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Image: The LSRFortessa cell analyzer offers the ultimate in choice for flow cytometry, providing power, performance, and consistency (Photo courtesy of BD Biosciences).

Flow Cytometry Standardized for Predicting Transplant Rejection

Understanding the immunological phenotype of transplant recipients on standard immunosuppression, immune-cell therapies and new drug treatments is essential for improving transplantation outcome. Read more
12 Jun 2019 | Immunology
Image: The SEQPRO LIPO IS assay is for the genetic diagnosis of familial hypercholesterolemia (Photo courtesy of Progenika Biopharma).

Genetic Familial Hypercholesterolemia Prevalent in Premature CVD

Premature coronary artery disease (CAD) is a major cause of mortality and morbidity. Increased low-density lipoprotein-cholesterol (LDL-C) level is a major risk factor for CAD and thus the main target for its prevention. Read more
12 Jun 2019 | Clinical Chemistry
Image: The PLATELIA ASPERGILLUS Ag Test (Photo courtesy of Bio-Rad Laboratories).

Invasive Pulmonary Aspergillosis Diagnosed by Molecular Test

Invasive aspergillosis (IA) is a common opportunistic fungal infection, mainly affecting patients with severe and prolonged neutropenia. Read more
12 Jun 2019 | Microbiology
Image: The XN-30 automated hematology analyzer that has an automatic measurement functions for red blood cells infected by malaria parasites (Photo courtesy of Sysmex).

Automated Hematology Analyzer Assessed for Malaria Diagnosis

Malaria remains a major cause of morbidity and mortality around the world. Sub-Saharan Africa is most affected with Plasmodium falciparum accounting for 99% of estimated cases. Read more
11 Jun 2019 | Hematology
Image: The KRYPTOR compact PLUS fully automated random access immunoassay analyzer (Photo courtesy of BRAHMS).

Plasma Copeptin Reveals Presence and Severity of Liver Disease

Vasopressin (VP) is a hormone secreted by the pituitary gland in response to increased plasma osmolality, low plasma volume, and low blood pressure. Read more
11 Jun 2019 | Clinical Chemistry
Image: A typical human serum mannose-binding lectin enzyme-linked immunoassay kit (Photo courtesy of Hycult Biotech).

Mannose-Binding Lectin Associated with IgG Subclass Deficiency

Mannose-binding lectin (MBL; mannan-binding protein or lectin) is involved in innate immune defense, is produced largely by hepatocytes and is encoded by MBL2 (chromosome 10q21. Read more
11 Jun 2019 | Immunology
Image: A representation of a methylated DNA molecule. The two white spheres represent methyl groups bound to two cytosine nucleotide molecules (Photo courtesy of Wikimedia Commons).

Disease-Related Epigenetic Variations Summarized in New DNA Methylation Atlas

A new DNA methylation atlas summarized a previously unexplored molecular level of human individuality called correlated regions of systemic interindividual variation (CoRSIVs), which may provide a resource for future population-based investigations into how interindividual epigenetic variation modulates risk of disease. Read more
10 Jun 2019 | BioResearch
Image: Examples of migratory and non-migratory MDA-MB-231 breast cancer cells migrating in the MAqCI (Microfluidic Assay for quantification of Cell Invasion) device (Photo courtesy of Christopher L. Yankaskas, Johns Hopkins University).

Microfluidic Motility Device Indicates Likelihood of Breast Tumor Metastasis

A novel microfluidic motility test was shown to accurately predict a breast tumor's likelihood to generate metastases. Read more
10 Jun 2019 | Lab Tech.
Image: A new liquid biopsy test called DELFI (DNA evaluation of fragments for early interception) uses artificial intelligence to detect patients with cancer by identifying altered DNA fragmentation in the blood (Photo courtesy of Carolyn Hruban, Johns Hopkins University).

Machine Learning Approach Detects Cancer by Analyzing DNA in Blood Samples

Researchers have described a proof-of-principle approach for the screening, early detection, and monitoring of human cancer based on a machine learning approach that evaluates fragmentation patterns of cell-free DNA across the genome. Read more
10 Jun 2019 | BioResearch
Image: A molecule model of Apo E (Photo courtesy of Wikimedia Commons).

Study Confirms Association of AD and High Levels of LDL Cholesterol

High LDL cholesterol levels have been linked to the risk of developing early-onset Alzheimer's disease (AD). Read more
10 Jun 2019 | Clinical Chemistry
Image: The cBot 2 System streamlines the sequencing workflow by automating cluster generation. It was a required accessory instrument for HiSeq sequencers (Photo courtesy of Illumina).

Sequencing Study Links DNA Alterations to Type 2 Diabetes

According to statistics from the World Health Organization, over 400 million people worldwide have diabetes. Read more
06 Jun 2019 | Molecular Diagnostics
Image: A diagram of the 3D-printed microchip electrophoresis device that can sensitively detect three serum biomarkers of preterm birth (Photo courtesy of Brigham Young University).

3D-Printed Device Detects Biomarkers of Preterm Birth

Preterm birth (PTB), defined as birth before the 37th week of gestation, is the leading complication of pregnancy and it affects about 1 in 10 pregnancies worldwide. Read more
06 Jun 2019 | Clinical Chemistry

Channels

Clinical Chemistry

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Reagent Strips Test Analyzed for CSF in Neurological Disorders
Lipid Levels from Non-Fasting Patients Deemed Suitable for Assessing CVD Risk
Bioimpedance Spectroscopy Preferred for Post-Breast Surgery Lymphedema Risk
Image: Tendinous xanthomas on the hand of a patient with familial hypercholesterolemia (Photo courtesy of ScreenPro FH).

Blood Donations Screened for Familial Hypercholesterolemia

Familial hypercholesterolemia is an autosomal-dominant disorder that often causes premature coronary artery disease. Unfortunately, familial hypercholesterolemia remains largely undiagnosed.... Read more

Molecular Diagnostics

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CtDNA Forecasts Non-Metastatic Colorectal Cancer Recurrence
Stem Cell Transplantation Increases Risk of Infection-Related Mortality
Liquid Biopsy Identifies Mutations Predicting Ovarian Cancer Treatment Response
Image: A diagram of genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes (Photo courtesy of Peking University).

Genomic Analysis Uncovers Differences in Liver Cancer Subtypes

Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy arising from the liver. ICC makes up about 10% of all cholangiocarcinomas. It arises from the peripheral bile ducts within the... Read more

Hematology

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Sickle Cell Disease Screening Helps Save Lives of Migrants
Multiple Myeloma Sequences Reveal Prognostic Immunoglobulin Translocation
Early Sepsis Detection Test Approved for U.S. Marketing
Image: A blood film showing typical red and white blood cells (Photo courtesy of Sherri Wick).

Neutrophil-Lymphocyte Ratio Proves Possible Biomarker for ED

Erectile dysfunction is described as the impotency to obtain or sustain an erection sufficiently in order to enable convincing sexual intercourse. Erectile dysfunction (ED) is estimated to affect about... Read more

Immunology

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Cysteine-Rich 61 Biomarker Reflects RA Disease Activity
Urinary Biomarkers Diagnose Serious Kidney Allergic Reaction
Diagnostic Process Detects Alzheimer’s Years before Symptoms Appear
Image: The unique pipette tip created with a 3D printer to perform enzyme-linked immunosorbent assays (Photo courtesy of the University of Connecticut).

Novel 3D-Printed Technology Lowers Cost of ELISA

Traditional enzyme-linked immunosorbent assay (ELISA) tests are performed on plates featuring 96 micro-wells; each well works as a separate testing chamber where samples can be combined with various agents... Read more

Microbiology

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FDA Clears CT/NG Assays for Extragenital Testing
Oral Bacteria Found in Cerebral Emboli of Stroke Patients
Rapid Assay Detects Pyrazinamide-Resistant Tuberculosis
Image: The Nextera XT Index kit is used to prepare whole genome sequencing libraries for bacterial isolates (Photo courtesy of Dr. Thippeswamy Sannasiddappa).

Airway Microbiome Altered in Severe Asthma Linked to Neutrophils

Patients with mild-to-moderate asthma can experience difficulty breathing and it is especially difficult for those with Severe Asthma where symptoms can be life threatening. In either case, patients cannot... Read more

Pathology

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Biomarker Predicts Appropriate Immunotherapy for Cancer Patients
Glioblastoma Driver Mutations Appear Long Before Diagnosis
Virus-Associated Liver Cancer Detected by Blood Tests
Image: A lymph node with almost complete replacement by metastatic melanoma. The brown pigment is focal deposition of melanin (Photo courtesy of Gabriel Caponetti, MD).

Blood Test Measures Effectiveness of Aggressive Cancer Treatments

Blood tests that track the amount of tumor DNA can, after only one month of drug therapy, detect how well treatment is working in patients with skin cancer. In the USA, more than 7,200 individuals are... Read more

Lab Tech.

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Technology Developed to Capture Tumor Cells
Siemens Healthineers Hemoglobin A1c Test Now Available on Atellica Solution
Biomarker Test Developed for Chronic Fatigue Syndrome
Image: Left: Images of a blebbing, highly metastatic PC3 prostate cancer cell (top) and a non-blebbing normal RWPE-1 prostate cell being forced into a microfluidic channel. Middle: Outlines of the images on the left highlighting blebbing and cell deformation. Right: Percentage of highly metastatic PC3, moderately metastatic DU145, and normal RWPE-1 cells that bleb while being forced into a channel along with the standard deviation (SD) (Photo courtesy of Fazle Hussain, Texas Tech University).

Increased Bleb Formation Characterizes Metastatic Cancer Cells

A recent paper described an inexpensive fluid biopsy device that is able to distinguish highly metastatic prostate cancer cells from moderately metastatic prostate cancer cells and normal cells.... Read more

Industry News

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Global Urinalysis Market Valued at USD 2 Billion by 2022
Baxter and bioMérieux in Alliance to Develop Acute Kidney Injury Diagnostics
Beckman Coulter Life Sciences Enters Partnership with Apostle
Image: The global automated immunoassay analyzer market is expected to achieve significant growth, driven by product innovations and increased clinical applications (Photo courtesy of iStock).

Global Automated Immunoassay Analyzer Market Driven by Increase in Applications

The global automated immunoassay analyzer market is expected to achieve significant growth over the coming years, driven by innovations in the existing products and increased clinical applications of these systems.... Read more

BioResearch

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Gene Set Isolated in Transformation of Skin Cells into Embryonic Tissues
Large GWAS Pinpoints Ovarian Cancer Risk Genes
Blood Test Distinguishes between Forms of Inflammatory Bowel Disease
Image: A micrograph showing retinal cells derived from a patient\'s skin cells, via induced pluripotent stem cells. The cells are organized in a polygonal shape and have taken on characteristic pigmentation (Photo courtesy of the University of California, San Diego).

Laboratory Model Reveals Genetic Risk Loci for AMD

Eye disease researchers used advanced stem cell technology to create a laboratory model of age-related macular degeneration (AMD), which enabled in-depth analysis of the genetics underlying the syndrome.... Read more

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