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Augmented Reality Surgical Navigation Minimizes Radiation Exposure

GI Bleeding Raises Colorectal Cancer Risk in Anticoagulated Patients

3D Skin Printer Covers Large Burn Wound Areas

Functional Brace Suitable for Ruptured Achilles Tendon

Smart Insulin Patch Automatically Manages Glucose Levels

Proteogenomic Characterization of Endometrial Carcinoma Analyzed

Image: Proteogenomic Characterization of Endometrial Carcinoma (Photo courtesy of the Clinical Proteomic Tumor Analysis Consortium).

Endometrial cancer is a cancer that arises from the endometrium which is the lining of the uterus or womb. It is the result of the abnormal growth of cells that have the ability to invade or spread to other parts of the body. Read more
24 Feb 2020

All-Digital Histopathology Attained by Infrared-Optical Hybrid Microscopy

24 Feb 2020

Uric Acid in Saliva Is a Biomarker for Body Fat Accumulation in Adolescents

24 Feb 2020

Ratio of Serum Very-long-chain to Long-chain Ceramides Is Predictive of Dementia Risk

24 Feb 2020

The Randox Laboratories Diagnostic Test Distinguishes Coronavirus from Other Respiratory Infections

21 Feb 2020

Factor IX Inhibitor Incidence in Pediatric Hemophilia B Examined

20 Feb 2020

Industry Spotlight

New AI System Performs as Well as Expert Pathologists in Identifying Prostate Cancer

Researchers at the Karolinska Institutet (Stockholm, Sweden) and Tampere University (Tampere, Finland) have developed a method based on artificial intelligence (AI) for histopathological diagnosis and grading of prostate cancer. Read more
24 Feb 2020

Quest Diagnostics Acquires Blueprint Genetics

Quest Diagnostics (Secaucus, NJ, USA), a provider of diagnostic information services, has acquired Blueprint Genetics (Helsinki, Finland), a specialty genetic testing company with expertise in gene variant interpretation based on next generation sequencing (NGS) and proprietary bioinformatics. Read more
30 Jan 2020

Nova Biomedical Launches New BioProfile FLEX2 On-Line Autosampler

Nova Biomedical (Waltham, MA, USA) has launched the BioProfile FLEX2 On-Line Autosampler (OLS), a modular system that connects as many as 10 bioreactors to one FLEX2 analyzer for up to three weeks of walkaway, automated sampling, analysis, and feedback control of key cell culture analytes. Read more
03 Jan 2020

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In Other News

Image: Normal electrocardiogram (ECG) and an ECG showing QT interval prolongation (long QT syndrome). The P wave represents atrial depolarization; the QRS complex, ventricular depolarization; and the T wave, ventricular repolarization. The QT interval is measured from the beginning of the QRS complex to the return of the T wave to the isoelectric line (Photo courtesy of Mayo Clinic).

Modular Targeted Capture Assay Detects Clinically Significant Oncology Alterations

The rapid discovery of clinically significant genetic variants has translated to next-generation sequencing assays becoming out-of-date by the time they are designed, validated, and implemented. Read more
19 Feb 2020 | Molecular Diagnostics

Image: Photomicrograph of a lymph node with almost complete replacement by metastatic melanoma (Photo courtesy of Wikimedia Commons)

Assessment of Circulating Tumor Cells Identifyies Stage III Melanoma Patients at Risk for Relapse

Circulating tumor cells found in liquid biopsy specimens have been shown to be useful biomarkers for identifying stage III melanoma patients at risk for relapse. Read more
19 Feb 2020 | Molecular Diagnostics

Image: Histopathology of Lung adenocarcinoma (Photo courtesy of Nikon).

Lung Adenocarcinoma Genomic Features Differ in East Asians, Europeans

Lung adenocarcinoma is a subtype of non-small cell lung cancer (NSCLC). Lung adenocarcinoma is categorized as such by how the cancer cells look under a microscope. Read more
18 Feb 2020 | Molecular Diagnostics

Image: The ABX Pentra 400 is a compact clinical chemistry benchtop autoanalyzer (Photo courtesy of Horiba Medical).

Glycemic Markers Influenced by Chronic Kidney Disease

Chronic kidney disease (CKD) is estimated to affect about 10% of the general adult population and is even more prevalent in diabetic patients. Read more
18 Feb 2020 | Clinical Chemistry

Image: The photo shows a portable lab that plugs into a smartphone to diagnose diseases like malaria or coronavirus (Photo courtesy of Joseph Fuqua II, University of Cincinnati Creative Services)

Autonomous Microchannel Analyzer Combines with Smartphone for Off-Site Disease Diagnostics

A novel microchannel capillary flow assay platform for detection of pathogenic microorganisms or other antigens combines with a smartphone for display, data transfer, storage, and analysis. Read more
18 Feb 2020 | Molecular Diagnostics

Image: The BCS XP System is one of the most widely used fully automated hemostasis analyzers, delivers accurate and precise results (Photo courtesy of Siemens Healthcare).

Physical Activity and Thrombophilic Risk Investigated

Among the effects of physical exercise on coagulation, the influence on protein anticoagulant system and PC deficiency-related thrombophilic risk are still controversial. Read more
18 Feb 2020 | Hematology

Image: Serum from patients with or at increased risk for type 1 diabetes often possess antibodies that react with the cytoplasm of pancreatic islet cells, which is determined by indirect immunofluorescence testing of serum samples with blood group O human pancreas (Photo courtesy of American Diabetes Association).

Islet Autoantibody Screening Reveal Pediatric Type 1 Diabetes Risk

Type 1 diabetes (T1D) is a chronic progressive autoimmune disorder with complex polygenic susceptibility, usually associated with certain HLA alleles (IDDM1 locus). Read more
17 Feb 2020 | Clinical Chemistry

Image: Blood test for D-dimer showed high sensitivity and specificity in the prediction of ischemic stroke in patients with infective endocarditis (Photo courtesy of Blue Horizon).

D‐dimer Levels Predict Ischemic Stroke in Infective Endocarditis

Infective endocarditis (IE) is a life‐threatening disease, especially in developing countries. IE may present many extra‐cardiac symptoms or signs, in which neurological complications are the most prominent and severe. Read more
17 Feb 2020 | Clinical Chemistry

Image: Solution structure of IL-18 (interleukin 18) protein (Photo courtesy of Wikimedia Commons)

Protein Panel Predicts Risk for Development of Cerebral Small Vessel Disease

A network of six inflammatory biomarkers centered on interleukin-18 (IL-18) is able to predict risk for development of cerebral small vessel disease (CSVD), a brain disease currently diagnosed by MRI (magnetic resonance imaging) scan. Read more
17 Feb 2020 | Molecular Diagnostics

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$Image: In the brain of mice with Alzheimer\'s, areas near amyloid plaques (A) appear with fewer neural networks (B), dying neurons (C) and higher OCIAD1 (D). In cultured neuronal cells, the OCIAD1 proteins (E) appear in the mitochondria (F) (Photo courtesy of Houston Methodist Research Institute).$

Ovarian Cancer Protein Contributes to Alzheimer`s Disease Neurodegeneration

Alzheimer's disease is a complex neurological disorder with pathological hallmarks of hyperamyloidosis (senile plaques), neurofibrillary tangles containing hyperphosphorylated tau, and extensive neurodegeneration... Read more

Image: The Sebia Hydragel 18 Apo E Isofocusing showing different apoE isoforms from 16 patients tested. The “control serum” provided in the Sebia kit is included in each series, together with two already typed serum samples as internal controls (as an example, E3/E2 and E4/E4) (Photo courtesy of Sorbonne University).

Semi-Automatic Isoelectric Focusing Evaluated for Apolipoprotein E Phenotyping

Plasma apolipoprotein E (apoE) mainly arises from liver hepatocytes (75%), but the brain (astrocytes, oligodendrocytes, microglia, astrocytes) also synthesizes apoE found in the cerebrospinal fluid.... Read more

Image: The Q Exactive Hybrid Quadrupole-Orbitrap mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Urinary Method Detects Toxin Exposure from Harmful Algal Blooms

During harmful algal blooms (HABs), species of cyanobacteria release toxic peptides, including microcystins and nodularin into waterways, impacting wildlife and humans living in these marine environments.... Read more

Image: Synergy H1 Hybrid Multi-Mode Reader is a configurable microplate reader (Photo courtesy of BioTek)

Higher Female TSH Associated With Lower Mannan-Binding Lectin

Mannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Lower MBL levels are associated with, among other conditions, hypothyroidism and adverse pregnancy outcomes.... Read more

Molecular Diagnostics

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Coronavirus Health Crisis: The Race for Diagnostic Remedies

A new coronavirus designated COVID-19 and also known as 2019-nCoV, is rapidly spreading from its origin in Wuhan, Hubei Province, China. At present the number of infected globally is reported at 60,595... Read more

Image: Histopathology of early gastric cancer, an intramucosal adenocarcinoma. A blood test used in a targeted methylation (TM) sequencing assay may help detect hard-to-detect gastrointestinal cancers in asymptomatic individuals (Photo courtesy of Andrey Bychkov, MD, PhD).

Blood Test Lead to Earlier Detection of Gastrointestinal Cancers

Gastrointestinal cancer refers to malignant conditions of the gastrointestinal tract (GI tract) and accessory organs of digestion, including the esophagus, stomach, biliary system, pancreas, small intestine,... Read more

Two Rapid Tests for Diagnosis of the Novel Chinese Coronavirus

Two new rapid diagnostic tests are set to enable clinicians to detect individuals infected with the potentially pandemic “Chinese” coronavirus. A novel coronavirus of zoonotic origin (2019-nCoV) has... Read more

Image: Vivalytic: The molecular diagnostics point-of-care analyzer (Photo courtesy of Randox Laboratories)

Rapid Diagnostic Tests Set to Distinguish Coronavirus from Other Respiratory Infections

The global health diagnostics company Randox Laboratories (Crumlin, United Kingdom) has announced the imminent release of a rapid diagnostic test for the 2019-nCoV strain of coronavirus.... Read more

Hematology

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Image: The DOAC dipstick is a diagnostic urine test strip, which is intended for qualitative detection of the absence or presence of direct oral anticoagulants (DOACs: Dabigatran, Apixaban, Edoxaban and Rivaroxaban) in human urine by visual identification of colors (Photo courtesy of DOASENSE GmbH).

Direct Oral Anticoagulants Determined by RDT in Urine Samples

The rapid determination of the presence of direct oral anticoagulants (DOACs) in a patient remains a major challenge in emergency medicine and for rapid medical treatment decisions. All DOACs are excreted... Read more

Image: The BD FACSVerse Flow Cytometer (Photo courtesy of BD Biosciences).

Immune Profiles Analyzed in Acute Myeloid Leukemia Bone Marrow

In acute myeloid leukemia (AML), myeloid lineage precursor cells modified by somatic mutations and transcriptomic dysregulation infiltrate the bone marrow (BM) and disrupt normal hematopoiesis.... Read more

Image: Acute Myeloid Leukemia: The blasts are medium to large in size and have an elevated nuclear: cytoplasmic ratio. The nuclear chromatin is fine and there are prominent nucleoli. Frequent blasts show indented or “cup-shaped” nuclear contours (Photo courtesy of Elizabeth Courville, MD).

Bone Marrow Donors May Transfer Pathogenic Mutations to Patients

Clonal hematopoiesis of indeterminate potential, or CHIP, is characterized by the presence of mutant hematopoietic stem cell clones in the bone marrow without overt signs of disease. However, emerging... Read more

Image: Schematic diagram of deep vein thrombosis (DVT) that is associated with metabolic syndrome (Photo courtesy of MediConnect).

Metabolic Syndrome Associated with Increased Blood Clot Recurrence Risk

People with metabolic syndrome which are a set of conditions including obesity, impaired glucose metabolism, elevated levels of fats and cholesterol in the blood, and high blood pressure, are more likely... Read more

Immunology

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Image: The Spark multimode reader performs accurate and sensitive measurements of fluorescent cell-based assays (Photo courtesy of TECAN).

Two Chikungunya Virus IgM Enzyme-Linked Immunoassays Evaluated

Chikungunya virus (CHIKV) is an alphavirus transmitted by Aedes (Stegomyia) spp. mosquitoes. Transmission was initially restricted to small outbreaks and sporadic cases in Africa and Asia, but since early... Read more

Image: The MILLIPLEX MAP Human Cytokine/Chemokine Magnetic Bead Panel - Premixed 30 Plex - Immunology Multiplex Assay (Photo courtesy of Merck).

Diagnostic Efficacy of Immunomarkers in Fungal Bloodstream Infection

Fungemia is the presence of fungi or yeasts in the blood and is a life‐threatening condition with the global mortality rate surging more than fivefold in the past decade. It has been reported that the... Read more

Image: A melanoma on a patient`s skin: a new test predicts which melanoma patients are at risk of cancer recurrence and metastases (Photo courtesy of US National Cancer Institute).

Technique Predicts Cancer Recurrence Risk for Melanoma Patients

Many primary melanomas can be cured by having this lesion removed, but melanoma can also recur and spread; an analysis of the removed lesion can offer some information on the likelihood that the cancer will recur.... Read more

Image: Biomarkers, including interleukin-6, have been isolated that can identify delirium risk and severity (Photo courtesy of Blood Tests London).

Biomarkers Identified for Delirium Risk and Severity

An estimated seven million hospitalized Americans suffer from the acute confusion and disorientation, characteristics of delirium, including a majority of patients in medical or surgical intensive care units (ICUs).... Read more

Microbiology

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Image: The FUJI DRI-CHEM IMMUNO AG1 analyzer (Photo courtesy of FUJI FILM).

Rapid Antigenic Diagnostic Test Validated for Ebola Virus Disease

Hemorrhagic fever outbreaks are difficult to diagnose and control in part because of a lack of low-cost and easily accessible diagnostic structures in countries where etiologic agents are present.... Read more

Image: The LIOFeron TB/LTBI is a novel interferon-gamma release test for diagnosing latent tuberculosis (LTBI)/TB infection (Photo courtesy of Lionex GmbH).

Novel Reliable Assay for Tuberculosis and LTBI Tested

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) complex organisms, is still one of the most prevalent human infections worldwide estimated in 2018 with 1.2 million deaths among human immunodeficiency... Read more

Image: Illustration of a 2019- novel coronavirus (nCoV) virion (Photo courtesy of Alissa Eckert, MS/CDC).

CDC Provides Test Protocol for Novel Coronavirus

The US Centers for Disease Control and Prevention (Atlanta GA, USA) has publicly posted its assay for novel coronavirus 2019-nCoV and is now developing the test into kits. The CDC diagnostic test is a... Read more

Real-Time PCR Developed for Eumycetoma Diagnosis

Mycetoma, a progressive and disfiguring disease, is one of the neglected tropical diseases, caused by both bacteria and fungi. Eumycetoma is the fungal type and mainly caused by species of the genus Madurella.... Read more

Pathology

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Image: Workflow of cancer personalized profiling by deep sequencing (CAPP-Seq) circulating tumor-DNA analysis (ctDNA) (Photo courtesy of Rashedul Islam Rony, PhD).

Lung Cancer Liquid Biopsy Guides MRD-Directed Adjuvant Therapy

Minimal residual disease (MRD) is the name given to small numbers of leukemic cells (cancer cells from the bone marrow) that remain in the person during treatment or after treatment when the patient is... Read more

$Image: The myTAIHEART test is a powerful non-invasive test that uses a small sample of blood to determine if a patient is at a low or increased risk of rejecting their heart transplant. myTAIHEART works by measuring the fraction of cell-free DNA (cfDNA) present in the bloodstream that is attributable to the transplanted heart. An elevated donor fraction (DF%) is associated with an increased risk of acute cellular rejection (Photo courtesy of TAI Diagnostics).$