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Image: A new blood test has been developed capable of detecting multiple cancer types. The new test looks for DNA, which cancer cells shed into the bloodstream when they die (Photo courtesy of weeksnews).

New Blood Test Capable of Detecting Multiple Cancer Types

A new blood test in development has shown ability to screen for numerous types of cancer with a high degree of accuracy, a trial of the test shows. Read more
16 Oct 2019 | Molecular Diagnostics
Image: The NovoCyte flow cytometer (Photo courtesy of ACEA Bio).

Blood Monocyte Functions Altered in Parkinson's Disease

Parkinson's disease is characterized by the slow degeneration of the neurons in brain due to the abnormal accumulation of a protein called alpha-synuclein. Read more
15 Oct 2019 | Immunology
Image: In acute myeloid leukemia (AML), defective blood cells (stained purple) are present. When the cells have a double mutation of both the IDH2 and SRSF2 genes (bottom right), the number of defective cells rises considerably, indicating a more lethal disease (Photo courtesy of Cold Spring Harbor Laboratory).

Two Different Mutations Identified as Cause of AML

Two very different mutations have been identified as unexpected partners in crime for causing the blood cancer acute myeloid leukemia (AML). Read more
15 Oct 2019 | Molecular Diagnostics
Image: The cobas 6500 urine analyzer series is a fully automated work area solution designed for laboratories that process 100 – 500 urine samples per day (Photo courtesy of Roche Diagnostics).

Automated Urine Analyzer And Components Evaluated

Urinalysis is a very common technique used in clinical practice, providing crucial information on the functioning of the kidneys and other organ systems, and aiding clinical decision-making in various diseases, such as diabetes, glomerulonephritis, and suspected urinary tract infections. Read more
15 Oct 2019 | Clinical Chemistry
Image: Spiked rods of monosodium urate crystals photographed under polarized light from a synovial fluid sample. Formation of monosodium urate crystals in the joints is associated with gout (Photo courtesy of Wikimedia Commons).

Panel of Genetic Loci Accurately Predicts Risk of Developing Gout

A large GWAS (genome-wide association study) highlighted genetic loci associated with the metabolic regulation of serum levels of uric acid (urate) and identified a panel of 183 loci linked to the risk of developing gout. Read more
14 Oct 2019 | BioResearch
Image: A representation of CEACAM5 protein (Photo courtesy of Wikimedia Commons).

Disrupted TGFB Signaling Linked to Increased Cancer-Related Bacteria

Following careful analysis of DNA sequences collected in The Cancer Genome Atlas, researchers have proposed that CEACAM (carcinoembryonic antigen related cell adhesion molecule) proteins disrupt TGFB signaling, which alters the composition of the intestinal microbiome to promote development of colorectal cancer. Read more
14 Oct 2019 | BioResearch
Image: A test to detect opioid drugs in exhaled breath was developed. In this photograph, a volunteer breathes normally into the human breath sampler. Samples are frozen before being taken to the laboratory for analysis (Photo courtesy of Dr. Cristina Davis, University of California, Davis).

Breath Analysis May Replace Blood Sampling to Monitor Drug Usage

A simple and non-invasive technique to collect exhaled breath condensate (EBC) from chronic pain patients was developed, and its usefulness was confirmed by comparing metabolites in breath and blood samples following use of different analgesic opioid drugs. Read more
14 Oct 2019 | Molecular Diagnostics
Image: Human Kallikrein 4 (KLK4) protein complexed with nickel and p-aminobenzamidine (Photo courtesy of Wikimedia Commons).

Gene Fusion Protein Proposed as Prostate Cancer Biomarker

A novel gene fusion product has been proposed as a biomarker for the non-invasive diagnosis of prostate cancer. Read more
14 Oct 2019 | BioResearch
Image: The Quant-iT PicoGreen dsDNA assay kit (Photo courtesy of Thermo Fisher Scientific).

Stunted Microbiota and Opportunistic Pathogen Colonize C-Section Birth

Immediately after birth, newborn babies experience rapid colonization by microorganisms from their mothers and the surrounding environment. Read more
10 Oct 2019 | Microbiology
Image: Abnormal serum hepatic enzymes and lipid levels are associated with glycemic control in patients with type 2 diabetes mellitus (Photo courtesy of SRL Diagnostics).

Liver Biomarkers Tied to Glycemic Control in Diabetes

As liver biomarkers serve as an effective indicator of liver injury in patients whom liver functions are somewhat above average. Read more
10 Oct 2019 | Clinical Chemistry
Image: A specific Parkinson’s gene mutation has been linked to a higher risk of leukemia and colon cancer (Photo courtesy of BioNews Services).

Parkinson’s Gene Mutation Linked to Higher Risk of Leukemia

Parkinson's disease is a progressive nervous system disorder that affects movement. Symptoms start gradually, sometimes starting with a barely noticeable tremor in just one hand. Read more
10 Oct 2019 | Molecular Diagnostics
Image: The association of genetic liability to psychotic experiences with neuropsychotic disorders and traits has been explored (Photo courtesy of Cardiff University).

Genetic Links Uncovered Between Psychotic Experiences

Psychotic experiences, such as hallucinations and delusions, are features of psychiatric disorders, such as schizophrenia, but they are also reported by approximately 5% to 10% of the general population. Read more
09 Oct 2019 | Molecular Diagnostics

Channels

Clinical Chemistry

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Insulin Sensitivity and Adiponectin Level Predict Insulin Therapy Response
Deficiency of Vitamin D Linked to Increased Mortality
C‐Peptide Associated with NAFLD Inflammatory Progression
Image: The ABX Micros CRP 200 hematology analyzer (Photo courtesy of Horiba Medical).

Human CRP-Levels Compared Using Point-of-Care Methods

Due to the rapid increase of the C-reactive protein (CRP) concentration in the event of an inflammatory disease, CRP is regarded as one of the most important acute phase proteins. Inflammation and CRP... Read more

Molecular Diagnostics

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Non‐Invasive Prenatal Diagnosis of Spinal Muscular Atrophy Validated
Mitochondrial Clearance Failure Provides Diagnostic Marker for Parkinson's Disea...
Breakthrough Kit May Enable Early Alzheimer's Diagnosis
Image: A custom-designed Affymetrix Axiom array (Photo courtesy of Thermo Fisher Scientific).

Some High-Cholesterol Genes Differ Between Countries

Genome-wide association studies (GWAS) have been very successful in identifying genetic variants linked to cardiovascular disease (CVD) and to cardiometabolic traits. Due to the improving predictive accuracy... Read more

Hematology

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Laser Incubator Developed for Rapid Blood Group Typing
Biomarker in Adolescence Linked to Early Mortality
Next-Gen Sequencing Matches Blood Group Antigens for Transfusion
Image: The Gen-S hematology analyzer (Photo courtesy of Beckman Coulter).

Hematological Parameters Detect Patients with Acute VTE

Venous thromboembolism (VTE) encompasses deep venous thrombosis (DVT) and pulmonary embolism (PE). VTE causes cardiovascular death and disability and the risk of PE‐associated mortality and morbidity extends... Read more

Immunology

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Commercial TB Test Compared to Recombinant Allergen Skin Test
Immunoassays Compared for Diagnosis of Acute Murine Typhus Infections
Differential Immune Responses Triggered against Salmonella enterica
Image: The Navios Flow Cytometer offers a solution for advanced cytometry applications with workflows for high throughput laboratories (Photo courtesy of Beckman Coulter).

Early Diagnosis of Tularemia Accomplished by Flow Cytometry

Tularemia is a zoonotic disease that occurs in the Northern Hemisphere and is caused by Francisella tularensis. In Europe, more than 500 cases are reported annually and Turkey and the USA also have substantial... Read more

Microbiology

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Immunochromatographic Strip Test Developed for Rift Valley Fever
RT-PCR Evaluated for Diagnosis of Imported Schistosomiasis
Multiplexed Immunoassay System Differentiates Malaria Species
Image: A peripheral blood smear showing Wuchereria bancrofti microfilaria, found in a patient with lymphatic filariasis (Photo courtesy of Medical Chemical Corporation).

Molecular Changes Associated with Treating Lymphatic Filariasis

Lymphatic filariasis (LF) is a disabling neglected tropical disease that is caused by the mosquito-borne filarial parasites Wuchereria bancrofti, Brugia malayi and B. timori. Adult worms live in the human... Read more

Pathology

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Diagnostic Biomarker Expression Compared for Metastatic Tumors
Protein Panel Developed for Early Detection of Lung Cancer
Vaping Illness Characterized by Lipid-Laden Cells in Lungs
Image: The Quick-Ray Manual Tissue Microarrayer Set (Photo courtesy of Unitma).

Diagnostic Panel Analysis of Lung Cancer Compared

Lung cancer is the leading cause of cancer death. Non-small cell lung carcinomas are the most common type of lung cancers. They can further be divided into adenocarcinomas and squamous cell carcinomas.... Read more

Lab Tech.

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New QC Reagents Compatible with Multiple Immunoassay Platforms
Microfluidic Device Rapidly Diagnoses Sepsis
Electronic Device May Help Diagnose Early Bladder Cancer
Image: Scientists have developed a test that detects deadly zinc deficiencies in a single drop of the blood. The test could be made compact enough so that many fit in an aid worker’s pocket. It could help expose broad malnutrition in crisis regions (Photo courtesy of Georgia Institute of Technology).

Pocket-Sized Zinc Deficiency Test Evaluated

Easy-to-perform, relatively inexpensive blood diagnostics have transformed at-home healthcare for some patients, but they require analytical equipment and are not easily adapted to measuring other biomarkers.... Read more

BioResearch

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Semen Exosome MicroRNA Proves Biomarker for Prostate Cancer
Genetic Loci Link Plasma Lipid Levels to CVD Risk
Newly Identified Gene Network Aids in Early Diagnosis of Autism Spectrum Disorde...
Image: A ball-and-stick model of the 5-hydroxymethylcytosine (5hmC) molecule (Photo courtesy of Wikimedia Commons).

NIV Test to Diagnose and Monitor Vascular Complications in Diabetes

By applying a sensitive test for analysis of DNA taken from patients with Type II diabetes, researchers were able to diagnose and monitor the presence and severity of diabetic vascular complications such... Read more

Industry News

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AI-Enabled Technology to Help Global Molecular Imaging Market Reach USD 11.13 Bi...
Researchers Develop World’s First AI-Augmented Ova and Parasite Detection Tool
Global Immunoassay Market to Reach USD 19.76 Billion by 2025 with Increased Use in...
Image: Erba Mannheim Brazil, a subsidiary of Erba Mannheim, will be located in Nova Lima, Brazil (Photo courtesy of Shutterstock).

ERBA Mannheim Opens New Subsidiary in Brazil

ERBA Mannheim has expanded its global footprint by opening a new subsidiary in Brazil. The new organization, Erba Mannheim Brazil, will be headquartered in Nova Lima, north of the nation’s capital, will... Read more

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