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Image: The epoc POC blood analysis system (Photo courtesy of Alere).

Capillary Blood Analysis Validated for POC System

The gold standard samples for blood gas analysis are arterial blood collected from arterial catheter or by arterial puncture, but the proper sampling of arterial blood is difficult, painful, and sometimes risky to obtain in patient in transport. Read more
22 Aug 2017 | Clinical Chemistry
Image: A glioblastoma induced by the new gene-editing and screening technology (Photo courtesy Chen Lab, Yale University).

CRISPR Technology Identifies Cancer-Causing Genes

Researchers have identified specific gene combinations that can cause the brain cancer glioblastoma, using their newly developed modified CRISPR technology that can also pinpoint triggers and primary drivers of other types cancers. Read more
22 Aug 2017 | Molecular Diagnostics
Image: Lung cancer cells. Researchers designed a new test to diagnose NSCLCs by testing for tumor cell RNA absorbed by circulating platelets (Photo courtesy of iStock).

Liquid Biopsy Approach Inspired by Swarm Behavior

Researchers have designed an algorithm for blood sample analysis where, rather than testing for evidence of cancer DNA or protein biomarkers, they test for tumor cell RNA absorbed by circulating platelets – i. Read more
21 Aug 2017 | Molecular Diagnostics
Image: A micrograph of esophageal candidiasis showing hyphae. Biopsy specimen stained by periodic acid-Schiff procedure (PAS stain) (Photo courtesy of Wikimedia).

Review Provides Insight into Therapeutic Interventions

A new review has outlined recommendations and a gold standard for identifying at-risk patients who are critically ill, or in receipt of organ transplants, for preventing, diagnosing and treating invasive fungal infections. Read more
21 Aug 2017 | Microbiology
Image: The spectral transmission-reflectance-intensity (TRI)-Analyzer attaches to a smartphone and analyzes patient blood, urine, or saliva samples as reliably as clinic-based instruments that cost thousands of dollars (Photo courtesy of the Department of Bioengineering, University of Illinois at Urbana-Champaign).

Smartphone-Based Analyzer Designed for Sample Testing

A handheld spectrophotometer that uses a smartphone camera to measure changes in absorption of natural light or emission of fluorescent light is the key to a mobile instrument that can evaluate biological samples with the accuracy of clinical laboratory analyzers but at a fraction of the cost. Read more
21 Aug 2017 | Lab Tech.
Image: A bioplasmonic paper-based device (BPD) for the detection of Zika virus (ZIKV) infection, via quantification of serum anti-ZIKV-nonstructural protein 1 (NS1) IgG and IgM (Photo courtesy of James Byard).

Biosensor Device Developed for Zika Diagnosis

A novel plasmonic biosensor-based detection system was developed that can diagnose recent or current Zika virus (ZIKV) infection in 15 minutes or less. Read more
21 Aug 2017 | Molecular Diagnostics
Image: The Brahms Kryptor automated immunoassay platform (Photo courtesy of Thermo Fisher Scientific).

Immunoassay Biomarkers Evaluated for Preeclampsia Diagnosis

Preeclampsia is one of the leading hypertensive disorders in pregnant women worldwide and it is estimated to cause more than 60,000 deaths per year. Read more
17 Aug 2017 | Immunology
Image: Various blood collection tubes for use in the clinical laboratory (Photo courtesy of Labs USA).

Trends in Metabolites Predict Mortality for Hospitalized Patients

Patients who are hospitalized for an extensive period are at risk for adverse outcomes and are likely to have a high mortality rate than those who have shorter stays. Read more
17 Aug 2017 | Clinical Chemistry

Channels

Clinical Chemistry

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Biomarkers Lead to Better Prognosis for CF Patients
Biomarker May Help Monitor MPS Disease Progression
Blood Test Identifies Key Alzheimer's Marker
Image: The compact PATHFAST Immunoanalyzer used for the presepsin point-of-care assay (Photo courtesy of LSI Medience Corporation).

Increased Probability of Sepsis Mortality Associated with SOFA Score

Sepsis-related organ failure assessment score, also known as sequential organ failure assessment score (SOFA score), is used to track a person's status during the stay in an intensive care unit (ICU) to... Read more

Molecular Diagnostics

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Blood Test Detects Brain Metastases While Treatable
Neurological Disease Traced to Gene Error
Dried Blood Assessment Equivalent to Drawn Blood Samples
Image: A histopathology of adrenal pheochromocytoma from an adrenectomy specimen showing the characteristic stippled (finely granular) chromatin (Photo courtesy of Nephron).

Mutations Related to Hereditary Neuroendocrine Tumors

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors with a strong hereditary component and half the genes whose alterations confer hereditary susceptibility to develop this condition code... Read more

Hematology

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Revision of Guidelines Beneficial for Assessing Orthostatic Hypotension
Antimicrobial Therapy Biomarker Enumerates Eosinophil Count Changes
Platelet Counts Compared for Thalassemia Patients
Image: Dyskeratosis congenita manifests as nail dystrophy where nail findings include ridging and longitudinal splitting. The nails may become thinned and atrophic leading to pterygium formation or absent nails. The changes in the fingernails and toenails may worsen over time (Photo courtesy of Dr. Maurice van Steensel).

CRISPR Illuminates Pediatric Bone Marrow Failure Syndrome

Children with dyskeratosis congenita experience progressive bone marrow failure, eventually losing the ability to make red blood cells, white blood cells and platelets and they are also at high risk of leukemia.... Read more

Immunology

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New Biomarkers Provide Diagnostic Tool for AD
New Test Rapidly Diagnoses Preeclampsia
Hormone Receptor Antibody Reagents Assessed for Breast Cancer
Image: The Luminex 200 multiplex analyzer (Photo courtesy of Luminex Corporation).

Cytokine Concentration Linked to Chronic Fatigue Syndrome

More than one million people in the USA suffer from chronic fatigue syndrome, also known as myalgic encephomyelitis and designated by the acronym ME/CFS. It is a disease with no known cure or even reliably... Read more

Microbiology

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Three Commercial Tests for Lyme Borreliosis Evaluated
Molecular Tests Predict TB Treatment Outcome
Methods Compared for Chagas Disease Diagnosis
Image: The VITEK MS, MALDI-TOF1 Mass Spectrometry System, an automated microbial identification system (Photo courtesy of bioMérieux).

Expanded Pathogen Identification Receives FDA Clearance

Mycobacteria, Nocardia and molds are complex organisms to identify, requiring days or weeks of specific culture conditions for appropriate growth and subsequent advanced methods for reliable identification... Read more

Pathology

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Microscopy Technique Enables More Informative Biopsies
Bacterium Actively Drives CRC Tumor Growth
Molecular Testing Evaluated for Thyroid Nodules
Image: The new fabric-based Velcro-like device (top), and the currently used standard metal scraping-device (bottom) (Photo courtesy of J. Diedrich, UC Riverside).

New Device Provides Better Biopsies for Cancer Testing

In a study comparing a new frictional fabric brush versus the currently used sharp scraper for endocervical curettage, the new device provided better tissue yield with less pain and discomfort.... Read more

Lab Tech.

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Pumps Achieve High-Speed Sorting of Large Cells
Innovative Nanosensor Developed for Disease Diagnosis
Mass Spectrometry Detection for the Masses
Image: A prototype of the D4 assay (Photo courtesy of Daniel Joh, Duke University).

Smartphone-Based ELISA Developed for Blood Antigens

A novel high speed, lab-on-a-chip ELISA test for antigens in blood samples depends on a unique nonstick polymer coating that eliminates the need for multiple incubation and washing steps.... Read more

Industry News

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Global Clinical Lab Services Market to Reach USD 327 Billion by 2025
Global Hematology Analyzer Market to Surpass USD 2 Billion by 2024
Brazilian IVD Market Fueled by Growing Demand
Image: Quidel has entered into definitive agreements to acquire Triage and BNP assets from Alere (Photo courtesy of iStock).

Quidel to Acquire Alere Triage Assets

Quidel Corporation (San Diego, CA, USA), a provider of rapid diagnostic testing solutions, cellular-based virology assays and molecular diagnostic systems, has entered into definitive agreements to acquire... Read more

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