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02 Sep 2018 - 05 Sep 2018

Eurotox 2018 54th Congress of the European Societies of Toxicology

09 Sep 2018 - 12 Sep 2018

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09 Sep 2018 - 13 Sep 2018

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Robotic TKR System Optimizes Implant Fit and Alignment

Insertion Support Assists Hemodialysis Catheter Placement

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Expedited Surgery Imperative for Post-Hip Fracture Survival

Implantable Infusion Pump Treats Pulmonary Hypertension

BiotechDaily

Researchers Identify Two Proteins Required to Reverse Senescence

PARP-Inhibitors Reduce Damage in Some Neurological Disorders

Preconditioning Enhances Stem Cell Transplantation in CF Model

RBC Transporters Used for Targeting Nanoparticle Drug Carriers

CRISPR Variant Enables More Accurate Genome Editing

$Image: A new study suggests obesity that affects the liver could play a part in the long-term onset of Alzheimer\'s and dementia (Photo courtesy of Deposit Photos).$

Alzheimer’s Disease Risk Impacted by Liver and Diet

Reduced levels of plasmalogens are associated with an increased risk of Alzheimer’s Disease. Plasmalogens are created in the liver and are dispersed through the bloodstream in the form of lipoproteins.
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21 Aug 2018

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Genetic Mutation Identified in Childhood Brain Disorder

21 Aug 2018

Biomarkers Linked to Fatigue in Parkinson’s Disease

21 Aug 2018

Coherent Fluctuation Nephelometry Used to Diagnose Bacteriuria

20 Aug 2018

Fifth-Generation Cardiac Troponin Assays Compared

20 Aug 2018

Biomarker-Based Blood Test Developed for Early Cancer Diagnosis

20 Aug 2018

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In Other News

Image: Molecular basis of familial hypercholesterolemia with a dominant pattern of inheritance: impaired low-density lipoprotein cholesterol clearance due to variations in LDLR, APOB, PCSK9 (Photo courtesy of Mayo Clinic).

Genetic Testing for Hypercholesterolemia Improves Diagnosis

Familial Hypercholesterolemia (FH) is caused by a genetic defect that hinders the body's ability to remove low-density lipoprotein (LDL) cholesterol from the blood. Read more
16 Aug 2018 | Molecular Diagnostics

Image: Mannitol salt agar plate with oxacillin showing methicillin-resistant Staphylococcus aureus (Photo courtesy of Medical College, Pondicherry).

Time To Blood Culture Positivity Predicts Infective Endocarditis

Blood cultures are used to detect the presence of bacteria or fungi in the blood, to identify the type present, and to guide treatment. Read more
16 Aug 2018 | Microbiology

Image: The FilmArray System is the new standard for syndromic infectious disease diagnostics (Photo courtesy of BioFire Diagnostics).

Multiplex Testing Speeds Up CNS Infection Diagnosis

A variety of viral, bacterial, and fungal pathogens cause infections of the central nervous system (CNS), which range in severity from mild and self-limiting to severe and life-threatening. Read more
16 Aug 2018 | Microbiology

Image: Positive and negative results detected by the lateral flow immunochromatographic assay AcQuickDx test for Angiostrongylus cantonensis (Photo courtesy of Faculty of Medicine Siriraj Hospital).

Immunochromatographic Test Rapidly Diagnoses Parasitic Infection

The rat lungworm Angiostrongylus cantonensis is a food-borne zoonotic parasite that causes eosinophilic meningitis in humans. Read more
15 Aug 2018 | Immunology

Image: Spiral-shaped Helicobacter pylori is the only bacteria known to colonize the human stomach. An estimated 50% of humans harbor H. pylori in their gut, but only some develop ulcers or stomach cancer (Photo courtesy of Boston University).

Diagnostic Accuracy in H. pylori Fecal Test Assessed

Helicobacter pylori (H. pylori) infection occurs among 48.5% of the general population worldwide, with high geographic variability. Read more
15 Aug 2018 | Microbiology

Image: Early diagnosis of Parkinson’s disease is important because it affects the choice of therapy and is subject to a relatively high degree of error (Photo courtesy of Technion - Israel Institute of Technology).

Breath Test Detects Early-Stage Parkinson's Disease

Parkinson's disease (PD) is a degenerative disease that destroys brain tissue and affects movement. It has four main symptoms: stiffness, shaking, slowness, and problems with coordination and balance. Read more
15 Aug 2018 | Clinical Chemistry

Image: A diagram of the causes of diabetes insipidus resulting from the lack of vasopressin (ADH) production in the hypothalamus or the pituitary gland (Photo courtesy of Maria Khatun Mona, RN).

Test Enables Quick Diagnosis for Rare Hormone Disorder

The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. Read more
14 Aug 2018 | Clinical Chemistry

Image: The G4 Platinum continuous glucose monitoring (CGM) system (Photo courtesy of Dexcom).

Diagnostic Tool Created for Hypoglycemia-Associated Autonomic Failure

Low blood sugar, or hypoglycemia, is a major complication of type 1 and type 2 diabetes. People with diabetes can have difficulty self-administering the exact insulin dose at the correct time to keep blood sugar levels in healthy ranges. Read more
14 Aug 2018 | Clinical Chemistry

Image: One drop of blood is enough for TBIcheck to diagnose a possible mild brain trauma. If a line appears below the control line, the injured person will have to go to the hospital for a CT scan (Photo courtesy of the University of Geneva).

Mild Brain Trauma Diagnosed with POC Device

Every year in Europe, three million people are admitted into hospitals for suspected mild traumatic brain injury (mTBI) cases. Read more
14 Aug 2018 | Lab Tech.

Image: The figure illustrates how T cells are detected in a blood sample with Epiontis ID. In T cells, the CD3 gene region is epigenetically active (yellow); in all other cell types, this region is epigenetically inactive (blue). The number of epigenetically active CD3 gene copies directly translates to the number of T cells in the sample (Photo courtesy of Precision for Medicine).

Epigenetic Diagnostic Tool Detects Diseases in Newborns

Newborns are routinely screened for inheritable diseases by analyzing dried blood spots (DBS) from blood taken from a heel-prick. Read more
13 Aug 2018 | Immunology

Image: The blood brain barrier and astrocytes type 1: The astrocytes type 1 surrounding capillaries in the brain (Photo courtesy of Shutterstock).

New Glioma Test Provides Answers during Surgical Procedures

A new diagnostic test detects certain mutations in glioma tumors during brain surgery and identifies those sensitive to metabolic chemotherapeutic agents. Read more
13 Aug 2018 | Molecular Diagnostics

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Blood Biomarker Indicates Extent of Traumatic Brain Injury

An estimated 54 million to 60 million people worldwide sustain a traumatic brain injury (TBI) annually. In the USA, more than 2.5 million people are diagnosed with TBI each year and most of those are from... Read more

Image: A photomicrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma of the lung, from a fine needle aspiration specimen (Photo courtesy of Nephron).

Cancer Risk Assessed by Circulating Protein Biomarker Panel

The question has been asked whether a risk prediction model based on circulating protein biomarkers improve on a traditional risk prediction model for lung cancer and the current USA screening criteria.... Read more

Image: An ELISA for quantitative determination of leptin in human serum and plasma (Photo courtesy of Diagnostic Automation).

Leptin to Adiponectin Ratio Predicts Metabolic Function in Obesity

There is an epidemic of obesity and the metabolic syndrome in the USA and across the world. Both entities are associated with high mortality, mainly as a result of cardiovascular disease.... Read more

HDL Does Not Always Lower Risk of CV Disease

High-density lipoproteins (HDL) are a family of particles found in the blood that vary in sizes and cholesterol contents. HDL has traditionally been measured as the total cholesterol carried by the HDL... Read more

Gene Test Distinguishes Kawasaki Disease from Other Illnesses

Kawasaki disease (KD), the most common acquired heart disease in children, can be diagnosed using a blood test that measures a 13-transcript gene expression signature. Currently there are no simple... Read more

Image: The Applied Biosystems 7500 real-time PCR System (Photo courtesy of Thermo Fisher Scientific).

Infections Defined in Urothelial Bladder Tumors

Bladder cancer is estimated to be the 9th most common cancer worldwide and over 90% of bladder tumors are classed as urothelial bladder carcinomas (UBCs), with 75% to 80% presenting at non-muscle-invasive... Read more

Image: A comparison of healthy bone and osteoporosis (Photo courtesy of PharmacyPedia).

Fracture Risk Predicted with New Genetic Screen

Low bone mineral density (BMD) is the major determinant for osteopenia and osteoporosis, which increase the chances of fragility fracture especially for elderly women. Low BMD is also a risk factor for... Read more

Image: A diagram of the hypothesis for the onset mechanism of childhood steroid-sensitive nephrotic syndrome (Photo courtesy of Kobe University).

Susceptible Genes Identified for Childhood Kidney Disease

Childhood nephrotic syndrome, also known as nephrosis, is an incurable disease with an unknown cause, characterized by large amounts of protein leaving the body in the patient's urine, and protein levels... Read more

Mutations Identified As Cause for Rare Bone Marrow Disorder

Scientists have helped solve a decades-old mystery about which mutations are responsible for an inherited bone marrow disorder. The answer may allow some children to avoid the risk and expense of bone... Read more

Image: The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies (Photo courtesy of PerkinElmer).

Homogeneous BTK Occupancy Assay Developed

Bruton’s tyrosine kinase (BTK), a member of the tyrosine kinase expressed in the hepatocellular carcinoma (TEC) family of cytoplasmic protein tyrosine kinases, was initially identified as the pathogenic... Read more

$Image: A blood smear from a patient with acute myeloid leukemia showing very large, immature myeloblasts with many nucleoli. A distinctive feature of these blasts is a linear red \"Auer rod\" composed of crystallized granules (Photo courtesy of University of Utah Medical School).$

Acute Myeloid Leukemia Risk Predicted in Healthy Individuals

The incidence of acute myeloid leukemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present... Read more

Image: A blood smear shows size heterogeneity of peripheral red blood cells, known as anisocytosis (Photo courtesy of Dr. Jay Park, MD).

Hematological Parameters Predict Severity of Acute Pancreatitis

Acute pancreatitis (AP) is an acute inflammation of the pancreatic parenchyma induced by activated pancreatic enzymes due to multiple causes. Current severity scores include multiple variables and some... Read more

Immunology

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IgM Antibodies Improve Risk Stratification for Antiphospholipid Syndrome

The antiphospholipid syndrome (APS) is an autoimmune hypercoagulable state and is characterized by thrombosis and/or pregnancy morbidity with the persistent presence of antiphospholipid antibodies (aPL).... Read more

Image: A photomicrograph of pigmented malignant melanoma in a Papanicolaou stained cytology specimen, (Photo courtesy of Nephron).

Melanoma Biomarkers Predict Checkpoint Blocker Response

The outlook for patients with advanced melanoma has dramatically improved in recent years because of drugs known as immune checkpoint inhibitors, which mobilize the immune system to attack cancer.... Read more

Image: The SPIFE Touch electrophoresis analyzer (Photo courtesy of Helena).

Urine and Blood Tests Better at Diagnosing Myeloma

Screening and diagnosis of monoclonal gammopathies is generally based on electrophoretic examination of serum and urine proteins, namely serum protein electrophoresis (SPEP)/serum protein immunofixation... Read more

Image: The BN ProSpec chemistry analyzer is a dedicated, compact system that offers a consolidated menu of specialty and routine reagents for reliable plasma protein testing (Photo courtesy of Siemens Healthcare).

Humoral Immunity Disorders Associated with Antibody Deficit

Primary Immunodeficiencies (PID) are a heterogeneous group of diseases and they are rare diseases, but not as rare as once thought, with approximately 400 new PID cases are diagnosed annually in the USA.... Read more

Microbiology

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Image: The NeuMoDx GBS assay is run on the 288 molecular system (Photo courtesy of NeuMoDx Molecular).

FDA Clears Diagnostic Assay for Group B Strep

Group B Streptococcus (GBS) is a Gram-positive bacterium found in 10% to 35% of healthy adults and is a commonly found bacterium within the human body. A person who carries GBS and does not present symptoms... Read more

Image: A scanning electron micrograph (SEM) of Mycoplasma genitalium, which is a common cause of sexually transmitted infections, ranking only second to Chlamydia trachomatis in prevalence (Photo courtesy of Thomas Deerinck, NCMIR).

Molecular Tests Available for Multiple STIs

Mycoplasma genitalium (MG) is a sexually transmitted, small and pathogenic bacterium that lives on the ciliated epithelial cells of the urinary and genital tracts in humans. It is spread through unprotected... Read more

Image: The Loop Mediated Isothermal Amplification (LAMP) test for the detection of malaria under ultra-violet light, positives two right tubes (Photo courtesy of HUMAN Diagnostics).

LAMP Accurately Screens for Malaria in Pregnancy

Pregnant women are especially susceptible to Plasmodium infections and have the risk of developing severe disease and birth complications. These might include maternal anemia, intra-uterine growth retardation,... Read more

Bacterial Test Is Well-Suited for Mid-Sized Labs

Bacterial sepsis and its associated complications are a major cause of morbidity and the 10th leading cause of mortality in the USA. Early diagnosis and the institution of appropriate antimicrobial therapy... Read more

Pathology

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Urine Test Accurately Detects Bladder Cancer Recurrence

Urinary tests have been studied for the detection of bladder tumors; however, most of these tests have not been implemented in clinical practice because of cost issues, practical aspects, or insufficient... Read more

New Target Protein for Colon Cancer Identified

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer-related death in men and women in the USA. Pathogenic mediators that regulate CRC tumorigenesis... Read more

Image: A histopathology of mixed germ cell tumor of the testes demonstrating the high-grade cytology, typical for embryonal carcinoma (Photo courtesy of Nephron).

Integrated Analyses Offer Molecular Insights to Tumor Subtypes

The most common malignancy of young adult males of European descent are testicular germ cell tumors (TGCTs) of the type derived from germ cell neoplasia in situ (GCNIS). There are two major histologic... Read more

Circulating Tumor Cell-Based AR-V7 Test Validated

A blood test to determine whether to treat patients with metastatic castration-resistant prostate cancer (mCRPC) with an androgen receptor signaling inhibitor (ARSI) or taxane is an unmet medical need.... Read more

Lab Tech.

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New Troponin Assays Receive US Marketing Clearance

Two high precision assays for the measurement of the cardiac marker troponin I (TnIH) have been certified for marketing in the United States. The detection of a rise and/or fall of cardiac troponin... Read more

Image: Dr. Marnie Winter examining fetal trophoblastic cells isolated using inertial microfluidics (Photo courtesy of Future Industries Institute).

Fetal Genetic Abnormalities Detected in Early Pregnancy

Lab-on-a-chip (LOC) technology integrates laboratory functions on a chip ranging from a few millimeters to a few square centimeters. The special design of the device allows large volumes of blood to be... Read more

$Image: Motion-based immunological detection of Zika virus using Platinum (Pt)-Nanomotors and a cell phone (Photo courtesy of Brigham and Women\'s Hospital).$