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Image: The Viscotek high temperature gel permeation chromatography system (Photo courtesy of Malvern Instruments).

Mucin Concentration Used As Bronchitis Biomarker

Chronic bronchitis is characterized by recurring bouts of airway inflammation accompanied by a persistent cough and phlegm production. Read more
22 Sep 2017 | Clinical Chemistry
Image: The Genome-wide Association Studies fact sheet (Photo courtesy of the National Human Genome Research Institute).

Genes behind Gestation Length and Preterm Delivery Identified

Despite evidence that genetic factors contribute to the duration of gestation and the risk of preterm birth, robust associations with genetic variants have not been identified. Read more
21 Sep 2017 | Molecular Diagnostics
Image: Scientists measured the transport of bacteria across the colon biopsy in an Ussing chamber (Photo courtesy of Karin Söderlund Leifler).

IBS Colon Reacts Differently to Bacteria

Irritable bowel syndrome disturbs bowel function and the condition leads to repeated episodes of abdominal pain, and usually gives rise to constipation or diarrhea. Read more
21 Sep 2017 | Pathology
Image: A diagram of the ImmunoSignature Technology (Photo courtesy of HealthTell).

Molecular Test Detects Chagas in Blood Donors

The most prevalent parasitic infection in Latin America causes Chagas’ disease. Diagnosis is based on serologic tests because direct detection of Trypanosoma cruzi is very difficult beyond its brief acute phase. Read more
21 Sep 2017 | Microbiology
Image: A histopathology of pancreatic ductal adenocarcinoma. A moderately differentiated adenocarcinoma shows encircling of an islet and stromal desmoplasia. The desmoplasia is manifested by fibromyxoid stroma with a haphazard arrangement of cells (Photo courtesy of Pathpedia).

Combination Liquid Biopsy Diagnoses Early Cancer

Few patients with pancreatic cancer survive longer than five years, in part because most patients are identified only after their disease has progressed to an advanced stage. Read more
20 Sep 2017 | Pathology
Image: Liquid Biopsy: Solid tumor masses may shed (1) circulating tumor DNA (ctDNA) and circulating tumor RNA (ctRNA), (2) apoptotic circulating tumor cells (CTCs), or (3) intact CTCs into the circulation. In addition, ctDNA and ctRNA may enter the bloodstream after apoptosis of circulating and non-circulating tumor cells (4) (Photo courtesy of H. McDonald / Science Translational Medicine).

Liquid Biopsy Test Launched for NRAS Mutations

The NRAS gene encodes for the N-Ras protein, which is involved in communicating signals from the exterior of the cell to the cell's interior (called signal transduction). Read more
20 Sep 2017 | Molecular Diagnostics
Image: The Tumor Mutation Burden test detects cell free tumor DNA in the blood and allows for stratification of patients not eligible to have a tumor biopsy (Photo courtesy of the US National Cancer Institute).

Blood Test Predicts Immunotherapy Efficacy

A test developed with the US-based genetic testing specialist could be significant because, although potent, it is difficult to predict which patients will respond to immunotherapies, which are setting new care standards in some types of tumors. Read more
20 Sep 2017 | Molecular Diagnostics
Image: A human malignant melanoma cell viewed through a fluorescent, laser-scanning confocal microscope. Invasive structures involved in metastasis appear as greenish-yellow dots, while actin (green) and vinculin (red) are components of the cell’s cytoskeleton (Photo courtesy of Vira V. Artym, PhD, PMP).

Early Stage Melanoma Identified by Simple Blood Test

Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. Read more
20 Sep 2017 | Molecular Diagnostics

Channels

Clinical Chemistry

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Febrile Rhabdomyolysis Diagnosed in West African Refugees
CSF Pleocytosis Level Investigated as Diagnostic Predictor
World’s First Portable Fingerprint Drug Test Launched
Image: The ARCHITECT i2000SR immunoassay analyzer (Photo courtesy of Abbott Laboratories).

Various Factors Influence Cardiac Troponin Concentrations

Cardiovascular diseases are the second most common cause of death in Japan, and the number of new cases is continuously growing. Among the cardiovascular diseases, one-third is attributed to ischemic heart... Read more

Molecular Diagnostics

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Tumor Marker Levels Serve As Indicators of Disease Progression
Risk of Preeclampsia Linked to Fetal Genes
New Diagnostic Test Improves Detection of Tuberculosis
Image: An ATR attachment for infrared spectroscopy. The sample is in the steel containers either side of the pink crystal (Photo courtesy of Wikimedia Commons).

Direct Spectroscopy Used for Diagnosis of Neurodegenerative Disorders

Advanced spectroscopy methods were used to establish a direct diagnostic test for Alzheimer's disease and other types of neurodegenerative disorders. Neurodegenerative diseases lack early and accurate... Read more

Hematology

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New LC-MS/MS Test Introduced for TMA
Hematologic Abnormalities Found in HIV-Infected Children
CRISPR Illuminates Pediatric Bone Marrow Failure Syndrome
Image: The novel automated slide-based approach: a microscope slide is moved under a blunt needle, providing a constant flow of whole blood. Typically, 1 μL of blood is deposited (Photo courtesy of James W. Winkelman, MD, et al).

Automated Slide-Based Approach Introduced for CBCs

The most commonly performed clinical laboratory test is the complete blood count (CBC). Currently, laboratory CBC systems obtain cell counts and morphologic information by maintaining the blood cells in... Read more

Immunology

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Immunoassay May Simplify Screening for Liver Cancer
Vitamin D Affects Circulating T Cells in Children
Inflammatory Marker Associated with Newborn Amygdala
Image: Chronic neuro-inflammation as measured by high levels of circulating inflammatory cytokines and activated astrocytes and microglia in the brain (Photo courtesy of Dr. Oksana Kaidanovich-Beilin et al).

Blood Inflammatory Molecules Increased in ALS

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a fatal neurodegenerative disease characterized by the degeneration of motor neurons in brain and spinal cord.... Read more

Microbiology

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Newly Emerged Superbug Discovered
Epstein-Barr Virus Increases Risk of MS
Rapid Diagnostic Test for Malaria Evaluated
Image: Found in children’s throats, Kingella kingae bacteria has also been linked to bone and joint infections (Photo courtesy of the CDC).

Child Throat Bacteria Also Found in Joint Infections

Using sensitive diagnostics, researchers have found that the presence of the Kingella kingae in children's throats was strongly linked to bone and joint infection with the same bacterium.... Read more

Pathology

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Tumor Marker Tests Overused in Primary and Secondary Care
Blood Test Predicts Prostate Tumor Resistance
AI Could Help Identify Early Skin Cancer
Image: The MasSpec Pen rapidly and accurately detects live cancer during surgery, helping improve treatment and reduce the chances of cancer recurrence (Photo courtesy of the University of Texas at Austin).

Handheld Mass Spectrometer Identifies Cancer Tissue in Seconds

A team of scientists and engineers has invented a powerful device that rapidly identifies living cancerous tissue, giving surgeons precise diagnostic information about what tissue to cut or preserve.... Read more

Lab Tech.

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Malaria Diagnosis Employs Hydrophilic-Treated Plastic Plates
Smartphone-Based Analyzer Designed for Sample Testing
Smartphone-Based ELISA Developed for Blood Antigens
Image: Paper-based diagnostic device that detects biomarkers and identifies diseases by performing electrochemical analyses. The assays change color to indicate specific test results. The device can be plugged into the handheld potentiostat, at left (Photo courtesy of Purdue University, Aniket Pal).

Disposable POC Device Introduced for Low-Resource Areas

A recent paper described a novel diagnostic device fabricated from various types of paper to be used for point-of-care testing in areas lacking electricity and other resources. The developers at Purdue... Read more

Industry News

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DiaSorin to Acquire Siemens' ELISA Immunodiagnostics Business
Siemens to Acquire Blood Gas Subsidiary of Alere
Quidel to Acquire Alere Triage Assets
Image: Mexico\'s in vitro diagnostic (IVD) market is valued at USD 405 million for 2016, making it the second largest in Latin America (Photo courtesy of iStock).

Mexico IVD Market Valued at USD 405 Million for 2016

Mexico's in vitro diagnostic (IVD) market is valued at USD 405 million for 2016, making it the second largest in Latin America, and is considered moderate in its regulatory process and foreign investment... Read more

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