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Image: The Epi ProColon screening test is a blood-based colorectal cancer screening test is an in vitro polymerase chain reaction assay for the qualitative detection of Septin9 gene methylation in DNA isolated from the patient’s plasma (Photo courtesy of Epigenomics).

Blood Test Complements Colonoscopy for Lynch Syndrome Patients

Lynch syndrome (LS) subjects are genetically predisposed to a high risk for colorectal cancer (CRC) and regular colonoscopy is currently the only CRC screening option recommended for these subjects, although compliance is suboptimal. Read more
16 Jul 2019 | Molecular Diagnostics
Image: The BD Barricor tube is a single-use, plastic evacuated tube with a mechanical separator used to collect, separate, transport and process venous blood specimens (Photo courtesy of Becton, Dickinson and Company).

Samples Quality Improved Using Low-Vacuum Tubes

Centrifugation is a time consuming step, which contributes to increase the turnaround time (TAT) in laboratories, likewise hemolyzed samples that needs a re-sampling could delay management of patients. Read more
16 Jul 2019 | Clinical Chemistry
Image: A photomicrograph of an unstained, formalin preserved stool specimen mount, revealed the presence of a Paragonimus westermani trematode egg. Human infections of this lung fluke are most common in eastern Asia and in South America (Photo courtesy of the CDC).

Antibody Tests Recommended for Parasitic Infection Diagnosis

Pleural parasitic infestation (PPI) is a disease prevalent in certain parts of the world and it is frequently misdiagnosed due to its lack of standardized diagnostic criteria. Read more
16 Jul 2019 | Microbiology
Image: Digitally colorized photomicrograph of fluorescent antibody labeled Streptococcus pneumoniae bacteria in spinal fluid sample (Photo courtesy of the CDC).

Nasal Microbiome Influences Pneumonia and Related Diseases

A recent study examined the influence of the natural microbial flora in the nose and viral co-infection on the acquisition of Streptococcus pneumoniae bacteria and the development of pneumococcal diseases. Read more
15 Jul 2019 | Microbiology
Image: A researcher preparing blood samples for Actiphage testing (Photo courtesy of the University of Nottingham, School of Bioscience).

Bacteriophage-Based Blood Test Rapidly Detects TB Bacteria

A blood test based on bacteriophage that infect living Mycobacterium tuberculosis (Mtb) bacteria has been shown to diagnose human tuberculosis (TB) and may be able to predict which patients with latent tuberculosis will progress to the active form of the disease. Read more
15 Jul 2019 | Microbiology
Image: A scanning electron micrograph (SEM) of a human T-cell from the immune system of a healthy donor (Photo courtesy of [U.S.] NIAID).

Regulatory T-cell Responsiveness Predicts Risk of Cancer Relapse

The risk of future breast cancer relapse can be predicted by analyzing the signaling responsiveness of peripheral blood Treg II cells (CD45RA−FOXP3hi Treg cells) to immunosuppressive T helper type 1 (TH1) and T helper type 2 (TH2) cytokines. Read more
15 Jul 2019 | Molecular Diagnostics
Image: A micrograph of a colonic biopsy showing inflammation of the large bowel in a case of inflammatory bowel disease (Photo courtesy of Wikimedia Commons).

Metabolomics Analysis Method Used for Diagnosis of IBD

A team of Canadian researchers used an advanced metabolomics approach to differentiate inflammatory bowel syndrome (IBS) from other related gastrointestinal disorders. Read more
15 Jul 2019 | Molecular Diagnostics
Image: A bone marrow aspirate from a patient suffering from Hemophagocytic Lymphohistiocytosis showing a macrophage that has ingested a nucleated red cell (Photo courtesy of UF).

Dengue Infection Complicated by Hyperinflammatory Condition

The global incidence of dengue infection has grown dramatically and been estimated to 390 million infections yearly. Read more
11 Jul 2019 | Clinical Chemistry
Image: The Sensititre Complete Automated Antibiotic Susceptibility Testing (AST) System performs all susceptibility testing on a single platform utilizing the superior sensitivity of true MIC results (Photo courtesy of Thermo Fisher Scientific).

Commercial System Effective for Cefiderocol Susceptibility Testing

The novel formulation of the cephalosporin antibiotic makes it very effective against gram-negative non-fastidious bacteria that are otherwise highly resistant to antibiotics, including carbapenem-resistant strains of Enterobacteriaceae and non-fermenters. Read more
11 Jul 2019 | Microbiology
Image: Research shows fibromyalgia patients may have a distinct composition of gut microbiome species (Photo courtesy of Christopher Bergland).

Microbiome Composition Altered in Fibromyalgia Patients

Fibromyalgia (FM) is a prevalent syndrome, characterized by chronic widespread pain, fatigue and impaired sleep, that is challenging to diagnose and difficult to treat. Read more
11 Jul 2019 | Microbiology
Image: A histological section showing the pushing border between the adenoma and the surrounding parenchyma (arrows) from a patient with primary hyperaldosteronism (Photo courtesy of iStock).

Confirmation Testing for Primary Hyperaldosteronism Remains Essential

Primary aldosteronism, also known as primary hyperaldosteronism (PHA) or Conn's syndrome, refers to the excess production of the hormone aldosterone from the adrenal glands, resulting in low renin levels. Read more
10 Jul 2019 | Clinical Chemistry
Image: The SIRscan 2000 Automatic Agar Reader-Incubator for susceptibility testing (Photo courtesy of i2a Diagnostics).

Urine Test Produces Antibiotic Susceptibility Results Directly

Antibiotic susceptibility testing, or AST, is a widely used method of evaluating antibiotic resistance and determining patient treatment plans in clinical settings. Read more
10 Jul 2019 | Microbiology

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Clinical Chemistry

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Maternal HbA1c Influences Autism Risk in Offspring
New Biomarker Test Improves Diagnosis of Ovarian Cancer
Ion-Selective Electrode Methods Compared for Electrolytes
Image: Micronutrient deficiencies, especially zinc, are common in contemporary celiac disease (Photo courtesy of Nan Schiller).

Micronutrient Deficiencies Common in Celiac Disease

Celiac disease is an immune reaction to consuming gluten, a protein found in wheat, barley and rye. Eating gluten triggers an immune response in the small intestine that over time damages the intestine's... Read more

Molecular Diagnostics

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Test Determines If Cancer Patients Require Chemotherapy
Automated Approach Predicts Alzheimer's Disease Risk
Levels of NfL Increase Accuracy of Stroke Risk Prediction
Image: A diagram of how the X-Linked DDX3X RNA helicase dictates translation reprogramming and metastasis in melanoma (Photo courtesy of Lund University).

Protein Linked to Aggressive Skin Cancer

Almost 300,000 people worldwide develop malignant melanoma each year. The disease is the most serious form of skin cancer and the number of cases reported annually is increasing, making skin cancer one... Read more

Hematology

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Potential Biomarker Identified for Relapse of Acquired Hemophilia A
New Method Rapidly Monitors Sickle Cell Disease
Automated Hematology Analyzer Assessed for Malaria Diagnosis
Image: The risk of thromboembolic and bleeding outcomes following hematological cancers is very high (Photo courtesy of the University of Warwick).

Thromboembolic Risk Increases after Hematological Cancers

Hematological cancer includes leukemia, bone marrow cancer and cancers of the lymph nodes. Therapeutic advances have improved survival after hematological cancers. In turn, patients may be at increased... Read more

Immunology

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Immune-Related Gene Implicated in Chronic Candida Infection Risk
Higher Estrogen Levels Linked to Severe Disease in Scleroderma
Flow Cytometry Standardized for Predicting Transplant Rejection
Image: A 3D-reconstructed image of a doublet of a T cell (CD3, green) and a monocyte (CD14) (Photo courtesy of La Jolla Institute for Immunology).

Circulating T Cell-Monocyte Complexes Indicate Immune Perturbations

Communication between immune cells is a major component of immune responses, either directly through cell-cell contacts or indirectly through the secretion of messenger molecules such as cytokines.... Read more

Microbiology

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Certain Antibiotic Combinations Could Target Heteroresistance
POC Urinalysis System Evaluated for Schistosomiasis
Microbiome Study Links Gut Bacteria to Specific Diseases
Image: The RealStar Zika Virus reverse transcription polymerase chain reaction (RT-PCR) (Photo courtesy of Altona Diagnostics).

Whole-Blood Testing Diagnoses Acute Zika Virus Infections

Zika virus infections are linked to congenital malformations in neonates from mothers infected during pregnancy and to neurologic disorders in adults. Reverse transcription polymerase chain reaction (RT-PCR)... Read more

Pathology

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Masspec Pen Evaluated for Rapid Diagnosis of Cancer
Novel Methylated DNA Markers Assay Detects Cancer
Unhealthy Gut Promotes Spread of Breast Cancer
Image: Identifying a metastatic colorectal cancer patient’s Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment (Photo courtesy of University of Southern California).

Identifying Colorectal Cancer Subtypes Improves Treatment Decisions

Colorectal cancer is the second leading cause of cancer death in the USA, and is expected to cause about 51,000 deaths in 2019, but until now, it was unclear which drugs were most effective for which patients.... Read more

Lab Tech.

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Microfluidic Motility Device Indicates Likelihood of Breast Tumor Metastasis
Increased Bleb Formation Characterizes Metastatic Cancer Cells
Technology Developed to Capture Tumor Cells
Image: (A and B) Photomicrographs of the layers of the device; (C) the mold ready for casting and (D) the chip mounted on a slide (Photo courtesy of San Diego State University).

Microfluidic Device Isolates Circulating Tumor Cell Clusters

The three main challenges of cancer treatment are metastases, recurrence, and acquired therapy resistance. These challenges have been closely linked to circulating cancer cell clusters. About 90% of... Read more

Industry News

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Beckman Coulter Introduces New Total Laboratory Automation Solution
Ortho Clinical Diagnostics Presents Cardiac Advances at EuroMedLab 2019
Global POC Diagnostics/Testing Market to Reach USD 22.8 Billion by 2025
Image: The global blood gas analyzers market is projected to surpass USD 940 million by 2026 (Photo courtesy of iStock).

Global Blood Gas Analyzers Market to Surpass USD 940 Million by 2026

The global blood gas analyzers market was valued at USD 594.6 million in 2017 and is projected to grow at a CAGR of 5.5% over the forecast period (2018 – 2026) to surpass USD 940 million by 2026.... Read more

BioResearch

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Prostate Cancer Risk Test Based on Urine-Derived EV-RNA
Study Explains Link between Genetic Variation and Vaccine Specificity and Persis...
Genetic Locus Linked to Diabetic Peripheral Neuropathy in Type II Diabetes
Image: The serum prostate cancer biomarker prostate-specific antigen (PSA) (Photo courtesy of Wikimedia Commons).

MicroRNA Biomarker Distinguishes Growth of Aggressive Prostate Tumors

A microRNA biomarker found in the urine of men with prostate cancer can distinguish slow growing cancers from potentially life-threatening aggressive tumors. Current screening tools, including biopsy... Read more

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