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Image: A high-magnification micrograph of diffuse proliferative lupus nephritis (Photo courtesy of Wikimedia Commons).

Urine Plasmin Identified as Strong Biomarker for Lupus Nephritis Diagnosis

Plasmin in the urine has been identified as the strongest predictor of estimated glomerular filtration rate (eGFR) and clinical renal disease in patients with lupus nephritis (LN). Read more
19 Aug 2019 | Molecular Diagnostics
Image: A scanning electron micrograph of two rod-shaped bacteria called Klebsiella pneumoniae that are resistant to treatment with the “last resort” antibiotic drug called carbapenem. In this image, the mustard-colored bacteria are interacting with the green-colored human white blood cells (Photo courtesy of National Institute of Allergy and Infectious Diseases).

Carbapenem-Resistant K. Pneumoniae Driven by Nosocomial Spread

Public health interventions to control the current epidemic of carbapenem-resistant Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and spread over a wide range of geographical scales. Read more
15 Aug 2019 | Microbiology
Image: An MIT-invented microfluidics device could help doctors diagnose sepsis, a leading cause of death in US hospitals, by automatically detecting elevated levels of a sepsis biomarker in about 25 minutes, using less than a fingerprick of blood (Photo courtesy of Felice Frankel).

Microfluidic Device Rapidly Diagnoses Sepsis

Sepsis is a life-threatening condition and early diagnosis is crucial to ensure that treatment is not delayed. Read more
15 Aug 2019 | Lab Tech.
Image: A histopathology of pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer, arising in the pancreas head region (Photo courtesy of KGH).

Pancreatic Cancer Risk Rises with Fasting Glucose

More than 56,000 Americans are expected to be diagnosed with pancreatic cancer in 2019, which is more than 150 people diagnosed every day. Read more
15 Aug 2019 | Clinical Chemistry
Image: The Mini8 Plus real time polymerase chain reaction (RT-PCR) thermocycler (Photo courtesy of Coyote Bioscience).

Direct Molecular Assay Developed for Zika Diagnosis

Zika virus (ZIKV), a mosquito-borne Flavivirus, is a positive single-stranded RNA virus with a nucleic acid length of about 10. Read more
14 Aug 2019 | Molecular Diagnostics
Image: The GeneXpert MTB/RIF assay is designed as a rapid diagnosis test of Tuberculosis (TB) and drug resistance (Photo courtesy of Cepheid).

Serum Siderocalin Measured in Patients with TB and HIV

Tuberculosis (TB) continues to be a significant cause of morbidity and mortality worldwide. The progression from uninfected or latently infected to active TB is often insidious and has minimal symptoms in the initial months, resulting in delayed diagnosis and poor outcomes. Read more
14 Aug 2019 | Clinical Chemistry
Image: The BC-6800 benchtop automatic hematology analyzer (Photo courtesy of Mindray).

Hematology Analyzer Screens for Malaria in Clinical Setting

Malaria is a vector-borne infectious disease that continues to have high morbidity and mortality globally. Read more
14 Aug 2019 | Microbiology
Image: A colored scanning electron micrograph (SEM) of Enterococcus faecalis. These bacteria generate 12,13-diHOME and the concentration of the lipid itself in the babies’ stool samples predicted which infants went on to develop allergies (Photo courtesy of Pete Wardell/CDC).

Allergy Risk Increased by Compound Found in Infant Gut

Gut microbiota (formerly called gut flora) is the name given today to the microbe population living in our intestine. Read more
14 Aug 2019 | Microbiology
Image: The Xevo TQ-S micro Triple Quadrupole Mass Spectrometry (Photo courtesy of Waters).

High Fetal Estrogen Levels Linked to Autism

The male-biased prevalence of autism, together with the finding that autistic girls have a higher mutational load than autistic boys, suggests that males have a higher likelihood of developing autism. Read more
13 Aug 2019 | Clinical Chemistry
Image: The FACSymphony A5 system is a novel cell analyzer that leverages the inherent benefits of flow cytometry and enables the simultaneous measurement of up to 50 different characteristics of a single cell (Photo courtesy of BD Biosciences).

T Follicular Helper Cells Retain Lymphoid Characteristics

T follicular helper cells (Tfh) are a subset of CD4+ T cells that provide B cell help within the follicles of secondary lymphoid tissues. Read more
13 Aug 2019 | Immunology
Image: Scientists determined that one-third of total cholesterol in plasma was present in remnant lipoproteins, which is in the triglyceride-rich lipoproteins intermediate-density lipoprotein (IDL) and very low-density lipoprotein (VLDL) (Photo courtesy of Harvard Medical School).

High Remnant Particle Cholesterol Levels Profiled in Blood

Three quarters of the Danish population have moderately elevated levels of cholesterol. If cholesterol levels are too high, risk of cardiovascular disease is increased. Read more
13 Aug 2019 | Clinical Chemistry
Image: The presence of lymphocytes within the tubular epithelium, attesting to acute cellular rejection of a renal graft (Photo courtesy of Wikimedia Commons).

Gene Panel Detects Early Signs of Kidney Transplant Rejection

A team of European kidney transplantation researchers has developed and validated an mRNA-based gene set found in peripheral blood that can identify patients with symptoms of antibody-based kidney transplant rejection. Read more
12 Aug 2019 | BioResearch

Channels

Clinical Chemistry

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Different Biochemical Parameters Found in Patients with IGR
Proteomics Approach Used for Analyses of Breast Cancer
Random Plasma Glucose Tests Could Predict Diabetes
Image: The cobas e 801 module is a high throughput immunochemistry module that performs a broad range of heterogeneous immunoassay tests (Photo courtesy of Roche Diagnostics).

Low Serum IGF1 Predicts CV Events in RA Women

Hypertension is a significant health threat and an independent predictor of cardiovascular (CV) events including coronary heart disease, stroke, heart failure, and dementia in the general population and... Read more

Molecular Diagnostics

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Liquid Biopsy Device Selectively Captures Circulating Tumor Cells
Amyloid Beta Blood Test Detects Asymptomatic Alzheimer’s Disease
Mutation Study Suggests Changes to Clinical Management
Image: The structure of human hemoglobin with alpha and beta subunits in red and blue, respectively, and the iron-containing heme groups in green (Photo courtesy of Wikimedia Commons).

Abnormal Hemoglobin Levels Predict Risk of Developing Dementia

Both elevated and diminished levels of serum hemoglobin have been linked to an increased risk of developing various types of dementia including Alzheimer’s disease. Investigators at Erasmus Medical... Read more

Hematology

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Abnormal Metabolite Observed in Early CKD Patients
Genetic Changes Linked to Leukemia in Down’s Syndrome Children
Thromboembolic Risk Increases after Hematological Cancers
Image: A blood smear from a patient with non-Hodgkin lymphoma showing very large lymphocytes (Photo courtesy of Venngage).

BRCA2 Mutations Linked to Pediatric Non-Hodgkin Lymphoma Risk

Inherited mutations in BRCA1 and BRCA2 genes are most typically associated with an increased risk of developing breast and ovarian cancer. BRCA2 was the third most frequently mutated gene (14 occurrences)... Read more

Immunology

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T Cell Antibody and Memory in H7N9 Survivors Characterized
Early B Cell Differentiation Activation Seen in Lupus
Blood Biomarkers Help Predict Recovery Time after Concussion
Image: An immunoglobulin G (IgG)-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis (Photo courtesy of Institut Pasteur).

Immunoglobulins and Neutrophils Play Unexpected Role in Anaphylaxis

Anaphylaxis may be brought about by various substances, including drugs (antibiotics or neuromuscular blocking agents), food and insect venom. Anaphylaxis is a hyperacute allergic reaction caused by an... Read more

Microbiology

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Novel Diagnostic Device Profiles Population of Gut Microbiome
Multiplex PCR Developed for Neglected Infectious Diseases
Clostridioides difficile Contamination Uncovered in Clinical Lab
Image: Burkholderia pseudomallei colonies grown on Ashdown\'s agar after four days incubation showing the characteristic cornflower head morphology (Photo courtesy of Gavin Koh).

Cost-Effectiveness of Media for Melioidosis Diagnosis Reviewed

Melioidosis is a frequently fatal disease caused by a soil bacterium called Burkholderia pseudomallei that is widespread in the rural tropics. The yield of B. pseudomallei from sites with a normal flora... Read more

Pathology

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Urine Test Used to Individualize Bladder Cancer Treatment
Rare Inherited Enzyme Disorder Yields Insight into Fibrosis
Test Improves Accuracy in Identifying Precancerous Pancreatic Cysts
Image: A scientist assembling the cartridge assay that distinguishes cancer from benign aspirates from mammographically suspicious breast lesions (Photo courtesy of Wanjun Ding).

Molecular Test Accurately Distinguishes Breast Tumors

A new laboratory test has been developed to identify chemical changes to a group of cancer-related genes that can accurately detect which breast tumors are cancerous or benign, and do it in far less time... Read more

Lab Tech.

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New Systems Offer Cost-Effective Urinalysis at Any Lab Scale
Microfluidic Device Isolates Circulating Tumor Cell Clusters
Microfluidic Motility Device Indicates Likelihood of Breast Tumor Metastasis
Image: A new study suggests that cutting-edge electronic devices can help doctors diagnose early stage bladder cancer (Photo courtesy of Ana Sandoiu).

Electronic Device May Help Diagnose Early Bladder Cancer

It is estimated that bladder cancer will affect 80,470 people in the USA this year, and about 17,670 deaths are likely to result from these cases. Doctors diagnose approximately half of all bladder cancers... Read more

BioResearch

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Using Transcriptome Analysis to Detect Asymptomatic Alzheimer’s Disease
Rare Neurodegenerative Disorders Share DNA Repeat Mutation
Genetic Loci Significantly Associated with Anorexia Nervosa
Image: A micrograph of non-alcoholic fatty liver disease (NAFLD). The liver has a prominent (centrilobular) macrovesicular steatosis (white/clear round/oval spaces) and mild fibrosis (green). The hepatocytes stain red. Macrovesicular steatosis is lipid accumulation that is so large it distorts the cell\'s nucleus (Photo courtesy of Wikimedia Commons).

Single Mutation Linked to Fatty Disorders of Liver and Skin

The common liver disorder non-alcoholic fatty liver disease (NAFLD) has been found to share a genetic linkage with Chanarin-Dorfman syndrome, a rare skin condition. NAFLD, which affects more than one-third... Read more

Industry News

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Beckman Coulter Introduces New Total Laboratory Automation Solution
Ortho Clinical Diagnostics Presents Cardiac Advances at EuroMedLab 2019
Global POC Diagnostics/Testing Market to Reach USD 22.8 Billion by 2025
Image: The global blood gas analyzers market is projected to surpass USD 940 million by 2026 (Photo courtesy of iStock).

Global Blood Gas Analyzers Market to Surpass USD 940 Million by 2026

The global blood gas analyzers market was valued at USD 594.6 million in 2017 and is projected to grow at a CAGR of 5.5% over the forecast period (2018 – 2026) to surpass USD 940 million by 2026.... Read more

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