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First-Ever Highly Sensitive Antibody Tests Could Detect Infection with All Known Human Coronaviruses, Including New SARS-CoV-2 Variants

Pioneering Automated COVID-19 Test Robot Can Process 20,000 Samples for SARS-CoV-2 Testing Per 24 Hours

Eurofins Launches Quantitative Antibody Test to Measure Immune Response to COVID-19 and Vaccines

Siemens and Sysmex Extend Agreement to Provide One of the Largest Portfolios of Hemostasis Testing Systems and Reagents

New Simple, 15-Minute Sample-to-Answer COVID-19 Test Used with Desktop Detection System Costs Less than USD 2

Prolonged Maternal Zika Viremia Evaluated for Adverse Perinatal Outcomes

UPLC-MS/MS Method Simultaneously Determines Plasma Catecholamines and Their Metabolites

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Diagnosing Disease Conditions by Analyzing Plasma Protein Expression Patterns

Researchers Create Menagerie of Biocompatible Micromachines

Adsorption Procedure Enhances Efficiency of Drug Transport

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ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

03 Mar 2021 - 05 Mar 2021
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64th Congress of the German Society for Endocrinology

06 Mar 2021 - 10 Mar 2021
Virtual Venue

13 Mar 2021 - 18 Mar 2021
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USCAP 110th Annual Meeting - United States & Canadian Academy of Pathology

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Augmented Reality System Advances Joint Arthroplasty

On-Skin, Wearable Bioelectronic Device Could Aid Early Detection of COVID-19

Cooling Technology Helps Prevent Oral Mucositis

Machine Learning Model Uncovers Genetic Predisposition to Severe COVID-19

Air Cleaning Device Kills Indoor Pathogens, Including SARS-CoV-2

Rapid Point-of-Care COVID-19 Antigen Test Based on Waveguide Technology Could Deliver Results in Under Six Minutes

New COVID-19 Test to Scan Saliva or Nasal Swabs Using Specialized Probes for Detecting SARS-CoV-2 RNA Sequences

Siemens Lab-Based SARS-CoV-2 Antigen Assay (CoV2Ag) Obtains CE Mark for Use with Its High-Throughput Analyzers

Mathematical Model Estimates False-Negative Rate for COVID-19 Tests

Two New Diagnostic Tests Can Differentiate Between COVID-19 Variants and Multiple Viruses with Rapid Turnaround Times

PerkinElmer Launches New Highly Sensitive Point of Care COVID-19 Antigen Test for Mass Screening

World’s First AI Rapid Antigen Test System for COVID-19 Delivers Highly Accurate Results on Smartphone Within 5-8 Minutes

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Pulse-Controlled Amplification Tested for Infectious Disease Diagnostics

Image: The Pharos Micro prototype used in pulse-controlled amplification for infectious disease diagnostics (Photo courtesy of Bundeswehr Institute of Microbiology).

Molecular diagnostics has become essential in the identification of many infectious and neglected diseases, and the detection of nucleic acids often serves as the gold standard technique for most infectious agents. Read more
25 Feb 2021

22-Gene Genomic Classifier Validated in Recurrent Prostate Cancer Patients

25 Feb 2021

Blood Biomarker Predicts Dementia in Cerebral Small Vessel Disease

24 Feb 2021

Urinary Antigen Test Kit Evaluated for Diagnosing Legionella Pneumonia

24 Feb 2021

Stabilized Urinary Biogenic Amines Measured in Clinical Chemistry Laboratories

23 Feb 2021

Plasma or Urine Liquid Biopsy Tests May Guide Colorectal Cancer Treatment

23 Feb 2021

Industry Spotlight

Siemens and Sysmex Extend Agreement to Provide One of the Largest Portfolios of Hemostasis Testing Systems and Reagents

Siemens Healthineers (Erlangen, Germany) and Sysmex Corporation (Kobe, Japan) have renewed their long-standing global supply, distributorship, sales and service agreement for a broad portfolio of hemostasis products, including a multi-year extension. Read more
05 Feb 2021

Hologic Partners with Google Cloud to Focus on AI and Machine Learning for Advancing Digital Diagnostic Capabilities

Hologic, Inc. (Marlborough, MA, USA) and Google Cloud have entered into a new agreement to focus on enhancing artificial intelligence (AI) and machine learning (ML) to bring about breakthrough results in cervical cancer screening. Read more
04 Feb 2021

LGC Acquires Technopath Clinical Diagnostics to Strengthen Position in Clinical Diagnostics QC Market

LGC (Middlesex, UK) has acquired Technopath Clinical Diagnostics (Tipperary, Ireland), a developer and manufacturer of quality control (QC) solutions for clinical laboratories. Read more
03 Feb 2021

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Image: LightDeck (Photo courtesy of LightDeck Diagnostics)

Rapid Point-of-Care COVID-19 Antigen Test Based on Waveguide Technology Could Deliver Results in Under Six Minutes

A point-of-care COVID-19 antigen test currently under development promises to deliver results in less than six minutes by using the simple test procedure of waveguide technology. Read more
25 Feb 2021 | COVID-19

Image: Probes and magnetic beads capture RNA related to SARS-CoV-2 (Photo courtesy of Johns Hopkins Medicine)

New COVID-19 Test to Scan Saliva or Nasal Swabs Using Specialized Probes for Detecting SARS-CoV-2 RNA Sequences

A newly-developed test has the ability to analyze and detect the many subtle changes that can occur in the SARS-CoV-2 viral genome - so-called variants, such as those first identified in the UK and South Africa. Read more
25 Feb 2021 | COVID-19

Image: Atellica COVAg test (Photo courtesy of Siemens Healthineers)

Siemens Lab-Based SARS-CoV-2 Antigen Assay (CoV2Ag) Obtains CE Mark for Use with Its High-Throughput Analyzers

Siemens Healthineers’ (Erlangen, Germany) laboratory-based SARS-CoV-2 Antigen Assay (CoV2Ag) has obtained CE Mark and is now offered for the Atellica Solution and ADVIA Centaur analyzers, widely available in laboratories worldwide. Read more
25 Feb 2021 | COVID-19

Mathematical Model Estimates False-Negative Rate for COVID-19 Tests

Researchers have developed a mathematical model to estimate false-negative rate for COVID-19 tests.

The mathematical means of assessing tests’ false-negative rate develop by researchers at the Beth Israel Deaconess Medical Center (BIDMC Boston, MA, USA) allows an apples-to-apples comparison of the various assays' clinical sensitivity. Read more
24 Feb 2021 | COVID-19

Two New Diagnostic Tests Can Differentiate Between COVID-19 Variants and Multiple Viruses with Rapid Turnaround Times

Two new tests can differentiate between COVID-19 variants and multiple viruses with rapid turnaround times. Read more
24 Feb 2021 | COVID-19

PerkinElmer Launches New Highly Sensitive Point of Care COVID-19 Antigen Test for Mass Screening

PerkinElmer, Inc. (Waltham, MA; USA) has launched the PerkinElmer® COVID-19 Antigen Test for the qualitative detection of SARS-CoV-2 nucleocapsid protein antigen in nasal (NS) or nasopharyngeal (NP) swab specimens. Read more
24 Feb 2021 | COVID-19

Image: Glioblastoma omics highlights informative tumor features, immune subtypes (Photo courtesy of Washington University in St. Louis).

Proteogenomic and Metabolomic Studies Characterize Human Glioblastoma

Glioblastoma (GBM) is an aggressive type of cancer that can occur in the brain or spinal cord. Glioblastoma forms from cells called astrocytes that support nerve cells. Read more
23 Feb 2021 | Molecular Diagnostics

Image: LooK SPOT App (Photo courtesy of AETOSWire)

World’s First AI Rapid Antigen Test System for COVID-19 Delivers Highly Accurate Results on Smartphone Within 5-8 Minutes

The world’s first rapid COVID-19 antigen test system using artificial intelligence (AI) could revolutionize medical diagnostics, enabling early disease detection with consistent and accurate results. Read more
23 Feb 2021 | COVID-19

Image: T cell response in patients recovered from COVID-19 has been profiled using ImmunoScape TargetScape assay (Photo courtesy of The Scientist).

T Cell Response Profiled in COVID-19 Patients

The clinical spectrum of SARS-CoV-2 infection is highly variable, spanning from asymptomatic or subclinical infection, to severe or fatal disease. Read more
22 Feb 2021 | Immunology

Image: Micrograph showing a prostate cancer (conventional adenocarcinoma) with perineural invasion (Photo courtesy of Wikimedia Commons)

Study Confirms Value of the MyProstateScore Urine Test for Prostate Cancer Screening

A recent paper confirmed that the MyProstateScore test could be used with confidence to detect clinically significant (grade group higher than 2) prostate cancers when compared to commonly used prostate specific antigen-based diagnostic screening. Read more
22 Feb 2021 | Molecular Diagnostics

Agilent Launches New Immunoassay Kit to Detect SARS-CoV-2 Antibodies

Agilent Technologies (Santa Clara, CA, USA) has launched the Agilent Dako SARS-CoV-2 IgG Enzyme-Linked Immunosorbent Assay (ELISA) kit intended for the qualitative detection of immunoglobulin G (IgG) antibodies to SARS-CoV-2 in human serum or plasma. Read more
22 Feb 2021 | COVID-19

First-Ever Highly Sensitive Antibody Tests Could Detect Infection with All Known Human Coronaviruses, Including New SARS-CoV-2 Variants

Scientists have set the stage for the development of highly sensitive antibody tests for infection with all known human coronaviruses, including new variants of SARS-CoV-2. Read more
19 Feb 2021 | COVID-19

Image: The Immuno-storm chip is about the size of a 20c coin (Photo courtesy of AIBN)

New Diagnostic Device Identifies COVID-19 Patients at Risk of Potentially Lethal Cytokine Storm

Researchers have developed a diagnostic device, called an Immuno-storm chip, that could identify which cancer and COVID-19 patients are at risk of a potentially lethal ‘cytokine storm’. Read more
19 Feb 2021 | COVID-19

Channels

Clinical Chem.

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Image: Histopathology of drug-induced acute interstitial nephritis showing interstitial inflammation with prominent eosinophils and tubulitis (the presence of inflammatory cells within the tubular wall) (Photo courtesy of NephSim).

Biomarkers Evaluate Kidney Injury in Cancer Patients

Immune checkpoint inhibitors (ICI) are monoclonal antibodies that can unleash the immune system by blocking surface molecules that serve as important breaks (or checkpoints) that mediate negative regulation... Read more

Image: An association of epileptic and non-epileptic seizures and changes in circulating plasma proteins is linked to neuroinflammation (Photo courtesy of Evogen, Inc).

Blood Test Distinguishes Epileptic Seizures From PNES

Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations, and sometimes loss of awareness.... Read more

Image: Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection (Photo courtesy of Life Line Screening).

Abnormal Liver Function Test Associated with Severe SARS-CoV-2 Infection

COVID-19 predominantly affects the pulmonary tract causing mainly respiratory symptoms, however, involvement of other organ systems has been described, including myocarditis, acute kidney injury, neurological... Read more

New Control Mechanism Discovered in Innate Immune System

Proteases are enzymes that cleave other proteins. Most often, proteases occur in cascade networks, where a particular event triggers a chain reaction in which several proteases cleave and thereby activate... Read more

Molecular Diagnostics

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Image: Exome sequencing workflow: Double-stranded genomic DNA is fragmented by sonication. Linkers are then attached to the DNA fragments, which are then hybridized to a capture microarray designed to target only the exons (Photo courtesy of SarahKusala).

Exome Sequencing Identified Pathogenic Variants in Cerebral Palsy Patients

Cerebral palsy (CP) is a group of permanent movement disorders that appear in early childhood. Signs and symptoms vary among people and over time. Often, symptoms include poor coordination, stiff muscles,... Read more

Image: The crystal structure of the nucleosome core particle (Photo courtesy of Wikimedia Commons)

Analysis of Cell-free DNA in the Blood May Replace Examination of Biopsy Specimens for Disease Diagnosis

A recent paper described a blood-based liquid biopsy method for detection of a wide variety of diseases including several types of cancer. Cell-free DNA (cfDNA) in human plasma provides access to molecular... Read more

NanoString Technology Modernizes Liposarcoma Diagnostics

A recently published study showed that a newer NanoString-based method could allow for more rapid and cost-efficient diagnosis of liposarcomas than the commonly used fluorescence in situ hybridization (FISH) method.... Read more

Image: The NanoSight NS300 Instrument provides an easy-to-use, reproducible platform for nanoparticle characterization (Photo courtesy of Malvern Panalytical Instruments).

Early Plasma Biomarkers Discovered for Alzheimer's Disease

Alzheimer's disease (AD) is the predominant form of dementia and the most common neurodegenerative disorder. Advanced age and the presence of the ε4 allele of the apolipoprotein E gene (APOE) are the most... Read more

Hematology

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Image: TruSight Oncology 500 is a next-generation sequencing (NGS) assay that enables in-house comprehensive genomic profiling of tumor samples it accurately measures key current immuno-oncology biomarkers: microsatellite instability (MSI) and tumor mutational burden (TMB) (Photo courtesy of Illumina).

Next Generation Sequencing Finds More Gene Mutations for Leukemia

Myeloid malignancies are characterized by uncontrolled proliferation and/or defects in differentiation of abnormal myeloid progenitor cells. Myelodysplastic syndromes (MDS) and myeloproliferative neoplasms... Read more

Image: The DxH 800 hematology analyzer, can utilize accurate data about individual cell size, shape and structure to provide high-quality first-pass results with VCS technology (Photo courtesy of Beckman Coulter Inc).

Automated Leucocyte VCS Parameters Evaluated for Pathogenic Infections

Malaria and dengue are highly endemic in most parts of India. Mangalore, a city in coastal Karnataka, India, has high prevalence of both these vector‐borne infections with extensive range of clinical presentations.... Read more

Image: The Technothrombin TGA is a thrombin generation assay (TGA) based on monitoring the formation of thrombin by means of a fluorogenic substrate upon activation of the coagulation cascade by tissue factor (Photo courtesy of Technoclone).

TFP Inhibitor Levels Elevated in Bleeding Tendency Patients

Mild to moderate bleeding disorders (MBDs) are characterized by symptoms such as epistaxis, easy bruising, or menorrhagia, but bleeding can also be severe under certain circumstances such as hemorrhage... Read more

Image: Human erythrocytes showing variation in red cell distribution width (RDW), known as anisocytosis, higher levels may predict mortality in COVID-19 patients (Photo courtesy of Dr. Graham Beards)

RDW Levels Associated with Adverse Outcomes in COVID-19 Patients

The red cell distribution width (RDW) blood test measures the amount of red blood cell variation in volume and size. RDW is not used as an isolated parameter when interpreting a complete blood count (CBC);... Read more

Immunology

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Image: The MACSQuant Analyzer 10 flow cytometer has three lasers (405, 488, 638 nm), two scatter (FSC, SSC) and seven fluorescent channels (Photo courtesy of Miltenyi Biotec)

Proinflammatory T Cell Polarization Investigated in Early Knee Osteoarthritis

In osteoarthritis (OA), the cartilage in the knee joint gradually wears away. As the cartilage wears away, it becomes frayed and rough, and the protective space between the bones decreases.... Read more

Image: The Simoa HD-X fully automated immunoassay platform with multiplexing and custom assay capability (Photo courtesy of Quanterix Corporation).

Alzheimer's Progression Tracked with Blood Biomarkers

Alzheimer disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau in the brain. These neuropathological... Read more

Image: The CytoFLEX benchtop flow cytometer features up to three lasers for 13-color flow cytometry (Photo courtesy of Beckman Coulter Life Sciences).

Basophil Activation Test Predicts Pediatric Wheezing Prognosis

Although asthma is a common chronic airway inflammatory disease in children, the natural history of asthma remains unknown. It is difficult to diagnose asthma in children aged under five years because... Read more

Image: The FLUOstar Omega Microplate Reader (Photo courtesy of BMG LABTECH).

Combination Urinary Biomarker Panel Detects Pancreatic Cancer Earlier

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with only around 9% of patients surviving more than 5 years. Asymptomatic in its initial stages, PDAC is mostly diagnosed late,... Read more

Microbiology

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Image: The RealStar Zika Virus RT-PCR Kit 1.0 is an in vitro diagnostic test, based on real-time PCR technology, for the qualitative detection of Zika virus specific RNA in human serum or urine (Photo courtesy of Altona Diagnostics).

Prolonged Maternal Zika Viremia Evaluated for Adverse Perinatal Outcomes

The recent worldwide epidemic confirmed maternal–fetal transmission of Zika virus (ZIKV) and its association with adverse perinatal outcomes, particularly severe central nervous system lesions and fetal losses.... Read more

TAP1 Gene Polymorphisms Associated with Recurrent Respiratory Papillomatosis

Recurrent respiratory papillomatosis (RRP) is a respiratory tract disease that affects children and adults and is characterized by the recurrent proliferation of multiple papillomas. The proliferation... Read more

Image: The UriSed 3 PRO is a professional automated urine sediment analyzer with a revolutionary new optical system combining bright-field and phase contrast microscopy (Photo courtesy of 77 Elektronika)

Automated Urine Microscope Verified for Regional Laboratories

Automated Urine Microscopy examines a sample of urine under a microscope. It can check cells from the urinary tract, blood cells, crystals, bacteria, parasites, and cells from tumors. This test is often... Read more

Image: False-colored electron microscopic image of Bifidobacterium that are one of the major genera of bacteria that make up the gastrointestinal tract and are associated with variants in the lactase gene locus (Photo courtesy of The Keck Science Department of the Claremont Colleges)

ABO Histo-Blood Groups Influence Makeup of Gut Microbiome

Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure... Read more

Pathology

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Image: The Z2 Coulter Counter Analyzer can be used to analyze virtually any cell type and species variation (Photo courtesy of Beckman Coulter).

Biomarker Predicts Pancreatic Cancer Patients’ Response to CD40 Immunotherapy

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and currently the third leading cause of cancer deaths in the USA. Despite the fact that it only accounts for about... Read more

Image: Photomicrograph of a moderately differentiated colorectal carcinoma with dirty necrosis (Photo courtesy of Mikael Häggström, MD).

Blood Test Detects Early Colorectal Adenomas

Colonoscopies are the gold standard for screening but have low compliance rates due to the invasiveness of the procedure. Stool-based tests have poor compliance and low sensitivity for advanced adenomas... Read more

Image: The Leica Bond III stainer is fully automated Immunohistochemical and In Situ Hybridization (IHC and ISH stainer) (Photo courtesy of Leica Biosystems).

Mismatch Repair/Microsatellite Instability Evaluated Using Cytology Effusion Specimens

DNA mismatch repair (MMR) status is routinely assessed in colorectal and endometrial carcinoma as a method of cancer prevention, surveillance in patients with Lynch syndrome and their families, and for... Read more

Image: Photomicrograph of omental nodules indicated an adenocarcinoma infiltrating the adipose and fibrous tissues (Photo courtesy of Beijing Shijitan Hospital).

Metastatic Gastric Cancer Outcomes Informed by Single-Cell Transcriptome Profiles

Peritoneal Carcinomatosis (PC) is a late stage manifestation of several gastrointestinal malignancies including appendiceal, colorectal, and gastric cancer. In PC, tumors metastasize to and deposit on... Read more

Technology

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Image: A microneedle patch has been developed that can be applied to the skin, capture a biomarker of interest from interstitial fluid and, due to its unprecedented sensitivity, allow clinicians to detect its presence (Photo courtesy of Sisi Cao).

Biosensing Microneedle Patch Quantifies Biomarkers in Interstitial Fluid

Interstitial fluid (ISF) compared with other peripheral biofluids such as saliva, sweat and tears is a particularly rich source of soluble bioanalytes including proteins, peptides, metabolites and nucleic... Read more

Lab-on-a-Chip Infection Test Provides Cheaper, Faster Portable Diagnostics

Rapid screening and low-cost diagnosis play a crucial role in choosing the correct course of intervention when dealing with highly infectious pathogens. This is especially important if the disease-causing... Read more

Image: Cryptosporidium oocysts and the larger Giardia cysts stained by Crypto/Giardia IFA kit (Photo courtesy of Cellabs).

Smartphone Microscopic Method Detects Cryptosporidium and Giardia

Food and water-borne illness arising from the consumption of contaminated food and water are serious health hazards globally. Cryptosporidium and Giardia are the major food and water‒borne parasites.... Read more

Image: A test tube contains saliva that can be tested for the heart attack biomarker cardiac troponin (Photo courtesy of karenfoleyphoto).

Saliva Test Fast Tracks Heart Attack Diagnosis

Heart attacks need urgent diagnosis, followed by treatment to restore blood flow to blocked arteries. Diagnosis is based on symptoms (such as chest pain), an electrocardiogram (ECG) and a blood test for... Read more

BioResearch

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Genome Analysis Predicts Likelihood of Neurodisability in Oxygen-Deprived Newborns

A genomics-based blood test can predict likelihood that a baby suffering hypoxia at birth will suffer serious nervous disorders such as cerebral palsy or epilepsy at a later stage of development.... Read more

Image: A micrograph of a diffuse large B cell lymphoma (DLBCL) (Photo courtesy of Wikimedia Commons).

Gene Panel Predicts Disease Progession for Patients with B-cell Lymphoma

Cancer researchers developed a 29 gene–based weighted prognostic score for predicting event-free survival and overall survival of patients suffering from diffuse large B-cell lymphoma (DLBCL).... Read more

Image: A diagram of construction of a genomic library (Photo courtesy of Wikimedia Commons).

New Method Simplifies Preparation of Tumor Genomic DNA Libraries

A method has been described that simplifies preparation of tumor genomic DNA libraries by employing restriction enzymes and in vitro transcription to barcode and amplify genomic DNA prior to library construction.... Read more

New Tool Developed for Diagnosis of Chronic HBV Infection

A team of Chinese researchers has described the development of a new and powerful tool for the diagnosis and treatment of chronic hepatitis B virus (HBV) infection. Methods currently used to diagnose... Read more

Industry

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HORIBA Acquires MedTest Dx and Pointe Scientific to Expand Laboratory Chemistry Offerings

HORIBA, Ltd. (Kyoto, Japan) has acquired MedTest Holdings, Inc. (Canton, MI, USA), composed of MedTest Dx, Inc., Pointe Scientific, Inc., Clinitox Diagnostix, Inc., and Medical Laboratory Solutions, Inc.... Read more

Image: DxH 560 AL (Photo courtesy of Beckman Coulter)

Beckman Coulter Launches New DxH 560 AL Tabletop Hematology Analyzer for Small- and Medium-Sized Labs

Beckman Coulter (Brea, CA, USA) has launched the new DxH 560 AL, a tabletop hematology analyzer geared to reduce the time and resource constraints faced by small to mid-sized laboratories.... Read more

Roche Renews Partnership with Sysmex to Deliver Hematology Testing Solutions

Under the new framework of a Global Business Partnership Agreement (GBP) signed between Roche (Basel, Switzerland) and Sysmex Corporation (Kobe, Japan), both the companies have renewed their commitment... Read more

Nova Biomedical Adds Sample Retain Collector to BioProfile FLEX2 Cell Culture Analyzer

Nova Biomedical (Waltham, MA, USA) has added a Sample Retain Collector (SRC) for its BioProfile FLEX2 automated cell culture analyzer which measures up to 16 tests including pH, gases, metabolites, osmolality,... Read more

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