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AACC:
A Shared Passion for Positive Patient Outcomes: 2020 AACC Annual Scientific Meeting & Clin Lab Expo

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Events

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ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

30 Sep 2020 - 03 Oct 2020

BCLF 2020 - 28th Balkan Clinical Laboratory Federation Meeting

01 Oct 2020 - 02 Oct 2020
Virtual Venue

BSACI 2020 – Annual Conference of the British Society for Allergy and Clinical Immunology

14 Oct 2020 - 17 Oct 2020
Virtual Venue

SIOP 2020 – 52nd Annual Congress of the International Society of Paediatric Oncology (SIOP)

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Statins Reduce COVID-19 Severity by Removing Cholesterol Used by SARS-CoV-2 to Infect Cells

Researchers Predict Which Antibodies Provide Best Protection Against SARS-CoV-2 and Which COVID-19 Vaccines Might Help

Discovery of Highly Effective SARS-CoV-2 Antibodies to Aid Development of Passive Vaccination

Exposure to Mosquito-Transmitted Dengue May Provide Immunity Against COVID-19

FDA to Issue Stricter Guidance for Emergency Authorization of COVID-19 Vaccine

FDA Authorizes First Nanopore Sequencing-Based Test for SARS-CoV-2

FDA Authorizes First Point-of-Care Antibody COVID-19 Test

New Test Developed with Simplified Buffer Formations Enables Fast, Cheap and Accurate COVID-19 Diagnosis

New COVID-19 Antibody Assay Can Analyze Up to 40,000 Samples per Day Using Serum or Dried Blood

New ABC Test for Influenza A, Influenza B, and COVID-19 to Be Launched in First Week of October

Routine Blood Test Predicts Increased Mortality Risk in COVID-19 Patients

Four-in-One Test Kit for Detecting Influenza A, Influenza B, RSV and SARS-CoV-2 Set to Launch in November

Mannose-Binding Lectin Associated with Coagulopathy in Severe COVID-19

More COVID-19 News

Mannose-Binding Lectin Associated with Coagulopathy in Severe COVID-19

Image: An enzyme-linked immunosorbent assay for mannose-binding lectin found that this molecule is associated with coagulopathy in severe COVID-19 patients (Photo courtesy of Getty Images).

The ongoing COVID-19 pandemic has caused significant morbidity and mortality worldwide, as well as profound effects on society. COVID-19 patients have an increased risk of thromboembolic (TE) complications, which develop despite pharmacological thromboprophylaxis. Read more
24 Sep 2020

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Detects 3 SARS-CoV-2 targets in parallel, the targets are recommended by the WHO. No other tests worldwide focuses on 3 targets.
2 controls are included: Showing the sample quality; Extraction and inhibition control.

LINEAR CHEMICALS S.L.U

Ammonia Predicts Prognosis in Hepatitis B Virus‐Related Liver Failure

24 Sep 2020

Hematological Parameters Evaluated for Cervicocranial Arterial Dissection Stroke

23 Sep 2020

Genomic Copy Number Predicts Esophageal Cancer Years Before Transformation

23 Sep 2020

Paper-Based Microneedle Skin Patch for Continuous Glucose Monitoring

23 Sep 2020

Circulating Tumor DNA Analysis Directs Therapy in Breast Cancer

22 Sep 2020

Industry Spotlight

2020 AACC Annual Scientific Meeting & Clinical Lab Expo to Be an All Virtual Event Due to Coronavirus Pandemic

The American Association for Clinical Chemistry (AACC Washington, DC, USA) has decided to hold the 2020 AACC Annual Scientific Meeting & Clinical Lab Expo as a virtual event, rather than as a live meeting, due to the ongoing coronavirus pandemic. Read more
25 Aug 2020

QIAGEN to Focus on Molecular Testing amidst Coronavirus Pandemic after Voluntary Public Takeover Offer by Thermo Fisher Falls Short

QIAGEN N.V. (Venlo, Netherlands) plans to continue executing its growth strategy aimed at creating significant value for shareholders and other stakeholders after the voluntary public takeover offer by Thermo Fisher Scientific Inc. Read more
14 Aug 2020

Awareness Technology Announces ChemWell RPR Analyzer - The Most Significant Innovation in Syphilis Testing in Last 30 Years

Awareness Technology, Inc. (Palm City, FL, USA) has announced the most significant innovation in syphilis testing in the last 30 years with the launch of the ChemWell RPR automated nontreponemal analyzer for the detection of syphilis. Read more
17 Jul 2020

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In Other News

FDA Authorizes First Nanopore Sequencing-Based Test for SARS-CoV-2

The US Food and Drug Administration (FDA) has issued an emergency use authorization (EUA) to the Clear Dx SARS-CoV-2 novel descriptive diagnostic from Clear Labs (San Carlos, CA, USA), making it the first nanopore sequencing-based test for SARS-CoV-2 to receive EUA. Read more
25 Sep 2020 | COVID-19

New ABC Test for Influenza A, Influenza B, and COVID-19 to Be Launched in First Week of October

A new ABC Test (Influenza A/Influenza B/COVID-19) is anticipated to be ready for launch to US CLIA laboratory customers the first week of October 2020. Read more
25 Sep 2020 | COVID-19

FDA Authorizes First Point-of-Care Antibody COVID-19 Test

The US Food and Drug Administration (FDA Silver Spring, MD, USA) has issued an emergency use authorization (EUA) for the first serology (antibody) point-of-care (POC) test for COVID-19. Read more
25 Sep 2020 | COVID-19

Routine Blood Test Predicts Increased Mortality Risk in COVID-19 Patients

A standard test that assesses blood cells can identify which patients who are admitted to the hospital with COVID-19 face a high risk of becoming critically ill and dying. Read more
24 Sep 2020 | COVID-19

Image: Researchers at Karolinska Institutet have developed methods that completely circumvent the RNA-extraction procedure (Photo courtesy of Karolinska Institutet)

New Test Developed with Simplified Buffer Formations Enables Fast, Cheap and Accurate COVID-19 Diagnosis

A new method developed for fast, cheap, yet accurate testing for COVID-19 infection simplifies and frees the testing from expensive reaction steps, enabling upscaling of the diagnostics and making it particularly attractive for places and situations with limited resources, for repeated testing and for moving resources from expensive diagnostics to other parts of the care chain. Read more
24 Sep 2020 | COVID-19

Four-in-One Test Kit for Detecting Influenza A, Influenza B, RSV and SARS-CoV-2 Set to Launch in November

A new four-in-one test kit for detecting influenza A, influenza B, RSV and SARS-CoV-2 is set to be launched in the coming month of November before the flu season begins in the Northern hemisphere. Read more
24 Sep 2020 | COVID-19

New COVID-19 Antibody Assay Can Analyze Up to 40,000 Samples per Day Using Serum or Dried Blood

A new COVID-19 antibody assay can analyze up to 40,000 samples per day and is suitable for both serum and dried blood sampling. Read more
24 Sep 2020 | COVID-19

Global COVID-19 Test Kits Market to Surpass USD 13 Billion by 2026

The global COVID-19 test kits market with a current market value of USD 15.4 billion in 2020 is expected to record revenue of more than USD 13 billion by 2026, driven primarily by the high efficiency and accuracy of RT-PCR based COVID-19 detection kits for the detection of the SARS-CoV-2 virus. Read more
23 Sep 2020 | COVID-19

GK Pharmaceuticals Accu-Right SARS-CoV-2 RT-PCR Kit Granted FDA Emergency Use Authorization

GK Pharmaceuticals CMO (Manatí, Puerto Rico, USA) has been granted Emergency Use Authorization (EUA) by the US Food and Drug Administration (FDA) for the company’s GK ACCU-RIGHT SARS-CoV-2 assay. Read more
23 Sep 2020 | COVID-19

Image: SwabBot (Photo courtesy of Biobot Surgical Pte Ltd)

World's First Patient-Controlled Nasopharyngeal Swab Robot for COVID-19 Testing Reduces Risk of Exposure to SARS-CoV-2

A new robot for automated COVID-19 swab test could provide a solution to protect and reduce the risk of exposure faced by healthcare workers to the SARS-CoV-2 virus. Read more
23 Sep 2020 | COVID-19

Gut Microbiome Data Helps Routine Screening of Cardiovascular Disease

Besides genetics and environmental factors, gut microbiota has emerged as a new factor influencing cardiovascular disease (CVD). Read more
22 Sep 2020 | Microbiology

Image: The Aedes aegypti mosquito can spread various tropical diseases including dengue, zika, and chikungunya, which have similar symptoms (Photo courtesy of Gwangju Institute of Science and Technology)

A Paper-Based Nucleic Acid Testing Device for Rapid Diagnosis of Mosquito-Borne Viral Diseases

An all-in-one nucleic acid testing device loaded into a paper chip forms the basis for a simple, rapid diagnostic test for a range of mosquito-borne viral diseases. Read more
22 Sep 2020 | Molecular Diagnostics

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Clinical Chemistry

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Image: Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer (Photo courtesy of Thermo Fisher Scientific).

Molecular Diagnostics

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Image: Upconverting nanoparticles: With the combination of NIR-excitation (980 nanometers) and detection at a lower wavelength, the autofluorescence from biological samples is totally eliminated, and the particles are detectable through tissue sections and even in whole blood (Photo courtesy of Kaivogen Oy)

Novel Rapid Lateral Flow Assay Measures Ovarian Cancer Biomarker CA125

A radically modified lateral flow immunoassay was able to detect the ovarian cancer biomarker glycosylated CA125 in serum samples and rapidly differentiate epithelial ovarian cancer from benign endometriosis... Read more

Biosensing Platform Diagnoses Diseases Through Single Molecule Detection

A new diagnostic approach employs a DNA origami biosensor platform coupled with a nanopore read-out that enables individual biomarker detection. The ability to detect low concentrations of biomarkers... Read more

Image: Histopathology of the coronary artery demonstrating an intramural hematoma compressing the vessel lumen from outside from a patient with spontaneous coronary artery dissection (Photo courtesy of Professor Mary N Sheppard, MBBCh FRCPath).

Genetics Influence Risk for Spontaneous Coronary Artery Dissection

Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of myocardial infarction (MI) in young and otherwise healthy women, for which the etiology is incompletely understood.... Read more

Image: Using advanced biochemical analysis of patient serum, researchers found signatures that help predict which patients are at highest risk of dying from S. aureus bacteremia, a blood infection (Photo courtesy of University of California, San Diego)

Proteomics-Based Diagnostic Test Predicts Risk of Dying from Staphylococcus aureus Bacteremia

A diagnostic approach that integrates proteomic and metabolomic techniques enabled the identification of biomarkers that could predict which patients had the highest risk of dying from Staphylococcus aureus... Read more

Hematology

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Quantitative Agglutination Determined on Automatic Hematology Analyzer

The currently available agglutination identification methods are slide methods and test tube methods. Based on the distribution, uniformity and comprehensive changes of non-aggregated cells and agglutinating... Read more

Complex ABO Glycan Phenotypes Predicted by Lectin Microarrays

Serological classification of individuals as A, B, O, or AB is a mainstay of blood banking. ABO blood groups or ABH antigens, in addition to other surface glycans, act as unique red blood cell (RBC) signatures... Read more

Positive Lymphocyte Gene Rearrangement Evaluated for Hematologic Malignancies

The diagnosis of a lymphoid malignancy requires the establishment of monoclonality of a lymphocyte population through morphologic assessment and laboratory testing, such as flow cytometry, immunohistochemistry,... Read more

Image: A blood film with a normal mature lymphocyte with a single large nucleus is seen on the left, compared to two segmented neutrophils on the right with multiple nuclear lobes. The lymphocytes are decreased in comorbid diabetes and COVID-19 patients (Photo courtesy of Ed Reschke).

Lymphocyte Count Correlated to Comorbid Diabetes and COVID-19

The coronavirus disease (COVID-19) that erupted in China since December 2019 and has gradually spread throughout the world. At present, it has caused tens of thousands of deaths, and the efficacy of certain... Read more

Immunology

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Click Chip’ Detects Early-Stage Liver Cancer Biomarkers in Extracellular Vesicles

Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related deaths worldwide. The poor prognosis of HCC can be attributed to the fact that diagnosis is often made at a late stage in... Read more

Image: Histology of normal small intestinal mucosa in adequately treated celiac disease (A). Untreated coeliac disease shows the classic triad of infiltration of the epithelium with lymphocytes, crypt hyperplasia and villous atrophy (B) (Photo courtesy of Professor Jason Tye-Din, MBBS PhD).

Unique Antibody Profile Differentiates Gluten Sensitivity from Celiac Disease

Until recently, many doctors often dismissed the complaints of people who claimed to be sensitive to foods containing gluten but did not have celiac disease, a well-documented autoimmune disease triggered... Read more

Image: Increased MAIT and iNKT cell activation is associated with improved outcome in severe COVID-19 patients (Photo courtesy of the University of Tours).

Unconventional T Cells in COVID-19 Patients Predicts Disease Outcome

While most people infected with the SARS-CoV-2 virus experience relatively mild symptoms, some patients mount an aberrant inflammatory response that can damage the lungs and cause acute respiratory distress... Read more

New Gold and Copper Nanoshell-Enhanced Immunoblotting Technique Makes POC Diagnosis of Tuberculosis Easier

A team of researchers have developed a straightforward and naked-eye-sensitive nanoshell-enhanced immunoblotting technique to detect Mycobacterium tuberculosis (MTB) antigen 85B (Ag85B).... Read more

Microbiology

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Loop-Mediated Isothermal Amplification Kit Detects Chagas Disease

Chagas disease (CD), also known as American trypanosomiasis, is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi that affects about six to seven million people worldwide,... Read more

Traveler's Diarrhea Among Soldiers Linked to Gut Microbiome Changes

Travelers’ diarrhea (TD) is the most prevalent illness encountered by deployed military personnel and has a major impact on military operations, from reduced job performance to lost duty days.... Read more

Image: The Genie III instrument was used for the reverse transcriptase loop-mediated isothermal amplification-assay called N1 gene Single Tube Optigene LAMP (N1-STOP-LAMP) for COVID-19 (Photo courtesy of OptiGene Ltd).

Loop-Mediated Isothermal Amplification-Assay Rapidly Diagnoses COVID-19

The SARS-CoV-2 (COVID-19) pandemic of 2020 has resulted in unparalleled requirements for RNA extraction kits and enzymes required for virus detection, leading to global shortages. This has necessitated... Read more

$This photomicrograph of a Gram-stained urethral smear specimen, reveals some of the histopathology in an acute case of gonococcal urethritis, caused by the Gram-negative bacterium, Neisseria gonorrhoeae. (Image courtesy of [U.S.] Centers for Disease Control and Prevention\'s Public Health Image Library)$

Diagnostic Test Identifies Resistance Mutation that Enables Use of Inexpensive, Single Dose Gonorrhea Drug

By detecting the mutated gene responsible for resistance to the drug ciprofloxacin, it is possible to identify gonorrhea patients who can be cured by a single oral dose of this drug. Gonorrhea, a sexually... Read more

Pathology

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Image: De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection (Photo courtesy of UT Southwestern Medical Center).

Cancer-Associated T Cell Receptors Evaluated for Malignancy Detection

A key goal in oncology is diagnosing cancer early, when it is more treatable. Despite decades of progress, early diagnosis of asymptomatic patients remains a major challenge. Most methods for this involve... Read more

Signatera assays are the first circulating tumor DNA (ctDNA) tests custom-built for each patient based on the unique mutations in an individual patient’s tumor (Photo courtesy of Natera Inc).

Circulating tumor DNA Test Predicts Immunotherapy Response

Immunotherapy is a type of cancer treatment that helps the immune system fight cancer. Although some cancer patients derive dramatic and sustained benefit from immunotherapy, most cancer patients do not.... Read more

Image: The Aperio AT2 is the ideal digital pathology slide scanner for high-throughput clinical laboratories, delivering precise eSlides with low rescan rate (Photo courtesy of Leica Biosystems).

Digital Pathology Solution Resolves the Tissue Floater Conundrum

In routine clinical practice, pathologists may encounter extraneous pieces of tissue on glass slides that could be because of contamination from other specimens. These are typically called tissue floaters.... Read more

Image: The benchtop SH800S cell sorter permits sorting of a wide range of cell sizes for many applications using the 70-μm, 100-μm, and 130-μm microfluidic sorting chips (Photo courtesy of Sony Biotechnology).

Pediatric Ependymoma Single-Cell Analysis Signatures Linked to Outcomes

An ependymoma is a tumor that arises from the ependyma, a tissue of the central nervous system. Usually, in pediatric cases the location is intracranial, while in adults it is spinal. The common location... Read more

Technology

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Image: A test tube contains saliva that can be tested for the heart attack biomarker cardiac troponin (Photo courtesy of karenfoleyphoto).

Saliva Test Fast Tracks Heart Attack Diagnosis

Heart attacks need urgent diagnosis, followed by treatment to restore blood flow to blocked arteries. Diagnosis is based on symptoms (such as chest pain), an electrocardiogram (ECG) and a blood test for... Read more

Image: Schematic diagram of the OvCa-Chip microsystem that recreates vascular endothelium–mediated platelet extravasation in ovarian cancer (Photo courtesy of Texas A&M College of Engineering).

Microfluidic Device Explores Ovarian Cancer Interactions

In many cancers, platelet interactions with circulating tumor cells and their role in metastasis have been studied extensively. In ovarian cancer, platelet extravasation into the tumor and resulting metastasis... Read more

$The TriVersa NanoMate LESA uses chip-based electrospray ionization technology that combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated ion source platform (Photo courtesy of Advion BioSciences).$

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