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Events

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18 Nov 2019 - 21 Nov 2019
Medica 2019
21 Nov 2019 - 22 Nov 2019
JIB 2019 Journées de l’innovation en biologie médicale
02 Dec 2019 - 06 Dec 2019
Zdravookhraneniye 2019

In Other News

Image: Strongyloides stercoralis adult. The parasitic female lives threaded into the mucosal epithelium of the human small intestine (Photo courtesy of UVM Ecological Parasitology).

Systematic Serological Screening Programme Used for Strongyloidiasis

Strongyloidiasis is a soil-transmitted helminth infection caused by the nematode Strongyloides stercoralis and is endemic mainly in tropical and subtropical regions, but also in temperate regions. Read more
13 Nov 2019 | Immunology
Image: The Elecsys Troponin T-high sensitive (TnT-hs) assay can reduce the time needed to rule-in or rule-out non-ST segment elevation myocardial infarction (NSTEMI) to as little as just one hour (Photo courtesy of Roche).

Cardiac Biomarkers Identify High-Risk Kidney Disease Patients

Cardiovascular disease (CVD) claims more lives in people with chronic kidney disease (CKD) than complications of kidney disease and this can be explained in part by shared common risk factors including hypertension, diabetes, hyperlipidemia, smoking, and obesity. Read more
12 Nov 2019 | Clinical Chemistry
Image: Serum flotillin levels in patients with AD were lower than those in non-AD cases (Photo courtesy of Makoto Michikawa, Nagoya City University)

Researchers Recommend the Membrane Protein Flotillin as a Biomarker for Alzheimer’s Disease

A team of Japanese researchers have suggested adding the protein flotillin to the arsenal of biomarkers that can be used to diagnose Alzheimer’s disease. Read more
12 Nov 2019 | Molecular Diagnostics
Image: The hand-held Genie III scanner has a two-color fluorescence excitation and detection system (Photo courtesy of OPTIGENE Ltd).

Inexpensive LAMP-Based Schistosomiasis Tests Developed

Schistosomiasis is one of the most prevalent Neglected Tropical Diseases, affecting approximately 250 million people worldwide. Read more
12 Nov 2019 | Molecular Diagnostics
Image: The Abbott Architect i2000SR immunoassay analyzer (Photo courtesy of Abbott Diagnostics).

Reference Intervals Established for Serum Ferritin in Chinese Adults

As the foundation for the interpretation of medical laboratory data, reference intervals (RIs) for analytes are one of the most widely used clinical decision‐making tool. Read more
12 Nov 2019 | Hematology
Image: Translocation: a fragment of a chromosome is moved (trans-located) from one chromosome to another and joins a non-homologous chromosome. The balance of genes is still normal (nothing has been gained or lost), but can alter phenotype as it places genes in a new environment (Photo courtesy of Indiana University).

Chromosomal Abnormalities Associated with Recurrent Miscarriage

Recurrent miscarriage, or the loss of two or more pregnancies, affects between 1% and 2% of couples. Chromosomal abnormalities are the major genetic cause of miscarriage and are detected by routine analysis in about 1 in 50 couples. Read more
11 Nov 2019 | Molecular Diagnostics
Image: Histopathology of prostate cancer: crystalloids (bright eosinophilic rhomboid to prismatic structures, seen in ~40% cancer) and amorphous eosinophilic secretions (Photo courtesy the American Urological Association).

High Levels of Blood Hormones Raise Prostate Cancer Risk

Men with higher levels of 'free' testosterone and a growth hormone in their blood are more likely to be diagnosed with prostate cancer. Read more
11 Nov 2019 | Clinical Chemistry
Image: A liquid biopsy blood test that measures the amount of cell-free DNA (cfDNA) in the bloodstream correlates with how patients will progress after they are diagnosed with glioblastoma (Photo courtesy of University of Pennsylvania School of Medicine).

Use of Cell-free DNA Liquid Biopsy to Predict Glioblastoma Progression

Cancer researchers have demonstrated the potential clinical utility of liquid biopsy to measure plasma cell-free DNA (cfDNA) in patients with newly diagnosed glioblastoma in order to predict the progression of the disease. Read more
11 Nov 2019 | Molecular Diagnostics
Image: A scanning electron micrograph (SEM) of prostate cancer cells (Photo courtesy of Sloan Kettering Institute).

Prostate Cancer Methylation Levels Linked to Epigenetic Profiles

Prostate cancer is cancer that occurs in the prostate, a small walnut-shaped gland in men that produces the seminal fluid that nourishes and transports sperm. Read more
07 Nov 2019 | Molecular Diagnostics
Illustration

Measurable Residual Disease Assessed Post-Transplantation in Acute Lymphoblastic Leukemia

The detection of residual disease by techniques more sensitive than light microscopy is called measurable residual disease (MRD) and is an important prognostic marker, which dictates outcome of disease. Read more
07 Nov 2019 | Hematology
Image: A micrograph of ALL cancer cells (Photo courtesy of Baylor College of Medicine).

Metabolomic Profiling Identifies ALL Patients at Risk for MRD and Cancer Relapse

Metabolomic profiling of bone marrow from patients suffering from acute lymphoblastomic leukemia was used to identify those who were at high risk of developing minimal residual disease and cancer relapse. Read more
07 Nov 2019 | Molecular Diagnostics
Image: Blood drawn from a sickle cell patient (left) and from a patient after stem-cell transplant (right) (Photo courtesy of NIH Molecular and Clinical Hematology Branch).

Allogeneic Transplantation Outcomes Compared in Sickle Cell Disease Patients

Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. Read more
06 Nov 2019 | Hematology

Channels

Clinical Chemistry

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Vitamin D Deficiency Associated with Impaired Muscle Strength
CSF Test Developed for Uncommon Brain Diseases
Blood Based Biomarkers Characterize Parkinson’s Disease
Image: Preeclampsia is a pregnancy complication marked primarily by high blood pressure and organ damage. The diagnostic values of STAT4 and sEng in preeclampsia have been analyzed (Photo courtesy of Johns Hopkins University).

Diagnostic Values of Serum STAT4 and sEng Analyzed in Preeclampsia

Preeclampsia is a pregnancy complication characterized by high blood pressure and signs of damage to another organ system, most often the liver and kidneys. Preeclampsia usually begins after 20 weeks of... Read more

Molecular Diagnostics

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Metastatic Tumor Profiles Lead to Potential Treatment Targets
Full Analytical Data Validated for Target Selector ctDNA Assays
Blood and Urine Metabolic Biomarkers Monitor Short-term Dietary Changes
Image: The pancreas and surrounding organs (Photo courtesy of Wikimedia Commons).

Whole-exome Sequencing Identifies Mysterious Pancreatitis Mutation

By applying advanced whole-exome sequencing analysis techniques, researchers have identified a mutation linked to a rare form of inhertied pancreatitis. Pancreatitis is a disease that causes the pancreas... Read more

Hematology

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Hematological Parameters Detect Patients with Acute VTE
Laser Incubator Developed for Rapid Blood Group Typing
Biomarker in Adolescence Linked to Early Mortality
Image: A histopathology of primary central nervous system lymphoma showing small purple cells along the blood vessel in the brain (Photo courtesy of Columbia University Medical Center).

Biomarkers Analyzed for Central Nervous System Lymphoma

Primary central nervous system lymphoma (PCNSL) is a rare type of extranodal non-Hodgkin lymphoma (NHL) accounting for 3% of all newly diagnosed primary intracranial tumors. In patients presenting with... Read more

Immunology

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POC Test Based on Quantum Dots Detects Antibody Responses
Immunoassays Compared to Improve Diagnosis of Chagas Disease
Handling Procedures Affect Interleukin 6 Levels in Samples
Image: The MenoCheck picoAMH ELISA is FDA cleared for in vitro diagnostic use as an aid in the determination of menopausal status in women between 42 and 62 years of age (Photo courtesy of Ansh Laboratories).

Anti-Müllerian Hormone Immunoassay Validated

Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein with roles in regulation of fetal sexual differentiation and folliculogenesis in the adult ovary. AMH is increasingly used as a biomarker of ovarian... Read more

Microbiology

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Vaginal Biomarkers Predict Preterm Birth Risks
Nasopharyngeal Pneumococcal Density Associated with Invasive Lung Disease
LC-MS/MS Assay Directly Detects Urinary Bacteria
Image: The High Pure Viral RNA Kit is for general laboratory use and purifies viral RNA from a variety of samples such as serum and plasma (Photo courtesy of Roche Diagnostics).

Enterovirus D type 111 Genetically and Phenotypically Characterized

Members of the species Enterovirus D (EV-D) remain poorly studied. The two first EV-D types (EV-D68 and EV-D70) have regularly caused outbreaks in humans since their discovery five decades ago but have... Read more

Pathology

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Methylation Signature Identified for Brain Metastases of Lung Cancer
Multigene Testing for Breast Cancer Patients Proves Cost-Effective
Diagnostic Panel Analysis of Lung Cancer Compared
Image: A and B, Mucinous adenocarcinoma of colon and indeterminate PMS2 immunohistochemistry staining. C and D, Poorly differentiated carcinoma of colon and indeterminate MLH1 staining. E and F, Endometrial carcinoma and focal MSH6 staining (Photo courtesy of University of Texas Southwestern Medical Center).

Lynch Syndrome Screening by IHC Leads to Mutation Studies

Lynch syndrome or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that is associated with a high risk of colon cancer, as well as other cancers including endometrial... Read more

Lab Tech.

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Flow Cytometry Improved Updated Spectral Analyzer
Pocket-Sized Zinc Deficiency Test Evaluated
New QC Reagents Compatible with Multiple Immunoassay Platforms
Image: A novel three-dimensionally-printed cell trap captures white blood cells and eliminates red cells from a whole blood sample while isolating circulating tumor cells (CTCs) (Photo courtesy of Allison Carter, Georgia Institute of Technology).

Rapid Filter Method Created for Isolation of CTCs from Whole Blood

Isolation and analysis of circulating tumor cells (CTCs) from blood samples present a potential means for basic cancer research as well as diagnosis and personalized treatment of the disease.... Read more

BioResearch

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New Method Simplifies Preparation of Tumor Genomic DNA Libraries
New Tool Developed for Diagnosis of Chronic HBV Infection
Panel of Genetic Loci Accurately Predicts Risk of Developing Gout
Image: A micrograph of a diffuse large B cell lymphoma (DLBCL) (Photo courtesy of Wikimedia Commons).

Gene Panel Predicts Disease Progession for Patients with B-cell Lymphoma

Cancer researchers developed a 29 gene–based weighted prognostic score for predicting event-free survival and overall survival of patients suffering from diffuse large B-cell lymphoma (DLBCL).... Read more

Industry News

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ERBA Mannheim Opens New Subsidiary in Brazil
AI-Enabled Technology to Help Global Molecular Imaging Market Reach USD 11.13 Bi...
Researchers Develop World’s First AI-Augmented Ova and Parasite Detection Tool
Image: Baxter International has acquired Cheetah Medical to expand their patient monitoring portfolio (Photo courtesy of Shutterstock).

Baxter Acquires Cheetah Medical to Expand Specialized Patient Portfolio

Baxter International Inc. (Deerfield, IL, USA), a global medical products company, has acquired Cheetah Medical (Boston, MA, USA), a provider of non-invasive hemodynamic monitoring technologies.... Read more

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