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Image: A scanning electron micrograph (SEM) of ovarian cancer cells (Photo courtesy of SPL).

MALDI-TOF-MS Analysis Identifies Ovarian Cancer Patterns

Ovarian cancer (OC) is one of the leading causes of death among all gynecological malignancies and as there are no early specific symptoms, OC is diagnosed in advanced clinical stages in more than 70% cases when, despite appropriate treatment, five-year survival rate drops to 30%. Read more
18 Jul 2017 | Clinical Chemistry
Image: Myoblast fusion. This graphic depicts normal myoblast (early muscle cells with a single nucleus) fusing together to form myocytes (multinucleated muscle cells) during myogenesis. In Carey-Fineman-Ziter syndrome this cascade is disrupted because of a defect in the membrane protein myomaker (MYMK) required for cell-cell fusion (Photo courtesy of Darryl Leja, NHGRI).

Genetic Mutations Causing CFZ Syndrome Identified

Researchers have identified gene mutations that cause, via a defect in myoblasts fusion, the rare inherited muscle disorder Carey-Fineman-Ziter Syndrome (CFZS), and have thereby also uncovered a mechanism underlying muscle development. Read more
18 Jul 2017 | Molecular Diagnostics
Image: Research being conducted uses an atmospheric-pressure glow discharge plasma to probe samples for elemental and molecular species, and could lead to user-friendly MS analyses with broad capabilities (Photo courtesy of the Rensselaer Polytechnic Institute).

Mass Spectrometry Detection for the Masses

Researchers are developing a plasma-based technology to enable generalized use of mass spectrometry (MS) with new instruments that can analyze a much broader range of molecular species than current technology allows. Read more
17 Jul 2017 | Lab Tech.
Image: The new PERiPLEX point-of-care test (Photo courtesy of Mologic).

CE-Marked Immunoassay Rapidly Detects Infection Biomarkers

CE mark approval has been given for a point-of-care (POC) test for rapid detection of infection in patients on peritoneal dialysis (PD), enabling early diagnosis and treatment critical for preventing infection-related damage to the peritoneal membrane. Read more
17 Jul 2017 | Immunology
Image: A space-filling model of substance P (Photo courtesy of Wikimedia Commons).

Tear Substance Indicates Possible Nerve Damage in Diabetes Patients

Measurement of levels of substance P peptide in tears has been proposed as a method for determining possible nerve damage in individuals suffering from diabetes. Read more
17 Jul 2017 | Molecular Diagnostics
Image: A histopathology of urothelial carcinoma of the urinary bladder (Photo courtesy of Wikimedia Commons).

Urine Test Predicts Bladder Cancer Recurrence

A test that detects a specific enzyme in the urine is able to predict the likelihood of recurrence of disease in patients that have been treated for bladder cancer. Read more
17 Jul 2017 | Molecular Diagnostics
Image: A light microscopy of an egg of Amphimerus sp. observed in a fecal specimen from Ecuador, almost indistinguishable from some other liver fluke eggs (Photo courtesy of Universidad Central del Ecuador).

Assay Detects Fish Trematode DNA in Human Stools

Amphimeriasis is a fish-borne disease caused by the liver fluke Amphimerus spp. that has recently been reported as endemic in the tropical Pacific side of Ecuador with a high prevalence in humans and domestic animals. Read more
13 Jul 2017 | Molecular Diagnostics
Image: Clinical scientists analyzed the platelet counts of 249 patients with thalassemia, which were compared with the international reference method (IRM) for platelet counting in patients with thalassemia (Photo courtesy of Mahidol University).

Platelet Counts Compared for Thalassemia Patients

Platelet count is the component of complete blood count that is used to diagnose quantitative defect in platelets. Read more
13 Jul 2017 | Hematology

Channels

Clinical Chemistry

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Wearable Tool Created for Monitoring Diabetes
Thermo Clinical Analyzer Provides Range of Laboratory Tests
Amine Biomarkers Identify Risk of Alzheimer's Disease
Image: In a review of studies on opioid genetics, researchers pinpointed 10 genes that show the highest potential of refining the way opioids are prescribed and that healthcare providers should focus on implementing clinically (Photo courtesy of Getty Images).

Opioid-Related Deaths Possibly Prevented By Gene Testing

More than 17,500 Americans died in 2015 from prescription opioid overdoses, which are more than quadruple the amount of people who died from this cause in 1999, but it is not just abuse of these medications... Read more

Molecular Diagnostics

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Gene Mutation Causes Rare Immune Disorder
Study Validates Test to Predict Breast Cancer Risk
Protein Biomarker Panel Detects ASD in Young Boys
Image: The dipstick device, a single-component, customizable, inexpensive biosensor uses live cells to detect pathogens worldwide (Photo courtesy of Columbia University).

Yeast-Based Tool Developed for Pathogen Detection

The monitoring of global pathogen burden has been traditionally limited to a small number of specialized centers, but more effective detection could be performed in real time by making accurate diagnostics... Read more

Hematology

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Fully Automated Coagulation System Launched
Next-Generation Hematology Analyzer Introduced
Peripheral Blood Smears Still Need Evaluation
Image: A new test to aid in the detection of several leukemias and lymphomas has been approved by the FDA (Photio courtesy of Shutterstock).

FDA Approves New Diagnostic Tool for Leukemias and Lymphomas

A test for use with flow cytometry to aid in the detection of several leukemias and lymphomas, including chronic leukemia, acute leukemia, non-Hodgkin lymphoma, myeloma, myelodysplastic syndrome (MDS)... Read more

Immunology

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Toxoplasmosis POC Test Compared to Conventional Testing
Combined Molecular Test Distinguishes Benign Pancreatic Lesions
Reliable Test Sought for Anti-Phospholipid Antibody Syndrome
Image: The ImmunoDOT is a proprietary dotblot method reporting a semi-quantitative IgM titer for leptospirosis (Photo courtesy of GenBio).

Assays Evaluated for Early Diagnosis of Leptospirosis

Leptospirosis is a potentially life-threatening but curable zoonosis whose prognosis depends on accurate and timely diagnosis and because of its non-specific clinical presentation, laboratory testing is... Read more

Microbiology

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Women with HIV Frequently Pass CMV to Infant
Immunoassay Developed for Acute Typhoid Fever
HIV Testing Peaks with Charlie Sheen Disclosure
Image: The new QuantiFERON-TB Gold Plus blood test for latent-TB (Photo courtesy of QIAGEN).

FDA Approves Fourth-Generation Blood Test

The US Food and Drug Administration (FDA) has approved a next-gen assay for latent tuberculosis (TB) infection that combines breakthrough CD4/CD8 design for comprehensive immune response detection with... Read more

Pathology

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Liquid Biopsy Blood Tests Detect CtDNA
Simple Test Improves Treatment for Colon Cancer Patients
HPV Testing Leads to Earlier Detection of Pre-Cancer
Image: A scientist adjusting the versatile light-sheet microscope that can provide surgeons with real-time pathology data to guide cancer-removal surgeries and can also non-destructively examine tumor biopsies in 3D (Photo courtesy of Mark Stone/University of Washington).

Novel Microscope Scans Tumors and Examines Biopsies

Current pathology techniques involve processing and staining tissue samples, embedding them in wax blocks, slicing them thinly, mounting them on slides, staining them, and then viewing these two-dimensional... Read more

Lab Tech.

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Lab-on-a-Chip Nanotechnology Tracks Multiple Markers
Data Management System Integrates Complex Image Data
Web Calculator Estimates Survival of Bowel Cancer Patients
Image: Microfluidic bioassay devices are currently the preferred diagnostic tools. They measure concentration of disease biomarkers within a patient sample, such as blood, which is passed across a surface containing immobilized bioreceptors to capture the biomarker. They can indicate the likelihood of a disease based on presence/absence or based on comparison of the biomarker concentration in the sample relative to the normal body level (Image courtesy of Okinawa Institute of Science and Technology Graduate University).

Miniature Technology May Improve Disease Detection

Researchers have developed an improved microcontact printing technology to create an optimal disease diagnostic device of bioreceptor arrays for multiplexed microfluidic assays. Since efficiency of... Read more

Industry News

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PerkinElmer to Acquire EUROIMMUN
Robotic Use Increases to Speed Lab Workflow
Transasia Showcases Clinical Lab Solutions at APPI 2017
Image: A new alliance has been formed with the goal of driving digitization in medicine and healthcare (Photo courtesy of PixelsTech).

Alliance Formed to Digitalize Medicine and Healthcare

The Universitätsklinikum Erlangen, Siemens Healthineers (Erlangen, Germany), the Friedrich-Alexander-Universität-Erlangen-Nürnberg (FAU), the Fraunhofer Institute for Integrated Circuits (IIS), and Medical... Read more

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