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In Other News

Image: The cobas c 703 and cobas ISE neo increase testing capacity and automation to enhance lab workflows and patient care (photo courtesy of Roche)

Next Generation Automated Analyzers Increase Throughput for Clinical Chemistry and Electrolyte Testing

Clinical laboratories continue to face staffing shortages, limited space, and growing test volumes that pressure chemistry and electrolyte workflows. Read more
08 Apr 2026 | Clinical Chem.
Image: The collaboration pairs Pillar’s oncoReveal kitted NGS panels with CellCarta’s global laboratory network and biomarker expertise (photo courtesy of Pillar Biosciences)

Global Partnership Aims to Streamline NGS Tumor Profiling in Oncology Trials

CellCarta and Pillar Biosciences announced a global, multi-year strategic partnership on April 2, 2026 to broaden access to operationally streamlined next-generation sequencing (NGS) tumor profiling for biopharma sponsors and clinical research partners worldwide. Read more
07 Apr 2026 | Industry
Image: The method that profiles DNA methylation in cell-free DNA from a single blood sample to detect disease signals system-wide (photo courtesy of Shutterstock)

cfDNA Methylation Assay Enables Multi-Disease Detection from Single Blood Sample

Early, accurate detection of cancer and organ disease remains limited by cost, reliance on targeted mutation assays, and uncertainty about the signal’s tissue of origin. Read more
07 Apr 2026 | Molecular Diagnostics
Image: FINDER is the first molecular point-of-care platform with both FDA 510(k) clearance and CLIA waiver that combines molecular testing with chemistry, coagulation, and immunoassay capabilities on a single multifunctional system (photo courtesy of Baebies)

Rapid Point-of-Care RT-PCR Test Differentiates Influenza A/B and SARS-CoV-2 in Minutes

Respiratory viruses such as influenza A/B and SARS‑CoV‑2 continue to burden urgent care and emergency settings, where rapid, reliable differentiation guides therapy and infection control. Read more
07 Apr 2026 | Molecular Diagnostics
Image: Higher midlife vitamin D levels are linked to lower tau accumulation later, though the association does not establish causation (photo courtesy of Shutterstock)

Study Links Midlife Vitamin D to Lower Tau in Alzheimer's

Tau and amyloid beta proteins are established biomarkers of Alzheimer’s disease, with elevated tau in the brain serving as a marker of dementia. Read more
07 Apr 2026 | BioResearch
Image: Through neoadjuvant therapy combining chemotherapy with immune checkpoint inhibitors (ICI) for 46 LAGC patients and single-cell transcriptome sequencing, researchers found that tumor cells in the treatment-sensitive group specifically upregulated MHC-II (tumor-specific major histocompatibility complex class II, tsMHC-II) molecules (photo courtesy of Science China Press)

Tumor-Specific Biomarker Predicts Neoadjuvant Immunotherapy Response in Gastric Cancer

Gastric cancer is the fifth most common malignancy and the fourth leading cause of cancer mortality worldwide, with China bearing nearly half of the global burden. Read more
07 Apr 2026 | Pathology
Image: Laboratories in the EMEA region can now implement a digital, AI-assisted workflow for bone marrow morphology (photo courtesy of Cellavision)

AI-Powered Digital Workflow Standardizes Bone Marrow Aspirate Morphology

Bone marrow aspirate examination is central to diagnosing and monitoring blood cancers and other serious hematologic diseases, yet the process in many laboratories remains manual and highly dependent on specialist expertise. Read more
07 Apr 2026 | Hematology
Image: The findings could pave the way for a blood test to detect risk of cognitive decline years before dementia is typically diagnosed (photo courtesy of Adobe Stock)

Blood Metabolite Test Detects Early Cognitive Decline

Timely identification of individuals at risk of dementia remains difficult because symptoms commonly appear only after significant neurodegeneration. Read more
06 Apr 2026 | Clinical Chem.
Image: Graphical abstract (Liu J., Wang W., Sun Y. et al. Cell Rep Med. DOI: 10.1016/j.xcrm.2026.102704)

Common Metablolic Enzyme Could Predict Response to Cancer Immunotherapy

Immune checkpoint inhibitors can generate durable tumor control, but only about 20% of patients benefit and clinicians still lack robust tools to predict response. Read more
06 Apr 2026 | BioResearch
Image: Monitoring ctDNA is a powerful tool to assess the absence or presence of MRD (Photo courtesy of Natera)

ctDNA MRD Test Identifies Breast Cancer Patients Who May Avoid Surgery

Selecting surgery versus non-surgical management in early-stage breast cancer can be challenging for older patients, who often balance disease control with comorbidities and quality-of-life considerations. Read more
06 Apr 2026 | Molecular Diagnostics
Image: Caris Detect uses AI models to analyze peripheral blood for subtle signals of early-stage cancer (photo credit: Adobe Stock)

WGS MCED Assay Demonstrates Rising Sensitivity and High Specificity

Early detection of cancer remains difficult across many tumor types, and current single‑cancer screening modalities leave significant gaps. Read more
06 Apr 2026 | Molecular Diagnostics
Image: The findings inform MND care by linking variants to prognosis and highlighting inherited mutations that support family genetic testing (photo credit: Adobe Stock)

Newly Identfied Genetic Variants in MND Support Prognosis and Family Testing

Motor neuron disease (MND) is a neurodegenerative condition in which the nerves controlling movement fail, leading to progressive paralysis and early death, often about two years after diagnosis. Read more
06 Apr 2026 | BioResearch
Image: Understanding the role of the tumor microbiota opens new perspectives for cancer therapy.

International Consensus Standardizes Tumor Microbiota Detection and Reporting

Cancer outcomes are shaped not only by tumor genetics but also by the surrounding microenvironment, where low microbial biomass and contamination risks complicate measurement. Read more
03 Apr 2026 | BioResearch
image: HPV DNA (ctDNA) measured in blood could help tailor treatment for HPV-related throat cancer (photo credit: Adobe Stock)

Blood-Based ctDNA Test Enhances Risk Assessment in HPV-Related Throat Cancer

Human papillomavirus (HPV)-associated throat cancer affects more than 22,000 people in the United States each year, with higher incidence in men. Read more
03 Apr 2026 | Molecular Diagnostics

Channels

Clinical Chemistry

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New CLIA Status Brings Mass Spectrometry Steroid Testing to Routine Labs
Study Shows Dual Biomarkers Improve Accuracy of Alzheimer’s Detection
Blood-Based Screening Test Targets Early Detection of Colorectal Cancer
Image: Workflow of ProtAIDe-Dx on GNPC (An, L., Pichet Binette, A., Hristovska, I. et al. Nature Medicine (2026). https://doi.org/10.1038/s41591-026-04303-y)

AI-Based Blood Test Diagnose Multiple Brain Disorders from Blood Sample

Diagnosing the cause of age-related cognitive symptoms remains challenging because clinical presentations of neurodegenerative diseases often overlap, and multiple pathologies can co-occur... Read more

Molecular Diagnostics

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Whole Genome Sequencing in Routine Care Expands Rare Disease Detection
New AI Tool Improves Detection of Genetic Causes in Rare Disorders
New Molecular Test Boosts Accuracy of Bile Duct Cancer Diagnosis
Image: New findings show that transcriptome-enabled profiling can help identify therapeutic opportunities for patients who previously had no actionable results from DNA-only testing (photo courtesy of Shutterstock)

RNA Profiling Uncovers Therapeutic Targets in Solid Tumors

Many patients with advanced solid tumors exhaust broad DNA panel testing yet still lack biomarkers that match guideline-recommended therapies, limiting access to targeted options. Expanding molecular profiling... Read more

Hematology

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New Guidelines Aim to Improve AL Amyloidosis Diagnosis
Fast and Easy Test Could Revolutionize Blood Transfusions
Automated Hemostasis System Helps Labs of All Sizes Optimize Workflow
Image: Hemex Health’s Gazelle platform is designed to rapidly separate and detect hemoglobin fractions and variants using miniaturized electrophoresis technology (photo courtesy of Hemex Health)

Rapid Cartridge-Based Test Aims to Expand Access to Hemoglobin Disorder Diagnosis

Sickle cell disease and beta thalassemia are hemoglobin disorders that often require referral to specialized laboratories for definitive diagnosis, delaying results for patients and clinicians.... Read more

Immunology

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FDA Approval Expands Use of PD-L1 Companion Diagnostic in Esophageal and GEJ Car...
Study Identifies Inflammatory Pathway Driving Immunotherapy Resistance in Bladder...
Microfluidic Chip Detects Cancer Recurrence from Immune Response Signals
Image: Mycobacterium tuberculosis bacteria seen with a scanning electron microscope (Credit: CDC PHIL)

Antibody Blood Test Identifies Active TB and Distinguishes Latent Infection

Active tuberculosis (TB) remains a leading cause of death and illness worldwide, yet distinguishing contagious disease from latent infection continues to challenge clinicians. Standard screening tools... Read more

Microbiology

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Genomic Analysis Links Emerging Streptococcal Strains to Specific Infections
Rapid Urine Test Speeds Antibiotic Selection for UTIs
WHO Endorses Rapid Point-of-Care Testing to Improve TB Detection
Image: Researchers identified a previously undescribed Treponema species that was strongly associated with acute Noma disease (photo credit: Adobe Stock)

New Bacterial Target Identified for Early Detection of Noma

Noma is a rapidly progressing orofacial infection that begins as gingivitis and can destroy oral and facial tissues, primarily affecting young children living in extreme poverty. Without treatment, it... Read more

Pathology

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AI-Based Pathology Model Guides Chemotherapy Decisions in Breast Cancer
Biopsy-Based Gene Test Predicts Recurrence Risk in Lung Adenocarcinoma
AI-Powered Tool to Transform Dermatopathology Workflow
image: Ataraxis Breast CTX combines H&E pathology slides with clinical data to generate patient-specific prognostic and predictive outputs (photo courtesy of Ataraxis AI)

AI Tool Predicts Patient-Specific Chemotherapy Benefit in Breast Cancer

Selecting adjuvant chemotherapy for early-stage breast cancer is typically guided by recurrence risk and population-level averages rather than patient-specific benefit. However, existing clinicopathologic... Read more

Technology

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Breakthrough Mass Spectrometry Design Could Enable Ultra-Low Abundance Detection
Rapid Biosensor Detects Drug Sensitivity in Breast Tumors
Online Tool Supports Family Screening for Inherited Cancer Risk
Image: Graphical Abstract (Huiqian Hu et al., Med 7(3): 100966 (2026). DOI: 10.1016/j.medj.2025.100966)

New AI Tool Enables Rapid Treatment Selection in Pediatric Leukemia

Children with T-cell acute lymphoblastic leukemia face an aggressive disease that remains difficult to treat. Although remission rates have improved, many survivors experience long-term effects from intensive... Read more

Industry

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Lunit and CellCarta Collaborate to Expand AI Pathology in CDx Development
Integrated DNA Technologies Expands into Clinical Diagnostics
Co-Diagnostics Agreement Expands Commercial and Distribution Reach in South Asia
Image: The collaboration focuses on verified automation methods for Takara Bio USA’s SMART-Seq library preparation kits on Hamilton’s Microlab STAR Liquid Handling Systems (photo courtesy of Hamilton Company)

Takara Bio USA and Hamilton Partner Partner to Automate NGS Library Preparation

Takara Bio USA, Inc. (San Jose, CA, USA), a wholly owned subsidiary of Takara Bio Inc., and Hamilton Company (Reno, NV, USA) announced a development and co-marketing agreement to deliver integrated, automated... Read more

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