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Image: A liquid biopsy blood test that measures the amount of cell-free DNA (cfDNA) in the bloodstream correlates with how patients will progress after they are diagnosed with glioblastoma (Photo courtesy of University of Pennsylvania School of Medicine).

Use of Cell-free DNA Liquid Biopsy to Predict Glioblastoma Progression

Cancer researchers have demonstrated the potential clinical utility of liquid biopsy to measure plasma cell-free DNA (cfDNA) in patients with newly diagnosed glioblastoma in order to predict the progression of the disease. Read more
11 Nov 2019 | Molecular Diagnostics
Image: A scanning electron micrograph (SEM) of prostate cancer cells (Photo courtesy of Sloan Kettering Institute).

Prostate Cancer Methylation Levels Linked to Epigenetic Profiles

Prostate cancer is cancer that occurs in the prostate, a small walnut-shaped gland in men that produces the seminal fluid that nourishes and transports sperm. Read more
07 Nov 2019 | Molecular Diagnostics
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Measurable Residual Disease Assessed Post-Transplantation In Acute Lymphoblastic Leukemia

The detection of residual disease by techniques more sensitive than light microscopy is called measurable residual disease (MRD) and is an important prognostic marker, which dictates outcome of disease. Read more
07 Nov 2019 | Hematology
Image: A micrograph of ALL cancer cells (Photo courtesy of Baylor College of Medicine).

Metabolomic Profiling Identifies ALL Patients at Risk for MRD and Cancer Relapse

Metabolomic profiling of bone marrow from patients suffering from acute lymphoblastomic leukemia was used to identify those who were at high risk of developing minimal residual disease and cancer relapse. Read more
07 Nov 2019 | Molecular Diagnostics
Image: Blood drawn from a sickle cell patient (left) and from a patient after stem-cell transplant (right) (Photo courtesy of NIH Molecular and Clinical Hematology Branch).

Allogeneic Transplantation Outcomes Compared in Sickle Cell Disease Patients

Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. Read more
06 Nov 2019 | Hematology
Image: Preeclampsia is a pregnancy complication marked primarily by high blood pressure and organ damage. The diagnostic values of STAT4 and sEng in preeclampsia have been analyzed (Photo courtesy of Johns Hopkins University).

Diagnostic Values of Serum STAT4 and sEng Analyzed in Preeclampsia

Preeclampsia is a pregnancy complication characterized by high blood pressure and signs of damage to another organ system, most often the liver and kidneys. Read more
06 Nov 2019 | Clinical Chemistry
Image: The High Pure Viral RNA Kit is for general laboratory use and purifies viral RNA from a variety of samples such as serum and plasma (Photo courtesy of Roche Diagnostics).

Enterovirus D type 111 Genetically and Phenotypically Characterized

Members of the species Enterovirus D (EV-D) remain poorly studied. The two first EV-D types (EV-D68 and EV-D70) have regularly caused outbreaks in humans since their discovery five decades ago but have been neglected until the recent occurrence of severe respiratory diseases due to EV-D68. Read more
06 Nov 2019 | Microbiology
Image: The pancreas and surrounding organs (Photo courtesy of Wikimedia Commons).

Whole-exome Sequencing Identifies Mysterious Pancreatitis Mutation

By applying advanced whole-exome sequencing analysis techniques, researchers have identified a mutation linked to a rare form of inhertied pancreatitis. Read more
06 Nov 2019 | Molecular Diagnostics
Image: The HiSeq X Series incorporates patterned flow cell technology to generate an exceptional level of throughput for whole-genome sequencing (Photo courtesy of Illumina).

Metastatic Tumor Profiles Lead to Potential Treatment Targets

Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A better understanding of the characteristics of late-stage cancer is required to help adapt personalized treatments, reduce overtreatment and improve outcomes. Read more
05 Nov 2019 | Molecular Diagnostics
Image: Diagram of the Target Selector ctDNA platform featuring single copy detection sensitivity for clinically actionable EGFR, BRAF, and KRAS mutations (Photo courtesy of Biocept Inc).

Full Analytical Data Validated for Target Selector ctDNA Assays

Tumor tissue has traditionally been required for both cancer diagnosis and molecular biomarker testing. Read more
05 Nov 2019 | Molecular Diagnostics
Image: The LIAISON 25 OH Vitamin D TOTAL Assay is a fully automated assay measuring both D2 and D3 for a total result (Photo courtesy of Diasorin).

Vitamin D Deficiency Associated with Impaired Muscle Strength

Maintaining muscle mass and function throughout life is a crucial component of successful ageing. The progressive loss of skeletal muscle mass, accompanied by a loss of muscle strength or performance, in aging, is a feature of primary sarcopenia. Read more
05 Nov 2019 | Clinical Chemistry
Image: The MenoCheck picoAMH ELISA is FDA cleared for in vitro diagnostic use as an aid in the determination of menopausal status in women between 42 and 62 years of age (Photo courtesy of Ansh Laboratories).

Anti-Müllerian Hormone Immunoassay Validated

Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein with roles in regulation of fetal sexual differentiation and folliculogenesis in the adult ovary. Read more
04 Nov 2019 | Immunology

Channels

Clinical Chemistry

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Blood Based Biomarkers Characterize Parkinson’s Disease
Fluorimetric Assay Quantifies Galactocerebrosidase Activity in Dried Blood Spots
Fibroblast Growth Factor 23 Associated with Diabetic CV Risks
Image: Representative negative-stained transmission electron microscopy images of 4R RT-QuIC products seeded with brain homogenates from individuals with the designated diseases – frontotemporal dementia and Parkinsonism linked to chromosome 17; corticobasal degeneration; and progressive supranuclear palsy (Photo courtesy of National Institute of Allergy and Infectious Diseases).

CSF Test Developed for Uncommon Brain Diseases

Scientific studies have linked the abnormal deposition of tau in the brain to at least 25 different neurodegenerative diseases. However, to accurately diagnose these diseases, brain tissue often must be... Read more

Molecular Diagnostics

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Large-Scale Schizophrenia Exome Sequencing Identifies New Risk Genes
Post-Treatment Colon Cancer Recurrence Identified by ctDNA Detection
Degree of Amyloid-Beta Misfolding Is Predictor of Alzheimer’s Disease Risk
Image: Researchers have identified several chemical signatures, detectable in blood and urine, that can accurately measure dietary intake (Photo courtesy of Medical Xpress).

Blood and Urine Metabolic Biomarkers Monitor Short-term Dietary Changes

Metabolites found in plasma and urine samples may serve as responsive biomarkers reflecting short-term changes in the habitual diet. Unhealthy eating patterns have been linked to the increase in obesity... Read more

Hematology

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Hematological Parameters Detect Patients with Acute VTE
Laser Incubator Developed for Rapid Blood Group Typing
Biomarker in Adolescence Linked to Early Mortality
Image: A histopathology of primary central nervous system lymphoma showing small purple cells along the blood vessel in the brain (Photo courtesy of Columbia University Medical Center).

Biomarkers Analyzed for Central Nervous System Lymphoma

Primary central nervous system lymphoma (PCNSL) is a rare type of extranodal non-Hodgkin lymphoma (NHL) accounting for 3% of all newly diagnosed primary intracranial tumors. In patients presenting with... Read more

Immunology

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Immunoassays Compared to Improve Diagnosis of Chagas Disease
Handling Procedures Affect Interleukin 6 Levels in Samples
Immune Processes Linked to Multiple Sclerosis Genetics
Image: The Holomics Reader HRDR-300 mobile device was used to measure fluorescent intensity of the quantum dots complex after lateral migration of patient serum (Photo courtesy of Medical College of Georgia).

POC Test Based on Quantum Dots Detects Antibody Responses

Point-of-care (POC) assays, which can be performed at or near the site of care with a rapid turnaround time, are pivotal to transforming global disease control efforts, particularly in resource-constrained... Read more

Microbiology

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Nasopharyngeal Pneumococcal Density Associated with Invasive Lung Disease
LC-MS/MS Assay Directly Detects Urinary Bacteria
Methods Explored for Gram-Negative Non-Fermentative Bacteria ID
Image: The DuoSet ELISA kit for determining levels of MMP-3 and TIMP-1 (Photo courtesy of R&D Systems).

Vaginal Biomarkers Predict Preterm Birth Risks

Premature birth and its complications are the largest contributors to infant death in the USA and globally. Complications of preterm birth are the single largest cause of neonatal deaths and account for... Read more

Pathology

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Methylation Signature Identified for Brain Metastases of Lung Cancer
Multigene Testing for Breast Cancer Patients Proves Cost-Effective
Diagnostic Panel Analysis of Lung Cancer Compared
Image: A and B, Mucinous adenocarcinoma of colon and indeterminate PMS2 immunohistochemistry staining. C and D, Poorly differentiated carcinoma of colon and indeterminate MLH1 staining. E and F, Endometrial carcinoma and focal MSH6 staining (Photo courtesy of University of Texas Southwestern Medical Center).

Lynch Syndrome Screening by IHC Leads to Mutation Studies

Lynch syndrome or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that is associated with a high risk of colon cancer, as well as other cancers including endometrial... Read more

Lab Tech.

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Flow Cytometry Improved Updated Spectral Analyzer
Pocket-Sized Zinc Deficiency Test Evaluated
New QC Reagents Compatible with Multiple Immunoassay Platforms
Image: A novel three-dimensionally-printed cell trap captures white blood cells and eliminates red cells from a whole blood sample while isolating circulating tumor cells (CTCs) (Photo courtesy of Allison Carter, Georgia Institute of Technology).

Rapid Filter Method Created for Isolation of CTCs from Whole Blood

Isolation and analysis of circulating tumor cells (CTCs) from blood samples present a potential means for basic cancer research as well as diagnosis and personalized treatment of the disease.... Read more

BioResearch

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New Method Simplifies Preparation of Tumor Genomic DNA Libraries
New Tool Developed for Diagnosis of Chronic HBV Infection
Panel of Genetic Loci Accurately Predicts Risk of Developing Gout
Image: A micrograph of a diffuse large B cell lymphoma (DLBCL) (Photo courtesy of Wikimedia Commons).

Gene Panel Predicts Disease Progession for Patients with B-cell Lymphoma

Cancer researchers developed a 29 gene–based weighted prognostic score for predicting event-free survival and overall survival of patients suffering from diffuse large B-cell lymphoma (DLBCL).... Read more

Industry News

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ERBA Mannheim Opens New Subsidiary in Brazil
AI-Enabled Technology to Help Global Molecular Imaging Market Reach USD 11.13 Bi...
Researchers Develop World’s First AI-Augmented Ova and Parasite Detection Tool
Image: Baxter International has acquired Cheetah Medical to expand their patient monitoring portfolio (Photo courtesy of Shutterstock).

Baxter Acquires Cheetah Medical to Expand Specialized Patient Portfolio

Baxter International Inc. (Deerfield, IL, USA), a global medical products company, has acquired Cheetah Medical (Boston, MA, USA), a provider of non-invasive hemodynamic monitoring technologies.... Read more

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