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Image: The structure of a lipopolysaccharide (Photo courtesy of Wikimedia Commons).

MicroRNA Pair Serves as Biomarkers for Rapid Sepsis Diagnosis

Two microRNAs that could be the basis of a test to help physicians classify patients into those with organ failure who are at high risk of sepsis and death and those patients with milder infections have been identified. Read more
16 Jul 2018 | Molecular Diagnostics
Image: Reducing variability of quantitative suspension array assays is critical to the success of multi-center and large sero-epidemiological studies (Photo courtesy of Pau Fabregat).

Optimization of Analytical Procedures Reduces Variability of Results

A team of Spanish researchers recently described the development and optimization of several "quantitative suspension array" assays (qSAT) designed to assess natural and vaccine-induced responses to malaria and other parasites. Read more
16 Jul 2018 | Molecular Diagnostics
Image: The HumaStar 80 clinical chemistry analyzer (Photo courtesy of Human Diagnostics).

Biochemical Changes in Stored Donor Units Analyzed

Blood transfusion with allogeneic blood products is a common medical intervention to treat anemia or prepare patients for surgical procedures and generally, the blood units are secured and stored prior to expected transfusion. Read more
12 Jul 2018 | Hematology
Image: Genetic risk correlations among brain disorders and quantitative phenotypes (Photo courtesy of the Brainstorm Consortium).

Genetic Connections Uncovered Between Psychiatric Disorders

Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. Read more
12 Jul 2018 | Molecular Diagnostics
Image: The AR-V7 protein is a prognostic and predictive biomarker. Detection of AR-V7-positive tumor cells by the Oncotype DX test indicates that the patient will no longer benefit from commonly prescribed ARSI therapies but can still benefit from chemotherapy to prolong survival (Photo courtesy of Genomic Health/Epic Sciences).

Circulating Tumor Cell-Based AR-V7 Test Validated

A blood test to determine whether to treat patients with metastatic castration-resistant prostate cancer (mCRPC) with an androgen receptor signaling inhibitor (ARSI) or taxane is an unmet medical need. Read more
12 Jul 2018 | Pathology
Image: The Procleix Panther system, a fully integrated and automated nucleic acid technology system for blood and plasma screening (Photo courtesy of Grifols Diagnostics).

Two Viral Blood Screening Assays Get FDA Clearance

Hello,

A global producer of plasma-derived medicines and a developer of diagnostic solutions announced today that it has received approval from the U. Read more
11 Jul 2018 | Hematology
Image: Colonies of Pseudomonas aeruginosa on blood agar after cultivation for 48 hours at 37°C. Small, smooth colonies are Enterococcus faecalis (Photo courtesy of microbiologypictures).

Female Bladder Bacteria Reveal Urogenital Microbiota

Contrary to medical dogma, urine is not sterile, even in asymptomatic individuals. For over 60 years, the standard urine culture protocol has represented the primary tool for detecting bacteria in clinical microbiology laboratories. Read more
11 Jul 2018 | Microbiology
Image: The Accela liquid chromatography system (Photo courtesy of Thermo Fisher Scientific).

Lipid Species Offer Insights into Metabolic Health

Heart disease is the number one killer in the USA, and high triglyceride levels in the blood are cited as just one of several risk factors. Read more
11 Jul 2018 | Clinical Chemistry
Image: A bronchial tube, cells stained red and blue are part of the bronchial epithelium, or lining. This demonstrates the existence among these cells of a rare cell type (stained blue-green), believed to be a tuft cell. The scientists have discovered a new type of lung cancer with origins in these cells, which overexpress a gene-regulating protein called POU2F3, a potential target for therapy (Photo courtesy of Cold Spring Harbor Laboratory).

New Genre of Small-Cell Lung Cancer Discovered

Small cell lung cancer (SCLC) is widely considered to be a tumor of pulmonary neuroendocrine cells; however, a variant form of this disease has been described that lacks neuroendocrine features. Read more
10 Jul 2018 | Pathology
Image: A stained cerebrospinal fluid preparation from a case of acute bacterial (pneumococcal) meningitis. There are numerous neutrophils and bacteria (Photo courtesy of Dr. Edmund S. Cibas, MD).

Rising Diagnosis of Viral Meningitis Is Often Delayed

As the incidence of bacterial meningitis decreases, the proportion of meningitis cases caused by viruses is increasing and the use of molecular diagnostics has also led to increased recognition of neurological viral infections. Read more
10 Jul 2018 | Microbiology
Image: Motion-based immunological detection of Zika virus using Platinum (Pt)-Nanomotors and a cell phone (Photo courtesy of Brigham and Women\'s Hospital).

Rapid Zika Detection Test Uses Smartphone Technology

The Zika virus, which continues to cause microcephaly and other neurological complications in infants whose mothers were infected during pregnancy, remains a public health concern. Read more
10 Jul 2018 | Lab Tech.

Channels

Clinical Chemistry

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Blood Test Predicts Coronary Disease Death Risk
Method Identifies Cancer in Early Onset Diabetics
Vitamin D Levels Linked to Colorectal Cancer Risk
Image: A new electrochemical method developed to test the presence of a bacterial infection using strips is faster and more accurate than methods currently on the market (Photo courtesy of the University of Texas at San Antonio).

New Method Can Quickly and Accurately Detect Infections

A method has been developed that can show quickly and accurately whether a person has been infected with harmful bacteria or other pathogens and additionally, this new method shows the exact severity of... Read more

Molecular Diagnostics

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Variant CJD Diagnosed by Protein Misfolding Amplification
Recurrent Rearrangements Identified in Soft Tissue Tumors
DNA Code Unraveled for Rare Neurologic Disease
Image: An artist\'s depiction of the operating principle of single-molecule sequencing (Photo courtesy of Osaka University).

Current-Tunneling Measurements Analyze Single DNA Molecules

A team of Japanese genomics researchers has devised a method for cancer diagnosis, which is based on the analysis of single molecules of DNA without the need for chemical modification or amplification.... Read more

Hematology

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NIV Test Developed for Fetal Rhesus Factor
Sequencing Enables Precise Match for Blood Transfusions
Early Sepsis Indicator Alerts Emergency Department Clinicians
Image: The BD Vacutainer UltraTouch push button blood collection set (Photo courtesy of Becton Dickinson).

Novel Device Contributes to Positive Phlebotomy Experience

Phlebotomy is a necessary procedure that may be a source of pain, stress and anxiety for some patients. While smaller gauge needles are known to lessen patient discomfort, they are often associated with... Read more

Immunology

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Gene Signatures and Biomarkers Predict RA Onset
Antibodies Interpreted after Scrub Typhus Infection
Serum Markers Used to Develop Lupus Risk Index
Image: Specific IgE antibodies against inhalation allergens that commonly occur in Southern Europe can be detected and differentiated using the new multiparameter immunoblot EUROLINE DPA-Dx Pollen Southern Europe (Photo courtesy of EUROIMMUN).

Immunoblot Test Differentiates Pollen Allergies Diagnoses

Specific immunoglobulin E (IgE) antibodies against inhalation allergens that commonly occur in Southern Europe can be detected and differentiated using a new multiparameter immunoblot test.... Read more

Microbiology

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Loop-Mediated Isothermal Amplification Identifies Malaria Species
Vaginal Bacteria Linked to Cervical Cancer
Malaria Rapid Tests Remain Positive after Drug Treatment
Image: The Xpert Xpress Flu/RSV Assay Cassette (Photo courtesy of Cepheid).

Saliva Specimens Diagnose Respiratory Virus by POC Assay

The use of saliva as a specimen for the detection of respiratory viruses has been proposed as an alternative to nasopharyngeal aspirate or nasopharyngeal swab: saliva may have the advantage to cause less... Read more

Pathology

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Fine-Scale Histologic Features Estimated at Low Magnification
Hereditary Breast Cancer Tests Double Detection Rate
Cell Block Prep Method Modified for Molecular Studies
Image: A histopathology of papillary non–muscle-invasive bladder cancer (Photo courtesy of American Urological Association).

Simple Test Could Reduce Treatment of Bladder Cancer

Bladder cancer is relatively common and imposes the highest per patient cost on the healthcare system of the USA than the management of any other cancer type. Most bladder cancers are early-stage tumors... Read more

Lab Tech.

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Tissue-Imaging Technology Enables Real-Time Diagnostics
Biochip Developed to Detect Prostate Cancer Cells
Testing Device Integrates Robotic Phlebotomy with Sample Processing
Image: The Vacuette Serum Fast Tubes, which offer a coagulation time of only five minutes (Photo courtesy of Greiner Bio-One).

Blood Separation Tubes Combine Serum Analysis with Plasma Analysis

A new line of blood separation tubes combines the quality of serum analysis with the speed of plasma analysis. Greiner Bio-One (Kremsmünster, Austria) has released the Vacuette Serum Fast Tube, which... Read more

Industry News

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Global Molecular Diagnostics Market to Reach USD 11 Billion by 2023
Global POC Coag Test Market Driven by Increasing Geriatrics
Global PCR Market to Surpass USD 7 Billion by 2025
Image: CerTest Biotec has opened a new facility in Spain for R&D and manufacture of molecular diagnostics products (Photo courtesy of CerTest Biotec).

CerTest Biotec Opens New Facility for Diagnostic Products

CerTest Biotec (Zaragoza, Spain), a biotechnology company focused on the development and manufacturing of IVD diagnostic products, has opened a new facility in Spain for the research, development and manufacture... Read more

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