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In Other News

Image: The BN II Nephelometer System is an easy-to-use, reliable nephelometric analyzer that offers a broad range of protein assays (Photo courtesy of Siemens Healthcare).

Urinary Biomarkers Associated with Kidney Disease Risk Factors

The improved life expectancy among treated human immunodeficiency virus (HIV)-positive patients has been tempered by the excess burden of age-related non-infectious co-morbidities, including chronic kidney disease (CKD). Read more
14 Jan 2019 | Clinical Chemistry
Image: The BD MAX System is a fully automated platform that gives the power to consolidate and standardize a broad range of molecular tests including the BD Max enteric panel (Photo courtesy of Becton Dickinson).

Enteric Viral Panel Gets FDA Clearance

Acute viral gastroenteritis can be contracted by virtually any patient and spread within close community settings such as daycare centers, nursing facilities, and cruise ships. Read more
10 Jan 2019 | Lab Tech.
Image: A High Pure PCR template preparation kit (Photo courtesy of Roche Diagnostics).

LAMP Test Rapidly Detects Sexually Transmitted Chlamydia

Chlamydia trachomatis is the leading cause of sexually transmitted diseases (STDs) in females and males in both developed and developing countries, with more than 110 million cases annually. Read more
10 Jan 2019 | Microbiology
Image: A peripheral blood film from a patient with plasma cell leukemia showing four plasma cells and rouleaux formation of erythrocytes (Photo courtesy of the Tsuyako Saito).

New Definition for Plasma Cell Leukemia Proposed

Plasma cell leukemia (PCL) is an uncommon but aggressive malignancy that accounts for 1% to 2% of all plasma cell dyscrasias. Read more
09 Jan 2019 | Hematology
Image: A diagram showing normal and polycystic ovary syndrome, in the latter the ovaries may develop numerous small collections of fluid (follicles) and fail to regularly release eggs (Photo courtesy of Mayo Clinic).

New Risk Loci Identified for Polycystic Ovary Syndrome

Polycystic ovary syndrome is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Read more
09 Jan 2019 | Molecular Diagnostics
Image: The FLUOstar Omega is a multi-mode microplate reader and has six detection modes (Photo courtesy of BMG LabTech).

Test Detects Protein Associated with Alzheimer’s and CTE

An ultrasensitive test has been developed that detects a corrupted protein associated with Alzheimer’s disease and chronic traumatic encephalopathy (CTE). Read more
09 Jan 2019 | Clinical Chemistry
Image: The NovaSeq 6000 sequencing system platform (Photo courtesy of Illumina).

Diverse Chronic Kidney Diseases Diagnosed with Exome Sequencing

Exome sequencing is emerging as a first-line diagnostic method in some clinical disciplines, but its usefulness has yet to be examined for most constitutional disorders in adults, including chronic kidney disease, which affects more than 1 in 10 persons globally. Read more
08 Jan 2019 | Molecular Diagnostics
Image: A comparison of OncoScan array CGH assay–derived metastasis potential scores (MPSs) for indolent primary tumor (iPT) and metastasis-prone primary tumor (mPT) samples (Photo courtesy of Albert Einstein College of Medicine).

Rapid Next-Gen Sequencing Method Predicts Prostate Cancer Risks

Prostate cancer is the most commonly diagnosed male cancer and the second leading cause of cancer deaths among men in the USA, with approximately 220,000 new diagnoses and approximately 27,000 deaths each year. Read more
08 Jan 2019 | Molecular Diagnostics
Image: The Hitachi 7600 chemistry analyzer (Photo courtesy of Hitachi).

Bilirubin Improves Risk Prediction of Cardiovascular Death

Diabetes is one of the most prevalent disorders worldwide and cardiovascular (CV) disease is the leading cause of mortality and morbidity in diabetic patients. Read more
07 Jan 2019 | Clinical Chemistry
Image: Howell-Jolly body–like inclusion within neutrophil (arrow). It appears as a completely detached and densely basophilic inclusion in the cytoplasm of neutrophil. Photos were taken from different cases (Photo courtesy of University of Texas Health Science Center at Houston).

Howell-Jolly Body-Like Inclusions Correlated with Myelodysplastic Syndrome

Howell-Jolly body–like inclusions have been previously associated with patients who are human immunodeficiency virus (HIV) infected, taking antiviral medications, and immunosuppressed. Read more
07 Jan 2019 | Hematology
Image: The Dimension EXL 200 integrated chemistry system (Photo courtesy of Siemens Healthcare).

Serum Magnesium Levels Associated with CAP Mortality

Community acquired pneumonia (CAP) is a common illness affecting hundreds of millions worldwide, with increasing hospital admissions throughout the years mainly due to the aging population. Read more
07 Jan 2019 | Clinical Chemistry

Channels

Clinical Chemistry

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Salivary Urea Nitrogen Dipstick Detects Acute Kidney Disease
Molecular Cause Found for Rare Autoimmune Disorders
HbA1c Assessed in Diabetics Awaiting Liver Transplantation
Image: During the oral glucose tolerance test (OGTT) blood glucose is tested two hours after drinking 75 grams of glucose, but a test one hour afterwards may be sufficient to diagnose diabetes (Photo courtesy of the US National Institutes of Health).

Diagnostic Accuracy Demonstrated in Oral Glucose Tolerance Test

The incidence of overweight and obesity among children has increased dramatically in recent decades, with about one-third of children in the USA currently being either overweight or obese.... Read more

Molecular Diagnostics

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Epigenetic Cervical Cancer Test Has Perfect Detection Rate
Neuroblastoma Molecular Analysis Leads to Prognostic Markers
Genetic and Epigenetic Features Found in Glioma Tumors
Image: Genome-wide human SNP array 6.0 GeneChip (Photo courtesy of Affymetrix).

Metastatic Colorectal Cancer Linked to Transcription Factors

Colorectal cancer (CRC) is a kind of malignant human tumor with high mortality around the world. The incidence of colorectal cancer shows a gender difference and is prone to the elderly.... Read more

Hematology

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Potential Screening for Tailoring Treatment of AML
Transfusions with Older Blood Linked to Adverse Events
Acute Myeloid Leukemia Regulatory Networks Identified
Image: Blood smears from normal and macrocytic anemia patients (Photo courtesy of Myrtle Porter).

Macrocytic Anemia Associated with HBV Liver Impairment Severity

Cirrhosis is an end-stage disease that invariably leads to death and it is the 14th most common cause of death in adults worldwide and results in 1.03 million deaths per year. Chronic infection with hepatitis... Read more

Immunology

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Potential Biomarkers Found for Acute Aortic Dissection
Dengue Virus Specific T-Cell Responses Correlated with Disease Severity
Levels of IgA Nephropathy Associated with Disease Severity
Image: PLATEILA DENGUE NS1 AG: Qualitative or semi-quantitative detection of dengue virus NS1 antigen in human serum or plasma by enzyme immunoassay (Photo courtesy of Bio-Rad).

Dengue Virus IgM Serotyped by ELISA

Dengue virus (DENV) is an arthropod-borne flavivirus that is endemic in tropical and subtropical regions, causing hundreds of millions of infections annually. It is subdivided into four serotypes, DENV-1–4.... Read more

Microbiology

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Tick-Borne Diseases Diagnosed with Multiplex Molecular Panel
HCV-RNA Present in Body Fluids in High Viral Load Patients
Urinary Biomarkers for Tuberculosis Explored
Image: A colored scanning electron micrograph (SEM) of Faecalibacterium prausnitzii, one of the most abundant anaerobic bacteria in the human gut microbiota, and its relative abundance is a biomarker of intestinal health in adults (Photo courtesy of BioFoundations).

Gut Microbes Differ Between Two Common Conditions

Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are two of the most common diseases of the gastrointestinal tract. Unlike IBD, IBS does not cause inflammation, ulcers or other damage... Read more

Pathology

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Less-Invasive Biosensor Created for Breast Cancer Diagnosis
Inflammatory Bowel Disease Linked to Prostate Cancer
Methylation-Based Liquid Biopsy Test Detects Liver Cancer
Image: The Oncomine Focus Assay is performed using the Ion Torrent technology. The test is designed to help oncologists expedite selection of a treatment plan for their patients in days instead of weeks (Photo courtesy of Thermo Fisher Scientific).

Sequencing Assay Adopted for Advanced Lung Cancer Reflex Testing

Guidelines are rapidly moving toward upfront profiling with next-generation sequencing (NGS) of all advanced lung cancers, but there are still practical issues with this testing method that can limit clinical... Read more

Lab Tech.

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New Test Measures Men's Fertility
Low-Cost Diagnostic Developed Using Nanostructures
Residual Tissue Repositories Suitable for MS-Based Proteomics
Image: Conceptual representation for the detection of bacteria concentration and proliferation. The electrical signal of the resonator is analyzed through a vector network analyzer (VNA) to gather resonant profile for bacteria in different concentrations and environmental pH, and for long-term screening of their growth (Photo courtesy of the University of British Columbia).

Inexpensive Biosensor Provides Rapid Diagnosis of Bacterial Infections

Bacterial infection is a common problem throughout hospitals around the worlds. Every hour of delay in antibiotic treatment increases the mortality rate of patients by 7.6% with sepsis and septic shocks.... Read more

Industry News

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Global POC Urinalysis Market Driven by Nephropathic Disorders and UTIs
Siemens Healthineers and Primary Health Care Enter Contract for In Vitro Diagnos...
Roche Launches Roche Healthcare Consulting
Image: The Vacuette Safelink tube holder (Photo courtesy of Greiner Bio-One).

Greiner Bio-One Launches Tube Holder for Blood Collection

Greiner Bio One International (Kremsmünster, Oberösterreich, Austria) has launched the innovative VACUETTE SAFELINK tube holder with male luer lock that facilitates quick and easy blood collection.... Read more

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