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In Other News

Image: A micrograph of urothelial carcinoma of the urinary bladder (Photo courtesy of Baylor College of Medicine).

Clinical Trial Highlights Poor Prognosis for Bladder Cancer Patients

Analysis of the IMvigor 210 clinical trials involving patients with platinum-refractory or cisplatin-ineligible urothelial carcinoma (the most common type of bladder cancer) who were treated with the PD-L1 inhibitor atezolizumab identified a resistance signature as an immune biomarker that may aid in development of personalized treatment of the disease. Read more
20 May 2019 | Molecular Diagnostics
Image: (A) Low magnification view of cancer nodule with the central tumor bulk consisting predominantly of invasive cribriform Gleason pattern four. (B) Low magnification view of the same cancer nodule with an outer rim of accentuated syntaphilin (SNPH) staining. The invasive front is defined as the external rim of each cancer nodule abutting the adjacent stroma as outlined in this image as the zone between the dotted and solid lines. Arrows denote accentuated SNPH staining at the tumor-stromal interface (Photo courtesy of the American Journal of Pathology).

Prostate Cancer Severity Indicated by Location and Concentration of Syntaphilin

A biomarker has been identified that may enable doctors to predict which patients with early indications of prostate cancer will be likely to develop the much more serious invasive and metastatic form of the disease. Read more
20 May 2019 | Molecular Diagnostics
Image: The Atellica CH Enzymatic Hemoglobin A1c (A1c_E) Assay (Photo courtesy of Siemens Healthineers).

Siemens Healthineers Hemoglobin A1c Test Now Available on Atellica Solution

The Atellica CH Enzymatic Hemoglobin A1c (A1c_E) Assay is an easy-to-implement chemistry test, offering precise and accurate results for diabetic patient management. Read more
18 May 2019 | Lab Tech.
Image: The ARCHITECT i2000SR immunoassay analyzer (Photo courtesy of Abbott).

Blood Test May Predict Cardiovascular Disease

According to the latest statistics from the American Heart Association (AHA), almost half of the people living in the USA have some form of cardiovascular disease. Read more
16 May 2019 | Clinical Chemistry
Image: A nanoelectronics assay: stressed blood cells could be a biomarker for chronic fatigue (Photo courtesy of The Scientist).

Biomarker Test Developed for Chronic Fatigue Syndrome

Myalgic encephalomyelitis, or chronic fatigue syndrome (ME/CFS), is a serious condition that may affect up to 2. Read more
16 May 2019 | Lab Tech.
Image: The HumaLoop M: The easy-to-use Loopamp technology for primary and district laboratories (Photo courtesy of Human Diagnostics).

LAMP Malaria Test Detects Less-Diagnosed Species

A new loop-mediated isothermal amplification (LAMP) molecular assay has been developed that can detect Plasmodium vivax, a species of the parasite that causes malaria. Read more
16 May 2019 | Microbiology
Image: A close-up of a non–small-cell lung cancer (NSCLC) cell (Photo courtesy of Getty Images).

Clinical Validation Bolsters Liquid Biopsy Evidence Base

Non–small-cell lung cancer (NSCLC) accounts for more than 85% of lung cancer – the majority of patients who present have advanced-stage disease and are treated with systemic therapies. Read more
15 May 2019 | Molecular Diagnostics
Image: QuantiFERON-TB Gold (QFT) is a simple blood test that aids in the detection of Mycobacterium tuberculosis, the bacteria which causes tuberculosis (TB). QFT is an interferon-gamma (IFN-γ) release assay, commonly known as an IGRA, and is a modern alternative to the tuberculin skin test (Photo courtesy of Qiagen).

Bronchoalveolar Lavage Explored for TB Diagnosis

Tuberculosis (TB) is among the top 10 causes of death worldwide, and the leading cause from a single infectious agent. Read more
15 May 2019 | Microbiology
Image: The RealTime HBV is an in vitro polymerase chain reaction (PCR) assay for the quantitation of Hepatitis B Virus (HBV) DNA in human plasma or serum from HBV-infected individuals (Photo courtesy of Abbott Molecular).

Serum HBV RNA Quantification Monitors Chronic Hepatitis B Infection

Chronic hepatitis B viral infection is a global health problem, especially in the Asian-Pacific region. Read more
15 May 2019 | Microbiology
Image: EndoPredict is a second-generation breast cancer recurrence test for highly accurate assessment of 10-year risk of distant recurrence (Photo courtesy of Myriad Genetics).

Breast Cancer Test Determines Most Effective Treatment

For the clinical management of patients with estrogen receptor (ER)-positive breast cancer, several clinico-pathological and molecular characteristics of the tumor have to be considered for prognosis and treatment decisions. Read more
14 May 2019 | Molecular Diagnostics
Image: The RealTime High-Risk HPV assay is designed for the detection of high-risk HPV genotypes in cervical specimens from women with precancerous lesions of the cervix uteri (≥ CIN2) and cervical cancer to provide clinically meaningful results in cervical cancer screening (Photo courtesy of Abbott Molecular).

Urine Test Could Prevent Cervical Cancer

The strategy of cervical screening depends on reducing the incidence of cervical cancer through the detection and treatment of its precursor lesion, high-grade cervical intraepithelial neoplasia (CIN2+). Read more
14 May 2019 | Molecular Diagnostics
Image: A photomicrograph showing tumor-infiltrating lymphocytes in a case of colorectal cancer with evidence of high microsatellite instability (MSI-H) on immunostaining (Photo courtesy of Nephron).

Biomarker Predicts Appropriate Immunotherapy for Cancer Patients

Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA mismatch repair activity. Read more
14 May 2019 | Pathology

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Clinical Chemistry

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Blood Protein Signature Reported for Diabetic Kidney Disease
Glucose Test in Pregnancy Can Detect CV Risk
High HbA1c Levels Linked to Pregnancy Risks
Assessment of LDL cholesterol levels in two patients (Photo courtesy of Randox).

Randox Unveils an Assay for the Rapid Measurement of Small Dense LDL Cholesterol (sdLDL-C)

A kit for the automated measurement of small dense low-density lipoprotein cholesterol (sdLDL-C) is now available with dedicated controls and calibrators available and instrument-specific applications... Read more

Molecular Diagnostics

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Machine-Learning System Used to Diagnose Genetic Diseases
New Genetic Test Detects Mutations in High-Risk Groups
Neurofilament Light Considered as NIV Biomarker for Alzheimer's Disease
Image: The SureSelect XT combines sequencing library preparation and gDNA preparative reagents with the SureSelect target enrichment system (Photo courtesy of Agilent Technologies).

Liquid Biopsy Utility Reinforced in Early Cancer Trials Results

Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) supports blood-based genomic profiling but is not yet routinely implemented in the setting of a clinical phase I trials.... Read more

Hematology

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Early Sepsis Detection Test Approved for U.S. Marketing
High-Res Genotyping Improves Survival for Stem Cell Transplantation
Different Clinical Hematology Lab Configurations Compared
Image: The Bioanalyzer 2100 system is a microfluidic platform that provides quantitation and quality control of DNA and RNA by capillary electrophoresis (Photo courtesy of Agilent Technologies).

Multiple Myeloma Sequences Reveal Prognostic Immunoglobulin Translocation

Multiple myeloma is the second most common hematological cancer, which affects terminally differentiated antibody secreting B cells, known as plasma cells. Clinical manifestations of myeloma include hypercalcemia,... Read more

Immunology

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Novel Genes and Pathways Discovered in Celiac Disease
Novel Software Reduces Variability in ELISA Biomarker Tests
Recombinant Capture Molecule Used for Viral Disease Diagnosis
Image: The Helios CyTOF mass cytometry platform (Photo courtesy of Fluidigm).

Immune Cell Profiling Assay Boosts Use of Mass Cytometry

A new, multiplexed, antibody-based assay for immune cell profiling on its mass cytometry platform has been launched. The assay is comprised of a single-tube assay pre-loaded with 30 metal-labeled antibodies... Read more

Microbiology

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Sequencing Shows Promise for Diagnosing Prosthetic Joint Infections
Rapid Test for Chlamydia Antigen Antibodies Optimized
Diagnostic Methods Compared for Human Granulocytic Anaplasmosis
Image: A photomicrograph of human papilloma virus associated oropharyngeal cancer. The tissue has been stained to show the presence of the virus by in situ hybridization (Photo courtesy of Jennifer L. Hunt, MD).

Oral HPV-DNA Persists after Oropharyngeal Cancer Treatment

Head and neck cancers affect some 53,000 people in the USA each year, according to the National Cancer Institute, and human papilloma virus (HPV) has been implicated in many of those cases.... Read more

Pathology

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Virus-Associated Liver Cancer Detected by Blood Tests
EBUS More Reliable Than Histology for Cancer Diagnoses
Liquid Biopsy Proves Effective as Biopsy for NSCLC
Image: A diagram of evolutionary trajectories of IDH-WT glioblastomas revealing a common path of early tumorigenesis instigated years ahead of initial diagnosis (Photo courtesy of German Cancer Research Center).

Glioblastoma Driver Mutations Appear Long Before Diagnosis

Glioblastomas are the most common high-grade (cancerous) primary brain tumor in adults. They can also occur, rarely, in children. Glioblastomas belong to a group of brain tumors known as gliomas, as they... Read more

Lab Tech.

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Glaswarenfabrik Karl Hecht Celebrates 100-year Anniversary
Genetic Methods Rapidly Diagnoses Huntington's Disease
Enteric Viral Panel Gets FDA Clearance
Image: Normal and abnormal control cells from the ClearLLab 10C kit (Photo courtesy of Beckman Coulter).

Flow Cytometry Leukemia/Lymphoma Antibody Panel Receives Approval

A panel of immune-phenotyping flow cytometer reagents that identifies both lymphoid and myeloid cell lines has been granted diagnostic marketing clearance by the [U.S.] Food and Drug Administration to... Read more

Industry News

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Global Urinalysis Market Valued at USD 2 Billion by 2022
Baxter and bioMérieux in Alliance to Develop Acute Kidney Injury Diagnostics
Beckman Coulter Life Sciences Enters Partnership with Apostle
Image: The global automated immunoassay analyzer market is expected to achieve significant growth, driven by product innovations and increased clinical applications (Photo courtesy of iStock).

Global Automated Immunoassay Analyzer Market Driven by Increase in Applications

The global automated immunoassay analyzer market is expected to achieve significant growth over the coming years, driven by innovations in the existing products and increased clinical applications of these systems.... Read more

BioResearch

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Large GWAS Pinpoints Ovarian Cancer Risk Genes
Blood Test Distinguishes between Forms of Inflammatory Bowel Disease
Genome-wide Association Study Identifies New Bipolar Disorder Loci
Image: A micrograph showing four-cell stage mouse embryos (Photo courtesy of Kirill Makedonski, the Hebrew University of Jerusalem).

Gene Set Isolated in Transformation of Skin Cells into Embryonic Tissues

A team of developmental biologists identified a set of five genes that is capable of transforming skin cells into pluripotent stem cells and then into all three of the cell types that comprise the early... Read more

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