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Biochip Assay Rapidly Detects Mycobacterial Isolates

New Technique Detects Breaks in Mitochondrial DNA

Unexplained Liver Disease Diagnosed by Whole-Exome Sequencing

Multiplex Assay Detects Pathogens in NF Patients

Early Sepsis Detection Test Approved for U.S. Marketing

C-Peptide Responsiveness May Explain HbA1c Variation

Novel Genes and Pathways Discovered in Celiac Disease

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Weak AI security Exposes IoT Medical Devices to Risk of Cyberattacks

Disposable Anesthesia Device Demand Driven by Lower Risk of Transmitting Infections

Transseptal Access Dilator Facilitates LAA Closure

Perfusion System Increases Donor Lung Availability

Hydrogen Inhalation Protects Brain during Circulatory Arrest

Image: The Atellica CH Enzymatic Hemoglobin A1c (A1c_E) Assay (Photo courtesy of Siemens Healthineers).

Siemens Healthineers Hemoglobin A1c Test Now Available on Atellica Solution

The Atellica CH Enzymatic Hemoglobin A1c (A1c_E) Assay is an easy-to-implement chemistry test, offering precise and accurate results for diabetic patient management.
Read more
18 May 2019

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Blood Test May Predict Cardiovascular Disease

16 May 2019

Biomarker Test Developed for Chronic Fatigue Syndrome

16 May 2019

LAMP Malaria Test Detects Less-Diagnosed Species

16 May 2019

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Clinical Validation Bolsters Liquid Biopsy Evidence Base

15 May 2019

Bronchoalveolar Lavage Explored for TB Diagnosis

15 May 2019

Industry Spotlight

Global POC Diagnostics/Testing Market to Reach USD 22.8 Billion by 2025

The global point of care (POC) diagnostics/testing market size is expected to grow at a CAGR of 3.3% over the forecast period 2019-2025 to reach USD 22. Read more
03 May 2019

Global Automated Immunoassay Analyzer Market Driven by Increase in Applications

The global automated immunoassay analyzer market is expected to achieve significant growth over the coming years, driven by innovations in the existing products and increased clinical applications of these systems. Read more
18 Apr 2019

Global Urinalysis Market Valued at USD 2 Billion by 2022

The global urinalysis market is expected to grow at a CAGR of 7.5% from 2018 to 2022 to reach a value of USD 2. Read more
26 Mar 2019

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In Other News

Image: The RealTime HBV is an in vitro polymerase chain reaction (PCR) assay for the quantitation of Hepatitis B Virus (HBV) DNA in human plasma or serum from HBV-infected individuals (Photo courtesy of Abbott Molecular).

Serum HBV RNA Quantification Monitors Chronic Hepatitis B Infection

Chronic hepatitis B viral infection is a global health problem, especially in the Asian-Pacific region. Read more
15 May 2019 | Microbiology

Image: EndoPredict is a second-generation breast cancer recurrence test for highly accurate assessment of 10-year risk of distant recurrence (Photo courtesy of Myriad Genetics).

Breast Cancer Test Determines Most Effective Treatment

For the clinical management of patients with estrogen receptor (ER)-positive breast cancer, several clinico-pathological and molecular characteristics of the tumor have to be considered for prognosis and treatment decisions. Read more
14 May 2019 | Molecular Diagnostics

Image: The RealTime High-Risk HPV assay is designed for the detection of high-risk HPV genotypes in cervical specimens from women with precancerous lesions of the cervix uteri (≥ CIN2) and cervical cancer to provide clinically meaningful results in cervical cancer screening (Photo courtesy of Abbott Molecular).

Urine Test Could Prevent Cervical Cancer

The strategy of cervical screening depends on reducing the incidence of cervical cancer through the detection and treatment of its precursor lesion, high-grade cervical intraepithelial neoplasia (CIN2+). Read more
14 May 2019 | Molecular Diagnostics

Image: A photomicrograph showing tumor-infiltrating lymphocytes in a case of colorectal cancer with evidence of high microsatellite instability (MSI-H) on immunostaining (Photo courtesy of Nephron).

Biomarker Predicts Appropriate Immunotherapy for Cancer Patients

Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA mismatch repair activity. Read more
14 May 2019 | Pathology

Image: A photomicrograph of human papilloma virus associated oropharyngeal cancer. The tissue has been stained to show the presence of the virus by in situ hybridization (Photo courtesy of Jennifer L. Hunt, MD).

Oral HPV-DNA Persists after Oropharyngeal Cancer Treatment

Head and neck cancers affect some 53,000 people in the USA each year, according to the National Cancer Institute, and human papilloma virus (HPV) has been implicated in many of those cases. Read more
14 May 2019 | Microbiology

Image: A micrograph showing four-cell stage mouse embryos (Photo courtesy of Kirill Makedonski, the Hebrew University of Jerusalem).

Gene Set Isolated in Transformation of Skin Cells into Embryonic Tissues

A team of developmental biologists identified a set of five genes that is capable of transforming skin cells into pluripotent stem cells and then into all three of the cell types that comprise the early embryo: the embryo itself, the placenta, and the extra-embryonic tissues, such as the umbilical cord. Read more
13 May 2019 | BioResearch

Image: A micrograph of a mucinous ovarian carcinoma (Photo courtesy of Wikimedia Commons).

Large GWAS Pinpoints Ovarian Cancer Risk Genes

Results of a large genome-wide association study identified 34 genes that are associated with an increased risk for developing the earliest stages of ovarian cancer. Read more
13 May 2019 | BioResearch

Image: A micrograph of a colonic biopsy showing inflammation of the large bowel in a case of inflammatory bowel disease (Photo courtesy of Wikimedia Commons).

Blood Test Distinguishes between Forms of Inflammatory Bowel Disease

A recently developed blood test distinguishes between mild and severe forms of inflammatory bowel disease and is potentially a step towards realizing personalized therapy for the syndrome. Read more
13 May 2019 | BioResearch

Image: Brain imaging studies have revealed differences in the volume of various brain regions between patients with bipolar disorder and healthy control subjects (Photo courtesy of Wikimedia Commons).

Genome-wide Association Study Identifies New Bipolar Disorder Loci

Results obtained by a large genome-wide association study performed on individuals with bipolar disorder identified 20 new genetic associations involving genes encoding ion channels, neurotransmitter transporters, and synaptic components. Read more
13 May 2019 | BioResearch

Assessment of LDL cholesterol levels in two patients (Photo courtesy of Randox).

Randox Unveils an Assay for the Rapid Measurement of Small Dense LDL Cholesterol (sdLDL-C)

A kit for the automated measurement of small dense low-density lipoprotein cholesterol (sdLDL-C) is now available with dedicated controls and calibrators available and instrument-specific applications for use with a wide range of biochemistry analyzers. Read more
13 May 2019 | Clinical Chemistry

Image: The Helios CyTOF mass cytometry platform (Photo courtesy of Fluidigm).

Immune Cell Profiling Assay Boosts Use of Mass Cytometry

A new, multiplexed, antibody-based assay for immune cell profiling on its mass cytometry platform has been launched. Read more
09 May 2019 | Immunology

Image: The SureSelect XT combines sequencing library preparation and gDNA preparative reagents with the SureSelect target enrichment system (Photo courtesy of Agilent Technologies).

Liquid Biopsy Utility Reinforced in Early Cancer Trials Results

Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) supports blood-based genomic profiling but is not yet routinely implemented in the setting of a clinical phase I trials. Read more
09 May 2019 | Molecular Diagnostics

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Clinical Chemistry

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Image: Nodular glomerulosclerosis in the kidney of a patient with diabetic nephropathy; the acellular light purple areas within the capillary tufts are the destructive mesangial matrix deposits (Photo courtesy of the CDC).

Blood Protein Signature Reported for Diabetic Kidney Disease

Diabetic nephropathy or diabetic kidney disease (DKD), is a result of vascular abnormalities that accompany diabetes and increases mortality risk. Furthermore, diabetes mellitus is a main risk factor for... Read more

Image: In gestational diabetes, each 1 mmol/L increase in glucose concentration was associated with a 13% higher risk for cardiovascular disease (CV) disease (Photo courtesy of National Institute of Child Health and Human Development).

Glucose Test in Pregnancy Can Detect CV Risk

Gestational diabetes has consistently been associated with an increased future risk of cardiovascular disease (CVD), regardless of the antepartum screening protocol or diagnostic criteria by which gestational... Read more

Image: The glycated hemoglobin (HbA1c) test is an indicator of long-term glucose levels and high levels are linked to risks in pregnancy (Photo courtesy of Healthengine).

High HbA1c Levels Linked to Pregnancy Risks

For pregnant women with diabetes mellitus some particular challenges exist for both mother and child. If the woman has diabetes as an intercurrent disease in pregnancy, it can cause early labor, birth... Read more

Image: Low serum creatinine is associated with the risk of diabetes (Photo courtesy of Jo Lewin).

Low Serum Creatinine Associated with Diabetes Risk

Creatinine is the only metabolite of creatine phosphate in the skeletal muscle and under the steady state; it is created at a relatively constant rate by the body depending on the total skeletal muscle mass.... Read more

Molecular Diagnostics

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Image: The NovaSeq 6000 system offers high-throughput sequencing across a broad range of applications (Photo courtesy of Illumina).

Machine-Learning System Used to Diagnose Genetic Diseases

By informing timely targeted treatments, rapid whole-genome sequencing can improve the outcomes of seriously ill children with genetic diseases, particularly infants in neonatal and pediatric intensive... Read more

Image: The QuickGene-610L nucleic acid isolation system (Photo courtesy of Autogen).

New Genetic Test Detects Mutations in High-Risk Groups

A new low-cost genetic test has been developed that accurately identified more than 200 known disease-causing gene variations in two high-risk populations, the Old Order Amish and Old Order Mennonites... Read more

Image: Neurofilaments (red) in cultured rat brain cells (Photo courtesy of Wikimedia Commons).

Neurofilament Light Considered as NIV Biomarker for Alzheimer's Disease

Results presented in a recently published paper suggested that plasma neurofilament light protein may serve as a noninvasive biomarker to monitor neurodegeneration in Alzheimer disease (AD).... Read more

Image: The blood test by Natera detects breast cancer relapses (Photo courtesy of the University of Leicester).

Personalized Detection of ctDNA Antedates Breast Cancer

Breast cancer is one of the most commonly diagnosed cancers worldwide and the second leading cause of cancer-related deaths in women. The current standard of care for women with primary (non-metastatic)... Read more

Hematology

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Image: The Bioanalyzer 2100 system is a microfluidic platform that provides quantitation and quality control of DNA and RNA by capillary electrophoresis (Photo courtesy of Agilent Technologies).

Multiple Myeloma Sequences Reveal Prognostic Immunoglobulin Translocation

Multiple myeloma is the second most common hematological cancer, which affects terminally differentiated antibody secreting B cells, known as plasma cells. Clinical manifestations of myeloma include hypercalcemia,... Read more

Image: The Early Sepsis Indicator kit was designed for use on automated hematology instruments such as the DxH 900 analyzer (Photo courtesy of Beckman Coulter).

Early Sepsis Detection Test Approved for U.S. Marketing

A test for the early detection of sepsis has been approved for marketing in the United States as an in vitro diagnostic product. Sepsis is caused by an inflammatory immune response triggered by an infection.... Read more

Image: The PacBio RS II sequencer uses single molecule, real time (SMRT) sequencing technology (Photo courtesy of Pacific Biosciences).

High-Res Genotyping Improves Survival for Stem Cell Transplantation

Allogeneic hematopoietic cell transplantation (HCT) provides a curative treatment option for individuals with hematologic diseases. Recipients and donors are considered to be compatible or “well matched”... Read more

Different Clinical Hematology Lab Configurations Compared

Automated hematology analyzers are key clinical laboratory instruments that measure blood counts, identify subsets of nucleated blood cells, and ﬂag specimens for further manual analysis.... Read more

Immunology

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Image: The ABI 7900HT Fast Real-Time PCR System (Photo courtesy of Thermo Fisher Scientific).

Novel Genes and Pathways Discovered in Celiac Disease

Celiac disease (CD) is a chronic systemic autoimmune disease that occurs globally in genetically predisposed individuals in response to ingestion of gluten-containing grains. While the pathognomonic damage... Read more

Novel Software Reduces Variability in ELISA Biomarker Tests

Protein biomarkers are measured frequently in plasma, serum or other matrices by solid phase Enzyme-Linked Immunosorbent Assay (ELISA) methods in which the antigen of interest in the sample is bound by... Read more

Recombinant Capture Molecule Used for Viral Disease Diagnosis

Crimean-Congo hemorrhagic fever (CCHF) is an infectious disease endemic in a variety of countries in southeastern Europe, the Middle East, Asia, and Africa. The virus (CCHFV) transmission occurs via the... Read more

Image: Human IL-6 Luminex Performance ELISA Assay (Photo courtesy of R&D Systems).

Haptoglobin Expression Linked to Newborn Outcomes

Proteomics has facilitated discovery of biomarkers to better understand the pathophysiology of early-onset neonatal sepsis with the goal of identifying as early as possible the newborns more likely to... Read more

Microbiology

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Sequencing Shows Promise for Diagnosing Prosthetic Joint Infections

A method is being developed for diagnosing infections associated with prosthetic joint implants that promises to provide results in a matter of hours as opposed to a week or more. The current gold standard... Read more

Rapid Test for Chlamydia Antigen Antibodies Optimized

Trachoma, resulting from repeated infection with the bacterium Chlamydia trachomatis (Ct), is the leading infectious cause of blindness. Trachoma is targeted for elimination as a public health problem by 2020.... Read more

Image: A visualization of morulae in the cytoplasm of a granulocyte during examination of blood smears is highly suggestive of a diagnosis of Human Granulocytic Anaplasmosis (Photo courtesy of the US Centers for Disease Control and Prevention).

Diagnostic Methods Compared for Human Granulocytic Anaplasmosis

Human granulocytic anaplasmosis (HGA) is a tick-borne intracellular bacterial infection caused by Anaplasma phagocytophilum. The disease is present in North America, Europe, and northern Asia, areas with... Read more

Image: A graphic representation of Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy (Photo courtesy of the University of Pennsylvania).

Certain Bacteria Strains Associated with Diabetic Wounds

About 10% of Americans have been diagnosed with diabetes, and one quarter of these patients will develop a wound that does not heal. In the worst case outcome, which occurs in up to 25% percent of these... Read more

Pathology

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Image: A diagram of evolutionary trajectories of IDH-WT glioblastomas revealing a common path of early tumorigenesis instigated years ahead of initial diagnosis (Photo courtesy of German Cancer Research Center).

Glioblastoma Driver Mutations Appear Long Before Diagnosis

Glioblastomas are the most common high-grade (cancerous) primary brain tumor in adults. They can also occur, rarely, in children. Glioblastomas belong to a group of brain tumors known as gliomas, as they... Read more

Image: A histopathology of hepatocellular carcinoma: a mononuclear inflammatory cell infiltrate extends from portal areas and disrupts the limiting plate of hepatocytes which are undergoing apoptosis, the so-called interface hepatitis of chronic active hepatitis. In this case, the hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (HBcAb) were positive (Photo courtesy of University of Utah Medical School).

Virus-Associated Liver Cancer Detected by Blood Tests

Viral infection with either hepatitis C virus (HCV) or Hepatitis B virus (HBV) is the chief cause of liver cancer in the world today, accounting for 80% of hepatocellular carcinoma (HCC).... Read more

EBUS More Reliable Than Histology for Cancer Diagnoses

Radial probe endobronchial ultrasound (EBUS) is a minimally invasive procedure that improves localization of peripheral pulmonary lesions. Cytology samples of the suspect lesion site collected by radial... Read more

Image: The Guardant360 kit for biopsy-free tissue sequencing for cancer (Photo courtesy of Guardant Health).

Liquid Biopsy Proves Effective as Biopsy for NSCLC

Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively... Read more

Lab Tech.

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Flow Cytometry Leukemia/Lymphoma Antibody Panel Receives Approval

A panel of immune-phenotyping flow cytometer reagents that identifies both lymphoid and myeloid cell lines has been granted diagnostic marketing clearance by the [U.S.] Food and Drug Administration to... Read more

Image: Liquid handling products from Hecht-Assistant (Photo courtesy of Glaswarenfabrik Karl Hecht).

Glaswarenfabrik Karl Hecht Celebrates 100-year Anniversary

In 1919, Karl Hecht laid the foundation for the Glaswarenfabrik in Sitzendorf-Unterweißbach in Thuringia, Germany. Over the decades the company continuously specialized in production and distribution of... Read more

Image: A sketch of µLAS chip with two independent channels actuated with the same pressure and voltage. Each channel contains a funnel region that functions to separate and concentrate DNA in line (Photo courtesy of University of Lausanne).

Genetic Methods Rapidly Diagnoses Huntington's Disease

People with Huntington's disease suffer from jerky body movements and decreasing mental abilities. The condition usually leads to death 15 to 20 years after diagnosis. The cause of the disease is a region... Read more

Image: The BD MAX System is a fully automated platform that gives the power to consolidate and standardize a broad range of molecular tests including the BD Max enteric panel (Photo courtesy of Becton Dickinson).

Enteric Viral Panel Gets FDA Clearance

Acute viral gastroenteritis can be contracted by virtually any patient and spread within close community settings such as daycare centers, nursing facilities, and cruise ships. Norovirus is the most... Read more

Industry News

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Image: Baxter International and bioMérieux have joined together to develop future biomarkers that focus on identifying and treating acute kidney injury (AKI) (Photo courtesy of iStock).

Baxter and bioMérieux in Alliance to Develop Acute Kidney Injury Diagnostics

Baxter International Inc. and bioMérieux announced an agreement to develop future biomarkers with the goal to rapidly identify and inform treatment of acute kidney injury (AKI). The announcement was made... Read more

Beckman Coulter Life Sciences Enters Partnership with Apostle

Beckman Coulter Life Sciences (Indianapolis, IN, USA) has entered into a partnership with Apostle Inc. (Menlo Park, CA, USA) for the launch of Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit,... Read more

Image: The global digital pathology market is projected to reach USD 600 million by 2022 (Photo courtesy of Shutterstock).

Worldwide Digital Pathology Market to Reach USD 600 Million by 2022

The worldwide digital pathology market is projected to grow at a CAGR of 8.5% from 2017-2022 to reach USD 600 million by 2022, despite the presence of headwinds that are suppressing market potential and... Read more

Global In Vitro Diagnostics Market to Reach USD 90 Billion by 2025

The global in vitro diagnostics market was valued at USD 55.00 billion in 2016 and is projected to grow at a healthy CAGR of 5.60% between 2017 and 2025 to reach USD 89.8 billion by the end of 2025.... Read more

BioResearch

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Novel Fluidic Nanodevices Created by Liquid 3D Printing

Researchers have used a novel three-dimensional (3D) printing technique to create an all-liquid fluidic device that is capable performing a wide range of applications - from making battery materials to... Read more

Image: New research shows genetic risk factors for adult-onset asthma were largely a subset of the genetic risk for childhood-onset asthma but with overall smaller effects, suggesting a greater role for non-genetic risk factors in adult-onset asthma (Photo courtesy of Shutterstock).

Adult Asthma Genes Are Subset of Childhood-Onset Disease

A large asthma-related genome-wide association study found that the genes involved in adult-onset asthma were largely a subset of genes associated with the childhood-onset disease. Asthma is a chronic... Read more

Image: T-cells interacting with the transparent gel (Photo courtesy of Hawley Pruitt, Johns Hopkins University).

Hydrogel Cultivation Generates Large Populations of Activated T-Cells

A novel hydrogel-based culture system was used to generate activated immune T-cells that were shown to be able to block growth of melanoma tumors in a mouse model. Current T-cell therapies require the... Read more

Image: A histopathological image of multiple myeloma from a bone marrow aspirate (Photo courtesy of Wikimedia Commons).

Gene Translocation Marker Linked to Drug Resistance and Poor Prognosis

Cancer researchers have identified a genetic marker linked to the likelihood of a bad prognosis for some patients suffering from multiple myeloma. Multiple myeloma is a malignancy of antibody-secreting... Read more

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