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In Other News

Image: The CellSearch Platform for identification, isolation, and enumeration of circulating tumor cells (Photo courtesy of Menarini Silicon Biosystems).

Liquid Biopsy Detects Cancer across Multiple Biomarkers

Although biomarker-directed therapy is in its infancy in prostate cancer compared to some other tumor types, there is a great need for predictive biomarker testing, and great interest in noninvasive methods. Read more
06 Dec 2018 | Molecular Diagnostics
Image: Gene recombination in neurons that produces thousands of new gene variants within Alzheimer’s disease brains have been identified (Photo courtesy of Sanford Burnham Prebys Medical Discovery Institute).

DNA Recombination in Brain Linked to Alzheimer's Disease

Alzheimer's disease is a public health crisis. The cause of the disease remains unknown and no meaningful treatment exists. Read more
05 Dec 2018 | Molecular Diagnostics
Image: Neuropathy is the damage of peripheral nerves; pain and loss of sensation in the extremities and can be caused by diabetes (Photo courtesy of Alnoor Ladhani).

Routine Vitamin B12 Screening May Prevent Irreversible Nerve Damage

The increasing incidence of type-2 diabetes is a serious health issue worldwide. Its prevalence is associated with poor diet and unhealthy lifestyle choices, and it is characterized by high blood glucose levels that need to be controlled by medication. Read more
05 Dec 2018 | Clinical Chemistry
Image: The NextSeq 550 System delivers the power of high-throughput sequencing with the speed, simplicity, and affordability of a benchtop next-generation sequencing (NGS) system (Photo courtesy of Illumina).

Genes Identified That Predispose People to Chronic Kidney Disease

Chronic kidney disease (CKD) affects 10% to 15% of the population worldwide and is now recognized as the most rapidly increasing contributor to global burden of disease. Read more
05 Dec 2018 | Molecular Diagnostics
Image: The ARCHITECT B.R.A.H.M.S PCT assay, which is a two-step immunoassay using chemiluminescent microparticle immunoassay (CMIA) technology (Photo courtesy of Abbott Laboratories).

Commercial Fully Automated Procalcitonin Immunoassay Compared

Procalcitonin (PCT), a 13-kDa peptide precursor of calcitonin, has gained widespread acceptance as an early and specific biomarker for the presence of systemic bacterial infection. Read more
04 Dec 2018 | Clinical Chemistry
Image: The automated ELISpot reader allows analyzing both enzymatic and fluorescent (FluoroSpot) based EliSpot assays (Photo courtesy of Autoimmun Diagnostika).

Dengue Virus Specific T-Cell Responses Correlated with Disease Severity

Dengue virus (DENV) is the cause of the most common mosquito-borne viral infection worldwide, and over half of the global population live in areas where there is intense dengue transmission putting them at risk of dengue infection. Read more
04 Dec 2018 | Immunology
Image: The BD Phoenix identification and susceptibility combo panels (Photo courtesy of Becton, Dickinson and Company).

Phenotypic Test Identifies Antibiotic-Resistant Bacterial Infections

Carbapenemase-producing organisms (CPO) are gram-negative bacteria that are resistant to the carbapenem class of antibiotics, which are commonly used for severe or high-risk bacterial infections. Read more
04 Dec 2018 | Microbiology
Image: The Kalazar Detect Rapid Test for Visceral Leishmaniasis (VL) is a rapid immunochromatographic strip assay for the qualitative detection of antibodies to L. donovani complex in human serum to aid in the presumptive diagnosis of VL (Photo courtesy of InBios).

LAMP Assay Validated for Visceral Leishmaniasis

Visceral leishmaniasis (VL) is one of the most neglected infectious diseases with an annual incidence of 50,000 to 90,000 new cases worldwide. Read more
03 Dec 2018 | Microbiology
Image: The IMMULITE 1000 system is a small bench top immunoassay analyzer (Photo courtesy of Siemens Healthcare Diagnostics).

Levels of IgA Nephropathy Associated with Disease Severity

IgA nephropathy (IgAN) is the most common cause of primary glomerulonephritis. IgAN is associated with a poor prognosis, about 20% to 40% of patients with IgAN progress slowly to end-stage renal failure 20 to 25 years after diagnosis. Read more
03 Dec 2018 | Immunology
Image: An illustration showing detection of a single influenza virion using a solid-state nanopore (Photo courtesy of Osaka University).

Nanopore Method Detects Single Influenza Virus at Single Particle Level

A team of Japanese researchers has introduced a novel sensor concept capable of discriminating various types of influenza virus in a label-free fashion by their distinct particle properties. Read more
03 Dec 2018 | Molecular Diagnostics
Image: The nCounter platform provides a simple and cost effective solution for multiplex analysis of up to 800 RNA, DNA, or protein targets from diverse samples (Photo courtesy of NanoString).

Highly Multiplexed Broad Pathogen Assay Detects Infectious Diseases

Identifying the causative agent in an acute febrile illness can be challenging diagnostically, especially when organisms in a particular region have overlapping clinical presentation or when that pathogen’s presence is unexpected. Read more
29 Nov 2018 | Molecular Diagnostics

Channels

Clinical Chemistry

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Proteins Used for Diagnosing ALS
Chromaffin Cell Tumors Diagnosed by Plasma Panel
Cardiac Troponin Assays Compared in Large Cohort
Image: The FLEXMAP 3D instrument is an advanced and versatile multiplexing platform. The platform uses both magnetic and non-magnetic microspheres and is capable of simultaneously measuring up to 500 genes or proteins from a small sample (Photo courtesy of Luminex).

Plasma Human Proteins Associated with Acute Pediatric Malaria

Severe malaria caused by Plasmodium falciparum continues to be one of the leading infectious causes of morbidity and mortality in children worldwide. The intimate interaction between the pathophysiology... Read more

Molecular Diagnostics

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Sensitive Tumor Detection Uses Cell-Free DNA Methylomes
Recognized Cause of Pediatric Mitochondrial Disease Found
Ovarian Cancer Test Measures Biomarker Serum Levels
Image: The Chromium Single Cell Gene Expression Solution provides high-throughput, single cell expression measurements that enable discovery of gene expression dynamics and molecular profiling of individual cell types (Photo courtesy of 10X Genomics).

Pregnancy-Related Immune Changes Revealed by Placenta Sequencing

A team of scientists has used single-cell RNA sequencing to map expression profiles in the placenta, focusing on the decidua tissue that forms from the lining of the uterus and placental trophoblast tissue... Read more

Hematology

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Malaria Parasitaemia Correlated with Monocyte to Lymphocyte Ratio
Rapid Test for Sickle-Cell Disease Evaluated
RNA Defects Linked to Multiple Myeloma Progression
Image: A bone marrow smear of a patient with Acute Myeloid Leukemia; dysplastic changes are noted in both the granulocytic and erythroid lineages (Photo courtesy of Peter Maslak).

Acute Myeloid Leukemia Regulatory Networks Identified

Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. AML is a heterogeneous disease caused... Read more

Immunology

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Diagnostic Test Aids Determination of Menopausal Status
Cytokine Levels Could Predict Immunotherapy Problems
Biomarkers May Predict Zika-Related Birth Defects
Image: The ALPHA Histoplasma Enzyme Immunoassay (EIA) test kit (Photo courtesy of IMMY).

Diagnostic Accuracy of Histoplasma Urine Antigen Assay Evaluated

Histoplasmosis is an endemic mycosis in many regions of Latin America. In the human immunodeficiency virus (HIV) infected population it manifests as progressive disseminated histoplasmosis (PDH), an entity... Read more

Microbiology

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Cell-Free DNA Sequencing Test for Infectious Disease Analyzed
POC Immune Response Test Cleared for Europe
Highly Sensitive Immunoassay Detects Malarial Histidine-Rich Protein 2
authorization (Photo courtesy of Chembio Diagnostic Systems).

Ebola Test with Portable Reader Authorized for Emergency Use

Ebola is a rare but deadly virus that causes fever, body aches, and diarrhea, and sometimes bleeding inside and outside the body. As the virus spreads through the body, it damages the immune system and organs.... Read more

Pathology

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Genetic Test Helps Patients Avoid Unnecessary Thyroid Surgery
Breast Cancer Risk Variant Type Determines Tumor Aggressiveness
Generic Test Developed for Early Detection of Cancer
Image: The Quant-iT high sensitivity PicoGreen double-stranded DNA Assay Kit (Photo courtesy of Invitrogen).

Biomarker Found for Prostate Cancer Treatment Response

Prostate cancer is one of the most common cancers in males and has one of the highest five-year survival rate when diagnosed in the localized stage. When diagnosed in the advanced stage or when a localized... Read more

Lab Tech.

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Low-Cost Diagnostic Developed Using Nanostructures
Residual Tissue Repositories Suitable for MS-Based Proteomics
Magnetic Nanoparticle Tool Developed to Detect MicroRNA
Image: The Cap‐Score detects and analyzes localization patterns using fluorescent microscopy to distinguish fertile from infertile sperm cells (Photo courtesy of Androvia LifeSciences).

New Test Measures Men's Fertility

Male fertility is a serious and growing concern globally. Yet, the field of andrology faces critical gaps in diagnostic technologies and knowledge, affecting scientific advancement as well as clinical... Read more

Industry News

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Increasing Conditions and Diseases Drive Global POC Hematology Diagnostics Marke...
Western Blotting Processors Market to Reach USD 329 Million by 2028
Global IVD Market to Reach USD 77 Billion by 2023
Image: The global hemostasis/coagulation analyzers market is expected to grow to USD 9.55 billion by 2026, driven mainly by the growing incidence of blood disorders (Photo courtesy of Analyticon Biotechnologies.

Global Hemostasis/Coagulation Analyzers Market to Reach USD 9.5 Billion by 2026

The global hemostasis/coagulation analyzers market was valued at USD 3.65 billion in 2017 and is expected to grow at a CAGR of 9.9% over the period 2018 to 2026 to reach USD 9.55 billion by 2026, driven... Read more

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