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Trending Articles

Mannose-Binding Lectin Associated with Coagulopathy in Severe COVID-19

Ammonia Predicts Prognosis in Hepatitis B Virus‐Related Liver Failure

World's First Paper-Based COVID-19 Test Could Be Game-Changer for Coronavirus Testing

Smartphone Microscopic Method Detects Cryptosporidium and Giardia

Roche to Launch Elecsys SARS-CoV-2 Antigen Test for High-Volume COVID-19 Testing

Extremely Rapid COVID-19 Diagnostic Test Detects and Identifies SARS-CoV-2 Virus in Under Five Minutes

Hypokalemia Is Associated With COVID-19 Severity

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5 Plenaries With World-Renowned Scientists: 2020 AACC Annual Scientific Meeting & Clinical Lab Expo

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ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

27 Oct 2020 - 31 Oct 2020
Virtual Venue

ASHG 2020 – American Society of Human Genetics

28 Oct 2020 - 30 Oct 2020
Virtual Venue

MEDLAB Asia Pacific 2020

28 Oct 2020 - 31 Oct 2020
Virtual Venue

AOCE-SICEM 2020 – 17th Asia-Oceania Congress of Endocrinology

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Potential Cancer Drug That Kills Infected Cells by Stopping Glucose Supply Shows Promise Against COVID-19

Use of Genetic Sequencing to Track SARS-CoV-2 Mutations Can Improve Diagnostic Testing Accuracy and Vaccine Effectiveness

Unique AI-Based Counting System Advances Accuracy and Throughput for COVID-19 Vaccine

Study Finds Corticosteroids to Be Most Effective Treatment for Cytokine Storm in COVID-19 Patients

AstraZeneca US COVID-19 Vaccine Trial to Resume Upon Completion of FDA Review

Future COVID-19 Tests Could Be Based on Biomarkers and Molecular Profiles of Individuals

Mass Spectrometry-Based Device Uses Breath Samples to Rapidly Identify COVID-19 Strains

Rapid COVID-19 Antigen Tests Less Effective at Detecting SARS-CoV-2 in People with Low Virus Levels, Finds Study

ThermoGenesis’ Breakthrough Lateral Flow Immunoassay Test Reader to Help Track Antibody Response of COVID-19 Vaccine Recipients

New COVID-19 Mass Screening Method Could Be 20 Times Cheaper Than Individual Testing

New Simple, Portable and Easy-To-Use Technology Diagnoses COVID-19 Infection in Just 30 Minutes

CerTest Biotec and BD Secure CE Mark for Combination COVID-19, Influenza, RSV Test on BD MAX System

Saline Oral Rinse COVID-19 RT-PCR Test Could Be a Game-Changer for Coronavirus Testing

More COVID-19 News

Comprehensive Molecular Profiling Matches Pediatric Patients to Therapies

Image: Photomicrograph of histology of a Ewing sarcoma in lung. The PAS stain highlights glycogen and the staining was negative with a PAS diastase stain (Photo courtesy of Nephron).

A major challenge of using a comprehensive profiling approach for precision medicine is separating pathogenic from non-pathogenic molecular changes within a tumor. Read more
22 Oct 2020

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Bio-Rad Laboratories

Urine-Based Liquid Biopsy Test Detects Urothelial Carcinoma

22 Oct 2020

Methods for Automated Anti-Neutrophil Cytoplasmic Antibodies Compared

21 Oct 2020

New Diagnostic Tests for Rotavirus and Norovirus Infections Evaluated

21 Oct 2020

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LINEAR CHEMICALS S.L.U

Breath Test Developed for Head and Neck Cancer Diagnosis

20 Oct 2020

Analysis of Placental Cell Free DNA and RNA Predicts Gestational Complications

20 Oct 2020

BIOHIT Healthcare OY

Industry Spotlight

Mindray Hematology Solution Helps High-Volume Lab Run 2,820,000 CBC Tests Annually

High-volume laboratories face several challenges, including high instrument failure rate, errors due to several manual steps, low efficiency and long TAT, and heavier workload for the lab staff. Read more
20 Oct 2020

2020 AACC Annual Scientific Meeting & Clinical Lab Expo to Be an All Virtual Event Due to Coronavirus Pandemic

The American Association for Clinical Chemistry (AACC Washington, DC, USA) has decided to hold the 2020 AACC Annual Scientific Meeting & Clinical Lab Expo as a virtual event, rather than as a live meeting, due to the ongoing coronavirus pandemic. Read more
25 Aug 2020

QIAGEN to Focus on Molecular Testing amidst Coronavirus Pandemic after Voluntary Public Takeover Offer by Thermo Fisher Falls Short

QIAGEN N.V. (Venlo, Netherlands) plans to continue executing its growth strategy aimed at creating significant value for shareholders and other stakeholders after the voluntary public takeover offer by Thermo Fisher Scientific Inc. Read more
14 Aug 2020

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In Other News

Future COVID-19 Tests Could Be Based on Biomarkers and Molecular Profiles of Individuals

A new study has shown how variations in SARS-CoV-2 host gene expression can be linked to variations in COVID-19 susceptibility and symptom severity. Read more
23 Oct 2020 | COVID-19

New COVID-19 Mass Screening Method Could Be 20 Times Cheaper Than Individual Testing

Using a new mathematical approach to screen large groups for COVID-19 could be around 20 times cheaper than individual testing, suggests a study by researchers at The University of Edinburgh (Edinburgh, UK). Read more
22 Oct 2020 | COVID-19

Image: BreathTest-1000™ mass spectrometer (Photo courtesy of Business Wire)

Mass Spectrometry-Based Device Uses Breath Samples to Rapidly Identify COVID-19 Strains

Scientists are leveraging mass spectrometry technology to develop a rapid, non-invasive device that will use breath samples to identify COVID-19 strains. Read more
22 Oct 2020 | COVID-19

Image: The POSTECH researchers designed the test kit to produce nucleic acid binding reaction to show fluorescence only when COVID-19 RNA is present (Photo courtesy of POSTECH)

New Simple, Portable and Easy-To-Use Technology Diagnoses COVID-19 Infection in Just 30 Minutes

A new one-pot diagnostic method for detecting pathogenic RNAs with PCR-level sensitivity allows anyone to easily and quickly diagnose COVID-19 in just 30 minutes. Read more
22 Oct 2020 | COVID-19

Rapid COVID-19 Antigen Tests Less Effective at Detecting SARS-CoV-2 in People with Low Virus Levels, Finds Study

Researchers from the Erasmus University Medical Center (Rotterdam, the Netherlands) have cautioned that not all rapid COVID-19 antigen tests that provide results within 30 minutes may be equally effective at detecting the SARS-CoV-2 virus. Read more
22 Oct 2020 | COVID-19

Image: VIASURE SARS-CoV-2 (N1 + N2) Real Time PCR Detection Kit (Photo courtesy of Becton, Dickinson and Company)

CerTest Biotec and BD Secure CE Mark for Combination COVID-19, Influenza, RSV Test on BD MAX System

CerTest Biotec (Zaragoza, Spain), along with Becton, Dickinson and Company (BD Franklin Lakes, NJ, USA), have announced that the VIASURE SARS-CoV-2 (N1 + N2) Real Time PCR Detection Kit adapted for the BD MAX System has been CE marked. Read more
22 Oct 2020 | COVID-19

ThermoGenesis’ Breakthrough Lateral Flow Immunoassay Test Reader to Help Track Antibody Response of COVID-19 Vaccine Recipients

A new breakthrough lateral flow immunoassay test reader technology aims to facilitate the widespread use of inexpensive, mass-produced, FDA-authorized SARS-CoV-2 lateral flow immunoassay (LFIA) tests to distinguish seropositive members of populations of concern (individuals who already have SARS-CoV-2 antibodies), who might be a lower priority for the earliest immunization. Read more
21 Oct 2020 | COVID-19

Image: Oral Rinse COVID-19 RT-PCR Test (Photo courtesy of OralDNA Labs)

Saline Oral Rinse COVID-19 RT-PCR Test Could Be a Game-Changer for Coronavirus Testing

A new COVID-19 RT-PCR test allows testing from a saline oral rinse collection, eliminating the need for a nasal swab and avoiding the difficulty some individuals have in providing sufficient saliva for saliva direct testing. Read more
21 Oct 2020 | COVID-19

Image: Glycated albumin levels in tears allows for noninvasive glucose testing (Photo courtesy of The University of Melbourne).

Glycated Albumin Levels in Tears Allow Noninvasive Glucose Testing

The glucose test helps determine if a person’s glucose level is too high or too low, which can indicate the presence of Type 2 diabetes and other medical conditions. Read more
20 Oct 2020 | Clinical Chemistry

Image: New Testing Process Could Make It Faster, Easier, And Less Expensive to Measure COVID-19 Antibody Levels (Photo courtesy of John W. Braun Jr., USAMRIID VIO)

New Testing Process Could Make It Faster, Easier, And Less Expensive to Measure COVID-19 Antibody Levels

Researchers testing alternative ways to measure COVID-19 antibody levels have developed a process that is faster, easier and less expensive to use on a large scale, and holds promise for accurately identifying potential donors who have the best chance of helping infected patients through convalescent plasma therapy. Read more
20 Oct 2020 | COVID-19

Image: Cong Zeng and Jack Evans were first authors of a paper describing a new assay that detects neutralizing antibodies against SARS-CoV-2 (Photo courtesy of Ohio State News)

New Lab Testing Procedure Specifically Identifies SARS-CoV-2 Neutralizing Antibodies

Scientists have developed a new lab testing procedure for the detection of antibodies against SARS-CoV-2 that gives results more quickly than existing assays and specifically identifies so-called “neutralizing” antibodies - those that protect by blocking infection of cells. Read more
20 Oct 2020 | COVID-19

New Serology Assay Accelerates COVID-19 Research through Rapid Characterization of Immune Response to SARS-CoV-2 Antigens

A new SARS-CoV-2 multi-antigen assay for Simple Western offers quantitative characterization of patient serum or plasma derived human IgG antibodies reactive against recombinant Nucleocapsid protein (N), S1 receptor binding domain protein (RBD), S1 subunit full length, S2 subunit full length, and Spike (S1+S2) viral antigens within one 3-hour run. Read more
20 Oct 2020 | COVID-19

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Clinical Chemistry

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Image: An ELISA kit for Galectin-3 which can predict cardiovascular events in patients with type-2 diabetes (Photo courtesy of Immuno-Biological Laboratories).

Galectin-3 Predicts Cardiovascular Disease Risk in Diabetic Patients

Cardiovascular disease (CVD) is a general term for conditions affecting the heart or blood vessels. It's usually associated with a build-up of fatty deposits inside the arteries (atherosclerosis) and an... Read more

Image Some of the components of the cobas 8000 modular analyzer series (Photo courtesy of Roche).

Methods for Intra-Erythrocyte Magnesium and Its Determinants Compared

Magnesium is the second most abundant intracellular cation and is essential for regulation of many functions within the cell, including modulation of ion channels, protein synthesis and energy metabolism.... Read more

Glycated Hemoglobin Screening Reveals Undiagnosed Diabetes

Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include... Read more

Image: The UF-5000 fully automated flow cytometer based on renowned fluorescence flow cytometry (FFC), represents the latest in urinalysis technology (Photo courtesy of Sysmex Corporation).

Urine Osmolality Measurement Evaluated on Automated Analyzer

Urinalysis is a convenient and non‐invasive screening tool for use in both an outpatient and inpatient setting. Automated flow cytometry‐based urine analyzer is increasingly being used to identify and... Read more

Molecular Diagnostics

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Image: Ultrasound scan of fetus showing hydrops fetalis (Photo courtesy of Wikimedia Commons)

Exome Sequencing Identifies Genetic Loci Linked to the Fetal Syndrome Nonimmune Hydrops Fetalis

An exome sequencing technique was used to identify genetic loci linked to development of about 30% of cases of nonimmune hydrops fetalis (NIHF). Hydrops fetalis is a condition in the fetus characterized... Read more

Image: Mutations Disrupting Neuritogenesis Genes Confer Risk for Cerebral Palsy (Photo courtesy of Sudarshan Dayanidhi, PhD, and Richard L. Lieber, PhD).

Mutations Disrupting Neuritogenesis Genes Confer Risk for Cerebral Palsy

Cerebral palsy (CP) is a group of permanent movement disorders that appear in early childhood. Signs and symptoms vary among people and over time. Often, symptoms include poor coordination, stiff muscles,... Read more

Image: Mitochondrial DNA comprises the small circular chromosome found inside mitochondria. The mitochondria, and thus mitochondrial DNA, are passed from mother to offspring (Photo courtesy of Wikimedia Commons)

Elevated Levels of Defective Mitochondrial DNA Predict Likelihood of Reproductive Success

A sperm biomarker has been found that may be able to supplement or replace the semen parameters that poorly predict reproductive success yet are the most prevalent diagnostic tool for male infertility.... Read more

Image: DBS sampling is simple, inexpensive and can be self-collected by the patient at home, using a simple finger prick (Photo courtesy of University of Birmingham)

Use of Dried Blood Samples Facilitates Tracking of COVID-19 Antibodies

A recent study confirmed that dried blood spot samples could be used as an alternative to venous blood for detecting antibodies to the SARS-CoV-2 virus (COVID-19). A confirmed diagnosis of COVID-19... Read more

Hematology

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Image: The ACL TOP 750 analyzer is for advanced automation and quality management in hemostasis testing (Photo courtesy of Instrumentation Laboratory).

Elevated Clotting Factor V Found with Severe COVID-19

Coagulopathy causes morbidity and mortality in patients with coronavirus disease 2019 (COVID‐19) due to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection. Most doctors now know that... Read more

Image: Scanning electron microscope image shows SARS-CoV-2 (yellow) the virus that causes COVID-19, isolated from a patient in the USA, emerging from the surface of cells (pink) cultured in the laboratory (Photo courtesy of NIAID-RML).

RBC Distribution Width Associated with COVID-19 Mortality Risk

COVID-19 has a high rate of hospitalization, critical care requirement, and mortality. Identifying patients at highest risk for severe disease is important to facilitate early, aggressive intervention... Read more

Microfluidic Label-Free Bioprocessing of Reticulocytes from Erythroid Culture

Blood transfusions save millions of lives every year, but over half the world's countries do not have sufficient blood supply to meet their needs. The ability to manufacture red blood cells (RBCs) on demand,... Read more

New Diagnosed Anemia Linked to Crohn’s Disease Risk

Inflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC). IBD is a chronic inflammatory gastrointestinal disorder that involves complex interactions among genetic, environmental,... Read more

Immunology

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Image: The BD FACSymphony A5 flow cytometer (Photo courtesy of BD Biosciences).

MAIT Cell Activation Dynamics Associated with COVID-19 Disease Severity

The balance between protective versus pathological immune responses in COVID-19 has been a concern since the onset of the pandemic. SARS-CoV-2 infection can lead to acute respiratory distress syndrome... Read more

Image: LIAISON XL is a fully automated chemiluminescence analyzer, performing complete sample processing as well as measurement and evaluation (Photo courtesy of Diasorin).

Serum Thyroglobulin Assays Compared for Differentiated Thyroid Carcinoma

Measurement of serum thyroglobulin (Tg) plays a key role in the post‐thyroidectomy management of differentiated thyroid carcinoma (DTC). In this context, the performance of new‐generation thyroglobulin... Read more

Mannose-Binding Lectin Associated with Coagulopathy in Severe COVID-19

The ongoing COVID-19 pandemic has caused significant morbidity and mortality worldwide, as well as profound effects on society. COVID-19 patients have an increased risk of thromboembolic (TE) complications,... Read more

Click Chip’ Detects Early-Stage Liver Cancer Biomarkers in Extracellular Vesicles

Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related deaths worldwide. The poor prognosis of HCC can be attributed to the fact that diagnosis is often made at a late stage in... Read more

Microbiology

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Image: Yellow color shows thiamine degradation on an agar plate of cultured Paenibacillus thiaminolyticus (Photo courtesy of Catherine A. Richter, PhD).

Bacterium and Viral Coinfection Contributes to Postinfectious Hydrocephalus

Neonatal sepsis often precedes postinfectious hydrocephalus (PIH), although the manifestations of hydrocephalus typically emerge in the months after the neonatal period as sufficient cerebrospinal fluid... Read more

Image: DPP Ebola Antigen System is a 15 minute rapid test for detection of Ebola Virus Specific Antigen (Photo courtesy of Chembio Diagnostic Systems).

Performance Compared for Three Ebola Rapid Diagnostic Tests

Ebola is a rare but deadly virus that causes fever, body aches, and diarrhea, and sometimes bleeding inside and outside the body. As the virus spreads through the body, it damages the immune system and organs.... Read more

Image: A low level of potassium (K+), known as hypokalemia, in the blood serum in COVID-19 patients is associated with disease severity and the need for invasive mechanical ventilation (Photo courtesy of Remedy Health Media).

Hypokalemia Is Associated With COVID-19 Severity

Early studies reported various electrolyte abnormalities at admission in patients who later presented the severe form of coronavirus disease 2019 (COVID-19). Electrolyte imbalance may not only... Read more

Gut Microbiome Data Helps Routine Screening of Cardiovascular Disease

Besides genetics and environmental factors, gut microbiota has emerged as a new factor influencing cardiovascular disease (CVD). Although cause-effect relationships are not clearly established, the reported... Read more

Pathology

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Image: Photomicrograph showing tumor-infiltrating lymphocytes in colorectal carcinoma which are suggestive of microsatellite instability (Photo courtesy of Nephron)

Lymphocytic Infiltration Explored as Biomarker for Stable Colorectal Tumors

Identifying stage II patients with colorectal cancer (CRC) at higher risk of progression is a clinical priority in order to optimize the advantages of adjuvant chemotherapy while avoiding unnecessary toxicity.... Read more

Image: Photomicrograph of histopathology of hepatocellular carcinoma, the most common form of primary liver cancer, showing end-stage cirrhosis - blue collagen (fibrosis) Mallory bodies; loss of normal liver architecture; and nuclear atypia. (Photo courtesy of Nephron).

Hematological Biomarkers Predict Prognosis in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is an inflammation-related cancer, where non-resolving inflammation contributes to its development and progression. Peripheral inflammatory cells have been shown to be associated... Read more

Image: Photomicrograph of histology of a poorly differentiated squamous cell carcinoma (SCC) that is p16 positive (Photo courtesy of Nephron).

HPV, p16 Offers Different Prognostic Clues in Oropharyngeal Cancer

Human papillomavirus infection (HPV infection) is an infection caused by human papillomavirus (HPV), a DNA virus from the Papillomaviridae family. About 90% of HPV infections cause no symptoms and resolve... Read more

Image: De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection (Photo courtesy of UT Southwestern Medical Center).

Cancer-Associated T Cell Receptors Evaluated for Malignancy Detection

A key goal in oncology is diagnosing cancer early, when it is more treatable. Despite decades of progress, early diagnosis of asymptomatic patients remains a major challenge. Most methods for this involve... Read more

Technology

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Image: Cryptosporidium oocysts and the larger Giardia cysts stained by Crypto/Giardia IFA kit (Photo courtesy of Cellabs).

Smartphone Microscopic Method Detects Cryptosporidium and Giardia

Food and water-borne illness arising from the consumption of contaminated food and water are serious health hazards globally. Cryptosporidium and Giardia are the major food and water‒borne parasites.... Read more

Image: A test tube contains saliva that can be tested for the heart attack biomarker cardiac troponin (Photo courtesy of karenfoleyphoto).

Saliva Test Fast Tracks Heart Attack Diagnosis

Heart attacks need urgent diagnosis, followed by treatment to restore blood flow to blocked arteries. Diagnosis is based on symptoms (such as chest pain), an electrocardiogram (ECG) and a blood test for... Read more

Image: Schematic diagram of the OvCa-Chip microsystem that recreates vascular endothelium–mediated platelet extravasation in ovarian cancer (Photo courtesy of Texas A&M College of Engineering).

Microfluidic Device Explores Ovarian Cancer Interactions

In many cancers, platelet interactions with circulating tumor cells and their role in metastasis have been studied extensively. In ovarian cancer, platelet extravasation into the tumor and resulting metastasis... Read more

$The TriVersa NanoMate LESA uses chip-based electrospray ionization technology that combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated ion source platform (Photo courtesy of Advion BioSciences).$

Nanoparticle System Captures Heart-Disease Biomarker From Blood

Physicians currently use an antibody-based test called enzyme-linked immunosorbent assay (ELISA) to help diagnose heart attacks based on elevated levels of cardiac troponin I (cTnI) in the patient's blood sample.... Read more

BioResearch

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Genome Analysis Predicts Likelihood of Neurodisability in Oxygen-Deprived Newborns

A genomics-based blood test can predict likelihood that a baby suffering hypoxia at birth will suffer serious nervous disorders such as cerebral palsy or epilepsy at a later stage of development.... Read more

Image: A micrograph of a diffuse large B cell lymphoma (DLBCL) (Photo courtesy of Wikimedia Commons).

Gene Panel Predicts Disease Progession for Patients with B-cell Lymphoma

Cancer researchers developed a 29 gene–based weighted prognostic score for predicting event-free survival and overall survival of patients suffering from diffuse large B-cell lymphoma (DLBCL).... Read more

Image: A diagram of construction of a genomic library (Photo courtesy of Wikimedia Commons).

New Method Simplifies Preparation of Tumor Genomic DNA Libraries

A method has been described that simplifies preparation of tumor genomic DNA libraries by employing restriction enzymes and in vitro transcription to barcode and amplify genomic DNA prior to library construction.... Read more

New Tool Developed for Diagnosis of Chronic HBV Infection

A team of Chinese researchers has described the development of a new and powerful tool for the diagnosis and treatment of chronic hepatitis B virus (HBV) infection. Methods currently used to diagnose... Read more

Industry News

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Awareness Technology Announces ChemWell RPR Analyzer - The Most Significant Innovation in Syphilis Testing in Last 30 Years

Awareness Technology, Inc. (Palm City, FL, USA) has announced the most significant innovation in syphilis testing in the last 30 years with the launch of the ChemWell RPR automated nontreponemal analyzer... Read more

Nova Biomedical Adds PT/INR Test to Allegro Analyzer for POC Testing

Nova Biomedical (Waltham, MA, USA) has added PT/INR testing for its Allegro capillary blood analyzer for point-of-care (POC) testing in primary care settings. With the ability to test for clotting disorders... Read more

Global Blood Glucose Monitoring Devices Market to Reach USD 13 Billion by 2023

The global blood glucose monitoring devices (BGMDs) market was valued at nearly USD 8 billion in 2018 and is projected to grow at a fast-paced CAGR of approximately 11% to reach USD 13 billion by 2023,... Read more

Global ELISA Kits Market to Surpass USD 418.5 Billion by 2025

The global ELISA (Enzyme-Linked Immunosorbent Assay) Kits market is projected to grow at a CAGR of 3.8% to surpass USD 418.5 billion by the year 2025, driving a CAGR of 4% in the worldwide Research ELISA... Read more

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