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Trending Articles

Mannose-Binding Lectin Associated with Coagulopathy in Severe COVID-19

Ammonia Predicts Prognosis in Hepatitis B Virus‐Related Liver Failure

Click Chip’ Detects Early-Stage Liver Cancer Biomarkers in Extracellular Vesicles

Gut Microbiome Data Helps Routine Screening of Cardiovascular Disease

Beckman Coulter SARS-CoV-2 IgM Antibody Test Receives FDA Emergency Use Authorization

World's First Paper-Based COVID-19 Test Could Be Game-Changer for Coronavirus Testing

Hematological Parameters Evaluated for Cervicocranial Arterial Dissection Stroke

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A Shared Passion for Positive Patient Outcomes: 2020 AACC Annual Scientific Meeting & Clin Lab Expo

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ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

22 Oct 2020 - 25 Oct 2020
Virtual Venue

27 Oct 2020 - 31 Oct 2020
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ASHG 2020 – American Society of Human Genetics

28 Oct 2020 - 30 Oct 2020
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MEDLAB Asia Pacific 2020

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Once-Weekly Insulin as Effective as Daily Dose

Spine Truss System Forestalls Supplemental Fixation

Digital Tumor Dashboard Improves Case Review Efficiency

Pfizer to Seek FDA Emergency Use Authorization for Its COVID-19 Vaccine in Late November

Researchers Find Existing Medications That Could Speed Recovery of COVID-19 Patients

New Testing Process Could Make It Faster, Easier, And Less Expensive to Measure COVID-19 Antibody Levels

New Serology Assay Accelerates COVID-19 Research through Rapid Characterization of Immune Response to SARS-CoV-2 Antigens

New Rapid Lateral Flow Antigen COVID-19 Testing Platform Processes 200-300 People Each Hour and Reports Results in 15 Minutes

World’s Simplest High-Throughput RT-PCR Test for COVID-19 Could Increase Testing Capacity by Millions per Week

New Lab Testing Procedure Specifically Identifies SARS-CoV-2 Neutralizing Antibodies

Engineered COVID-19 Antibody Enables Extremely Rapid Identification of SARS-CoV-2 in Nasal Mucus, Saliva, and Blood

Novel COVID-19 Immunity Test Predicts Both Infection Risk in Healthy Individuals and Disease Severity in Patients

New Blood Test Accurately Predicts COVID-19 Patients at Risk of Severe Infection

More COVID-19 News

Breath Test Developed for Head and Neck Cancer Diagnosis

Image: Breath test developed for head and neck cancer diagnosis used a selected ion flow-tube mass spectrometer (Photo courtesy of Syft Technologies).

Breath testing is a noninvasive way to help doctors diagnose a number of conditions. By analyzing the breath, the physicians can measure the amount of certain gases, allowing doctors to arrive at a diagnosis quickly and accurately. Read more
20 Oct 2020

Advertisement Platelia SARS-CoV-2 Total Ab Assay
In just one test, detect total anti-nucleocapsid antibodies IgM, IgA, and IgG to SARS-CoV-2 to help identify individuals exposed to SARS-CoV-2, and who have developed an adaptive immune response.

Bio-Rad Laboratories

Analysis of Placental Cell Free DNA and RNA Predicts Gestational Complications

20 Oct 2020

Glycated Albumin Levels in Tears Allow Noninvasive Glucose Testing

20 Oct 2020

Galectin-3 Predicts Cardiovascular Disease Risk in Diabetic Patients

19 Oct 2020

Advertisement Real Time RT-PCR Test for COVID-19
Detects 3 SARS-CoV-2 targets in parallel, the targets are recommended by the WHO. No other tests worldwide focuses on 3 targets.
2 controls are included: Showing the sample quality; Extraction and inhibition control.

LINEAR CHEMICALS S.L.U

Exome Sequencing Identifies Genetic Loci Linked to the Fetal Syndrome Nonimmune Hydrops Fetalis

19 Oct 2020

Lymphocytic Infiltration Explored as Biomarker for Stable Colorectal Tumors

15 Oct 2020

BIOHIT Healthcare OY

Industry Spotlight

Mindray Hematology Solution Helps High-Volume Lab Run 2,820,000 CBC Tests Annually

High-volume laboratories face several challenges, including high instrument failure rate, errors due to several manual steps, low efficiency and long TAT, and heavier workload for the lab staff. Read more
20 Oct 2020

2020 AACC Annual Scientific Meeting & Clinical Lab Expo to Be an All Virtual Event Due to Coronavirus Pandemic

The American Association for Clinical Chemistry (AACC Washington, DC, USA) has decided to hold the 2020 AACC Annual Scientific Meeting & Clinical Lab Expo as a virtual event, rather than as a live meeting, due to the ongoing coronavirus pandemic. Read more
25 Aug 2020

QIAGEN to Focus on Molecular Testing amidst Coronavirus Pandemic after Voluntary Public Takeover Offer by Thermo Fisher Falls Short

QIAGEN N.V. (Venlo, Netherlands) plans to continue executing its growth strategy aimed at creating significant value for shareholders and other stakeholders after the voluntary public takeover offer by Thermo Fisher Scientific Inc. Read more
14 Aug 2020

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In Other News

Image: New Testing Process Could Make It Faster, Easier, And Less Expensive to Measure COVID-19 Antibody Levels (Photo courtesy of John W. Braun Jr., USAMRIID VIO)

New Testing Process Could Make It Faster, Easier, And Less Expensive to Measure COVID-19 Antibody Levels

Researchers testing alternative ways to measure COVID-19 antibody levels have developed a process that is faster, easier and less expensive to use on a large scale, and holds promise for accurately identifying potential donors who have the best chance of helping infected patients through convalescent plasma therapy. Read more
20 Oct 2020 | COVID-19

Image: Cong Zeng and Jack Evans were first authors of a paper describing a new assay that detects neutralizing antibodies against SARS-CoV-2 (Photo courtesy of Ohio State News)

New Lab Testing Procedure Specifically Identifies SARS-CoV-2 Neutralizing Antibodies

Scientists have developed a new lab testing procedure for the detection of antibodies against SARS-CoV-2 that gives results more quickly than existing assays and specifically identifies so-called “neutralizing” antibodies - those that protect by blocking infection of cells. Read more
20 Oct 2020 | COVID-19

New Serology Assay Accelerates COVID-19 Research through Rapid Characterization of Immune Response to SARS-CoV-2 Antigens

A new SARS-CoV-2 multi-antigen assay for Simple Western offers quantitative characterization of patient serum or plasma derived human IgG antibodies reactive against recombinant Nucleocapsid protein (N), S1 receptor binding domain protein (RBD), S1 subunit full length, S2 subunit full length, and Spike (S1+S2) viral antigens within one 3-hour run. Read more
20 Oct 2020 | COVID-19

Engineered COVID-19 Antibody Enables Extremely Rapid Identification of SARS-CoV-2 in Nasal Mucus, Saliva, and Blood

An engineered monoclonal antibody against the COVID-19 virus spike protein could enable extremely rapid identification of the SARS-CoV-2 virus in nasal mucus, saliva, and blood, as well as potentially allow for rapid identification of the virus present on surfaces, such as food, cell phones, door handles, etc. Read more
20 Oct 2020 | COVID-19

New Rapid Lateral Flow Antigen COVID-19 Testing Platform Processes 200-300 People Each Hour and Reports Results in 15 Minutes

A new rapid lateral flow antigen COVID-19 testing platform gives testers the ability to process an unprecedented 200-300 people each hour and report results within 15 minutes utilizing testing kits from Quidel, BD and Abbott. Read more
20 Oct 2020 | COVID-19

Novel COVID-19 Immunity Test Predicts Both Infection Risk in Healthy Individuals and Disease Severity in Patients

A novel immunity test for COVID-19 infection that measures cell-mediated immunity to the SARS-CoV-2 coronavirus can aid immunity assessments in individuals who have never been exposed to the virus, and those who may develop short-lived antibodies after exposure to the virus. Read more
20 Oct 2020 | COVID-19

World’s Simplest High-Throughput RT-PCR Test for COVID-19 Could Increase Testing Capacity by Millions per Week

An extraction-free, direct sample addition RT-PCR test for the detection of SARS-CoV-2 viral RNA in patients suspected of COVID-19 has the potential to increase testing capacity by millions per week. Read more
19 Oct 2020 | COVID-19

Image: Professor Gerry McElvaney (left), the study’s senior author and a consultant in Beaumont Hospital, and Professor Ger Curley (right). (Photo courtesy of RCSI Education and Research Centre in Beaumont Hospital)

New Blood Test Accurately Predicts COVID-19 Patients at Risk of Severe Infection

Scientists have developed, for the first time, a score that can accurately predict which patients will develop a severe form of COVID-19. Read more
19 Oct 2020 | COVID-19

Image: The test uses a convolutional neural network to classify microscopy images of single intact particles of different viruses (Photo courtesy of University of Oxford)

Extremely Rapid COVID-19 Diagnostic Test Detects and Identifies SARS-CoV-2 Virus in Under Five Minutes

An extremely rapid diagnostic test can differentiate SARS-CoV-2 from negative clinical samples, as well as from other common respiratory pathogens such as influenza and seasonal human coronaviruses, with high accuracy in less than five minutes. Read more
16 Oct 2020 | COVID-19

Image: INSTI COVID-19 Antibody Test (Photo courtesy of INSTI COVID-19 Antibody Test)

New 1-Minute COVID-19 Antibody Test Uses Innovative Flow-Through Technology to Deliver Results

A new one-minute antibody test for COVID-19 launched in Europe is the only test of its kind to use innovative flow-through technology to deliver results, making it far faster than other antibody tests currently available. Read more
16 Oct 2020 | COVID-19

Image: Testing a nanotube-based electrochemical biosensor (Photo courtesy of University of Nevada)

New COVID-19 Test Uses Nanotube-Based Electrochemical Biosensor for Rapid Detection of SARS-CoV-2 Virus in 30 Seconds

A new COVID-19 rapid test that uses a nanotube-based electrochemical biosensor has shown successful lab results by detecting the SARS-CoV-2 virus in about 30 seconds. Read more
16 Oct 2020 | COVID-19

World's First Paper-Based COVID-19 Test Could Be Game-Changer for Coronavirus Testing

An inexpensive paper-based COVID-19 test that could give fast results similar to a pregnancy test can become a game-changer for coronavirus testing. Read more
15 Oct 2020 | COVID-19

Channels

Clinical Chemistry

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Image Some of the components of the cobas 8000 modular analyzer series (Photo courtesy of Roche).

Methods for Intra-Erythrocyte Magnesium and Its Determinants Compared

Magnesium is the second most abundant intracellular cation and is essential for regulation of many functions within the cell, including modulation of ion channels, protein synthesis and energy metabolism.... Read more

Glycated Hemoglobin Screening Reveals Undiagnosed Diabetes

Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include... Read more

Image: The UF-5000 fully automated flow cytometer based on renowned fluorescence flow cytometry (FFC), represents the latest in urinalysis technology (Photo courtesy of Sysmex Corporation).

Urine Osmolality Measurement Evaluated on Automated Analyzer

Urinalysis is a convenient and non‐invasive screening tool for use in both an outpatient and inpatient setting. Automated flow cytometry‐based urine analyzer is increasingly being used to identify and... Read more

Image: The Vitros 350 clinical chemistry system (Photo courtesy of Ortho Clinical Diagnostic).

Ammonia Predicts Prognosis in Hepatitis B Virus‐Related Liver Failure

Acute‐on‐chronic liver failure (ACLF) is the rapid deterioration of liver function in chronic liver disease often associated with the development of serious complications such as hepatorenal syndrome and... Read more

Molecular Diagnostics

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Image: Mutations Disrupting Neuritogenesis Genes Confer Risk for Cerebral Palsy (Photo courtesy of Sudarshan Dayanidhi, PhD, and Richard L. Lieber, PhD).

Mutations Disrupting Neuritogenesis Genes Confer Risk for Cerebral Palsy

Cerebral palsy (CP) is a group of permanent movement disorders that appear in early childhood. Signs and symptoms vary among people and over time. Often, symptoms include poor coordination, stiff muscles,... Read more

Image: Mitochondrial DNA comprises the small circular chromosome found inside mitochondria. The mitochondria, and thus mitochondrial DNA, are passed from mother to offspring (Photo courtesy of Wikimedia Commons)

Elevated Levels of Defective Mitochondrial DNA Predict Likelihood of Reproductive Success

A sperm biomarker has been found that may be able to supplement or replace the semen parameters that poorly predict reproductive success yet are the most prevalent diagnostic tool for male infertility.... Read more

Image: DBS sampling is simple, inexpensive and can be self-collected by the patient at home, using a simple finger prick (Photo courtesy of University of Birmingham)

Use of Dried Blood Samples Facilitates Tracking of COVID-19 Antibodies

A recent study confirmed that dried blood spot samples could be used as an alternative to venous blood for detecting antibodies to the SARS-CoV-2 virus (COVID-19). A confirmed diagnosis of COVID-19... Read more

Image: Structure of the apolipoprotein(a) protein (Photo courtesy of Wikimedia Commons)

Elevated Levels of Lipoprotein(a) Predict Increased Risk for Developing Cardiovascular Diseases

Measurement of the blood biomarker lipoprotein(a) predicts risk of developing cardiovascular disease as well as determination of such standard factors as cholesterol and triglycerides. Lipoprotein(a)... Read more

Hematology

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Image: The ACL TOP 750 analyzer is for advanced automation and quality management in hemostasis testing (Photo courtesy of Instrumentation Laboratory).

Elevated Clotting Factor V Found with Severe COVID-19

Coagulopathy causes morbidity and mortality in patients with coronavirus disease 2019 (COVID‐19) due to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection. Most doctors now know that... Read more

Image: Scanning electron microscope image shows SARS-CoV-2 (yellow) the virus that causes COVID-19, isolated from a patient in the USA, emerging from the surface of cells (pink) cultured in the laboratory (Photo courtesy of NIAID-RML).

RBC Distribution Width Associated with COVID-19 Mortality Risk

COVID-19 has a high rate of hospitalization, critical care requirement, and mortality. Identifying patients at highest risk for severe disease is important to facilitate early, aggressive intervention... Read more

Microfluidic Label-Free Bioprocessing of Reticulocytes from Erythroid Culture

Blood transfusions save millions of lives every year, but over half the world's countries do not have sufficient blood supply to meet their needs. The ability to manufacture red blood cells (RBCs) on demand,... Read more

New Diagnosed Anemia Linked to Crohn’s Disease Risk

Inflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC). IBD is a chronic inflammatory gastrointestinal disorder that involves complex interactions among genetic, environmental,... Read more

Immunology

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Image: The BD FACSymphony A5 flow cytometer (Photo courtesy of BD Biosciences).

MAIT Cell Activation Dynamics Associated with COVID-19 Disease Severity

The balance between protective versus pathological immune responses in COVID-19 has been a concern since the onset of the pandemic. SARS-CoV-2 infection can lead to acute respiratory distress syndrome... Read more

Image: LIAISON XL is a fully automated chemiluminescence analyzer, performing complete sample processing as well as measurement and evaluation (Photo courtesy of Diasorin).

Serum Thyroglobulin Assays Compared for Differentiated Thyroid Carcinoma

Measurement of serum thyroglobulin (Tg) plays a key role in the post‐thyroidectomy management of differentiated thyroid carcinoma (DTC). In this context, the performance of new‐generation thyroglobulin... Read more

Mannose-Binding Lectin Associated with Coagulopathy in Severe COVID-19

The ongoing COVID-19 pandemic has caused significant morbidity and mortality worldwide, as well as profound effects on society. COVID-19 patients have an increased risk of thromboembolic (TE) complications,... Read more

Click Chip’ Detects Early-Stage Liver Cancer Biomarkers in Extracellular Vesicles

Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related deaths worldwide. The poor prognosis of HCC can be attributed to the fact that diagnosis is often made at a late stage in... Read more

Microbiology

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Image: Yellow color shows thiamine degradation on an agar plate of cultured Paenibacillus thiaminolyticus (Photo courtesy of Catherine A. Richter, PhD).

Bacterium and Viral Coinfection Contributes to Postinfectious Hydrocephalus

Neonatal sepsis often precedes postinfectious hydrocephalus (PIH), although the manifestations of hydrocephalus typically emerge in the months after the neonatal period as sufficient cerebrospinal fluid... Read more

Image: DPP Ebola Antigen System is a 15 minute rapid test for detection of Ebola Virus Specific Antigen (Photo courtesy of Chembio Diagnostic Systems).

Performance Compared for Three Ebola Rapid Diagnostic Tests

Ebola is a rare but deadly virus that causes fever, body aches, and diarrhea, and sometimes bleeding inside and outside the body. As the virus spreads through the body, it damages the immune system and organs.... Read more

Image: A low level of potassium (K+), known as hypokalemia, in the blood serum in COVID-19 patients is associated with disease severity and the need for invasive mechanical ventilation (Photo courtesy of Remedy Health Media).

Hypokalemia Is Associated With COVID-19 Severity

Early studies reported various electrolyte abnormalities at admission in patients who later presented the severe form of coronavirus disease 2019 (COVID-19). Electrolyte imbalance may not only... Read more

Gut Microbiome Data Helps Routine Screening of Cardiovascular Disease

Besides genetics and environmental factors, gut microbiota has emerged as a new factor influencing cardiovascular disease (CVD). Although cause-effect relationships are not clearly established, the reported... Read more

Pathology

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Image: Photomicrograph of histopathology of hepatocellular carcinoma, the most common form of primary liver cancer, showing end-stage cirrhosis - blue collagen (fibrosis) Mallory bodies; loss of normal liver architecture; and nuclear atypia. (Photo courtesy of Nephron).

Hematological Biomarkers Predict Prognosis in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is an inflammation-related cancer, where non-resolving inflammation contributes to its development and progression. Peripheral inflammatory cells have been shown to be associated... Read more

Image: Photomicrograph of histology of a poorly differentiated squamous cell carcinoma (SCC) that is p16 positive (Photo courtesy of Nephron).

HPV, p16 Offers Different Prognostic Clues in Oropharyngeal Cancer

Human papillomavirus infection (HPV infection) is an infection caused by human papillomavirus (HPV), a DNA virus from the Papillomaviridae family. About 90% of HPV infections cause no symptoms and resolve... Read more

Image: De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection (Photo courtesy of UT Southwestern Medical Center).

Cancer-Associated T Cell Receptors Evaluated for Malignancy Detection

A key goal in oncology is diagnosing cancer early, when it is more treatable. Despite decades of progress, early diagnosis of asymptomatic patients remains a major challenge. Most methods for this involve... Read more

Signatera assays are the first circulating tumor DNA (ctDNA) tests custom-built for each patient based on the unique mutations in an individual patient’s tumor (Photo courtesy of Natera Inc).

Circulating tumor DNA Test Predicts Immunotherapy Response

Immunotherapy is a type of cancer treatment that helps the immune system fight cancer. Although some cancer patients derive dramatic and sustained benefit from immunotherapy, most cancer patients do not.... Read more

Technology

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Image: Cryptosporidium oocysts and the larger Giardia cysts stained by Crypto/Giardia IFA kit (Photo courtesy of Cellabs).

Smartphone Microscopic Method Detects Cryptosporidium and Giardia

Food and water-borne illness arising from the consumption of contaminated food and water are serious health hazards globally. Cryptosporidium and Giardia are the major food and water‒borne parasites.... Read more

Image: A test tube contains saliva that can be tested for the heart attack biomarker cardiac troponin (Photo courtesy of karenfoleyphoto).

Saliva Test Fast Tracks Heart Attack Diagnosis

Heart attacks need urgent diagnosis, followed by treatment to restore blood flow to blocked arteries. Diagnosis is based on symptoms (such as chest pain), an electrocardiogram (ECG) and a blood test for... Read more

Image: Schematic diagram of the OvCa-Chip microsystem that recreates vascular endothelium–mediated platelet extravasation in ovarian cancer (Photo courtesy of Texas A&M College of Engineering).

Microfluidic Device Explores Ovarian Cancer Interactions

In many cancers, platelet interactions with circulating tumor cells and their role in metastasis have been studied extensively. In ovarian cancer, platelet extravasation into the tumor and resulting metastasis... Read more

$The TriVersa NanoMate LESA uses chip-based electrospray ionization technology that combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated ion source platform (Photo courtesy of Advion BioSciences).$

Nanoparticle System Captures Heart-Disease Biomarker From Blood

Physicians currently use an antibody-based test called enzyme-linked immunosorbent assay (ELISA) to help diagnose heart attacks based on elevated levels of cardiac troponin I (cTnI) in the patient's blood sample.... Read more

BioResearch

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Genome Analysis Predicts Likelihood of Neurodisability in Oxygen-Deprived Newborns

A genomics-based blood test can predict likelihood that a baby suffering hypoxia at birth will suffer serious nervous disorders such as cerebral palsy or epilepsy at a later stage of development.... Read more

Image: A micrograph of a diffuse large B cell lymphoma (DLBCL) (Photo courtesy of Wikimedia Commons).

Gene Panel Predicts Disease Progession for Patients with B-cell Lymphoma

Cancer researchers developed a 29 gene–based weighted prognostic score for predicting event-free survival and overall survival of patients suffering from diffuse large B-cell lymphoma (DLBCL).... Read more

Image: A diagram of construction of a genomic library (Photo courtesy of Wikimedia Commons).

New Method Simplifies Preparation of Tumor Genomic DNA Libraries

A method has been described that simplifies preparation of tumor genomic DNA libraries by employing restriction enzymes and in vitro transcription to barcode and amplify genomic DNA prior to library construction.... Read more

New Tool Developed for Diagnosis of Chronic HBV Infection

A team of Chinese researchers has described the development of a new and powerful tool for the diagnosis and treatment of chronic hepatitis B virus (HBV) infection. Methods currently used to diagnose... Read more

Industry News

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Awareness Technology Announces ChemWell RPR Analyzer - The Most Significant Innovation in Syphilis Testing in Last 30 Years

Awareness Technology, Inc. (Palm City, FL, USA) has announced the most significant innovation in syphilis testing in the last 30 years with the launch of the ChemWell RPR automated nontreponemal analyzer... Read more

Nova Biomedical Adds PT/INR Test to Allegro Analyzer for POC Testing

Nova Biomedical (Waltham, MA, USA) has added PT/INR testing for its Allegro capillary blood analyzer for point-of-care (POC) testing in primary care settings. With the ability to test for clotting disorders... Read more

Global Blood Glucose Monitoring Devices Market to Reach USD 13 Billion by 2023

The global blood glucose monitoring devices (BGMDs) market was valued at nearly USD 8 billion in 2018 and is projected to grow at a fast-paced CAGR of approximately 11% to reach USD 13 billion by 2023,... Read more

Global ELISA Kits Market to Surpass USD 418.5 Billion by 2025

The global ELISA (Enzyme-Linked Immunosorbent Assay) Kits market is projected to grow at a CAGR of 3.8% to surpass USD 418.5 billion by the year 2025, driving a CAGR of 4% in the worldwide Research ELISA... Read more

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