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Image: The spectral transmission-reflectance-intensity (TRI)-Analyzer attaches to a smartphone and analyzes patient blood, urine, or saliva samples as reliably as clinic-based instruments that cost thousands of dollars (Photo courtesy of the Department of Bioengineering, University of Illinois at Urbana-Champaign).

Smartphone-Based Analyzer Designed for Sample Testing

A handheld spectrophotometer that uses a smartphone camera to measure changes in absorption of natural light or emission of fluorescent light is the key to a mobile instrument that can evaluate biological samples with the accuracy of clinical laboratory analyzers but at a fraction of the cost. Read more
21 Aug 2017 | Lab Tech.
Image: A bioplasmonic paper-based device (BPD) for the detection of Zika virus (ZIKV) infection, via quantification of serum anti-ZIKV-nonstructural protein 1 (NS1) IgG and IgM (Photo courtesy of James Byard).

Biosensor Device Developed for Zika Diagnosis

A novel plasmonic biosensor-based detection system was developed that can diagnose recent or current Zika virus (ZIKV) infection in 15 minutes or less. Read more
21 Aug 2017 | Molecular Diagnostics
Image: The Brahms Kryptor automated immunoassay platform (Photo courtesy of Thermo Fisher Scientific).

Immunoassay Biomarkers Evaluated for Preeclampsia Diagnosis

Preeclampsia is one of the leading hypertensive disorders in pregnant women worldwide and it is estimated to cause more than 60,000 deaths per year. Read more
17 Aug 2017 | Immunology
Image: Various blood collection tubes for use in the clinical laboratory (Photo courtesy of Labs USA).

Trends in Metabolites Predict Mortality for Hospitalized Patients

Patients who are hospitalized for an extensive period are at risk for adverse outcomes and are likely to have a high mortality rate than those who have shorter stays. Read more
17 Aug 2017 | Clinical Chemistry
Image: The compact PATHFAST Immunoanalyzer used for the presepsin point-of-care assay (Photo courtesy of LSI Medience Corporation).

Increased Probability of Sepsis Mortality Associated with SOFA Score

Sepsis-related organ failure assessment score, also known as sequential organ failure assessment score (SOFA score), is used to track a person's status during the stay in an intensive care unit (ICU) to determine the extent of a person's organ function or rate of failure. Read more
17 Aug 2017 | Clinical Chemistry
Image: The Luminex 200 multiplex analyzer (Photo courtesy of Luminex Corporation).

Cytokine Concentration Linked to Chronic Fatigue Syndrome

More than one million people in the USA suffer from chronic fatigue syndrome, also known as myalgic encephomyelitis and designated by the acronym ME/CFS. Read more
16 Aug 2017 | Immunology
Image: A histopathology of adrenal pheochromocytoma from an adrenectomy specimen showing the characteristic stippled (finely granular) chromatin (Photo courtesy of Nephron).

Mutations Related to Hereditary Neuroendocrine Tumors

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors with a strong hereditary component and half the genes whose alterations confer hereditary susceptibility to develop this condition code for enzymes involved in the Krebs cycle. Read more
16 Aug 2017 | Molecular Diagnostics
Image: The Wescor Sweat Check Analyzer Model 3120 for total electrolyte analysis of sweat samples (Photo courtesy of ELITech Group).

Biomarkers Lead to Better Prognosis for CF Patients

Cystic fibrosis is a life-shortening and multi-organ autosomal recessive disease characterized by pancreatic insufficiency and recurrent lung infections that contribute to growth failure and progressive respiratory dysfunction. Read more
16 Aug 2017 | Clinical Chemistry

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Clinical Chemistry

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Blood Test Identifies Key Alzheimer's Marker
Serum Pepsinogen Validated for Atrophic Gastritis Diagnosis
Pre-Diagnostic Metabolite Concentrations Related to Cancer Risk
Image: Researchers have discovered a new biomarker that is associated with a rare metabolic disorder may facilitate better diagnosis and identification of new drugs for clinical trials (Photo courtesy of iStock).

Biomarker May Help Monitor MPS Disease Progression

Researchers have identified spermine as a potential biomarker associated with neuropathic forms of mucopolysaccharidoses (MPS), a family of rare metabolic disorders. Assaying for abnormally high levels... Read more

Molecular Diagnostics

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Neurological Disease Traced to Gene Error
Dried Blood Assessment Equivalent to Drawn Blood Samples
Test Discriminates Between Viral and Bacterial Infections
Image: The model illustrates clinical implications of BCBM CTC screening method for brain micro-metastasis before they become detectable by MRI. BCBM-associated CTCs can be used as a tool to evaluate responses to therapy for BCBM patients (Photo courtesy of Houston Methodist).

Blood Test Detects Brain Metastases While Treatable

A blood test is being generated that can identify breast cancer patients who are at increased risk for developing brain metastasis, and also monitor disease progression and response to therapy in real time.... Read more

Hematology

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Revision of Guidelines Beneficial for Assessing Orthostatic Hypotension
Antimicrobial Therapy Biomarker Enumerates Eosinophil Count Changes
Platelet Counts Compared for Thalassemia Patients
Image: Dyskeratosis congenita manifests as nail dystrophy where nail findings include ridging and longitudinal splitting. The nails may become thinned and atrophic leading to pterygium formation or absent nails. The changes in the fingernails and toenails may worsen over time (Photo courtesy of Dr. Maurice van Steensel).

CRISPR Illuminates Pediatric Bone Marrow Failure Syndrome

Children with dyskeratosis congenita experience progressive bone marrow failure, eventually losing the ability to make red blood cells, white blood cells and platelets and they are also at high risk of leukemia.... Read more

Immunology

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New Test Rapidly Diagnoses Preeclampsia
Hormone Receptor Antibody Reagents Assessed for Breast Cancer
Performance of Immunosuppressant Drug Assay Kits Analyzed
Image: The CytoViva hyperspectral imaging system (Photo courtesy of CytoViva).

New Biomarkers Provide Diagnostic Tool for AD

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder that results in the gradual deterioration of specific brain regions that hinders the person’s ability to think, recall memories, learn,... Read more

Microbiology

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Three Commercial Tests for Lyme Borreliosis Evaluated
Molecular Tests Predict TB Treatment Outcome
Methods Compared for Chagas Disease Diagnosis
Image: The VITEK MS, MALDI-TOF1 Mass Spectrometry System, an automated microbial identification system (Photo courtesy of bioMérieux).

Expanded Pathogen Identification Receives FDA Clearance

Mycobacteria, Nocardia and molds are complex organisms to identify, requiring days or weeks of specific culture conditions for appropriate growth and subsequent advanced methods for reliable identification... Read more

Pathology

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Microscopy Technique Enables More Informative Biopsies
Bacterium Actively Drives CRC Tumor Growth
Molecular Testing Evaluated for Thyroid Nodules
Image: The new fabric-based Velcro-like device (top), and the currently used standard metal scraping-device (bottom) (Photo courtesy of J. Diedrich, UC Riverside).

New Device Provides Better Biopsies for Cancer Testing

In a study comparing a new frictional fabric brush versus the currently used sharp scraper for endocervical curettage, the new device provided better tissue yield with less pain and discomfort.... Read more

Lab Tech.

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Pumps Achieve High-Speed Sorting of Large Cells
Innovative Nanosensor Developed for Disease Diagnosis
Mass Spectrometry Detection for the Masses
Image: A prototype of the D4 assay (Photo courtesy of Daniel Joh, Duke University).

Smartphone-Based ELISA Developed for Blood Antigens

A novel high speed, lab-on-a-chip ELISA test for antigens in blood samples depends on a unique nonstick polymer coating that eliminates the need for multiple incubation and washing steps.... Read more

Industry News

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Global Clinical Lab Services Market to Reach USD 327 Billion by 2025
Global Hematology Analyzer Market to Surpass USD 2 Billion by 2024
Brazilian IVD Market Fueled by Growing Demand
Image: Quidel has entered into definitive agreements to acquire Triage and BNP assets from Alere (Photo courtesy of iStock).

Quidel to Acquire Alere Triage Assets

Quidel Corporation (San Diego, CA, USA), a provider of rapid diagnostic testing solutions, cellular-based virology assays and molecular diagnostic systems, has entered into definitive agreements to acquire... Read more

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