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In Other News

Image: A peripheral blood film from a patient with sickle cell disease (Photo courtesy of Venngage).

New Method Rapidly Monitors Sickle Cell Disease

Sickle cell disease (SCD) is a hereditary disorder that affects red blood cells, distorting their natural disc shape into a crescent moon or "sickle" shape. Read more
26 Jun 2019 | Hematology
Image: Identifying a metastatic colorectal cancer patient’s Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment (Photo courtesy of University of Southern California).

Identifying Colorectal Cancer Subtypes Improves Treatment Decisions

Colorectal cancer is the second leading cause of cancer death in the USA, and is expected to cause about 51,000 deaths in 2019, but until now, it was unclear which drugs were most effective for which patients. Read more
25 Jun 2019 | Pathology
Image: The complete extraction-free, fully automated Liaison XL 1,25 dihydroxyvitamin D radioimmunoassay kit (Photo courtesy of DiaSorin).

Vitamin D Status Determined in Older Adults

Vitamin D has a known role in bone health, with growing evidence for beneficial effects on muscle strength and other non-skeletal outcomes. Read more
25 Jun 2019 | Clinical Chemistry
Image: Lupus Erythematosus (LE) Cells are neutrophils that have engulfed lymphocyte nuclei coated with and denatured by antibody to nucleoprotein (Photo courtesy of Dr. Moustafa Abdou).

Cardiovascular Risk Biomarkers Found for JSLE Patients

Systemic lupus erythematosus is an autoimmune disease typically affecting women between the ages of 15 and 50, and symptoms flare up unpredictably. Read more
25 Jun 2019 | Clinical Chemistry
Image: A colorized electron micrograph showing malaria parasite (right, blue) attaching to a human red blood cell. The inset shows a detail of the attachment point at higher magnification (Photo courtesy of [U.S.]NIAID via Wikimedia Commons).

Blood Drop Assay Designed for Monitoring Antimalarial Drug Resistance

A new method for analyzing DNA directly in a drop of blood was designed for monitoring development of resistance to antimalarial drugs. Read more
24 Jun 2019 | Molecular Diagnostics
Image: A micrograph of Neisseria meningitidis in cerebrospinal fluid (CSF) seen by Gram stain at 1000x magnification. Infection could be prevented by vaccination (Photo courtesy of Wikimedia Commons).

Study Explains Link between Genetic Variation and Vaccine Specificity and Persistence

To better explain how genetic variation affects antibody production and specificity following immunization, researchers conducted a GWAS (genome-wide association study) to examine the persistence of immunity following administration of three childhood vaccines. Read more
24 Jun 2019 | BioResearch
Image: An illustration depicting areas affected by diabetic peripheral neuropathy (DNP) (Photo courtesy of Wikimedia Commons).

Genetic Locus Linked to Diabetic Peripheral Neuropathy in Type II Diabetes

Results of a genome-wide association study (GWAS) have identified a genetic locus linked to the development of diabetic peripheral neuropathy (DPN) by individuals suffering from type II diabetes. Read more
24 Jun 2019 | BioResearch
Image: A micrograph of a coronary artery with the most common form of coronary artery disease (atherosclerosis) and marked luminal narrowing (Photo courtesy of Wikimedia Commons).

Polygenic Risk Scores Accurately Predict Risk of Coronary Artery Disease

Polygenic risk scores (PRS) based on an individual's genome sequence are emerging as potentially powerful biomarkers to predict the risk to develop coronary artery disease (CAD). Read more
24 Jun 2019 | BioResearch
: A tertiary structure of transfer RNA (tRNA) (Photo courtesy of Wikimedia Commons).

Stress-Induced tRNA Fragments Prove Early Predictors of Epileptic Seizures

Elevated levels of stress-induced fragments of transfer RNA in the blood may serve as biomarkers that indicate potential for an epileptic seizure hours before the event actually occurs. Read more
24 Jun 2019 | BioResearch
New research showed cfDNA testing was able to accurately identify trisomies in twin pregnancies (Photo courtesy of iStock).

cfDNA Testing Accurately Detects Fetal Trisomies in Twin Pregnancies

Results presented in a recently published paper indicated that the performance of cfDNA (cell-free DNA) testing for trisomy 21 (Down syndrome) in twin pregnancy was similar to that reported in singleton pregnancy and was superior to that of the first‐trimester combined test or second‐trimester biochemical testing. Read more
24 Jun 2019 | BioResearch
Protocol summary of Vibrio cholerae DNA harvest from specimens preserved on filter paper cards (Photo courtesy of Wellcome Trust Sanger Institute).

Cholera Diagnosed from Dried Spotted Filter Paper

Cholera outbreaks can rapidly induce high death tolls by overwhelming the capacity of health facilities, especially in remote areas or areas of civil unrest. Read more
20 Jun 2019 | Microbiology
The handheld MasSpec Pen device which can be connected to a Mass Spectrometer for diagnosing ovarian and other cancers (Photo courtesy of the University of Texas at Austin).

Masspec Pen Evaluated for Rapid Diagnosis of Cancer

Ovarian cancer is a highly lethal disease and the fifth leading cause of all cancer-related deaths in women. Read more
20 Jun 2019 | Pathology

Channels

Clinical Chemistry

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Trace Metal Concentrations Influence Glucose Regulation in Pregnancy
Genetic Familial Hypercholesterolemia Prevalent in Premature CVD
Plasma Copeptin Reveals Presence and Severity of Liver Disease
A new blood test promises near instant diagnosis of a heart attack using a newly discovered protein biomarker (Photo courtesy of iStock).

Novel Blood Test for Myocardial Infarction Tested

The level cardiac myosin-binding protein C (cMyC) in the blood increase more rapidly after a myocardial infarction, and to a higher extent, than troponin. This means meaning that the new test can rule... Read more

Molecular Diagnostics

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Study Results Validate Use of Tumor Markers to Treat Metastatic Cancer
Immunodiagnostic Test Predicts Progression of Pancreatic Cyst to Cancer
Kidney Transplant Rejection Linked to New Mismatch Locus
Representative histologic features of the small intestine. In the normal duodenal biopsy (A), the villi are elongated and the crypts relatively short. This is in contrast to the small intestinal tissue affected by celiac disease (B), which demonstrates marked villus blunting and crypt hyperplasia. (Photo courtesy of Tracy R. Ediger MD, and Ivor D. Hill, MD ChB).

Biomarker Found for Celiac Patients on Gluten-Free Diet

Celiac disease is a complex condition, routinely treated by means of a strict gluten-free diet (GFD). One of the diagnostic challenges of this disease is that patients need to be consuming gluten so that... Read more

Hematology

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Neutrophil-Lymphocyte Ratio Proves Possible Biomarker for ED
Sickle Cell Disease Screening Helps Save Lives of Migrants
Multiple Myeloma Sequences Reveal Prognostic Immunoglobulin Translocation
Image: The XN-30 automated hematology analyzer that has an automatic measurement functions for red blood cells infected by malaria parasites (Photo courtesy of Sysmex).

Automated Hematology Analyzer Assessed for Malaria Diagnosis

Malaria remains a major cause of morbidity and mortality around the world. Sub-Saharan Africa is most affected with Plasmodium falciparum accounting for 99% of estimated cases. Timely and accurate diagnosis... Read more

Immunology

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Flow Cytometry Standardized for Predicting Transplant Rejection
Mannose-Binding Lectin Associated with IgG Subclass Deficiency
Novel 3D-Printed Technology Lowers Cost of ELISA
The enzyme-linked immunosorbent assay for estradiol (E2) (Photo courtesy of Calbiotech).

Higher Estrogen Levels Linked to Severe Disease in Scleroderma

Systemic sclerosis (SSc) is an autoimmune, connective tissue disease of unknown etiology characterized by immune system dysregulation and excessive extracellular matrix (ECM) synthesis. As in most autoimmune... Read more

Microbiology

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Rapid Tests Assessed for Chronic Chagas Disease
Rare Gut Bacteria Linked to Restless Legs Syndrome
Invasive Pulmonary Aspergillosis Diagnosed by Molecular Test
The Prolisa C. difficile GDH EIA is a microwell assay for the qualitative detection of Clostridium difficile glutamate dehydrogenase (GDH) in fecal specimens. The test is intended for use as an aid in the diagnosis of C. difficile infections (Photo courtesy of Pro-Lab Diagnostics).

NA Amplification Tests for Clostridium Diagnosis Reviewed

Clostridioides (Clostridium) difficile infection (CDI) is the leading cause of health care-associated infections in the USA. It accounts for 15% to 25% of health care-associated diarrhea cases in all health... Read more

Pathology

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Unhealthy Gut Promotes Spread of Breast Cancer
Blood Test Measures Effectiveness of Aggressive Cancer Treatments
Biomarker Predicts Appropriate Immunotherapy for Cancer Patients
A histopathology of pancreatic ductal adenocarcinoma, a gland-forming cancer. In this example, the adenocarcinoma has wrapped around a nerve (center of the image) (Photo courtesy of JHM).

Novel Methylated DNA Markers Assay Detects Cancer

An estimated 56,770 people will be diagnosed with pancreatic cancer in the U.S. in 2019, and more than 45,750 will die from the disease. Pancreatic cancer is the third leading cause of cancer-related deaths... Read more

Lab Tech.

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Increased Bleb Formation Characterizes Metastatic Cancer Cells
Technology Developed to Capture Tumor Cells
Siemens Healthineers Hemoglobin A1c Test Now Available on Atellica Solution
Image: Examples of migratory and non-migratory MDA-MB-231 breast cancer cells migrating in the MAqCI (Microfluidic Assay for quantification of Cell Invasion) device (Photo courtesy of Christopher L. Yankaskas, Johns Hopkins University).

Microfluidic Motility Device Indicates Likelihood of Breast Tumor Metastasis

A novel microfluidic motility test was shown to accurately predict a breast tumor's likelihood to generate metastases. The difficulties involved in predicting which patients with breast cancer will... Read more

Industry News

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Global POC Diagnostics/Testing Market to Reach USD 22.8 Billion by 2025
Global Automated Immunoassay Analyzer Market Driven by Increase in Applications
Global Urinalysis Market Valued at USD 2 Billion by 2022
Image: The Multi-Test VITROS chemistry product slides (Photo courtesy of Ortho Clinical Diagnostics).

Ortho Clinical Diagnostics Presents Cardiac Advances at EuroMedLab 2019

Ortho Clinical Diagnostics (Raritan, NJ, USA) sponsored an educational workshop on high-sensitivity troponin assays and presented five scientific posters at EuroMedLab 2019, the 23rd IFCC-EFLM European... Read more

BioResearch

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Machine Learning Approach Detects Cancer by Analyzing DNA in Blood Samples
Laboratory Model Reveals Genetic Risk Loci for AMD
Gene Set Isolated in Transformation of Skin Cells into Embryonic Tissues
Image: A representation of a methylated DNA molecule. The two white spheres represent methyl groups bound to two cytosine nucleotide molecules (Photo courtesy of Wikimedia Commons).

Disease-Related Epigenetic Variations Summarized in New DNA Methylation Atlas

A new DNA methylation atlas summarized a previously unexplored molecular level of human individuality called correlated regions of systemic interindividual variation (CoRSIVs), which may provide a resource... Read more

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