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In Other News

Image: A micrograph of pancreatic ductal adenocarcinoma (the most common type of pancreatic cancer) (Photo courtesy of Wikimedia Commons).

Genetic Markers Predict Susceptibility of Pancreatic Tumors

A panel of genetic markers allows clinicians to match pancreatic tumors with appropriate existing chemotherapeutic drugs. Read more
18 Mar 2019 | Molecular Diagnostics
Image: A mouth ulcer (in this case associated with aphthous stomatitis) on the labial mucosa (lining of the lower lip) (Photo courtesy of Wikimedia Commons).

Study Identifies Gene Variations for Mouth Ulcers

An extensive genome-wide association study (GWAS) identified 97 common genetic variations that predisposed people to suffer from mouth ulcers. Read more
18 Mar 2019 | Molecular Diagnostics
Image: The Fecal Immunochemical Test has been shown to detect colorectal cancer up to two years earlier than colonoscopy alone (Photo courtesy of Pinnacle BioLabs).

Fecal Immunochemical Tests Performance Characterized for CRC

Many patients experience fear and anxiety before undergoing colonoscopy, which may result in negative experiences. Read more
14 Mar 2019 | Clinical Chemistry
Image: HbA1c provides a longer-term trend, similar to an average, of how high blood sugar levels have been over a period of time (Photo courtesy of Diabetes.co.uk).

HbA1c Levels May Help Predict CF-Related Diabetes

Cystic fibrosis-related diabetes (CFRD) shares some features with both type 1 and type 2 diabetes. In people with cystic fibrosis (CF), the thick, sticky mucus that is characteristic of the disease causes scarring of the pancreas. Read more
14 Mar 2019 | Clinical Chemistry
Image: The three-dimensional (3D) herringbone nanopatterned microfluidic chip that detects cancer faster (Photo courtesy of the University of Kansas).

Nanopatterned Microfluidic Chip Detects Cancer Markers

The performance of current microfluidic methods for exosome detection is constrained by boundary conditions, as well as fundamental limits to microscale mass transfer and interfacial exosome binding. Read more
13 Mar 2019 | Clinical Chemistry
Image: The Twista device allows portable, two channel fluorometric detection of eight Recombinase Polymerase Amplification (RPA) reactions (Photo courtesy of TwistDx).

Rapid Molecular Test Detects Macrolide Resistance

Emerging antimicrobial resistance is a significant threat to human health. However, methods for rapidly diagnosing antimicrobial resistance generally require multi-day culture-based assays. Read more
13 Mar 2019 | Microbiology
Image: The Guardant360 kit for biopsy-free tissue sequencing for cancer (Photo courtesy of Guardant Health).

Liquid Biopsy Proves Effective as Biopsy for NSCLC

Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). Read more
13 Mar 2019 | Pathology
Image: A diagram shows how the microfluidics device separates cancer cells from blood. The green circles represent cancer cells (Photo courtesy of Professor Ian Papautsky, PhD).

New Microfluidics Device Detects Cancer Cells in Blood

The ability to successfully isolate cancer cells is a crucial step in enabling liquid biopsy where cancer could be detected through a simple blood draw. Read more
12 Mar 2019 | Pathology
Image: A photomicrograph of a glomerulus with changes characteristic of a transplant glomerulopathy. Transplant glomerulopathy is considered a form of chronic antibody-mediated rejection (Photo courtesy of Nephron).

Blood Test Predicts Kidney Transplant Rejection

A renal transplant offers the best treatment for patients whose kidneys have failed, with around 3,000 carried out annually in the UK. Read more
12 Mar 2019 | Molecular Diagnostics
Image: The pHOx Ultra blood gas analyzer is used for routine blood gas analysis (Photo courtesy of Nova Biomedical).

Analysis Compared for Accurate Pleural Fluid pH Determination

Pleural effusion is the pathological accumulation of pleural fluid resulting from excess fluid production and/or increased transpleural pressure, increased capillary permeability, and impaired lymphatic drainage. Read more
12 Mar 2019 | Clinical Chemistry
Image: Immunohistochemical stain for CD137 performed on paraffin-embedded tissue sections (cytoplasmic and membranous) using monoclonal BBK-2 clone (original magnification ×400) (Photo courtesy of Peter N. Carbone, MD and Qian-Yun Zhang, MD, PhD).

Immunohistochemical Stain Facilitates cHL Diagnosis

Remarkable efforts are underway to exploit classic Hodgkin lymphoma's (cHL) complex interplay of molecular alterations, loss of B-cell programming, and dependency of tumor microenvironment. Read more
11 Mar 2019 | Pathology

Channels

Clinical Chemistry

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Vitamin D Measured in Human Hair
Blood Test Detects Alzheimer's Disease before Symptoms Appear
Procalcitonin Evaluated as Sepsis Diagnostic Marker
Image: Blood samples are loaded into a mass spectrometer to analyze them for signs of metabolic variations that could signal autism spectrum disorder (Photo courtesy of NeuroPointDX).

Blood Test Identifies Amino Acid Metabotypes Associated with Autism

Autism spectrum disorder (ASD) could benefit from new and improved diagnostic methods and the arrival of a newly commercialized blood test, along with other efforts headed toward a similar end goal, and... Read more

Molecular Diagnostics

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Clinical ddPCR Diagnostic Test System Gets FDA Clearance
Novel Test Measures Pain Biomarkers in Blood
Genetic Defect Linked to Pediatric Liver Disease
Image: Newly identified (red) and known (blue) genes linked to Alzheimer’s disease spike in this table plotting results from genome-wide association analysis of 94,437 individuals with late onset Alzheimer’s (Photo courtesy of Brian W. Kunkle, MD, PhD and colleagues).

Alzheimer's Disease Meta-Analysis Identifies New Risk Genes

The risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. Scientists have uncovered five new late-onset Alzheimer's disease risk genes in a genetic... Read more

Hematology

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Peripheral Blood Flow Cytometry Classifies Pediatric Acute Leukemia
Leukemia Prematurely Ages Bone Marrow Cells
Hypersegmented Neutrophils Associated with Reduced Lung Function
Image: A blood smear of a patient with monoclonal B-cell lymphocytosis. The two atypical lymphocytes are mature with a small rim of basophilic cytoplasm and clumped or cracked chromatin (Photo courtesy of Elizabeth Courville, MD).

Circulating Plasma DNA Potentially Identifies Incipient Tumors

Early cancer diagnosis might improve survival rates. As circulating tumor DNA (ctDNA) carries cancer-specific modifications, it has great potential as a noninvasive biomarker for detection of incipient tumors.... Read more

Immunology

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Atrophic Gastritis Prevalence Determined by Serological Evidence
Unique Form of Chronic Sinusitis Diagnosed in Older Patients
Blood Test Diagnoses Pancreatic Cancer Disease Earlier
Image: A diagram of how human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans (Photo courtesy of the University of Kiel).

Intestinal Mucosa Fungus Can Affect Lung Health

The composition of the microbiome, the countless bacteria, fungi and viruses that colonize our body surface, skin, intestines or lungs, makes a decisive contribution to human health or disease.... Read more

Microbiology

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Lateral Flow RPA Assay Developed for Cryptococcus in CSF
Unnecessary Testing for UTIs Significantly Reduced
Buruli Ulcer Pathogen Detected by Isothermal RPA Assay
Image: The Accuri C6 compact flow cytometer (Photo courtesy of BD Biosciences).

Cervical Microbes Potentially Tied to Infections and Lesions

Nearly all cervical cancers are causally associated with human papillomavirus (HPV). The burden of HPV-associated dysplasias in sub-Saharan Africa is influenced by human immunodeficiency virus (HIV).... Read more

Pathology

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Blood Test Detects Brain Damage Years before Symptoms
Bacterial Pathogen Discovered in Brains of Alzheimer's Patients
Simple Inexpensive Test Screens for Esophageal Cancer
Image: The Benchmark XT System, a fully automated staining system (Photo courtesy of Ventana Medical Systems).

Genetic Causes of Salivary Gland Carcinoma Discovered

Acinic cell carcinoma is the third most common malignant form of salivary gland cancer. These tumors are similar to normal salivary gland tissue and occur most frequently in the parotid gland.... Read more

Lab Tech.

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Genetic Methods Rapidly Diagnoses Huntington's Disease
Enteric Viral Panel Gets FDA Clearance
Inexpensive Biosensor Provides Rapid Diagnosis of Bacterial Infections
Image: Liquid handling products from Hecht-Assistant (Photo courtesy of Glaswarenfabrik Karl Hecht).

Glaswarenfabrik Karl Hecht Celebrates 100-year Anniversary

In 1919, Karl Hecht laid the foundation for the Glaswarenfabrik in Sitzendorf-Unterweißbach in Thuringia, Germany. Over the decades the company continuously specialized in production and distribution of... Read more

Industry News

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Beckman Coulter Launches ClearLLab 10C System for Clinical Flow Cytometry Labs
Lack of Regional Research in Precision Medicine Could Hamper Targeted Therapies
Middle East IVF Market Driven by High Demand for IVF and Related Treatments
Image: The global in vitro diagnostics market is projected to grow between 2017 and 2025 to reach almost USD 90 million by the end of 2025 (Photo courtesy of iStock).

Global In Vitro Diagnostics Market to Reach USD 90 Billion by 2025

The global in vitro diagnostics market was valued at USD 55.00 billion in 2016 and is projected to grow at a healthy CAGR of 5.60% between 2017 and 2025 to reach USD 89.8 billion by the end of 2025.... Read more

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