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Hepatic Dysfunction and Coagulopathy Quantified in Fatal Dengue Fever

High Performance of Rapid Influenza Diagnostic Test Validated

Distinct Myelodysplastic Syndrome Subtypes Identified by Genomic, Transcriptomic Analysis

Germline Genetic Testing Assesses Inherited Risk for Myeloid Malignancies

Immature Natural Killer Cells Predict Relapse After Cord Blood Transplantation

New Human Autoinflammatory Disease Identified

Circulating Trophoblast-Based Noninvasive Prenatal Testing Are Feasible

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Parental Decolonization Reduces NICU S. Aureus Infections

ORs Harbor Reproductive Hazards for Female Surgeons

Uterine Tamponade Effectively Prevents Maternal Hemorrhaging

Neuromodulation System Helps Treat Fecal Incontinence

Medical Thawing Device Delivers Plasma on Demand

Molecular Assays Developed for Hantavirus Pulmonary Syndrome

Image: This micrograph depicts an atypical, enlarged lymphocyte found in the blood smear from a hantavirus pulmonary syndrome (HPS) patient. This large atypical lymphocyte is an example of one of the laboratory findings, which when combined with a bandemia, i.e., immature white blood cells, and dropping platelet count, is characteristic of HPS (Photo courtesy of Centers for Disease Control and Prevention)

Hantavirus Pulmonary Syndrome (HPS) is a serious and often fatal disease caused by viruses known as hantaviruses. These anthropozoonotic diseases comprising of two clinical entities: Hemorrhagic Fever with Renal Syndrome (HFRS), which occurs in the Old World, and Hantavirus Pulmonary Syndrome (HPS) in the New World. Read more
16 Jan 2020

Dual Nucleic Acid Template Assay Developed for Cancer

16 Jan 2020

Extrachromosomal Circular DNA Identified in Maternal Plasma

16 Jan 2020

A Sweat-Based On-Site Immunoassay for Monitoring Marijuana Use

16 Jan 2020

Diagnostic Assay Identifies Leukemic Stem Cells

15 Jan 2020

Higher Female TSH Associated With Lower Mannan-Binding Lectin

15 Jan 2020

Industry Spotlight

Nova Biomedical Launches New BioProfile FLEX2 On-Line Autosampler

Nova Biomedical (Waltham, MA, USA) has launched the BioProfile FLEX2 On-Line Autosampler (OLS), a modular system that connects as many as 10 bioreactors to one FLEX2 analyzer for up to three weeks of walkaway, automated sampling, analysis, and feedback control of key cell culture analytes. Read more
03 Jan 2020

Global Hematology Diagnostic Devices and Equipment Market to Reach USD 2.35 Billion by 2022

The global hematology diagnostic devices and equipment market was valued at about USD 1.9 billion in 2018 and is projected to grow to at a CAGR of 5. Read more
03 Jan 2020

AI-based Software Analyzes Cancer Cells from Digitized Pathology Slides to Improve Diagnoses

Researchers from UT Southwestern (Dallas, TX, USA) have developed a software tool that uses artificial intelligence (AI) to recognize cancer cells from digital pathology images, allowing clinicians to predict patient outcomes. Read more
31 Dec 2019

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In Other News

Image: Schematic diagram of, circulating tumor DNA (ctDNA); circulating tumor cell (CTC); cell-free DNA (cfDNA) in the peripheral blood stream of a colon cancer patient (Photo courtesy of Oncology Letters)

Tumor DNA Platform Classifies Colorectal Cancer

Most colorectal cancers are due to old age and lifestyle factors, with only a small number of cases due to underlying genetic disorders. Read more
15 Jan 2020 | Molecular Diagnostics

Image: The NEO Iris is a fully automated immunohematology analyzer for in vitro diagnostic testing of human blood (Photo courtesy of Immucor)

Glycoprotein-Specific Direct Platelet Autoantibody Testing in Immune Thrombocytopenia

Autoantibodies directed against platelet glycoproteins have long been accepted as a major pathophysiologic mechanism in immune thrombocytopenia (ITP), but platelet autoantibody (PA) testing has previously shown poor sensitivity for ITP diagnosis. Read more
14 Jan 2020 | Hematology

Image: The Roche cobas electro-chemiluminescence immunoassay kit for alpha-fetoprotein (AFP) (Photo courtesy of Toliopoulos Diagnostics).

Plasma HSP90α Levels Used for Detection of Hepatocellular Carcinoma

Liver cancer is composed mostly of primary liver cancers and secondary liver cancers. Hepatocellular carcinoma (HCC), as the major type of primary liver cancer, is the fifth most common tumor worldwide and the third leading cause of cancer mortality, responsible for 745,500 cancer deaths annually. Read more
14 Jan 2020 | Pathology

Image: Structure of the UCH-L1 protein (Photo courtesy of Wikimedia Commons)

Biomarker-Based Blood Test Does Not Completely Replace CT Scan for Diagnosis of Elderly Concussion Patients

A recent study confirmed that the GFAP/UCH-L1 blood test could predict with 100% accuracy which elderly concussion patients did not have brain tissue damage and were not in need of a CT scan. Read more
14 Jan 2020 | Molecular Diagnostics

Image: The ABI PRISM 3500 Genetic Analyzer Platform (Photo courtesy of Applied Biosystems)

Multiplex Nested Polymerase Chain Reaction Developed for Congenital Infections

Infections are the leading cause of perinatal mortality in low- and middle-income countries, which have a higher prevalence of infections, and are responsible for 50% of infant deaths in the first year of life. Read more
13 Jan 2020 | Molecular Diagnostics

Image: Photomicrograph of bone marrow aspirate of a pediatric patient with acute myeloid leukemia (Photo courtesy of St. Jude Children's Research Hospital).

Biomarker Predicts Prognosis in Acute Myeloid Leukemia Patients

Acute myeloid leukemia (AML) is the most prevalent adult acute leukemia, which is characterized by abnormal proliferation and the accumulation of immature myeloid precursor cells in the bone marrow, peripheral blood, and even some tissues, contributing to the destruction of the hematopoietic system. Read more
13 Jan 2020 | Hematology

Image: Micrograph showing a lymph node invaded by ductal breast cancer and with extranodal extension of the tumor. The dark purple (center) shows lymphocytes (part of a normal lymph node). Surrounding the lymphocytes and extending into the surrounding fat (top of image) is the ductal breast cancer (Photo courtesy of Wikimedia Commons)

Large GWAS Study Finds DNA Variants Linked to Risk of Developing Breast Cancer

A large multinational study identified more than 350 DNA variants associated with the more than 150 regions of the genome known to be linked to the risk for developing breast cancer. Read more
13 Jan 2020 | Molecular Diagnostics

Image: NMR solution structure of neuropeptide Y (Photo courtesy of Wikimedia Commons)

Peptide Biomarker Predicts Risk of Dying in Patients with Stable Heart Failure

Cardiovascular disease researchers have identified a biomarker that predicts when a patient with chronic stable heart failure (CHF) is likely to die. Read more
13 Jan 2020 | Molecular Diagnostics

Image: The Karius Test, which uses microbial cell-free DNA (mcfDNA-seq), can predict bloodstream infections in leukemia patients up to three days before the onset of symptoms (Photo courtesy of Karius)

Blood-Based Sequencing Identifies Pediatric Cancer Infections Before Symptoms

Infections are common, yet life-threatening complications that affect immuno-compromised cancer patients and bloodstream infection (BSI) is a common, life-threatening complication of treatment for cancer. Read more
09 Jan 2020 | Molecular Diagnostics

Image: Micrograph of a diffuse large B cell lymphoma, from a bone marrow aspirate; the nucleus may be convoluted and irregular (Photo courtesy of Peter Maslak)

Molecular Profiles, Microenvironment Signatures May Improve Lymphoma Prognosis

The tumor microenvironment includes surrounding blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix that encapsulate the cancerous cells. Read more
09 Jan 2020 | Hematology

Image: 22q11.2 deletion syndrome is a disorder caused by the deletion of a small piece of chromosome 22. The deletion occurs near the middle of the chromosome at a location designated q11.2 (Photo courtesy of U.S. National Library of Medicine)

Common Variant Modifiers for Syndromic Heart Condition Located

DiGeorge syndrome, also known as 22q11. 2 deletion syndrome, is a syndrome caused by the deletion of a small segment of chromosome 22. Read more
09 Jan 2020 | Molecular Diagnostics

Image: Examples of negative and positive Chagas Stat-Pak RDT results. From left to right, negative, weakly positive, and strongly positive Stat-Pak results are shown (Photo courtesy of Yves Jackson)

Rapid Diagnostic Tests for Chagas Disease Field Evaluated

Chagas disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is the neglected tropical disease exerting a highest burden in the Western hemisphere. Read more
08 Jan 2020 | Microbiology

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Clinical Chemistry

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Cardiac Blood Test Predicts Post-Surgical Outcomes

Globally, of the 200 million adults who undergo major surgery, 18% will experience serious cardiac and vascular complications including death within 30 days following their intervention, such as hip and... Read more

Image: Design of the CareStart G6PD deficiency screening test and interpretation of the results: Panel A, no color change for sample with deficient G6PD enzymatic activity; Panel B, distinct purple color for sample with normal G6PD enzymatic activity (Photo courtesy of Charles Darwin University).

Rapid Diagnostic Test for The Detection of G6PD Deficiency Evaluated

To reduce the risk of drug-induced hemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the... Read more

Image: The PATHFAST system combines the accuracy of a full-scale laboratory analyzer with the flexibility of a mobile solution (Photo courtesy of LSI Medience Corporation)

Presepsin Concentrations Predicts Commensurate Decline in Kidney Function

Chronic kidney disease (CKD) is a worldwide health problem and its prevalence is rising, particularly in the elderly, mainly reflecting the increased life expectancy of the global population.... Read more

Image: Biochemical markers in blood samples are affected by adiposity in children (Photo courtesy of Photo Tom Mallinson).

Biochemical Markers Affected by Adiposity in Children

Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21%–24% children and adolescents are... Read more

Molecular Diagnostics

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Image: The Agilent Technologies 2100 Bioanalyzer system is an established automated electrophoresis tool for the sample quality control of biomolecules (Photo courtesy of Laboratory Controls LLC)

Urinary Cell-Free DNA Detects Urothelial Carcinoma

Most bladder cancers start in the innermost lining of the bladder, which is called the urothelium or transitional epithelium. As the cancer grows into or through the other layers in the bladder wall, it... Read more

An Omics Approach for Predicting Mutations in Protein-Metal Binding Sites

A deep learning approach was developed that was able to predict how mutations in the metal-binding sites of metalloproteins were related to various diseases. Metalloproteins play important roles in... Read more

Image: Scanning electron micrograph of inside the nucleus of a cancer cell, chromosomes are indicated by blue arrows and circular extrachromosomal DNA are indicated by orange arrows (Photo courtesy of Paul S. Mischel, MD, UC San Diego)

Extrachromosomal Circular DNA Drives Oncogenic Genome Remodeling in Neuroblastoma

Circularized DNA falling outside of linear chromosomes may serve as a recurrent source of somatic rearrangements in neuroblastoma, a pediatric cancer affecting immature cells in the sympathetic nervous system.... Read more

Standard Pathology Tests Outperform Molecular Subtyping in Bladder Cancer

Evolving diagnostic approaches include compiling databanks on gene expression and mutations present in a cancer type to find patterns of gene expression that are then used to subtype tumors that "pathologically... Read more

Hematology

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Image: The TEG 6s system provides rapid, comprehensive and accurate identification of an individual’s hemostasis condition in a laboratory or point-of-care setting (Photo courtesy of Haemonetics Corporation).

Hypercoagulability Evaluated in New‐Onset Systemic Lupus Erythematosus Patients

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that involves T cell, B cell, and dendritic cell dysfunction, as well as antinuclear autoantibody production. Several clinical and... Read more

Image: FoundationOne Heme next-generation sequencing test can be used to assess routine cancer specimens for all genes that are currently known to be somatically altered and unambiguous drivers of oncogenesis in hematologic malignancies and sarcomas (Photo courtesy of Foundation Medicine)

Germline Genetic Testing Assesses Inherited Risk for Myeloid Malignancies

Inherited risk for hematologic malignancies was historically thought to be relatively rare; however, the increased use of next-generation sequencing has identified more patients with germline genetic mutations... Read more

Image: The LH 750 hematology analyzer is equipped with advanced technologies with nucleated red blood cell (NRBC) enumeration and random access capabilities (Photo courtesy of Fameco Medical)

Hepatic Dysfunction and Coagulopathy Quantified in Fatal Dengue Fever

Dengue fever (DF) is currently one of the most severe public health problems. Each year, an estimated 390 million dengue infections occur around the world. Clinical presentations of dengue are diverse... Read more

Fresh Red Blood Cells Transfusions No Better Than Older Ones

Red blood-cell transfusions are commonly administered in critically ill children who have illnesses that increase the need for transfusion, such as trauma, cancer chemotherapy, major surgery with significant... Read more

Immunology

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Image: The Diagnostic Performance of C6 Enzyme Immunoassay for Lyme Arthritis has been evaluated (Photo courtesy of Lonnie R. Marcum, PT, BSHCA)

Immunoassay May Help Identify Pediatric Lyme Arthritis

In the USA, Lyme arthritis is the most common feature of late stage infection with the tick-borne spirochete, Borrelia burgdorferi, usually beginning months after the initial tick bite. Patients with Lyme... Read more

Immature Natural Killer Cells Predict Relapse After Cord Blood Transplantation

Umbilical cord blood transplantation (CBT) has become an accepted alternative treatment of patients with hematologic cancers or other disorders. Many of the disadvantages of CBT, including limited numbers... Read more

Image: Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations (Photo courtesy of Cornell University)

Immune System Altered in Chronic Fatigue Syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe, chronic, and debilitating disease that can cause a range of symptoms including pain, severe exhaustion, cognitive impairment, and... Read more

Image: Innate immune cells: heterozygous mutations of the RIPK1 caspase-8 cleavage site cause the autoinflammatory disease CRIA syndrome (Photo courtesy of Walter and Eliza Hall Institute)

New Human Autoinflammatory Disease Identified

Autoinflammatory diseases are caused by abnormal activation of the innate immune system, leading to recurrent episodes of fever and inflammation that can damage vital organs. Scientists from Australia... Read more

Microbiology

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Image: Flongle is an adapter (flow cell dongle) for the MinION or GridION that enables direct, real-time DNA or RNA sequencing on smaller, single-use flow cells (Photo courtesy of Oxford Nanopore Technologies).

Nanopore Sequencing Rapidly Diagnoses Gut Condition in Preterm Infants

The culture-independent, sensitive, data-rich nature of metagenomic sequencing, combined with powerful bioinformatics tools, have allowed scientists to differentiate patient groups from healthy individuals... Read more

Image: The NUCLISENS EASYMAG instrument is designed to meet the most critical needs when it comes to premium quality total nucleic acid extraction. The system automates an enhanced magnetic silica version of BOOM technology, a gold standard for efficient universal extraction of RNA and DNA (Photo courtesy of bioMérieux).

Asthma Severity Linked to Microbiome of Upper Airway

More than six million children under the age 18 have asthma in the USA. Asthma exacerbations have high impact on children, their families, the health care system, and may lead to subsequent decline in lung function.... Read more

Image: The C. DIFF QUIK CHEK COMPLETE test is a rapid membrane enzyme immunoassay for the simultaneous detection of Clostridium difficile glutamate dehydrogenase antigen and toxins A and B in a single reaction well (Photo courtesy of Abbott)

C. Diff Carriers Are Source of Infections in Hospitals

Clostridioides difficile is a spore-forming, gram-positive anaerobic bacillus spread by fecal–oral transmission of spores, which remain viable for long periods of time ex vivo. Although C.... Read more

High Performance of Rapid Influenza Diagnostic Test Validated

Influenza is a leading infectious cause of morbidity and mortality worldwide. Annually, about 5% to 10% of adults and 20% to 30% of children have symptoms of influenza-like illness (ILI), and approximately... Read more

Pathology

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Liquid Biopsy Detects Breast Cancer Residual Disease

The concept of circulating DNA or tumor cells to identify patients with residual cancer present after early-stage, putatively curative treatment has made rapid strides across multiple tumor types since... Read more

Image: The cancer screening platform was a multitarget stool DNA test (MT-sDNA), that uses multiple biomarkers to ensure the highest levels of sensitivity (Photo courtesy of Exact Sciences Laboratory)

Stool DNA Test Helps Detect Precancerous Lesions

Colorectal cancer (CRC) is the third most common cancer and is one of the leading causes of cancer-related mortality. Although CRC incidence is increasing, a decrease in mortality has been observed due... Read more

Circulating Progenitor Cell Traffic Reflects Blood Vessel Repair

Identifying patients with otherwise stable coronary artery disease (CAD) who are high-risk and would benefit from more intense or invasive interventions is currently a major theme in cardiology studies.... Read more

Image: Histopathology of Wilms tumor or nephroblastoma which is a type of kidney cancer that is seen predominantly in children (Photo courtesy of Nephron).

Childhood Kidney Cancer Arises from Altered Normal Tissue

While kidney cancer in children is rare, the most common type is Wilms tumor, which mostly affects children under the age of five. Most cases of Wilms tumor can be cured through surgery to remove the afflicted... Read more

Lab Tech.

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Image: Schematic of an array of nanotubes decorated with gold nanoparticles that capture virus molecules for in situ Raman spectroscopy for label-free optical virus identification (Photo courtesy of Professor Mauricio Terrones)

Fast and Inexpensive Device Captures and Identifies Viruses

Currently, virologists estimate that 1.67 million unknown viruses are in animals, a number of which can be transmitted to humans. Known viruses, such as H5N1, Zika and Ebola have caused widespread illness and death.... Read more

Paper-Based Test Could Diagnose Lyme Disease at Early Stages

Caused by the tick-borne spirochete Borrelia burgdorferi, Lyme disease (LD) is the most common vector-borne infectious disease in North America and Europe and timely diagnosis and treatment are effective... Read more

Image: A CyteFinder instrument is an automated six channel fluorescence microscopes that rapidly image slides and employ machine learning to identify rare cells (Photo courtesy of RareCyte)

Circulating Trophoblast-Based Noninvasive Prenatal Testing Are Feasible

Circulating cells from the fetus or placenta in a pregnant woman’s blood, primarily trophoblasts and nucleated fetal red blood cells (fnRBCs), have long been appreciated as potential targets for noninvasive... Read more

Implement Diagnostics System Improves Infectious Disease Testing

A team of scientists recently began using machine-learning tools and assessed them in a prospective clinical trial to determine whether artificial intelligence could perform better than specialists in... Read more

BioResearch

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Image: A micrograph of a diffuse large B cell lymphoma (DLBCL) (Photo courtesy of Wikimedia Commons).

Gene Panel Predicts Disease Progession for Patients with B-cell Lymphoma

Cancer researchers developed a 29 gene–based weighted prognostic score for predicting event-free survival and overall survival of patients suffering from diffuse large B-cell lymphoma (DLBCL).... Read more

Image: A diagram of construction of a genomic library (Photo courtesy of Wikimedia Commons).

New Method Simplifies Preparation of Tumor Genomic DNA Libraries

A method has been described that simplifies preparation of tumor genomic DNA libraries by employing restriction enzymes and in vitro transcription to barcode and amplify genomic DNA prior to library construction.... Read more

New Tool Developed for Diagnosis of Chronic HBV Infection

A team of Chinese researchers has described the development of a new and powerful tool for the diagnosis and treatment of chronic hepatitis B virus (HBV) infection. Methods currently used to diagnose... Read more

Image: Spiked rods of monosodium urate crystals photographed under polarized light from a synovial fluid sample. Formation of monosodium urate crystals in the joints is associated with gout (Photo courtesy of Wikimedia Commons).

Panel of Genetic Loci Accurately Predicts Risk of Developing Gout

A large GWAS (genome-wide association study) highlighted genetic loci associated with the metabolic regulation of serum levels of uric acid (urate) and identified a panel of 183 loci linked to the risk... Read more

Industry News

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Image: Global Lateral Flow Immunoassay based Rapid Test Market is expected to reach $8,494 million by 2026 (Photo courtesy of Allied Market Research)

Global Lateral Flow Immunoassay Based Rapid Test Market to Reach USD 8.49 Billion by 2026

The global lateral flow immunoassay (LFIA) based rapid test market was estimated to be worth USD 4.72 billion in 2018 and is expected to grow at a CAGR of 7.6% from 2019 to 2026 to reach USD 8.... Read more

Mast Group Launches MAST ISOPLEX CRE-Art Kit for Rapid Molecular Detection of Carbapenemase Producing Organisms

Mast Group Ltd. (Liverpool, UK) announced the expansion of its molecular product portfolio with the launch of the new MAST ISOPLEX CRE-ART kit for the rapid molecular detection of carbapenemase producing... Read more

Image: The Bench Top segment is the biggest driver to the global blood gas and electrolyte analyzers market (Photo courtesy of Market Research Business).

Global Blood Gas and Electrolyte Analyzers Market to Surpass USD 2.1 Billion by 2025

The global blood gas and electrolyte analyzers market is projected to grow at a CAGR of 6.5% during the forecast period, 2018-2025 to reach a value of over USD 2.1 billion by 2025, driven mainly by the... Read more

Image: In 2019, lab-on-a-chip/microfluidic diagnostics is expected to grow at the fastest CAGR, owing to its capability for scaling down whole lab processes on a single chip and expediting the process of disease diagnosis with highly precise quantitative results (Photo courtesy of Fotolia).

Global Microfluidic Immunoassay Market to Reach USD 2 Billion by 2025

The global microfluidic immunoassay market is expected to grow at a CAGR of 12.7% from 2019 to USD 2.0 billion by 2025, driven by greater benefits offered by Lab-on-chip (LOC) over conventional quantifiable... Read more

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