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Trending Articles

Serum-IgG Responses in Patients with Mild and Severe COVID-19

New Monotest Diagnoses Risk of Invasive Aspergillosis

Fecal Immunochemical Test Assessed in Suspected Colorectal Cancer

Stand-Alone COVID-19 Rapid POC Antigen Test Delivers Results in 10 Minutes Without Separate Analyzer

Lung Ultrasound Scan Findings Can Help Identify False-Negative COVID-19 Test Results

New COVID-19 Test That Identifies T-Cell Signature Better at Detecting Past Coronavirus Infection

PerkinElmer SARS-CoV-2 RT-PCR Assay Receives CE Mark for Saliva and Sample Pooling

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AACC:
AACC 2020 will be all virtual. December, 2020

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Events

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ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

01 Dec 2020 - 04 Dec 2020
Virtual Venue

6th Annual Conference of the Saudi Society for Clinical Chemistry (SSCC)

05 Dec 2020 - 08 Dec 2020
Virtual Venue

62 Annual Meeting & Exposition of the American Society of Hematology (ASH)

06 Dec 2020 - 08 Dec 2020
Virtual Venue

32nd Congress of the European Society of Pathology (ESP).

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Lightweight Tactical Ventilator Advances Field Medicine

Pfizer COVID-19 Vaccine Doses Flown to US from Belgium in First Mass Air Shipment for Quick Distribution

Drug to Reduce Bleeding During Surgery Can Prevent Severe COVID-19

New AI-Driven Model for Predicting COVID-19 Impact Dramatically Outperforms Other Models

AstraZeneca-Oxford COVID-19 Vaccine Headed for Additional Global Trial After Dosing Error

Machine Learning Algorithm for Identifying Single Virus Particles Could Lead to More Accurate, Fast COVID-19 Test

First-Ever COVID-19 Severity Test to Triage Patients Quickly and Accurately

FDA Grants EUA to One of the First Tests That Measures Specific Levels of COVID-19 Neutralizing Antibodies

Beckman Coulter Launches Semi-Quantitative Access SARS-CoV-2 IgG II Antibody Test

Self-Swab Kit for COVID-19 Test Granted Emergency Use Authorization by FDA

RapidRona Self-Collection COVID-19 Kit Secures FDA Emergency Use Authorization

Mast Group Launches New ESPLINE SARS-CoV-2 Lateral Flow Antigen Test

Cepheid Receives CE-IVD Registration for SARS-CoV-2, Flu A, Flu B and RSV Combination Test

More COVID-19 News

Distinct Inflammatory Profiles Distinguish COVID-19 From Influenza

Image: The Cytek Aurora spectral flow cytometer (Photo courtesy of Cytek Bioscience).

Acute respiratory failure occurs in a subset of COVID-19 patients. Understanding the etiology of respiratory failure in COVID-19 patients is critical for determining the best management strategies and pharmacologic targets for treatment. Read more
30 Nov 2020

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EUROIMMUN offers tests for direct virus detection and for support of immune response assessment after SARS-CoV-2 infection, e. g. ELISAs for detection of antibodies against viral spike protein S1 domain or modified nucleocapsidprotein.

Incretin Hormone Levels Linked to Arteriosclerosis

30 Nov 2020

Anticoagulant Adjustment Evaluated Using Different Prothrombin Time Tests

26 Nov 2020

Mitoses Counted with Digital Pathology in Breast Phyllodes Tumors

26 Nov 2020

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It is widely used in PCR Covid-19 testing, providing an easy way of sample collection also for school students and at home collection. The method is inexpensive and non-invasive.

LINEAR CHEMICALS S.L.U

SARS-CoV-2 RNA Test Assessed Among Recovered COVID-19 Patients

25 Nov 2020

Blood Biomarker Predicts Guillain-Barré Prognosis

25 Nov 2020

Industry Spotlight

Nova Biomedical Launches New Laboratory Blood Glucose Reference Analyzer

Nova Biomedical (Waltham, MA, USA) has launched Nova Primary, a rapid, accurate, easy to use, blood glucose laboratory analyzer that fills the need for a new glucose reference analyzer to replace the YSI STAT PLUS 2300 Glucose and L-Lactate analyzer from YSI, Inc. Read more
19 Nov 2020

New Monotest Diagnoses Risk of Invasive Aspergillosis

A new monotest using chemiluminescence, meets the need for the immediate testing of individual samples for patients at risk of invasive aspergillosis, without resorting to batching, cumulating samples, or sending out to an external laboratory. Read more
12 Nov 2020

Streck Launches Rapid, Modular qPCR Instrument with Market-Leading Speed

Streck (La Vista, NE, USA) has launched the Zulu RT, a rapid, modular qPCR instrument capable of performing four independent experiments simultaneously. Read more
11 Nov 2020

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In Other News

Image: Single virus particle detections using a solid-state nanopore (Photo courtesy of Osaka University)

Machine Learning Algorithm for Identifying Single Virus Particles Could Lead to More Accurate, Fast COVID-19 Test

A new system for single-virion identification of common respiratory pathogens that uses a machine learning algorithm trained on changes in current across silicon nanopores may lead to fast and accurate screening tests for diseases like COVID-19 and influenza. Read more
30 Nov 2020 | COVID-19

Self-Swab Kit for COVID-19 Test Granted Emergency Use Authorization by FDA

A kit that allows individuals to collect their own nasal swabs and ship the specimens to a lab for COVID-19 testing has received Emergency Use Authorization (EUA) from the US Food and Drug Administration (FDA). Read more
27 Nov 2020 | COVID-19

Image: AbioSCOPE (Photo courtesy of Abionic SA)

First-Ever COVID-19 Severity Test to Triage Patients Quickly and Accurately

A new test offers medical criteria of COVID-19 severity and likelihood of clinical deterioration within minutes of analyzing a blood sample, allowing healthcare practitioners to decide whether COVID-19 patients should be assigned to general wards, intensive care units (ICUs) or be discharged from the hospital. Read more
27 Nov 2020 | COVID-19

RapidRona Self-Collection COVID-19 Kit Secures FDA Emergency Use Authorization

RapidRona (Chicago, IL, USA) has received Emergency Use Authorization (EUA) from the FDA for its SARS-CoV-2 sample self-collection kit. Read more
27 Nov 2020 | COVID-19

FDA Grants EUA to One of the First Tests That Measures Specific Levels of COVID-19 Neutralizing Antibodies

The US Food and Drug Administration (FDA) has granted Emergency Use Authorization (EUA) to one of the first tests that measures specific levels of COVID-19 neutralizing antibodies. Read more
26 Nov 2020 | COVID-19

Image: ESPLINE SARS-CoV-2 lateral flow antigen test (Photo courtesy of Mast Group Ltd.)

Mast Group Launches New ESPLINE SARS-CoV-2 Lateral Flow Antigen Test

Mast Group Ltd. (Liverpool, UK) has launched the new ESPLINE SARS-CoV-2 lateral flow antigen test for the detection of COVID-19. Read more
26 Nov 2020 | COVID-19

Beckman Coulter Launches Semi-Quantitative Access SARS-CoV-2 IgG II Antibody Test

Beckman Coulter Diagnostics (Brea, CA, USA) has launched its Access SARS-CoV-2 IgG II assay that measures a patient’s relative level of antibodies in response to a previous SARS-CoV-2 infection. Read more
26 Nov 2020 | COVID-19

Image: Xpert Xpress SARS-CoV-2, Flu A, Flu B and RSV Combination Test (Photo courtesy of Cepheid)

Cepheid Receives CE-IVD Registration for SARS-CoV-2, Flu A, Flu B and RSV Combination Test

Cepheid (Sunnyvale, CA, USA) has received the CE-IVD marking for its Xpert Xpress SARS-CoV-2/Flu/RSV, a rapid molecular diagnostic test for qualitative detection of the viruses causing COVID-19, Flu A, Flu B, and RSV infections from a single patient sample. Read more
25 Nov 2020 | COVID-19

Image: An increase in Plasma P-tau217 may be considered as an early Alzheimer disease biomarker (Photo courtesy of Harvard Medical School).

Biomarker Detects Early Alzheimer’s Disease

In Alzheimer disease (AD), abnormal metabolism of amyloid-β (Aβ) and tau leads to accumulation of extracellular plaques formed by misfolded Aβ and intraneuronal neurofibrillary tangles containing phosphorylated tau (P-tau) protein. Read more
24 Nov 2020 | Immunology

Image: Elevated fructosamine levels were associated with increased periprosthetic joint infection risk (Photo courtesy of Kristine Houck, MA).

Elevated Fructosamine Levels Associated with Increased PJI Risk

Periprosthetic joint infection (PJI) is the most serious complication that lowers the quality of patients’ life by elevating the patients’ burden of cost and affecting the outcome of total joint arthroplasty. Read more
24 Nov 2020 | Clinical Chemistry

Image: Micrograph showing fibrosis of the liver caused by cirrhosis. The tissue in this example is stained with a trichrome stain, in which fibrosis is colored blue. The red areas are the nodular liver tissue (Photo courtesy of Wikimedia Commons)

Panel of Urinary Peptides Used to Diagnose Liver Fibrosis

A panel of 50 urinary peptides was shown to be a useful tool for the early diagnosis of liver fibrosis. Read more
24 Nov 2020 | Molecular Diagnostics

Image: The portable MinION sequencing platform runs one flow cell and desktop GridION can run up to five flow cells at any time (Photo courtesy of Oxford Nanopore).

Metagenomic Sequencing Quickly Identifies Pathogens in Body Fluids

Metagenomic next-generation sequencing (mNGS) is a shotgun sequencing approach in which all of the nucleic acid (DNA and RNA) in a clinical sample is sequenced at a very high depth, 10-20 million sequences per sample. Read more
23 Nov 2020 | Microbiology

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Clinical Chemistry

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Image: The QTRAP 6500+ Liquid Chromatography with tandem mass spectrometry system (Photo courtesy of Sciex).

Biomarkers Predict Whether RA Patients Will Respond to DMARDs

Rheumatoid arthritis (RA) is characterized by unremitting joint inflammation that results in bone and cartilage destruction and a decreased quality of life. RA may arise from a decreased ability of the... Read more

Breath Ammonia Biomarker Predicts Kidney Function in CKD Patients

Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months to years. Initially there are generally no symptoms; later, symptoms may... Read more

Image: The AbsoluteIDQ p180 kit provides scientists with highly reproducible metabolomics data to confidently obtain detailed knowledge about the metabolic phenotypes in their studies (Photo courtesy of BIOCRATES Life Sciences).

Metabolomics Profiles Associated with Diabetic Retinopathy

Diabetic retinopathy (DR), like diabetic neuropathy and nephropathy, is a common complication of diabetes. It is the leading cause of loss of vision in diabetic patients. Long-standing disease, along with... Read more

Image: The cobas c 501 module for clinical chemistry (Photo courtesy of Roche Diagnostics).

High-Sensitivity C-Reactive Protein Investigated in Acute Myocardial Infarction Patients

Type 2 diabetes mellitus (DM) is a common comorbidity in acute myocardial infarction (AMI), and it is associated with two-fold higher in-hospital and long-term mortality rates and with a higher risk of... Read more

Molecular Diagnostics

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Blood Biomarker Protein Correlates with Severity of Brain Damage in Stroke Patients

Researchers have identified a stroke-related biomarker protein that correlates with the severity of brain tissue damage as well as with functional outcome and mortality. The outcome of a stroke varies... Read more

Levels of MicroRNAs in Saliva Are Diagnostic for Mild Traumatic Brain Injury

Measurement of levels of microRNAs in saliva was used to diagnose the presence of concussion (mild traumatic brain injury or mTBI) in a group of patients suffering from head trauma. Mild traumatic brain... Read more

Image: Schematic diagram of cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP-seq) (Photo courtesy of Princess Margaret Cancer Centre).

Methylated DNA Profiling Explored for Prenatal Testing Applications

A method for analyzing cell-free methylated DNA being developed for use in cancer liquid biopsy testing can potentially also be used for prenatal testing applications. The method called, cell-free... Read more

Image: Model of C-reactive protein (CRP) (Photo courtesy of Wikimedia Commons)

CRP Tracking Predicts Potential Outcome for Hospitalized COVID-19 Patients

By tracking the increase in circulating levels of the inflammatory biomarker C-reactive protein, doctors are able to predict whether newly hospitalized COVID-19 patients will suffer respiratory deterioration... Read more

Hematology

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Image: The 5200 Fragment Analyzer system performs DNA QC and RNA QC for a broad range of samples including, gDNA, small RNA, cfDNA, large DNA fragments, and total RNA (Photo courtesy of Agilent Technologies).

CD200 Expression Marks Leukemia Stem Cells in Human AML

Acute myeloid leukemia (AML) is organized as a hierarchy sustained by a minor population of leukemia stem cells (LSCs) with self-renewal capacity that drive disease. The LSC populations of AML exhibit... Read more

Image: Fibrinogen Test: people with low fibrinogen levels show a rapid movement of blood up the device (Photo courtesy of Monash University).

Paper Diagnostic Directly Measures Fibrinogen in Whole Blood

Fibrinogen is a protein found in blood that is needed for clotting. When a patient experiences traumatic injury, such as a serious car accident, or major surgery and childbirth complications, fibrinogen... Read more

Image: A newborn baby’s foot with a peripheral intravenous catheter in the neonatal intensive care unit. Newborns undergoing surgery suffered worse outcomes if they had received preoperative blood transfusion (Photo courtesy of Atichayo).

Newborns Getting Preoperative Blood Transfusions Have More Complications

Blood transfusions in the neonatal patient population are common, but there are no established guidelines regarding transfusion thresholds. Little is known about postoperative outcomes in neonates who... Read more

Image: An Acousto Thermal Shift Assay `lab-on-a-chip` device shown next to a US quarter for size comparison. The device can diagnose sickle cell anemia (Photo courtesy of CU Boulder College of Engineering and Applied Science).

New Technology Rapidly Diagnoses Sickle Cell Disease

Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anemia (SCA). It results in an abnormality in the oxygen-carrying... Read more

Immunology

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Image: Autoantibody order, timing helps predict genetically susceptible children most likely to get type 1 diabetes (Photo courtesy of the Morsani College of Medicine).

Autoantibody Timing Predicts Genetically At-Risk Children for Diabetes

While antibodies are molecules produced by the body's immune system to detect and destroy specific viruses, bacteria and other harmful substances, autoantibodies are antibodies that target a person's own... Read more

Image: The iFlash 1800 chemiluminescence immunoassay analyzer (Photo courtesy of Shenzhen YHLO Biotech).

Serum-IgG Responses in Patients with Mild and Severe COVID-19

The coronavirus disease 2019 (COVID-19) pandemic continues, causing considerable morbidity and mortality worldwide. The severity of COVID-19 ranges from asymptomatic to fatal pneumonitis, with mildly symptomatic... Read more

Image: The EUROPattern Microscope Live: Ultrafast fluorescence microscopy that automatically detects anti-neutrophil cytoplasmic antibodies (Photo courtesy of EUROIMMUN AG).

Methods for Automated Anti-Neutrophil Cytoplasmic Antibodies Compared

The detection of anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence assays (IFA) is of diagnostic importance in vasculitis and some other inflammatory diseases.... Read more

Image: The BD FACSymphony A5 flow cytometer (Photo courtesy of BD Biosciences).

MAIT Cell Activation Dynamics Associated with COVID-19 Disease Severity

The balance between protective versus pathological immune responses in COVID-19 has been a concern since the onset of the pandemic. SARS-CoV-2 infection can lead to acute respiratory distress syndrome... Read more

Microbiology

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Image: The STANDARD F Dengue IgM/IgG FIA qualitatively analyzes Dengue virus specific IgM and IgG antibodies in serum, plasma and whole blood using fluorescent immunoassay (Photo courtesy of SD Biosensor).

Rapid Tests Evaluated in the Management of Dengue Fever

Dengue is a mosquito-borne infection caused by four distinct viruses (DENV 1-4) which belong to the flavivirus genus and may lead to diverse outcomes. The disease can be asymptomatic in about 75% of cases,... Read more

Antibodies Against Rabies Detected in Human Dried Blood Spots

Rabies is a viral disease that causes inflammation of the brain in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. Although preventable by vaccination for... Read more

Image: The AFIAS-6 (AFIAS-automated fluorescent immunoassay system) is an automated fluorescent immunoassay system that uses blood, urine, and other samples to measure quantitatively or semi-quantitatively the concentration of targeted analyte (Photo courtesy of Boditech Med Inc).

New Diagnostic Tests for Rotavirus and Norovirus Infections Evaluated

Acute gastroenteritis is one of the most impactful and common infectious diseases, accounting for millions of deaths annually in young children. Rotavirus and norovirus are leading causes of acute viral... Read more

Image: Yellow color shows thiamine degradation on an agar plate of cultured Paenibacillus thiaminolyticus (Photo courtesy of Catherine A. Richter, PhD).

Bacterium and Viral Coinfection Contributes to Postinfectious Hydrocephalus

Neonatal sepsis often precedes postinfectious hydrocephalus (PIH), although the manifestations of hydrocephalus typically emerge in the months after the neonatal period as sufficient cerebrospinal fluid... Read more

Pathology

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COVID-19 Lung Damage Caused by Persistence of Abnormal Cells

Several uncertainties still relate to the involvement of other organs in COVID-19. Besides indirect multi-organ injury, a few reports have suggested the possibility of direct injury caused by viral replication... Read more

Circulating Tumor Cell-Count Drives Therapy Choice for Breast Cancer

The choice between chemotherapy and endocrine therapy as first-line treatment for hormone receptor–positive, ERBB2 (also known as HER2)-negative metastatic breast cancer is usually based on the presence... Read more

Fecal Immunochemical Test Assessed in Suspected Colorectal Cancer

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include... Read more

Image: The HiSeq XTen human whole- genome sequencing system (Photo courtesy of Illumina).

Urine-Based Liquid Biopsy Test Detects Urothelial Carcinoma

Urine cytology, which is widely used to screen for bladder cancer, has high specificity but lacks sensitivity, especially for low-grade cancers. Cystoscopy, while more accurate than cytology, is an invasive... Read more

Technology

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Image: Cryptosporidium oocysts and the larger Giardia cysts stained by Crypto/Giardia IFA kit (Photo courtesy of Cellabs).

Smartphone Microscopic Method Detects Cryptosporidium and Giardia

Food and water-borne illness arising from the consumption of contaminated food and water are serious health hazards globally. Cryptosporidium and Giardia are the major food and water‒borne parasites.... Read more

Image: A test tube contains saliva that can be tested for the heart attack biomarker cardiac troponin (Photo courtesy of karenfoleyphoto).

Saliva Test Fast Tracks Heart Attack Diagnosis

Heart attacks need urgent diagnosis, followed by treatment to restore blood flow to blocked arteries. Diagnosis is based on symptoms (such as chest pain), an electrocardiogram (ECG) and a blood test for... Read more

Image: Schematic diagram of the OvCa-Chip microsystem that recreates vascular endothelium–mediated platelet extravasation in ovarian cancer (Photo courtesy of Texas A&M College of Engineering).

Microfluidic Device Explores Ovarian Cancer Interactions

In many cancers, platelet interactions with circulating tumor cells and their role in metastasis have been studied extensively. In ovarian cancer, platelet extravasation into the tumor and resulting metastasis... Read more

$The TriVersa NanoMate LESA uses chip-based electrospray ionization technology that combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated ion source platform (Photo courtesy of Advion BioSciences).$

Nanoparticle System Captures Heart-Disease Biomarker From Blood

Physicians currently use an antibody-based test called enzyme-linked immunosorbent assay (ELISA) to help diagnose heart attacks based on elevated levels of cardiac troponin I (cTnI) in the patient's blood sample.... Read more

BioResearch

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Genome Analysis Predicts Likelihood of Neurodisability in Oxygen-Deprived Newborns

A genomics-based blood test can predict likelihood that a baby suffering hypoxia at birth will suffer serious nervous disorders such as cerebral palsy or epilepsy at a later stage of development.... Read more

Image: A micrograph of a diffuse large B cell lymphoma (DLBCL) (Photo courtesy of Wikimedia Commons).

Gene Panel Predicts Disease Progession for Patients with B-cell Lymphoma

Cancer researchers developed a 29 gene–based weighted prognostic score for predicting event-free survival and overall survival of patients suffering from diffuse large B-cell lymphoma (DLBCL).... Read more

Image: A diagram of construction of a genomic library (Photo courtesy of Wikimedia Commons).

New Method Simplifies Preparation of Tumor Genomic DNA Libraries

A method has been described that simplifies preparation of tumor genomic DNA libraries by employing restriction enzymes and in vitro transcription to barcode and amplify genomic DNA prior to library construction.... Read more

New Tool Developed for Diagnosis of Chronic HBV Infection

A team of Chinese researchers has described the development of a new and powerful tool for the diagnosis and treatment of chronic hepatitis B virus (HBV) infection. Methods currently used to diagnose... Read more

Industry News

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Image: Absorbance 96 Plate Reader (Photo courtesy of Enzo Biochem)

Enzo Biochem Launches Portable Microplate Reader for Use with Its ELISA and Assay Kits

Enzo Biochem (New York, NY, USA) has launched a small portable microplate reader for use with the company’s immunoassays and, ultimately, molecular diagnostics, providing new opportunities in point-of-care medicine.... Read more

Image: Randox and Bosch Healthcare Collaboratively Combat COVID-19 with Game-Changing Partnership (Photo courtesy of Randox Laboratories)

Randox and Bosch Healthcare Alliance Targets COVID-19 Testing

A partnership between Randox Laboratories (Crumlin, UK) and Bosch Healthcare (Waiblingen, Germany) aims to alter the testing landscape in both laboratory and non-laboratory settings toward the rapid detection... Read more

Image: Mindray Hematology Solution Helps High-Volume Lab Run 2,820,000 CBC Tests Annually (Photo courtesy of Mindray)

Mindray Hematology Solution Helps High-Volume Lab Run 2,820,000 CBC Tests Annually

High-volume laboratories face several challenges, including high instrument failure rate, errors due to several manual steps, low efficiency and long TAT, and heavier workload for the lab staff.... Read more

2020 AACC Annual Scientific Meeting & Clinical Lab Expo to Be an All Virtual Event Due to Coronavirus Pandemic

The American Association for Clinical Chemistry (AACC Washington, DC, USA) has decided to hold the 2020 AACC Annual Scientific Meeting & Clinical Lab Expo as a virtual event, rather than as a live... Read more

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