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In Other News

The Fecal Swab Collection and Preservation System fecal collection kit (Photo courtesy of Norgen Biotek).

Rare Gut Bacteria Linked to Restless Legs Syndrome

One common sleep disorder in which the microbiome may play a role is restless legs syndrome (RLS). While the pathogenesis of RLS is not fully understood, a relative state of brain iron deficiency has been described in patients with RLS and appears to induce changes in several pathways known to be involved in the disease. Read more
18 Jun 2019 | Microbiology
A new study validated the use of tumor markers to select chemotherapy drugs for patients with metastatic pancreatic cancer (Photo courtesy of SPL).

Study Results Validate Use of Tumor Markers to Treat Metastatic Cancer

Promising results obtained in a recently conducted pilot study demonstrated the feasibility of using molecular tumor markers as the basis for selecting the chemotherapeutic agents to use in patients with metastatic pancreatic cancer. Read more
17 Jun 2019 | Molecular Diagnostics
In this photomicrograph, the brown areas were stained for a biomarker in tissue from a patient who developed pancreatic cancer from a cyst (Photo courtesy of Dr. Koushik Das, Washington University).

Immunodiagnostic Test Predicts Progression of Pancreatic Cyst to Cancer

By using an immunodiagnostic test to detect the Das-1 antibody biomarker in fluid from pancreatic cysts, researchers were able to identify those cysts that were likely to become cancerous with 95% accuracy. Read more
17 Jun 2019 | Molecular Diagnostics
Image: The NimbleGen MS 200 CGH LOH microarray detection scanner (Photo courtesy of Roche).

Kidney Transplant Rejection Linked to New Mismatch Locus

Approximately 20% of the kidney waiting list in the USA consists of candidates whose allografts have failed. Read more
13 Jun 2019 | Molecular Diagnostics
Image: The SLAN-96 real-time polymerase chain reaction (PCR) instrument (Photo courtesy of QuanDx/Zeesan Biotech).

Unexpected Prevalence of High-Risk HPV Types Demonstrated

Low- and middle-income countries have high incidences of cervical cancer linked to human papillomavirus (HPV), and without resources for cancer screenings these countries bear 85% of all cervical cancer cases. Read more
13 Jun 2019 | Molecular Diagnostics
Image: The nCounter Max analysis system (Photo courtesy of NanoString Technologies).

Custom NanoString Assay Detects Bowel Cancer Subtypes

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. The median overall survival of metastatic (m)CRC patients with unresectable disease remains around 24 months with standard chemotherapies. Read more
13 Jun 2019 | Molecular Diagnostics
Image: Research shows that trace metals concentrations in the blood may influence glucose regulation in pregnancy (Photo courtesy of bluehorizon).

Trace Metal Concentrations Influence Glucose Regulation in Pregnancy

Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels during pregnancy. Read more
12 Jun 2019 | Clinical Chemistry
Image: The LSRFortessa cell analyzer offers the ultimate in choice for flow cytometry, providing power, performance, and consistency (Photo courtesy of BD Biosciences).

Flow Cytometry Standardized for Predicting Transplant Rejection

Understanding the immunological phenotype of transplant recipients on standard immunosuppression, immune-cell therapies and new drug treatments is essential for improving transplantation outcome. Read more
12 Jun 2019 | Immunology
Image: The SEQPRO LIPO IS assay is for the genetic diagnosis of familial hypercholesterolemia (Photo courtesy of Progenika Biopharma).

Genetic Familial Hypercholesterolemia Prevalent in Premature CVD

Premature coronary artery disease (CAD) is a major cause of mortality and morbidity. Increased low-density lipoprotein-cholesterol (LDL-C) level is a major risk factor for CAD and thus the main target for its prevention. Read more
12 Jun 2019 | Clinical Chemistry
Image: The PLATELIA ASPERGILLUS Ag Test (Photo courtesy of Bio-Rad Laboratories).

Invasive Pulmonary Aspergillosis Diagnosed by Molecular Test

Invasive aspergillosis (IA) is a common opportunistic fungal infection, mainly affecting patients with severe and prolonged neutropenia. Read more
12 Jun 2019 | Microbiology
Image: The XN-30 automated hematology analyzer that has an automatic measurement functions for red blood cells infected by malaria parasites (Photo courtesy of Sysmex).

Automated Hematology Analyzer Assessed for Malaria Diagnosis

Malaria remains a major cause of morbidity and mortality around the world. Sub-Saharan Africa is most affected with Plasmodium falciparum accounting for 99% of estimated cases. Read more
11 Jun 2019 | Hematology
Image: The KRYPTOR compact PLUS fully automated random access immunoassay analyzer (Photo courtesy of BRAHMS).

Plasma Copeptin Reveals Presence and Severity of Liver Disease

Vasopressin (VP) is a hormone secreted by the pituitary gland in response to increased plasma osmolality, low plasma volume, and low blood pressure. Read more
11 Jun 2019 | Clinical Chemistry

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Clinical Chemistry

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3D-Printed Device Detects Biomarkers of Preterm Birth
Blood Donations Screened for Familial Hypercholesterolemia
Reagent Strips Test Analyzed for CSF in Neurological Disorders
Image: A molecule model of Apo E (Photo courtesy of Wikimedia Commons).

Study Confirms Association of AD and High Levels of LDL Cholesterol

High LDL cholesterol levels have been linked to the risk of developing early-onset Alzheimer's disease (AD). Early-onset Alzheimer's disease (EOAD), which manifests in individuals younger than age 65,... Read more

Molecular Diagnostics

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Genomic Analysis Uncovers Differences in Liver Cancer Subtypes
CtDNA Forecasts Non-Metastatic Colorectal Cancer Recurrence
Stem Cell Transplantation Increases Risk of Infection-Related Mortality
Image: The cBot 2 System streamlines the sequencing workflow by automating cluster generation. It was a required accessory instrument for HiSeq sequencers (Photo courtesy of Illumina).

Sequencing Study Links DNA Alterations to Type 2 Diabetes

According to statistics from the World Health Organization, over 400 million people worldwide have diabetes. The vast majority of these cases are type 2 and diabetes is estimated to be the seventh leading... Read more

Hematology

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Sickle Cell Disease Screening Helps Save Lives of Migrants
Multiple Myeloma Sequences Reveal Prognostic Immunoglobulin Translocation
Early Sepsis Detection Test Approved for U.S. Marketing
Image: A blood film showing typical red and white blood cells (Photo courtesy of Sherri Wick).

Neutrophil-Lymphocyte Ratio Proves Possible Biomarker for ED

Erectile dysfunction is described as the impotency to obtain or sustain an erection sufficiently in order to enable convincing sexual intercourse. Erectile dysfunction (ED) is estimated to affect about... Read more

Immunology

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Novel 3D-Printed Technology Lowers Cost of ELISA
Cysteine-Rich 61 Biomarker Reflects RA Disease Activity
Urinary Biomarkers Diagnose Serious Kidney Allergic Reaction
Image: A typical human serum mannose-binding lectin enzyme-linked immunoassay kit (Photo courtesy of Hycult Biotech).

Mannose-Binding Lectin Associated with IgG Subclass Deficiency

Mannose-binding lectin (MBL; mannan-binding protein or lectin) is involved in innate immune defense, is produced largely by hepatocytes and is encoded by MBL2 (chromosome 10q21.1). MBL promotes killing... Read more

Microbiology

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FDA Clears CT/NG Assays for Extragenital Testing
Oral Bacteria Found in Cerebral Emboli of Stroke Patients
Rapid Assay Detects Pyrazinamide-Resistant Tuberculosis
Image: The Nextera XT Index kit is used to prepare whole genome sequencing libraries for bacterial isolates (Photo courtesy of Dr. Thippeswamy Sannasiddappa).

Airway Microbiome Altered in Severe Asthma Linked to Neutrophils

Patients with mild-to-moderate asthma can experience difficulty breathing and it is especially difficult for those with Severe Asthma where symptoms can be life threatening. In either case, patients cannot... Read more

Pathology

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Biomarker Predicts Appropriate Immunotherapy for Cancer Patients
Glioblastoma Driver Mutations Appear Long Before Diagnosis
Virus-Associated Liver Cancer Detected by Blood Tests
Image: A lymph node with almost complete replacement by metastatic melanoma. The brown pigment is focal deposition of melanin (Photo courtesy of Gabriel Caponetti, MD).

Blood Test Measures Effectiveness of Aggressive Cancer Treatments

Blood tests that track the amount of tumor DNA can, after only one month of drug therapy, detect how well treatment is working in patients with skin cancer. In the USA, more than 7,200 individuals are... Read more

Lab Tech.

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Increased Bleb Formation Characterizes Metastatic Cancer Cells
Technology Developed to Capture Tumor Cells
Siemens Healthineers Hemoglobin A1c Test Now Available on Atellica Solution
Image: Examples of migratory and non-migratory MDA-MB-231 breast cancer cells migrating in the MAqCI (Microfluidic Assay for quantification of Cell Invasion) device (Photo courtesy of Christopher L. Yankaskas, Johns Hopkins University).

Microfluidic Motility Device Indicates Likelihood of Breast Tumor Metastasis

A novel microfluidic motility test was shown to accurately predict a breast tumor's likelihood to generate metastases. The difficulties involved in predicting which patients with breast cancer will... Read more

Industry News

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Global Urinalysis Market Valued at USD 2 Billion by 2022
Baxter and bioMérieux in Alliance to Develop Acute Kidney Injury Diagnostics
Beckman Coulter Life Sciences Enters Partnership with Apostle
Image: The global automated immunoassay analyzer market is expected to achieve significant growth, driven by product innovations and increased clinical applications (Photo courtesy of iStock).

Global Automated Immunoassay Analyzer Market Driven by Increase in Applications

The global automated immunoassay analyzer market is expected to achieve significant growth over the coming years, driven by innovations in the existing products and increased clinical applications of these systems.... Read more

BioResearch

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Machine Learning Approach Detects Cancer by Analyzing DNA in Blood Samples
Laboratory Model Reveals Genetic Risk Loci for AMD
Gene Set Isolated in Transformation of Skin Cells into Embryonic Tissues
Image: A representation of a methylated DNA molecule. The two white spheres represent methyl groups bound to two cytosine nucleotide molecules (Photo courtesy of Wikimedia Commons).

Disease-Related Epigenetic Variations Summarized in New DNA Methylation Atlas

A new DNA methylation atlas summarized a previously unexplored molecular level of human individuality called correlated regions of systemic interindividual variation (CoRSIVs), which may provide a resource... Read more

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