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In Other News

Image: The Bladder EpiCheck diagnostic kit (Photo courtesy of Nucleix).

Urine Test Accurately Detects Bladder Cancer Recurrence

Urinary tests have been studied for the detection of bladder tumors; however, most of these tests have not been implemented in clinical practice because of cost issues, practical aspects, or insufficient sensitivity or specificity as compared to the gold standard. Read more
10 Aug 2018 | Pathology
Image: The NeuMoDx GBS assay is run on the 288 molecular system (Photo courtesy of NeuMoDx Molecular).

FDA Clears Diagnostic Assay for Group B Strep

Group B Streptococcus (GBS) is a Gram-positive bacterium found in 10% to 35% of healthy adults and is a commonly found bacterium within the human body. Read more
10 Aug 2018 | Microbiology
Image: The Brain Trauma Indicator kit that measures the biomarkers, Ubiquitin Carboxy-terminal Hydrolase-L1 (UCH-L1) and Glial Fibrillary Acidic Protein (GFAP) (Photo courtesy of Banyan Biomarkers).

Blood Biomarker Indicates Extent of Traumatic Brain Injury

An estimated 54 million to 60 million people worldwide sustain a traumatic brain injury (TBI) annually. Read more
10 Aug 2018 | Clinical Chemistry
Image: A photomicrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma of the lung, from a fine needle aspiration specimen (Photo courtesy of Nephron).

Cancer Risk Assessed by Circulating Protein Biomarker Panel

The question has been asked whether a risk prediction model based on circulating protein biomarkers improve on a traditional risk prediction model for lung cancer and the current USA screening criteria. Read more
10 Aug 2018 | Clinical Chemistry
Image: The Applied Biosystems 7500 real-time PCR System (Photo courtesy of Thermo Fisher Scientific).

Infections Defined in Urothelial Bladder Tumors

Bladder cancer is estimated to be the 9th most common cancer worldwide and over 90% of bladder tumors are classed as urothelial bladder carcinomas (UBCs), with 75% to 80% presenting at non-muscle-invasive (NMIBC) stages and the remainder presenting at muscle-invasive (MIBC) and metastatic stages. Read more
09 Aug 2018 | Molecular Diagnostics
Image: A comparison of healthy bone and osteoporosis (Photo courtesy of PharmacyPedia).

Fracture Risk Predicted with New Genetic Screen

Low bone mineral density (BMD) is the major determinant for osteopenia and osteoporosis, which increase the chances of fragility fracture especially for elderly women. Read more
09 Aug 2018 | Molecular Diagnostics
Image: A diagram of the hypothesis for the onset mechanism of childhood steroid-sensitive nephrotic syndrome (Photo courtesy of Kobe University).

Susceptible Genes Identified for Childhood Kidney Disease

Childhood nephrotic syndrome, also known as nephrosis, is an incurable disease with an unknown cause, characterized by large amounts of protein leaving the body in the patient's urine, and protein levels in the bloodstream becoming extremely low. Read more
09 Aug 2018 | Molecular Diagnostics
Image: The HaloPlex system enables fast, simple and efficient analysis of genomic regions of interest in a large number of samples (Photo courtesy of Agilent Technologies).

Mutations Identified As Cause for Rare Bone Marrow Disorder

Scientists have helped solve a decades-old mystery about which mutations are responsible for an inherited bone marrow disorder. Read more
09 Aug 2018 | Hematology
Image: An ELISA for quantitative determination of leptin in human serum and plasma (Photo courtesy of Diagnostic Automation).

Leptin to Adiponectin Ratio Predicts Metabolic Function in Obesity

There is an epidemic of obesity and the metabolic syndrome in the USA and across the world. Both entities are associated with high mortality, mainly as a result of cardiovascular disease. Read more
08 Aug 2018 | Clinical Chemistry
Image: The ACL AcuStar testing analyzer offers full automation of highly sensitive immunoassays (Photo courtesy of Instrumentation Laboratory).

IgM Antibodies Improve Risk Stratification for Antiphospholipid Syndrome

The antiphospholipid syndrome (APS) is an autoimmune hypercoagulable state and is characterized by thrombosis and/or pregnancy morbidity with the persistent presence of antiphospholipid antibodies (aPL). Read more
08 Aug 2018 | Immunology
Image: The High-Sensitivity Troponin I assay (TnIH) (Photo courtesy of Siemens Healthineers).

New Troponin Assays Receive US Marketing Clearance

Two high precision assays for the measurement of the cardiac marker troponin I (TnIH) have been certified for marketing in the United States. Read more
08 Aug 2018 | Lab Tech.

Channels

Clinical Chemistry

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Saliva Test Could Improve Diabetes Control and Treatment
Transcutaneous Bilirubin Estimated in ELBW Infants
Accurate Test for Chronic Fatigue Syndrome Developed
Image: Postmenopausal factors may have an impact on the heart-protective qualities of high-density lipoproteins (HDL), also known as ‘good cholesterol (Photo courtesy of University of Pittsburgh Medical Center).

HDL Does Not Always Lower Risk of CV Disease

High-density lipoproteins (HDL) are a family of particles found in the blood that vary in sizes and cholesterol contents. HDL has traditionally been measured as the total cholesterol carried by the HDL... Read more

Molecular Diagnostics

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Genetic Alterations Correlated to Aggressive Prostate Cancer
DNA Methylation Linked to Depression in Middle-Aged and Elderly
Neuro Disorders Involving Epilepsy Include Distinct De Novo Variants
Image: A thyroid cancer cell (Photo courtesy in ShutterStock).

MicroRNA Panel Delivers Thyroid Cancer Diagnosis

A 19 microRNA panel established by using next-generation sequencing classifies indeterminate thyroid nodule samples as being either malignant or benign. MicroRNAs (miRNAs) and short interfering RNAs... Read more

Hematology

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Acute Myeloid Leukemia Risk Predicted in Healthy Individuals
Hematological Parameters Predict Severity of Acute Pancreatitis
FDA Recommends Pooled Blood Testing of Zika Screening
Image: The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies (Photo courtesy of PerkinElmer).

Homogeneous BTK Occupancy Assay Developed

Bruton’s tyrosine kinase (BTK), a member of the tyrosine kinase expressed in the hepatocellular carcinoma (TEC) family of cytoplasmic protein tyrosine kinases, was initially identified as the pathogenic... Read more

Immunology

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Urine and Blood Tests Better at Diagnosing Myeloma
Humoral Immunity Disorders Associated with Antibody Deficit
Immunoblot Test Differentiates Pollen Allergies Diagnoses
Image: A photomicrograph of pigmented malignant melanoma in a Papanicolaou stained cytology specimen, (Photo courtesy of Nephron).

Melanoma Biomarkers Predict Checkpoint Blocker Response

The outlook for patients with advanced melanoma has dramatically improved in recent years because of drugs known as immune checkpoint inhibitors, which mobilize the immune system to attack cancer.... Read more

Microbiology

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LAMP Accurately Screens for Malaria in Pregnancy
Bacterial Test Is Well-Suited for Mid-Sized Labs
Simple Blood Test Devised for Hepatitis B
Image: A scanning electron micrograph (SEM) of Mycoplasma genitalium, which is a common cause of sexually transmitted infections, ranking only second to Chlamydia trachomatis in prevalence (Photo courtesy of Thomas Deerinck, NCMIR).

Molecular Tests Available for Multiple STIs

Mycoplasma genitalium (MG) is a sexually transmitted, small and pathogenic bacterium that lives on the ciliated epithelial cells of the urinary and genital tracts in humans. It is spread through unprotected... Read more

Pathology

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Integrated Analyses Offer Molecular Insights to Tumor Subtypes
Circulating Tumor Cell-Based AR-V7 Test Validated
New Genre of Small-Cell Lung Cancer Discovered
Image: The Sensiscript reverse transcription kit is ideally suited for highly sensitive applications using very small amounts of RNA (Photo courtesy of Qiagen).

New Target Protein for Colon Cancer Identified

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer-related death in men and women in the USA. Pathogenic mediators that regulate CRC tumorigenesis... Read more

Lab Tech.

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Rapid Zika Detection Test Uses Smartphone Technology
Blood Separation Tubes Combine Serum Analysis with Plasma Analysis
Tissue-Imaging Technology Enables Real-Time Diagnostics
Image: Dr. Marnie Winter examining fetal trophoblastic cells isolated using inertial microfluidics (Photo courtesy of Future Industries Institute).

Fetal Genetic Abnormalities Detected in Early Pregnancy

Lab-on-a-chip (LOC) technology integrates laboratory functions on a chip ranging from a few millimeters to a few square centimeters. The special design of the device allows large volumes of blood to be... Read more

Industry News

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Greiner Bio-One Launches New Safety Blood Collection Set
Infectious Disease Testing to Remain Driver for Diagnostic Market
CerTest Biotec Opens New Facility for Diagnostic Products
Image: The new educational guide provides a quick overview of capillary blood sampling best practice (Photo courtesy of EKF Diagnostics).

EKF Diagnostics Releases Educational Guide to Good Capillary Blood Sampling

Global in vitro diagnostics company EKF Diagnostics (Penarth, Cardiff, UK) has published an educational guide, which provides a quick overview of capillary blood sampling best practice. The new guide aims... Read more

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