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Image: The QuantiFERON-TB Gold Plus Control Panel (Photo courtesy of Qiagen).

TB Interferon-Gamma Release Assay Assessed in Children

Pediatric tuberculosis (TB) remains a major public health issue with at least one million children newly identified with TB each year, representing 10% to 11% of all TB cases. Read more
16 Apr 2019 | Microbiology
Image: The hand and foot a patient with Opitz C Syndrome (Photo courtesy of Dr. Jorge Avina).

Genetic Diagnosis of Opitz C Syndrome Advanced

Opitz C syndrome (OCS), an ultra-rare disease that causes serious physical and intellectual disabilities, has a heterogeneous genetic base that makes its medical diagnostic and therapeutic intervention difficult. Read more
16 Apr 2019 | Molecular Diagnostics
Image: The high-density Human Omni 2.5-8 SNP array (Photo courtesy of Illumina).

Genome-Wide Screening Identifies Pancreatic Cancer Biomarkers

Surgery currently offers the only chance for a cure in pancreatic ductal adenocarcinoma (PDAC), but it carries a significant morbidity and mortality risk and results in varying oncologic outcomes. Read more
16 Apr 2019 | Molecular Diagnostics
Image: The Automatic QC RAPID Systems RAPIDPoint 500 blood gas analyzer (Photo courtesy of Siemens Healthcare).

Capillary and Venous Lactate Compared in ED Patients

Elevated lactate levels are a common finding in acutely unwell patients. Blood lactate level is a good predictor of patient outcome and high lactate levels are associated with high morbidity and mortality. Read more
16 Apr 2019 | Clinical Chemistry
Image: A diagram of the epidermal growth factor receptor (EGFR) (rainbow colored, N-terminus = blue, C-terminus = red) complexed its ligand epidermal growth factor (magenta) (Photo courtesy of Wikimedia Commons).

Targeting MicroRNA Blocks Drug Tolerance in Some Cancers

Cancer researchers have suggested that by exploiting the link between a specific microRNA and the tricarboxylic acid energy-producing cycle it may be possible to prevent or reverse the development of drug tolerance or resistance by non-small-cell lung carcinomas. Read more
15 Apr 2019 | BioResearch
Image: Researchers identified an RNA signature in the blood of pregnant lupus patients that could help predict the development of preeclampsia (Photo courtesy of Medical Xpress).

Profiling of Blood Transcriptome Predicts Complications in Pregnancies

Researchers have proposed profiling of the blood transcriptome as a method to predict complications in pregnancy that might be experienced by women with systemic lupus erythematosus. Read more
15 Apr 2019 | Molecular Diagnostics
Image: Dr. Brian Geiss displays a gold microwire that is one-fourth the size of a human hair (Photo courtesy of John Eisele, Colorado State University Photography).

New Test May Replace ELISA for Detecting Antibodies

A microwire-based test may replace enzyme-linked immunosorbent assay (ELISA) as the primary method to detect antibodies specific for pathogenic microorganisms in patient's sera. Read more
15 Apr 2019 | Molecular Diagnostics
Image: New imaging technology based on fluorescent chemical probes enables visualization of what cells eat, which could aid the diagnosis and treatment of diseases such as cancer (Photo courtesy of the University of Edinburgh).

Fluorescent Markers May Aid Cancer Diagnostics by Tracking Metabolites

A novel class of fluorescent markers allows real‐time tracking of essential metabolites in live cells in culture and in vivo in order to trace the acquisition of metabolic profiles from human cancer cells of variable origin. Read more
15 Apr 2019 | Molecular Diagnostics
Image: Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red) (Photo courtesy of the U.S. National Cancer Institute).

Nuclear Hormone Expression Predicts Cancer Aggressiveness

A large-scale retrospective analysis in patients revealed that expression of the nuclear hormone receptor "retinoic-acid-receptor-related orphan receptor gamma" (RORgamma) could predict pancreatic cancer aggressiveness, since it correlated positively with advanced disease and metastasis. Read more
15 Apr 2019 | Molecular Diagnostics
Image: A photomicrograph of acute myeloblastic leukemia from a bone marrow sample (Photo courtesy of Shutterstock).

Immune Signature Drives Leukemia Relapse after Transplantation

Transplantation of hematopoietic cells from a healthy individual (allogeneic hematopoietic cell transplantation (allo-HCT)) demonstrates that adoptive immunotherapy can cure blood cancers: still, post-transplantation relapses remain frequent. Read more
11 Apr 2019 | Hematology
Image: The AfinionHbA1c assay cartridge is used to test for quantitative determination of glycated hemoglobin (HbA1c) in human whole blood, which is used to monitor metabolic control in patients with diabetes (Photo courtesy of Alere).

HbA1c Point-of-Care Test Reliably Diagnoses Diabetes

Glycated hemoglobin is a form of hemoglobin that is covalently bound to glucose. It is formed in a non-enzymatic glycation pathway by hemoglobin's exposure to plasma glucose. Read more
11 Apr 2019 | Clinical Chemistry

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Clinical Chemistry

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New Automated Assay Measures Levels of sPLA2-IIA
C-Peptide Test Essential after Type 1 Diabetes Diagnosis
Increased Hormones Lead to Idiopathic Intracranial Hypertension
Image: The DS2 ELISA Automation System (Photo courtesy of Dynex Technologies).

Storage Conditions Affect Urinary Albumin and Creatinine

Moderately increased urinary albumin excretion, formerly known as microalbuminuria, has been established as a risk factor for diabetic kidney disease. Increasing albumin to creatinine ratio (ACR) within... Read more

Molecular Diagnostics

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Liquid Biopsy Potential Tested with ddPCR Technology
Malignant Pleural Mesothelioma Personalized by ctDNA Profiling
Fecal Microbes Used to Diagnose Liver Cirrhosis
Image: The HiSeq 2500 sequencing system offers unprecedented output (Photo courtesy of the University of Delaware).

Fusion Genes Diagnosis Uses Targeted RNA Sequencing

Chromosomal rearrangements that juxtapose two different genes together can form a fusion gene. Fusion genes play a causal role in tumorigenesis, accounting for ~20% of human cancer morbidity.... Read more

Hematology

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CRYOcheck Factor VIII Inhibitor Kit Cleared for Distribution
Significant Hemolysis Not Required for Thrombosis in PNH
Circulating Plasma DNA Potentially Identifies Incipient Tumors
Image: The TEG 5000 Thrombelastograph Hemostasis Analyzer System is utilized to help assess bleeding and thrombotic risks, and to monitor antithrombotic therapies (Photo courtesy of Haemonetics).

Biomarker Predicts Factor VIII Response in Hemophilia A

Hemophilia A is a genetic deficiency in clotting factor VIII (FVIII), which causes increased bleeding and usually affects males. In the majority of cases it is inherited as an X-linked recessive trait,... Read more

Immunology

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EBV-DNA Measured in Nasopharyngeal Carcinoma Patients
Immune Relationship to Lung Tumor Evolution Characterized
Recurrent Miscarriage Patients Show Activated Immune System
Image: Human IL-6 Luminex Performance ELISA Assay (Photo courtesy of R&D Systems).

Haptoglobin Expression Linked to Newborn Outcomes

Proteomics has facilitated discovery of biomarkers to better understand the pathophysiology of early-onset neonatal sepsis with the goal of identifying as early as possible the newborns more likely to... Read more

Microbiology

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Digital PCR Assay Diagnoses Paucibacillary Leprosy
New Guidelines Suggest Reduced Screening of Urine Cultures
Methods Compared to Diagnose Schistosomiasis Japonica
Image: Photomicrographs of tissues from patients with myoglobinopathy, a new muscular disease caused by a mutation in the myoglobin gene (Photo courtesy of Bellvitge Biomedical Research Institute).

Myoglobin Gene Mutation Causes New Muscle Disease

The cause of myoglobinopathy, a newly described disease of the muscles, has been traced to a mutation in the gene that encodes for the protein myoglobin (MB). Myoglobin, like hemoglobin (Hb), is a cytoplasmic... Read more

Pathology

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Virus-Associated Liver Cancer Detected by Blood Tests
EBUS More Reliable Than Histology for Cancer Diagnoses
Liquid Biopsy Proves Effective as Biopsy for NSCLC
Image: A diagram of evolutionary trajectories of IDH-WT glioblastomas revealing a common path of early tumorigenesis instigated years ahead of initial diagnosis (Photo courtesy of German Cancer Research Center).

Glioblastoma Driver Mutations Appear Long Before Diagnosis

Glioblastomas are the most common high-grade (cancerous) primary brain tumor in adults. They can also occur, rarely, in children. Glioblastomas belong to a group of brain tumors known as gliomas, as they... Read more

Lab Tech.

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Genetic Methods Rapidly Diagnoses Huntington's Disease
Enteric Viral Panel Gets FDA Clearance
Inexpensive Biosensor Provides Rapid Diagnosis of Bacterial Infections
Image: Liquid handling products from Hecht-Assistant (Photo courtesy of Glaswarenfabrik Karl Hecht).

Glaswarenfabrik Karl Hecht Celebrates 100-year Anniversary

In 1919, Karl Hecht laid the foundation for the Glaswarenfabrik in Sitzendorf-Unterweißbach in Thuringia, Germany. Over the decades the company continuously specialized in production and distribution of... Read more

Industry News

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Worldwide Digital Pathology Market to Reach USD 600 Million by 2022
Global In Vitro Diagnostics Market to Reach USD 90 Billion by 2025
Beckman Coulter Launches ClearLLab 10C System for Clinical Flow Cytometry Labs
Image: The MiniMax high efficiency, cell-free DNA isolation kit (Photo courtesy of Apostle / Beckman Coulter).

Beckman Coulter Life Sciences Enters Partnership with Apostle

Beckman Coulter Life Sciences (Indianapolis, IN, USA) has entered into a partnership with Apostle Inc. (Menlo Park, CA, USA) for the launch of Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit,... Read more

BioResearch

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Experimental Treatment Eases Symptoms of IBD in Model
MD Mouse Model Used to Tweak Gene-Editing Protocols
New Anticancer Drugs Interfere with DNA Binding Properties of EBV
Image: The wearable CTC collection device measures roughly 2 x 2.75 x 1 inches (5.08 x 6.98 x 2.54 cm), with the cancer-cell-capturing chip mounted on top. The catheter connecting to the patient runs through the hole in the top left corner (Photo courtesy of Dr. Tae Hyun Kim).

Prototype CTC Collection Device Tested Successfully in Model

A novel, wearable device for continuous isolation of circulating tumor cells (CTCs) from a peripheral vein was tested successfully in a dog model of human cancer. CTCs are now an established biomarker... Read more

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