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Image: This close-up of the glow-in-the-dark paper strip contains two copies of the test. The three glowing dots per test indicate that you can check on three different antibodies within one test (Photo courtesy of Bart van Overbeeke).

Rapid Test Uses Glow-in-the-Dark Paper

A practicable and reliable way to test for infectious diseases has been found and all that is needed are a special glowing paper strip, a drop of blood and a digital camera. Read more
16 Oct 2018 | Microbiology
Image: The LINEAR ARRAY HPV Genotyping Test is used for the detection of 37 high- and low-risk human papillomavirus genotypes (Photo courtesy of Roche Diagnostics).

Individual HPV Types Linked to HIV Infection

Although it is known that individuals living with human immunodeficiency virus (HIV) have a higher human papilloma virus (HPV) prevalence, the impact of individual HPV types on HIV acquisition is less clear. Read more
15 Oct 2018 | Microbiology
Image: Higher levels of the inflammatory biomarker soluble tumor necrosis factor receptor-1 (sTNFR-1) are tied to kidney decline in healthy adults (Photo courtesy of Enbrel).

Kidney Function Decline Linked with Inflammatory Marker Levels

Tumor necrosis factor receptor-1 (TNFR-1), which plays a causative role in endothelial cell dysfunction and inflammation, is expressed on the cell surface in glomerular and peritubular capillary endothelium of the kidneys. Read more
15 Oct 2018 | Clinical Chemistry
Image: A nanopore device can contain different binding proteins. Once inside the pore, these proteins act as transducers to identify specific small molecules in a sample of body fluid (Photo courtesy of Dr. Giovanni Maglia, University of Groningen).

Detection System Used for Monitoring Small Molecules

A biological nanopore-based detection system can continuously monitor glucose and asparagine levels in microliter samples of blood, urine, saliva, or other body fluid in real-time. Read more
15 Oct 2018 | Molecular Diagnostics
Image: The biotech company Igenomix has developed the first molecular test to identify the nine most common bacterial species underlying chronic endometritis, a persistent inflammation of the uterine endometrium that particularly affects women with endometriosis (Photo courtesy of Patricia Inacio, PhD).

Test Developed for Uterine Infections Impacting Fertility

Approximately 10% of women in the general population may have chronic endometritis, but among infertile women undergoing IVF, the rate is 15%, with rates estimated as high as 60% among women experiencing recurring implantation failure or miscarriage. Read more
11 Oct 2018 | Microbiology
Image: The NextSeq 550 System brings the power of a high-throughput sequencing system to the benchtop (Photo courtesy of Illumina).

Antibiotic-Resistant Mutations Revealed by Sequencing Method

Antimicrobial resistance is on the rise and is responsible for millions of deaths every year. Bacterial populations consistently and rapidly overcome the challenge imposed by the use of a new antibiotic. Read more
11 Oct 2018 | Molecular Diagnostics
Image: A scanning electron micrograph of dividing breast cancer cells (Photo courtesy of National Cancer Institute).

Disease-Associated Variants in Genes Allow Early Diagnosis

Sequencing the exomes of patients can identify breast cancer risk variants, even in patients without a family history of cancer or who otherwise would not be considered to be at an elevated risk. Read more
10 Oct 2018 | Pathology
Image: The Autoscope uses deep-learning software to quantify the malaria parasites in a sample (Photo courtesy of Intellectual Ventures).

Automated Microscopy Compared for Routine Malaria Diagnosis

Microscopic examination of Giemsa-stained blood films remains a major form of diagnosis in malaria case management. Read more
10 Oct 2018 | Microbiology
Image: A diagram of urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment (Photo courtesy of University College London).

Urine Biopsies Help Monitor Bladder Cancer Treatment

Despite the advances in cancer immunotherapy, only a fraction of patients with bladder cancer exhibit responses to checkpoint blockade, highlighting a need to better understand drug resistance and identify rational immunotherapy combinations. Read more
10 Oct 2018 | Pathology
Image: Manhattan plot for meta-analysis (discovery) of GWAS of chronic back pain; Red line depicts genome-wide statistical significance; Blue line depicts suggestive significance (Photo courtesy of University of Washington).

New Gene Variants Associated with Chronic Back Pain

Back pain causes more years lived with disability than any other health condition worldwide. Although most adults experience a new (‘acute’) episode of back pain at some point in their lives, the societal burden of back pain is driven by the minority of individuals who fail to recover from such episodes and go on to develop persistent (‘chronic’) back pain (CBP). Read more
09 Oct 2018 | Molecular Diagnostics
Image: An albumin immunoturbidimetric assay urine or serum plasma; standard microalbumin range is 0.4-500mg/L (Photo courtesy of Sentinel Diagnostics).

Kidney Disease Biomarker May Indicate Lung Problems

Chronic lower respiratory diseases (CLRD) are the fourth leading cause-of-death and a major source of health care costs. Read more
09 Oct 2018 | Clinical Chemistry

Channels

Clinical Chemistry

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Blood Tests Differentiate Myocardial Injury from Infarction
High Blood Sugar During Pregnancy Increases Risk of Diabetes
Ovarian Cancer Biomarker Predicts Therapy Response
Image: The QTRAP 6500 Q-Trap mass spectrometer (MS) (Photo courtesy of Sciex).

Collection Tubes Influence Targeted Metabolomics Studies

Plasma and serum are the most widely used matrices in clinical studies. However, some variability in absolute concentrations of metabolites are likely to be observed in these collection tubes matrices.... Read more

Molecular Diagnostics

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Pneumonia Diagnosed by Nanopore Sequencing of Sputum
Dementia Assay Gets Favorable Evaluation
Disease Progression Apprised by Post-Treatment Mutation Sequencing
Image: The SureSelectXT HS technology target enrichment system (Photo courtesy of Agilent Technologies.

Cancer Liquid Biopsy Assay Detects Low-Level Mutations

Circulating free DNA sequencing (cfDNA-Seq) can portray cancer genome landscapes, but highly sensitive and specific technologies are necessary to accurately detect mutations with variant frequencies that... Read more

Hematology

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Biomarker Identified for Novel Asthma Treatment
New mRNA Cancer Drivers Revealed in Chronic Lymphocytic Leukemia
Blood Test Predicts Lymphoma Therapy Success
Image: A blood film from a patient with acute myeloid leukemia (Photo courtesy of the University of Toronto).

DNA Test Predicts Risk of Leukemia Relapse

Acute myeloid leukemia (AML) is the most common type of leukemia in adults, comprising about one quarter of all cases. The disease stems from an overproduction of immature blood cells in the bone marrow,... Read more

Immunology

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Tumor Markers Associated with H. Pylori Infection
Diagnostic Techniques Evaluated for Cystic Echinococcosis
Analysis of Nasal Polyps Suggests Mechanisms of Inflammation
Image: The Immage 800 immunochemistry system (Photo courtesy of Beckman Coulter).

Biomarkers Correlated with Idiopathic Inflammatory Myopathy

Patients with idiopathic inflammatory myositis (IIM) typically present with muscle weakness, myalgia and in case of dermatomyositis (DM) also skin involvement. Arthralgia is often present, but the articular... Read more

Microbiology

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Diagnostic Methods Compared for Detection of Malaria
Nanopore Sequencing Enables Outbreak Field Surveillance
New Test Procedure Diagnoses Multi-Resistant Pathogens
Image: The BD BACTEC MGIT automated mycobacterial detection system is a fully automated solution for mycobacterial liquid culture and susceptibility testing (Photo courtesy of Becton Dickinson).

TB Sequencing Could Replace Drug Susceptibility Testing

Tuberculosis (TB) is the most deadly infectious disease worldwide, causing 1.6 million deaths in 2017. Drug resistance is a particularly challenging and growing problem: as in 2017, it was estimated that... Read more

Pathology

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Standalone HPV Testing Recommended for Cervical Cancer Screening
Cancer Detection Device Proves Effective in Field Testing
Blood Test May Help Detect Kidney Cancer Earlier
Image: The iChip: The blood sample is passed into the CTC-iChip microfluidic system, which first removes red cells, plasma and free magnetic beads and then sorts out tagged white blood cells, leaving a purified solution of circulating tumor cells (Photo courtesy of Dr. Emre Ӧzkumur, PhD).

Liquid Biopsy Identifies Chronic Liver Diseases

A recently developed liquid biopsy cell-sorting device was able to detect circulating epithelial cells of hepatocyte origin in blood from healthy individuals, patients with chronic liver disease without... Read more

Lab Tech.

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Magnetic Nanoparticle Tool Developed to Detect MicroRNA
Simple Paper Test Detects False or Substandard Antibiotics
Mild Brain Trauma Diagnosed with POC Device
Image: The Q Exactive hybrid quadrupole-orbitrap mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Residual Tissue Repositories Suitable for MS-Based Proteomics

Mass spectrometry-based proteomics has become a powerful tool for the identification and quantification of proteins from a wide variety of biological specimens. The majority of studies utilizing tissue... Read more

Industry News

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Western Blotting Processors Market to Reach USD 329 Million by 2028
Global IVD Market to Reach USD 77 Billion by 2023
Stago Connect.One Network Allows Remote Monitoring of Analyzers
Image: Handheld hematology devices are expected to contribute to the growth of the global POC hematology diagnostics market (Photo courtesy of Philips Healthcare).

Increasing Conditions and Diseases Drive Global POC Hematology Diagnostics Market

The global Point of Care (POC) hematology diagnostics market is expected to grow at a CAGR of close to 9% over the forecast period 2018-2022 to reach a value of USD 2.7 billion by 2022, driven mainly by... Read more

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