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Events

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21 Feb 2019 - 22 Feb 2019
14th Annual Biomarkers Congress
21 Feb 2019 - 23 Feb 2019
Medical Fair India & Clin Lab India 2019
26 Feb 2019 - 28 Feb 2019
CHINALAB 2019
Informa Life Sciences Exhibitions
CELLAVISION AB

In Other News

Image: A diagram of whole-exome sequencing to identify genetic variants (Photo courtesy of NGXBIO).

Whole-Exome Sequencing Evaluates Fetal Structural Anomalies

In about 3% of pregnancies, ultrasound imaging will reveal a significant fetal physical anomaly and knowing the cause of the anomaly can help doctors and parents be better prepared, both during the pregnancy and after delivery. Read more
12 Feb 2019 | Molecular Diagnostics
Image: The Saliva Glucose Biosensor that measures glucose in saliva rather than blood (Photo courtesy of iQ Group Global).

New Glucose Biosensor Introduced for Diabetes Management

The world’s first saliva-based glucose test for diabetes management that measures glucose in saliva rather than blood has been introduced. Read more
11 Feb 2019 | Clinical Chemistry
Image: The Olympus AU680 automated analyzer (Photo courtesy of Beckman Coulter).

HDL Subclasses Linked to Mortality in Heart Failure Patients

Heart failure (HF) is a frequent cause of morbidity and mortality worldwide and is defined by the as an abnormality of the cardiac structure and function, resulting in a diminished ability of the heart to maintain optimal perfusion of metabolizing tissues. Read more
11 Feb 2019 | Clinical Chemistry
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Direct Blood PCR Detects Thromboembolism-Associated Mutations

Routine genetic testing is recommended in several clinical circumstances, particularly in patients with venous thrombosis at younger age, a strong family history of thrombotic disease, or in women with a history of venous thrombosis during pregnancy. Read more
11 Feb 2019 | Molecular Diagnostics
Image: The MAGPIX single or multiplex automated immunoassay reader (Photo courtesy of Bio-Rad).

Assays Detect Inherited Blood Disorders Associated with Malaria

Plasmodium parasites have co-evolved with human hosts and exert a considerable evolutionary pressure on mutations that confer a degree of protection against malaria. Read more
07 Feb 2019 | Hematology
Image: Positron Emission Tomography (PET) scans of the brain of a normal patient (left) versus an Alzheimer\'s disease patient, which may have been detected earlier by measuring Neurofilament light chain (NfL) in CSF (Photo courtesy of Science Photo Library).

Blood Test Detects Brain Damage Years before Symptoms

Alzheimer's disease is a major cause of dementia that destroys brain cells and tissue. As the brain damage spreads, it leads to symptoms such as confusion, memory loss, and diminishing capacity to function. Read more
07 Feb 2019 | Pathology
Image: Various types of data analysis using BeadStudio Methylation Module (Photo courtesy of Phoebe Lu).

DNA Methylation Test Detects Early Aggressive Prostate Cancer

Liquid biopsies that noninvasively detect molecular correlates of aggressive prostate cancer (PCa) could be used to triage patients, reducing the burdens of unnecessary invasive prostate biopsy and enabling early detection of high-risk disease. Read more
06 Feb 2019 | Molecular Diagnostics
Image: Vials of cerebrospinal fluid that can be sequenced for cell-free DNA in glioma patients (Photo courtesy of James Heilman, MD).

CSF Liquid Biopsy Sequencing Tracks Glioma Evolution

Genetic tumor profiling of gliomas is used to classify disease and guide therapy, but involves brain surgery for tissue collection; repeated tumor biopsies may be necessary for accurate genotyping over the course of the disease. Read more
06 Feb 2019 | Molecular Diagnostics
Image: Porphyromonas gingivalis gingipains in the neurons of Alzheimer\'s brain. P. gingivalis gingipains = red, neurons = yellow, astrocytes = green (Photo courtesy of Cortexyme).

Bacterial Pathogen Discovered in Brains of Alzheimer's Patients

Alzheimer’s disease (AD) patients exhibit neuroinflammation consistent with infection, including microglial activation, inflammasome activation, complement activation, and altered cytokine profiles. Read more
06 Feb 2019 | Pathology
Image: Chronic rhinosinusitis (CRS) in elderly patients is associated with an exaggerated neutrophilic proinflammatory response to pathogenic bacteria (Photo courtesy of Vanderbilt University Medical Center).

Unique Form of Chronic Sinusitis Diagnosed in Older Patients

Older patients with a diagnosis of chronic sinusitis, a disease of the nasal cavity and paranasal sinuses that often persists over many years, have a unique inflammatory signature that may render them less responsive to steroid treatment. Read more
05 Feb 2019 | Immunology
Image: The EsophaCap is packed into a gelatin capsule that dissolves in a patient’s stomach exposing the sponge, which gently collects cells from the whole surface of the esophagus when withdrawn. Cellular material will be examined using cytological, immunohistochemical and genomic methods (Photo courtesy of Swallow the Sponge).

Simple Inexpensive Test Screens for Esophageal Cancer

Cancer of the esophagus claims more than 400,000 lives around the world each year. With no efficient, reliable method of screening for the disease, by the time symptoms become apparent, it's often too late to save the patient. Read more
05 Feb 2019 | Pathology

Channels

Clinical Chemistry

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High-Sensitivity CRP Testing Underutilized
Biochemical Hypoglycemia Associated with Risk of Hypoglycemia
Calprotectin Independently Predicts Relapse in Treated RA
Image: An increase in fasting blood glucose level increases the risk of cardiovascular disease (Photo courtesy of Diabetes Self Care).

Long-Term Risk for CVD Stratified by Fasting Glucose Level

Cardiovascular disease (CVD) refers to any disease of the heart, vascular disease of the brain, or disease of the blood vessel. The most prevalent cardiovascular diseases include coronary heart disease... Read more

Molecular Diagnostics

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DNA Extraction Technique Improved for Chagas Diagnosis
Molecular Prognostic Biomarker Found for CNS Lymphoma
Gene-Based Risk Scores Predicts Alcoholic Cirrhosis
Image: Tumor Mutation Burden by Targeted Next Generation Sequencing Predicts Benefit to Immune Checkpoint Inhibitors for Cancer (Photo courtesy of Rutgers Cancer Institute).

Tumor Mutational Load Predicts Survival Post-Immunotherapy

A survey of thousands of advanced cancers suggests a way to identify those most likely to respond to groundbreaking therapies that unleash an immune response against tumors, but the results highlight how... Read more

Hematology

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Howell-Jolly Body-Like Inclusions Correlated with Myelodysplastic Syndrome
Macrocytic Anemia Associated with HBV Liver Impairment Severity
Potential Screening for Tailoring Treatment of AML
Image: A peripheral blood film from a patient with plasma cell leukemia showing four plasma cells and rouleaux formation of erythrocytes (Photo courtesy of the Tsuyako Saito).

New Definition for Plasma Cell Leukemia Proposed

Plasma cell leukemia (PCL) is an uncommon but aggressive malignancy that accounts for 1% to 2% of all plasma cell dyscrasias. PCL has been defined as the presence of ≥ 20% circulating plasma cells (CPCs)... Read more

Immunology

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Bench-Top Immunoanalyzer Evaluated for βhCG Assay
Unconventional Cells Trigger Cytokine Production in Spondyloarthritis
CD69 Biomarker Expression Predicts Atherosclerosis Risk
Image: Immunocytochemistry using anti- TRA-1-60 antibody (Photo courtesy of Novus Biologicals).

Blood Test Diagnoses Pancreatic Cancer Disease Earlier

Pancreatic cancer is difficult to diagnose because it often does not have obvious early symptoms; as by the time the disease is found, it typically is quite advanced, complicating treatment and leading... Read more

Microbiology

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Diagnostic Methods for Infectious Uveitis Investigated
Infant HIV Near Point-of-Care Test Field Evaluated
New Blood Tests for TB Could Accelerate Diagnosis
Image: An XN automated hematology analyzer that can also be used for malaria diagnosis (Photo courtesy of Sysmex).

Automated Malaria Diagnosis Evaluated Using Autoanalyzer

Early and accurate diagnosis of malaria is a critical aspect of efforts to control the disease, and several diagnostic tools are available. Microscopic assessment of a peripheral blood smear enables direct... Read more

Pathology

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Retina Protein Antibodies Used As Kidney Cancer Marker
Urinary Detection Method Developed for Prostate Cancer
Sequencing Assay Adopted for Advanced Lung Cancer Reflex Testing
Image: Blood test for organ transplant monitoring using DNA sequencing (Photo courtesy of National Heart, Lung and Blood Institute).

Blood Test Improves Detection of Severe Transplant Rejection

Lung transplant recipients have the shortest survival rates among patients who get solid organ transplantation of any kind as only about half live past five years. Lung transplant recipients face a high... Read more

Lab Tech.

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Enteric Viral Panel Gets FDA Clearance
Inexpensive Biosensor Provides Rapid Diagnosis of Bacterial Infections
New Test Measures Men's Fertility
Image: A sketch of µLAS chip with two independent channels actuated with the same pressure and voltage. Each channel contains a funnel region that functions to separate and concentrate DNA in line (Photo courtesy of University of Lausanne).

Genetic Methods Rapidly Diagnoses Huntington's Disease

People with Huntington's disease suffer from jerky body movements and decreasing mental abilities. The condition usually leads to death 15 to 20 years after diagnosis. The cause of the disease is a region... Read more

Industry News

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Luminex Acquires MilliporeSigma Flow Cytometry Portfolio
Next-Gen Products Driving Global POC Molecular Diagnostics Market
Global Urinalysis Market to Reach USD 1.5 Billion by 2024
Image: The global IVF market is currently estimated to be worth USD 10-12 billion (Photo courtesy of iStock).

Middle East IVF Market Driven by High Demand for IVF and Related Treatments

The global In Vitro Fertilization (IVF) market is currently estimated to be worth between USD 10 billion to USD 12 billion, while the IVF market in Middle East & North Africa (MENA) is estimated to... Read more

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