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Wireless-Controlled Soft Neural Implant Stimulates Brain Cells

New-Generation Devices Aid Growth of Global ECG Devices MarketNew-Generation Devices Aid Growth of Global ECG Devices Market

Continuous Fetal Monitor Could Prevent Millions of Stillbirths

Dynamic Brace Helps Restore Neck Motion to ALS Patients

Tiny Polymer Stent Could Treat Pediatric Urethral Strictures

Diagnostic Methods Compared for Soil-Transmitted Helminths

Image: The Mini-FLOTAC is a promising technique for detecting and counting helminth eggs in animals and humans, and can be used for fecal egg count (Photo courtesy of Università degli Studi di Napoli Federico II).

Soil-transmitted helminths (STHs) are a group of intestinal parasitic worms that excrete eggs through feces, which contaminate soil in areas where sanitation is poor and infect the human host orally or through skin contact.
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22 Aug 2019

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Troponin Complexes Explored in Acute MI Patients

22 Aug 2019

Portable Monitor Detects Acute Respiratory Distress Syndrome

22 Aug 2019

Hormone Levels of Diabetic Men Not Related to Prostate Cancer Risk

21 Aug 2019

Congenital Cytomegalovirus Infection Diagnosed Via Dried Blood Spots

21 Aug 2019

Circulating Tumor Cells Directly Detected in Blood Samples

21 Aug 2019

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Image: The NextSeq 500 next-generation sequencer (Photo courtesy of Illumina).

Combination of Gene Mutations Linked to Endometrial Cancer

The endometrium is the dynamic inner layer of the uterus, composed of stroma and epithelial cells that undergo monthly proliferation, differentiation, and shedding throughout the menstrual cycle in reproductive age women. Read more
21 Aug 2019 | Pathology

Image: Scientists combined multiphoton microscopy with automated image and statistical analysis algorithms to distinguish between healthy and diseased tissue. In this image, collected in a completely label-free, noninvasive manner, collagen is colored green while ovarian metastatic cell clusters are presented in red (Photo courtesy of Tufts University).

Non-Invasive Imaging Detects Cancer at Molecular Level

For cancer patients the presence of metastases dictates the staging assessment, which in turn defines the appropriate treatment path selected. Read more
20 Aug 2019 | Pathology

Image: The VS110 combines microscopy seamlessly with imaging to create a virtual slide that is an exact copy of the real specimen (Photo courtesy of Olympus).

Prognostic Value of Specific Biomarker in Prostate Cancer Authenticated

Prostate cancer (PC) is the most commonly diagnosed cancer in Canadian men. In men with high-risk PC, progression of the disease will lead to biochemical recurrence (BCR), distant metastases, and disease-specific mortality. Read more
20 Aug 2019 | Pathology

Image: The Architect 25-OH Vitamin D reagent kit (Photo courtesy of Abbott).

Two Vitamin D Immunoassays Compared

Vitamin D can be synthesized in skin from 7-dehydrocholesterol following ultraviolet light exposure, which produces Vitamin D3 (cholecalciferol). Read more
20 Aug 2019 | Clinical Chemistry

Image: A scanning electron microscope (SEM) photograph of Papillomavirus particles (Photo courtesy of the Institut Pasteur/Odile Croissant).

RNA-Based Test Developed for HPV Detection and Cancer Diagnosis

An RNA-based diagnostic test was developed that can detect human papillomaviruses (HPVs) with performances comparable to or better than an HPV DNA-based reference diagnostic kit. Read more
19 Aug 2019 | BioResearch

$Image: Circulating tumor DNA (ctDNA) is found in serum and plasma fractions from blood. The mechanism of ctDNA release is unknown, though apoptosis, necrosis, and active secretion from tumor cells have been hypothesized (Photo courtesy of Wikimedia Commons).$

Ultrasensitive Biopsy Technique Monitors Risk of Cancer Recurrence

An ultrasensitive liquid biopsy technique, which may be personalized for each breast cancer patient, can be used to monitor the patient over time and allow early detection of tumor recurrence. Read more
19 Aug 2019 | BioResearch

Image: A biopsy of small bowel showing celiac disease manifested by blunting of villi, crypt hypertrophy, and lymphocyte infiltration of crypts (Photo courtesy of Wikimedia Commons).

Interleukin-2 Suggested as Basis for Celiac Disease Diagnostic Test

A study designed to link changes in cytokine release following ingestion of gluten by individuals suffering from celiac disease found that interleukin-2 (IL-2) was the earliest and most prominent cytokine. Read more
19 Aug 2019 | Molecular Diagnostics

Image: A high-magnification micrograph of diffuse proliferative lupus nephritis (Photo courtesy of Wikimedia Commons).

Urine Plasmin Identified as Strong Biomarker for Lupus Nephritis Diagnosis

Plasmin in the urine has been identified as the strongest predictor of estimated glomerular filtration rate (eGFR) and clinical renal disease in patients with lupus nephritis (LN). Read more
19 Aug 2019 | Molecular Diagnostics

Image: A scanning electron micrograph of two rod-shaped bacteria called Klebsiella pneumoniae that are resistant to treatment with the “last resort” antibiotic drug called carbapenem. In this image, the mustard-colored bacteria are interacting with the green-colored human white blood cells (Photo courtesy of National Institute of Allergy and Infectious Diseases).

Carbapenem-Resistant K. Pneumoniae Driven by Nosocomial Spread

Public health interventions to control the current epidemic of carbapenem-resistant Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and spread over a wide range of geographical scales. Read more
15 Aug 2019 | Microbiology

Image: An MIT-invented microfluidics device could help doctors diagnose sepsis, a leading cause of death in US hospitals, by automatically detecting elevated levels of a sepsis biomarker in about 25 minutes, using less than a fingerprick of blood (Photo courtesy of Felice Frankel).

Microfluidic Device Rapidly Diagnoses Sepsis

Sepsis is a life-threatening condition and early diagnosis is crucial to ensure that treatment is not delayed. Read more
15 Aug 2019 | Lab Tech.

Image: A histopathology of pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer, arising in the pancreas head region (Photo courtesy of KGH).

Pancreatic Cancer Risk Rises with Fasting Glucose

More than 56,000 Americans are expected to be diagnosed with pancreatic cancer in 2019, which is more than 150 people diagnosed every day. Read more
15 Aug 2019 | Clinical Chemistry

Image: The Mini8 Plus real time polymerase chain reaction (RT-PCR) thermocycler (Photo courtesy of Coyote Bioscience).

Direct Molecular Assay Developed for Zika Diagnosis

Zika virus (ZIKV), a mosquito-borne Flavivirus, is a positive single-stranded RNA virus with a nucleic acid length of about 10. Read more
14 Aug 2019 | Molecular Diagnostics

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Image: The GeneXpert MTB/RIF assay is designed as a rapid diagnosis test of Tuberculosis (TB) and drug resistance (Photo courtesy of Cepheid).

Serum Siderocalin Measured in Patients with TB and HIV

Tuberculosis (TB) continues to be a significant cause of morbidity and mortality worldwide. The progression from uninfected or latently infected to active TB is often insidious and has minimal symptoms... Read more

Image: The Xevo TQ-S micro Triple Quadrupole Mass Spectrometry (Photo courtesy of Waters).

High Fetal Estrogen Levels Linked to Autism

The male-biased prevalence of autism, together with the finding that autistic girls have a higher mutational load than autistic boys, suggests that males have a higher likelihood of developing autism.... Read more

Image: Scientists determined that one-third of total cholesterol in plasma was present in remnant lipoproteins, which is in the triglyceride-rich lipoproteins intermediate-density lipoprotein (IDL) and very low-density lipoprotein (VLDL) (Photo courtesy of Harvard Medical School).

High Remnant Particle Cholesterol Levels Profiled in Blood

Three quarters of the Danish population have moderately elevated levels of cholesterol. If cholesterol levels are too high, risk of cardiovascular disease is increased. Often, low-density lipoprotein (LDL)... Read more

Image: The cobas e 801 module is a high throughput immunochemistry module that performs a broad range of heterogeneous immunoassay tests (Photo courtesy of Roche Diagnostics).

Low Serum IGF1 Predicts CV Events in RA Women

Hypertension is a significant health threat and an independent predictor of cardiovascular (CV) events including coronary heart disease, stroke, heart failure, and dementia in the general population and... Read more

Molecular Diagnostics

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Image: The structure of human hemoglobin with alpha and beta subunits in red and blue, respectively, and the iron-containing heme groups in green (Photo courtesy of Wikimedia Commons).

Abnormal Hemoglobin Levels Predict Risk of Developing Dementia

Both elevated and diminished levels of serum hemoglobin have been linked to an increased risk of developing various types of dementia including Alzheimer’s disease. Investigators at Erasmus Medical... Read more

Image: A circulating cancer cell (pink) attaches to carbon nanotube surface; white blood cells (blue) do not adhere and are later washed away (Photo courtesy of Curtis Sayers).

Liquid Biopsy Device Selectively Captures Circulating Tumor Cells

A new type of antigen-independent liquid biopsy captures device exploits the preferential attachment of circulating tumor cells (CTCs) to the surface of carbon nanotubes. The nanotube-CTC-chip is a... Read more

Image: A micrograph showing amyloid beta (brown) in senile plaques of the cerebral cortex (upper left of image) and cerebral blood vessels (right of image) with immunostaining (Photo courtesy of Wikimedia Commons).

Amyloid Beta Blood Test Detects Asymptomatic Alzheimer’s Disease

An assay has been developed that determines the ratio of amyloid beta peptides in the blood and correlates with the accumulation of these Alzheimer’s disease risk factors in the brain. Amyloid beta... Read more

Image: A photomicrograph showing tumor-infiltrating lymphocytes in colorectal carcinoma, which are suggestive of microsatellite instability, and may be seen in Lynch syndrome (Photo courtesy of Nephron).

Mutation Study Suggests Changes to Clinical Management

Lynch syndrome (LS) results from pathogenic variants in the mismatch repair (MMR) genes and is the most common hereditary cancer syndrome, affecting an estimated 1 in 300 individuals. Pathogenic variants... Read more

Hematology

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Image: A blood smear from a patient with non-Hodgkin lymphoma showing very large lymphocytes (Photo courtesy of Venngage).

BRCA2 Mutations Linked to Pediatric Non-Hodgkin Lymphoma Risk

Inherited mutations in BRCA1 and BRCA2 genes are most typically associated with an increased risk of developing breast and ovarian cancer. BRCA2 was the third most frequently mutated gene (14 occurrences)... Read more

Image: A histopathology of chronic interstitial nephritis in end-stage kidney disease. There is diffuse interstitial scarring with a nonspecific mononuclear infiltrate (Photo courtesy of Agnes B. Fogo MD, Michael Kashgarian MD).

Abnormal Metabolite Observed in Early CKD Patients

Chronic kidney disease (CKD) has been a growing health burden worldwide, and the patients with CKD continue to suffer from a wide range of complication including electrolyte imbalance, fluid overload,... Read more

Image: Bone marrow aspirate of a patient with myeloid leukemia associated with Down’s syndrome. The smear includes frequent atypical megakaryocytes. Blasts are increased (11%). As in the peripheral blood, a subset of the blasts has cytoplasmic blebs (Photo courtesy of Elizabeth L. Courville, MD).

Genetic Changes Linked to Leukemia in Down’s Syndrome Children

Of the 30% of children with Down's syndrome who are found to have 'myeloid preleukemia', only 10% of those will go on to develop myeloid leukemia (3% of all children with Down's syndrome).... Read more

Thromboembolic Risk Increases after Hematological Cancers

Hematological cancer includes leukemia, bone marrow cancer and cancers of the lymph nodes. Therapeutic advances have improved survival after hematological cancers. In turn, patients may be at increased... Read more

Immunology

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Image: The FACSymphony A5 system is a novel cell analyzer that leverages the inherent benefits of flow cytometry and enables the simultaneous measurement of up to 50 different characteristics of a single cell (Photo courtesy of BD Biosciences).

T Follicular Helper Cells Retain Lymphoid Characteristics

T follicular helper cells (Tfh) are a subset of CD4+ T cells that provide B cell help within the follicles of secondary lymphoid tissues. Tfh promote B cell class switching and affinity maturation, and... Read more

Immunoglobulins and Neutrophils Play Unexpected Role in Anaphylaxis

Anaphylaxis may be brought about by various substances, including drugs (antibiotics or neuromuscular blocking agents), food and insect venom. Anaphylaxis is a hyperacute allergic reaction caused by an... Read more

T Cell Antibody and Memory in H7N9 Survivors Characterized

Avian influenza A (H7N9) is a subtype of influenza viruses that have been detected in birds in the past. This particular A (H7N9) virus had not previously been seen in either animals or people until it... Read more

Image: Defective Selection of Autoreactive B Cells seen in Systemic Lupus Erythematosus (Photo courtesy of Sebastian Kaulitzki).

Early B Cell Differentiation Activation Seen in Lupus

In people with systemic lupus erythematosus, their B cells, part of the immune system, are abnormally activated. They produce antibodies that react against their own tissues, causing a variety of symptoms,... Read more

Microbiology

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Image: The BC-6800 benchtop automatic hematology analyzer (Photo courtesy of Mindray).

Hematology Analyzer Screens for Malaria in Clinical Setting

Malaria is a vector-borne infectious disease that continues to have high morbidity and mortality globally. Diagnosis based only on clinical symptoms has very low specificity as there is no combination... Read more

Image: A colored scanning electron micrograph (SEM) of Enterococcus faecalis. These bacteria generate 12,13-diHOME and the concentration of the lipid itself in the babies’ stool samples predicted which infants went on to develop allergies (Photo courtesy of Pete Wardell/CDC).

Allergy Risk Increased by Compound Found in Infant Gut

Gut microbiota (formerly called gut flora) is the name given today to the microbe population living in our intestine. A recent study of newborn infants has identified a compound produced by gut bacteria... Read more

$Image: Burkholderia pseudomallei colonies grown on Ashdown\'s agar after four days incubation showing the characteristic cornflower head morphology (Photo courtesy of Gavin Koh).$

Cost-Effectiveness of Media for Melioidosis Diagnosis Reviewed

Melioidosis is a frequently fatal disease caused by a soil bacterium called Burkholderia pseudomallei that is widespread in the rural tropics. The yield of B. pseudomallei from sites with a normal flora... Read more

Image: Bacteria in the gut are pulled into the helical channels by an osmotic “pump” generated by a calcium salt-filled chamber within the pill (Photo courtesy of Nano Lab, Tufts University).

Novel Diagnostic Device Profiles Population of Gut Microbiome

Researchers used a three-dimensional (3D) printer to manufacture a novel pill-like diagnostic tool capable of profiling the bacterial species comprising the gut microbiome in the critical area between... Read more

Pathology

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Molecular Test Accurately Distinguishes Breast Tumors

A new laboratory test has been developed to identify chemical changes to a group of cancer-related genes that can accurately detect which breast tumors are cancerous or benign, and do it in far less time... Read more

Urine Test Used to Individualize Bladder Cancer Treatment

Bladder cancer is the most common urologic cancer in China and is in the top 10 most common cause of cancer death in the USA, leading to approximately 17,000 deaths in 2018. Currently no method is available... Read more

Image: The LSRFortessa flow cytometer instrument (Photo courtesy of BD Biosciences).

Rare Inherited Enzyme Disorder Yields Insight into Fibrosis

Mammalian tissues and organs preserve their structural and functional homeostasis by means of their supportive connective tissue, a three-dimensional network of cells and extracellular matrix (ECM) with... Read more

Test Improves Accuracy in Identifying Precancerous Pancreatic Cysts

Pancreatic cysts are common and often pose a management dilemma, because some cysts are precancerous, whereas others have little risk of developing into invasive cancers. Early, accurate detection of pancreatic... Read more

Lab Tech.

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Image: A new study suggests that cutting-edge electronic devices can help doctors diagnose early stage bladder cancer (Photo courtesy of Ana Sandoiu).

Electronic Device May Help Diagnose Early Bladder Cancer

It is estimated that bladder cancer will affect 80,470 people in the USA this year, and about 17,670 deaths are likely to result from these cases. Doctors diagnose approximately half of all bladder cancers... Read more

New Systems Offer Cost-Effective Urinalysis at Any Lab Scale

With the growing prevalence of kidney-related diseases, proper screening and detection have become an increasing priority for clinicians. Two newly introduced systems, LAURA and LAURA XL, now aim to fill... Read more

Image: (A and B) Photomicrographs of the layers of the device; (C) the mold ready for casting and (D) the chip mounted on a slide (Photo courtesy of San Diego State University).

Microfluidic Device Isolates Circulating Tumor Cell Clusters

The three main challenges of cancer treatment are metastases, recurrence, and acquired therapy resistance. These challenges have been closely linked to circulating cancer cell clusters. About 90% of... Read more

Image: Examples of migratory and non-migratory MDA-MB-231 breast cancer cells migrating in the MAqCI (Microfluidic Assay for quantification of Cell Invasion) device (Photo courtesy of Christopher L. Yankaskas, Johns Hopkins University).

Microfluidic Motility Device Indicates Likelihood of Breast Tumor Metastasis

A novel microfluidic motility test was shown to accurately predict a breast tumor's likelihood to generate metastases. The difficulties involved in predicting which patients with breast cancer will... Read more

BioResearch

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Image: The presence of lymphocytes within the tubular epithelium, attesting to acute cellular rejection of a renal graft (Photo courtesy of Wikimedia Commons).

Gene Panel Detects Early Signs of Kidney Transplant Rejection

A team of European kidney transplantation researchers has developed and validated an mRNA-based gene set found in peripheral blood that can identify patients with symptoms of antibody-based kidney transplant... Read more

$Image: A micrograph of non-alcoholic fatty liver disease (NAFLD). The liver has a prominent (centrilobular) macrovesicular steatosis (white/clear round/oval spaces) and mild fibrosis (green). The hepatocytes stain red. Macrovesicular steatosis is lipid accumulation that is so large it distorts the cell\'s nucleus (Photo courtesy of Wikimedia Commons).$

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