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Image: The Oncotype DX analyzes 21 genes in the tumor to estimate a woman\'s risk of the cancer coming back after surgery (Photo courtesy of Genomic Health).

Biomarker Tests Benefit Certain Cancer Patients

The benefit of biomarker tests has been reinvestigated to support the decision for or against adjuvant systemic chemotherapy in certain breast cancer patients, that is, women with primary hormone receptor-positive, HER2/neu-negative breast cancer and 0 to 3 affected lymph nodes. Read more
17 Sep 2018 | Pathology
Image: The LSM 780 inverted laser scanning confocal microscope (Photo courtesy of Zeiss).

Biomarker Identified for Novel Asthma Treatment

Asthma is a widespread chronic airway disease characterized by airway obstruction, inflammation, and hyperresponsiveness. Read more
17 Sep 2018 | Hematology
Image: A photomicrograph of a Giemsa-stained, thin film blood smear that reveals the presence of numerous of ring-form, Plasmodium falciparum trophozoites, with some infected red blood cells (RBCs) harboring multiple organisms (Photo courtesy of CDC / Steven Glenn).

Diagnostic Techniques Compared for Malaria Diagnosis

Malaria is an overwhelming problem in tropical developing countries. It is currently the most important human parasitic disease in the world and continues to be a serious public health problem. Read more
13 Sep 2018 | Microbiology
Image: The GeneXpert system and MTB/RIF test cartridge for the molecular detection of Mycobacterium tuberculosis complex and rifampin resistance-associated mutations (Photo courtesy of Cepheid).

Rapid Molecular Tuberculosis Testing Reduces Patient Isolation

Molecular testing appears to be associated with facilitating faster, more patient-centered care for individuals placed in respiratory isolation while undergoing evaluation for active tuberculosis (TB) in hospitals in the USA. Read more
13 Sep 2018 | Microbiology
Image: The Archer FusionPlex Sarcoma Kit: A targeted sequencing assay to simultaneously detect and identify fusions of 26 genes associated with soft tissue cancers (Photo courtesy of Illumina).

Targeted Sequencing Approach for Sarcoma Gene Fusions Validated

Sarcomas are rare cancers that grow in a patient's connective tissue, such as bones, muscles, tendons, nerves, and fat. Read more
12 Sep 2018 | Molecular Diagnostics
Image: The Q Exactive hybrid quadrupole-orbitrap mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Residual Tissue Repositories Suitable for MS-Based Proteomics

Mass spectrometry-based proteomics has become a powerful tool for the identification and quantification of proteins from a wide variety of biological specimens. Read more
12 Sep 2018 | Lab Tech.
Image: Nucleic acid hybridization on an electrically reconfigurable network of gold-coated magnetic nanoparticles enables microRNA detection in blood (Photo courtesy of University of New South Wales).

Magnetic Nanoparticle Tool Developed to Detect MicroRNA

A magnetic nanoparticle-based technique has been developed to directly detect microRNA (miRNA) in unprocessed whole blood samples in about thirty minutes. Read more
12 Sep 2018 | Lab Tech.
Image: A blood film from a patient with Chronic Lymphocytic Leukemia (CLL); a large lymphocyte (arrow) has a notched nucleus and demonstrates the variable appearance of some of the lymphocytes in CLL (Photo courtesy of Peter Maslak).

New mRNA Cancer Drivers Revealed in Chronic Lymphocytic Leukemia

New evidence has emerged showing that the inactivation or alteration of cancer suppressor genes can take place even if DNA itself remains unaltered. Read more
11 Sep 2018 | Hematology
Image: Breast tissue from a relapsed patient with active phosphorylation markers (left; brown color), compared to breast tissue from a patient without relapse and who does not have these active markers (right) (Photo courtesy of Centro Nacional de Investigaciones Oncológicas).

Prognostic Biomarkers Identified for Aggressive Breast Cancer

The rarest, but also the most aggressive and hard to treat, form of breast cancer, is known as triple negative. Read more
11 Sep 2018 | Clinical Chemistry
Image: A photomicrograph of a Onchocerca volvulus microfilaria larva, the cause of onchocerciasis, also known as river blindness (Photo courtesy of Dr. Lee Moore / CDC).

Urine Test Detects River Blindness Filarial Worm

River blindness is a filarial disease, like elephantiasis, and occurs when the parasitic worm Onchocerca volvulus takes up residence in the skin. Read more
11 Sep 2018 | Microbiology
Image: The M8 serves as a dual microscope and scanner with all features accessible via a touch screen computer, making it a truly digital microscope (Photo courtesy of PreciPoint).

Colorectal Carcinoma Tumor Budding Automatically Evaluated

Tumor budding, meaning a detachment of tumor cells at the invasion front of colorectal carcinoma (CRC) into single cells or clusters has been shown to correlate to an inferior clinical outcome by several independent studies. Read more
10 Sep 2018 | Pathology

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Clinical Chemistry

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Inflammation Biomarkers Identified as Risk of Polyneuropathy
Sleep Disorder Linked with Abnormal Lipid Levels
Blood Test Identifies Gestational Diabetes Risk in First Trimester
Image: The MAGPIX clinical multiplexing analyzer system (Photo courtesy of Luminex).

Biomarker Low Predictive Power Validated for eGFR Decline

Glomerular filtration rate (GFR) is a measure of the function of the kidneys. This test measures the level of creatinine in the blood and uses the result in a formula to calculate a number that reflects... Read more

Molecular Diagnostics

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Breast and Ovarian Cancers Associated with Predisposition Genes
Unexplained Illness Puts Pathogen Discovery to Test
New Test Predicts Potential Success of BCG Immunotherapy for Bladder Cancer
Image: A micrograph of prostate adenocarcinoma, acinar type, the most common type of prostate cancer (Photo courtesy of Wikimedia Commons).

Elevated Gene Expression Correlates with Prostate Cancer Severity

Elevated expression of the gene ANO7 has been shown to correlate with the severity and possible outcome of prostate cancer (PrCa). Based on earlier studies showing that genetic signals at 2q37, the... Read more

Hematology

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Coagulation Tests Affected by Sodium Citrate Concentration
Mutations Identified As Cause for Rare Bone Marrow Disorder
Homogeneous BTK Occupancy Assay Developed
Image: Bone marrow aspirate from a patient with diffuse large B cell lymphoma (Photo courtesy of Peter Maslak).

Blood Test Predicts Lymphoma Therapy Success

A blood test can predict which patients with a type of cancer called diffuse large B cell lymphoma are likely to respond positively to initial therapy and which are likely to need more aggressive treatment.... Read more

Immunology

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Serum S-100β Elevated in Septic Shock Patients with Delirium
Biochemical Markers Predict Risk of Incident Diabetes
Biomarkers Linked to Fatigue in Parkinson’s Disease
Image: Diagram of the Seq-Well low-cost platform for single-cell RNA sequencing (Photo courtesy of Shalek Lab).

Analysis of Nasal Polyps Suggests Mechanisms of Inflammation

Allergic inflammation can develop from persistent activation of type 2 immunity in the upper airway, resulting in chronic rhinosinusitis, which ranges in severity from rhinitis to severe nasal polyps.... Read more

Microbiology

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Performance of Blood Culture Molecular Panels Evaluated
Methods Discriminate Dengue Severity during Acute Infection
Persistent Trichomoniasis Infection Found in Pregnant Women
Image: The UF-5000 Urine fluorescence flow cytometry analyzer (Photo courtesy of Sysmex).

Fluorescence Analyzers Evaluated for Diagnoses of UTIs

Urinary tract infections (UTIs) are among the most frequent infections in both hospitalized and outpatients. As a result, urine specimens constitute a significant proportion of routine microbiology laboratory... Read more

Pathology

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Urine Test Accurately Detects Bladder Cancer Recurrence
New Target Protein for Colon Cancer Identified
Integrated Analyses Offer Molecular Insights to Tumor Subtypes
Image: A histopathology of non-small cell lung cancer from a fine needle aspirate showing marked variation in nuclear size and shape, irregularly distributed nuclear chromatin, and large, prominent nucleoli (Photo courtesy of Ed Uthman, MD).

Blood-Based Test Predicts Benefits of Lung Cancer Treatment

Although programmed death-ligand 1–programmed death 1 (PD-L1–PD-1) inhibitors are broadly efficacious, improved outcomes have been observed in patients with high PD-L1 expression or high tumor mutational... Read more

Lab Tech.

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Mild Brain Trauma Diagnosed with POC Device
New Troponin Assays Receive US Marketing Clearance
Fetal Genetic Abnormalities Detected in Early Pregnancy
Image: A simple, paper-based test can quickly identify a falsified or substandard antibiotic (Photo courtesy of John Eisele).

Simple Paper Test Detects False or Substandard Antibiotics

In the developing world, the manufacture and the distribution of substandard, non-legitimate medicines is widespread. It has been estimated that up to 10% of all drugs worldwide could be falsified with... Read more

Industry News

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EKF Diagnostics Releases Educational Guide to Good Capillary Blood Sampling
Greiner Bio-One Launches New Safety Blood Collection Set
Infectious Disease Testing to Remain Driver for Diagnostic Market
Image: The global critical care diagnostics (CCD) market is expected to reach USD 1.3 billion by 2024 (Photo courtesy of iStock).

Global Critical Care Diagnostics Market to Reach USD 1.3 Billion by 2024

The global critical care diagnostics (CCD) market is estimated to have been valued at USD 837.6 million in 2015 and is expected to reach USD 1.3 billion by 2024, driven by increasing awareness among physicians,... Read more

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