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Image: Hookworm eggs examined microscopically on wet mount using the Kato-Katz technique (eggs of Ancylostoma duodenale and Necator americanus cannot be distinguished morphologically. The embryo in (B) has begun cellular division and is at an early (gastrula) developmental stage (Photo courtesy of Vishnu Vardhan Serla / Maheep Sangha).

Diagnostic Sensitivity of Kato-Katz Technique Estimated

Soil-transmitted helminthiasis (STH) and schistosomiasis are two of the most prevalent neglected tropical diseases with more than one billion and over 250 million people affected worldwide, respectively. Read more
17 Oct 2017 | Microbiology
Image: The ADVIA 2120 hematology analyzer (Photo courtesy of Siemens Healthcare).

Diagnostic Performance of Blood Counts Compared

The use of point-of-care testing is increasing, however many hematology analyzers can only determine granulocyte count without further differentiation into neutrophils, eosinophils and basophils. Read more
17 Oct 2017 | Hematology
Image: The Synapt G2 high definition mass spectrometer (HDMS) (Photo courtesy of Waters).

Metabolomics Analysis Applied to Investigate MPS

Inborn errors of metabolism (IEM) represent a group of about 500 rare diseases with an overall estimated incidence of 1/2,500. Read more
17 Oct 2017 | Clinical Chemistry
Image: The GEM 4000 whole blood analyzer (Photo courtesy of Werfen UK).

Umbilical Cord Bilirubin Predicts Neonatal Jaundice

Hyperbilirubinemia is one of the commonest causes of admission to hospital in the neonatal period amongst term babies in all settings. Read more
17 Oct 2017 | Clinical Chemistry
Image: Smell problems can increase people’s risk for health-related conditions and can also be a sign of neurodegenerative disease (Photo courtesy of Getty Images).

Tests for Smell Loss May Detect Alzheimer’s and PD

In a new approach to testing for olfaction dysfunction, researchers have developed “white smells,” mixtures of several odor molecules, which help reduce test bias and patient subjectivity, thus also creating a more globally applicable testing format. Read more
16 Oct 2017 | Clinical Chemistry
Image: Three-dimensional images showing the complex vascular system in ovarian cancer (left) and bladder cancer (right). Thick vessels are colored red, thin vessels colored blue (Photo courtesy of Nobuyuki Tanaka / Karolinska Institutet).

New 3D App Provides More Accurate Cancer Diagnosis

With further development of light-sheet microscopy based 3D imaging, researchers were able to examine tumor biopsy tissue in more detail than current 2D methods, resulting in improved intratumoral heterogeneity phenotyping and diagnosis of solid tumors. Read more
16 Oct 2017 | Pathology
Image: The structure of the TOP2A protein (Photo courtesy of Wikimedia Commons).

Gene Pair Distinguishes Forms of Prostate Cancer

Cancer researchers have identified a biomarker comprising a pair of genes that distinguishes between indolent and aggressive prostate cancers. Read more
16 Oct 2017 | Molecular Diagnostics
Image: The microfluidic device SlipChip is designed to compartmentalize single molecules (Photo courtesy of SlipChip / CalTech).

Rapid Method Determines Antibiotic Susceptibility

A novel micro-fluidic device used a sensitive digital real-time loop-mediated isothermal amplification (dLAMP) assay to rapidly determine bacterial antibiotic susceptibility. Read more
16 Oct 2017 | Molecular Diagnostics

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Clinical Chemistry

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Serum Magnesium Levels Linked to Dementia Risk
New Urine Analyzer Evaluated for Performance
Field Evaluation of Quantitative G6PD Diagnostics Reviewed
Image: The FreeStyle Libre Flash Glucose Monitoring System (Photo courtesy of Abbott).

Monitoring System No Longer Requires Fingerstick Calibration

People with diabetes must regularly test and monitor their blood sugar to make sure it is at an appropriate level, which is often done multiple times per day by taking a fingerstick sample and testing... Read more

Molecular Diagnostics

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Technology Diagnoses Pneumonia Caused by Undetected Pathogens
Rapid Diagnostic Used in Sepsis Management
Predatory Bacteria Found in Lung Microbiome of CF Patient
Image: Clinical uses of Warfarin, a drug that is used for the treatment of existing blood clots and to prevent new blood clots formation inside the body (Photo courtesy of Dr. Manish Goyal).

Genetic Testing Determines Safest Dose of Blood Thinner

Warfarin, commonly known as Coumadin, is frequently used to prevent a life-threatening blood clot. It is often prescribed to people having hip or knee replacement surgery, as well as to individuals with... Read more

Hematology

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Automated Slide-Based Approach Introduced for CBCs
New LC-MS/MS Test Introduced for TMA
Hematologic Abnormalities Found in HIV-Infected Children
Image: The KX-21 N automated hematology analyzer (Photo courtesy of Sysmex Corporation).

Biomarkers of Sickle Cell and Hemoglobin SC Compared

Sickle cell disease (SCD) is a group of inherited diseases that includes sickle cell anemia (SCA), which is the homozygous state of the beta S (βS) allele and the most severe SCD genotype.... Read more

Immunology

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Tumor Microenvironment May Provide Biomarker for Women with TNBC
Low-Volume Aldosterone Immunoassay Validated for Small Samples
Blood Inflammatory Molecules Increased in ALS
Image: the ImmunoXpert is a pioneering in-vitro diagnostic test that accurately distinguishes between bacterial and viral infections based on the patient’s immune response (Photo courtesy of MeMed).

Blood Test Accurately Distinguishes Bacterial and Viral Infections

The difficulty in properly distinguishing between viral and bacterial infections results in one of two outcomes. Either there is an overuse of antibiotics, which results in a rise in antibiotic resistance;... Read more

Microbiology

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Rapid Screening Test Developed for Ebola Virus
Rapid Hepatitis C Testing Helps Screen Young Adults
Lipid Vesicles Replace Blood in New Bacteria Test
Image: The Aptima Mycoplasma genitalium Assay (Photo courtesy of Hologic).

New Aptima Mycoplasma genitalium Assay Evaluated

Mycoplasma genitalium (MG) frequently causes non-gonococcal urethritis (NGU) in males, and is associated with cervicitis, pelvic inflammatory disease, endometritis and probably infertility.... Read more

Pathology

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Immunocompromised Patients at Risk for Blastomycosis
Urinary Tract Biopsy Correlates Urothelial Carcinoma Diagnosis
IBS Colon Reacts Differently to Bacteria
Image: SelectMDx can be used to diagnose prostate cancer without doing a biopsy or an MRI scan (Photo courtesy of MDxHealth SA).

Liquid Biopsy Test Outperforms Prostate Cancer PCA3 Test

Of the nearly two million prostate biopsies performed each year, less than a third find cancer. Most of these men could have avoided a painful and invasive prostate biopsy procedure, with its associated... Read more

Lab Tech.

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Malaria Diagnosis Employs Hydrophilic-Treated Plastic Plates
Smartphone-Based Analyzer Designed for Sample Testing
Smartphone-Based ELISA Developed for Blood Antigens
Image: Paper-based diagnostic device that detects biomarkers and identifies diseases by performing electrochemical analyses. The assays change color to indicate specific test results. The device can be plugged into the handheld potentiostat, at left (Photo courtesy of Purdue University, Aniket Pal).

Disposable POC Device Introduced for Low-Resource Areas

A recent paper described a novel diagnostic device fabricated from various types of paper to be used for point-of-care testing in areas lacking electricity and other resources. The developers at Purdue... Read more

Industry News

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Companies with Lab-Developed Tests Raise USD 2 Billion
Top Trends Impacting Global POC Testing Market
Thermo LC-MS Solutions Receive ANVISA Registration in Brazil
Image: Abbott has closed the acquisition of Alere (Photo courtesy of iStock).

Abbott Closes Acquisition of Alere

Abbott (‎Lake Bluff, IL; USA) has closed the acquisition of Alere, Inc. (Waltham, MA; USA), following the receipt of all regulatory clearances required for the closing. Abbott is a global healthcare... Read more

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