastoma is cancer of the eye and cannot be biopsied. Aqueous humor is superior to blood to diagnose retinoblastoma (Photo courtesy of Aravind Eye Hospital).

Aqueous Humor Is Superior to Blood to Diagnose Retinoblastoma

Retinoblastoma is a cancer that forms in the light-detecting cells in the back of the eye. It often appears in children under two years of age and can lead to blindness or eye removal. Most cancers are... Read more

Lab Tech.

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Project Set to Develop Algorithm Able to Accurately Predict and Detect Sepsis
Rapid Filter Method Created for Isolation of CTCs from Whole Blood
Flow Cytometry Improved Updated Spectral Analyzer
Image: The nano-plasmonic exosome (nPLEX) sensor (Photo courtesy of Massachusetts General Hospital).

Novel Nanosensing Technologies Developed for Exosome Detection and Profiling

Exosomes are extracellular vesicles (EVs) that are produced in the endosomal compartment of most eukaryotic cells. Liquid biopsy technologies have been developed to do high-throughput exosome protein profiling... Read more

BioResearch

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New Method Simplifies Preparation of Tumor Genomic DNA Libraries
New Tool Developed for Diagnosis of Chronic HBV Infection
Panel of Genetic Loci Accurately Predicts Risk of Developing Gout
Image: A micrograph of a diffuse large B cell lymphoma (DLBCL) (Photo courtesy of Wikimedia Commons).

Gene Panel Predicts Disease Progession for Patients with B-cell Lymphoma

Cancer researchers developed a 29 gene–based weighted prognostic score for predicting event-free survival and overall survival of patients suffering from diffuse large B-cell lymphoma (DLBCL).... Read more

Industry News

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ERBA Mannheim Opens New Subsidiary in Brazil
AI-Enabled Technology to Help Global Molecular Imaging Market Reach USD 11.13 Bi...
Researchers Develop World’s First AI-Augmented Ova and Parasite Detection Tool
Image: Baxter International has acquired Cheetah Medical to expand their patient monitoring portfolio (Photo courtesy of Shutterstock).

Baxter Acquires Cheetah Medical to Expand Specialized Patient Portfolio

Baxter International Inc. (Deerfield, IL, USA), a global medical products company, has acquired Cheetah Medical (Boston, MA, USA), a provider of non-invasive hemodynamic monitoring technologies.... Read more

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