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Image: The new imaging approach uses microscopic glowing tags to reveal gene activity in individual C. diff cells (Photo courtesy of Nicholas DiBenedetto)

New Imaging Approach Could Help Predict Dangerous Gut Infection

Clostridioides difficile infections affect roughly half a million people in the United States each year and are a leading cause of infectious diarrhea in healthcare settings. Read more
10 Mar 2026 | Microbiology
Image: The new methyl-copying PCR method preserves DNA methylation patterns during amplification (Photo courtesy of Syndex Bio)

Novel mcPCR Technology to Transform Testing of Clinical Samples

DNA methylation is an important biological marker used in the diagnosis and monitoring of many diseases, including cancer. Read more
09 Mar 2026 | Pathology
Image: The study\'s results indicated that when Aβ levels were high, women had significantly higher plasma p‑tau217 levels than men (photo courtesy of Shutterstock

Sex Differences in Alzheimer’s Biomarkers Linked to Faster Cognitive Decline

Sex differences in Alzheimer’s disease present ongoing diagnostic challenges, with women often experiencing a disproportionate disease burden even when preclinical amyloid-beta levels are similar to men. Read more
09 Mar 2026 | Pathology
Image: The QUT research team included (left to right) Tuquabo Tesfamichael, Emad Kiriakous, and Prashant Sonar (photo courtesy of Queensland University of Technology)

Simple One-Hour Saliva Test Detects Common Cancers

Early detection is critical for improving cancer outcomes, yet many diagnostic tests rely on invasive procedures such as blood draws or biopsies. Read more
09 Mar 2026 | Molecular Diagnostics
Image: Fragments of tumor DNA in the blood can predict whether chemotherapy will be effective (Photo courtesy of Adobe Stock)

Blood Test Could Help Guide Treatment Decisions in Germ Cell Tumors

Chemotherapy is often highly effective for germ cell tumors, but in a subset of patients, the disease does not respond well to standard treatment. Read more
09 Mar 2026 | Molecular Diagnostics
Image: Study overview – A) Assembly of development and validation cohorts B) CHAI platform workflow described in five steps. (Hendifar, A. E. et al., J Clin Oncol (2026). DOI: 10.1200/JCO-25-02199))

AI Tool Predicts Chemotherapy Response from Biopsy Slides

Selecting first-line chemotherapy for advanced pancreatic cancer typically involves trying one of two approved regimens and switching if response is inadequate. Read more
09 Mar 2026 | Pathology
Image: Original illustration showing how exposure-linked mutation patterns may influence tumor immune visibility (Photo courtesy of Máté Manczinger, HUN-REN Szeged BRC)

Cancer Mutation ‘Fingerprints’ to Improve Prediction of Immunotherapy Response

Cancer cells accumulate thousands of genetic mutations, but not all mutations affect tumors in the same way. Read more
06 Mar 2026 | Immunology
Image: The biodegradable microneedle device analyzes glucose in interstitial fluid without requiring traditional blood sampling (Fukuhara, M. et al., J Mater Chem B (2025). DOI: 10.1039/D5TB00385G)

World’s First Optical Microneedle Device to Enable Blood-Sampling-Free Clinical Testing

Blood sampling is one of the most common clinical procedures, but it can be difficult or uncomfortable for many patients, especially older adults or individuals with certain medical conditions. Read more
06 Mar 2026 | Pathology
Image: Researchers have identified rare circulating bone precursor cells in blood that could signal heterotopic ossification (Photo courtesy of 123RF)

Blood Test Could Spot Common Post-Surgery Condition Early

Heterotopic ossification (HO), the abnormal formation of bone in soft tissue, is a common complication following hip replacement surgery. Read more
06 Mar 2026 | Molecular Diagnostics
Image: LLNL biologist James Thissen loads DNA samples for sequencing in a pathogen-agnostic method to identify respiratory viruses (Photo courtesy of Randy Wong/LLNL)

Pathogen-Agnostic Testing Reveals Hidden Respiratory Threats in Negative Samples

Polymerase Chain Reaction (PCR) testing became widely recognized during the COVID-19 pandemic as a powerful method for detecting viruses such as SARS-CoV-2. Read more
05 Mar 2026 | Pathology
Image: The blood-based biomarker can help identify patients at higher risk of cancer recurrence after surgery (Photo courtesy of 123RF)

New Blood Test Can Help Predict Testicular Cancer Recurrence

Stage 1 testicular germ cell tumor is typically treated with surgery followed by active surveillance. Read more
05 Mar 2026 | Molecular Diagnostics
Image:The technique enables sequencing of the M. tuberculosis genome directly from patient samples without culturing the bacteria first (Photo courtesy of Adobe Stock)

Rapid Sequencing Could Transform Tuberculosis Care

Tuberculosis remains the world’s leading cause of death from a single infectious agent, responsible for more than one million deaths each year. Read more
05 Mar 2026 | Microbiology
Image: The researchers created a detailed molecular profile associated with different stages of cognitive decline in Alzheimer’s (Photo courtesy of Shutterstock)

New Test Detects Alzheimer’s by Analyzing Altered Protein Shapes in Blood

Alzheimer’s disease begins developing years before memory loss or other symptoms become visible. Misfolded proteins gradually accumulate in the brain, disrupting normal cellular processes. Read more
04 Mar 2026 | Molecular Diagnostics
Image: The AI system analyzes diverse inputs in order to make a diagnosis based on traceable reasoning (Zhao, W., Wu, C., Fan, Y. et al. Nature (2026). doi.org/10.1038/s41586-025-10097-9)

AI Model Outperforms Clinicians in Rare Disease Detection

Rare diseases affect an estimated 300 million people worldwide, yet diagnosis is often protracted and error-prone. Read more
04 Mar 2026 | Technology

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Clinical Chemistry

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Electronic Nose Smells Early Signs of Ovarian Cancer in Blood
Simple Blood Test Offers New Path to Alzheimer’s Assessment in Primary Care
Existing Hospital Analyzers Can Identify Fake Liquid Medical Products
Image: The FAP‑Index combines a simple blood test measuring fibroblast activation protein (FAP) with routinely collected clinical information to generate a more precise assessment of fibrosis risk (Wang, Z V et al., J Gastroenterol Hepatol (2026). DOI: 10.1111/jgh.70294)

New Blood Test Index Offers Earlier Detection of Liver Scarring

Metabolic fatty liver disease is highly prevalent and often silent, yet it can progress to fibrosis, cirrhosis, and liver failure. Current first-line blood test scores frequently return indeterminate results,... Read more

Molecular Diagnostics

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Cell-Free DNA Predicts Bloodstream Infections in Children with Leukemia
Study Uses Blood Samples to Identify Diseases Years Before They Start
MicroRNA-Based Method Predicts CKD and Cardiovascular Risk
Image: Proteomic analysis of cerebrospinal fluid revealed a set of markers that better distinguishes MS from related inflammatory diseases (Photo courtesy of TUM, adapted by MPI of Biochemistry)

New Diagnostic Markers for Multiple Sclerosis Discovered in Cerebrospinal Fluid

Multiple sclerosis (MS) affects nearly three million people worldwide and can cause symptoms such as numbness, visual disturbances, fatigue, and neurological disability. Diagnosing the disease can be challenging... Read more

Hematology

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New Guidelines Aim to Improve AL Amyloidosis Diagnosis
Fast and Easy Test Could Revolutionize Blood Transfusions
Automated Hemostasis System Helps Labs of All Sizes Optimize Workflow
Image: Hemex Health’s Gazelle platform is designed to rapidly separate and detect hemoglobin fractions and variants using miniaturized electrophoresis technology (photo courtesy of Hemex Health)

Rapid Cartridge-Based Test Aims to Expand Access to Hemoglobin Disorder Diagnosis

Sickle cell disease and beta thalassemia are hemoglobin disorders that often require referral to specialized laboratories for definitive diagnosis, delaying results for patients and clinicians.... Read more

Immunology

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New Biomarker Predicts Chemotherapy Response in Triple-Negative Breast Cancer
Blood Test Identifies Lung Cancer Patients Who Can Benefit from Immunotherapy Drug...
Whole-Genome Sequencing Approach Identifies Cancer Patients Benefitting From PAR...
Image: The study identified a distinct immune signature associated with treatment-resistant myasthenia gravis (Dodd, Katherine C. et al., Med (2026). DOI: 10.1016/j.medj.2025.100987)

Immune Signature Identified in Treatment-Resistant Myasthenia Gravis

Myasthenia gravis is a rare autoimmune disorder in which immune attack at the neuromuscular junction causes fluctuating weakness that can impair vision, movement, speech, swallowing, and breathing.... Read more

Microbiology

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Hidden Gut Viruses Linked to Colorectal Cancer Risk
Three-Test Panel Launched for Detection of Liver Fluke Infections
Rapid Test Promises Faster Answers for Drug-Resistant Infections
Image: New findings enable enable the detection of a blood virome signature for Crohn’s disease (photo courtesy of Adobe Stock)

Blood-Based Viral Signature Identified in Crohn’s Disease

Crohn’s disease is a chronic inflammatory intestinal disorder affecting approximately 0.4% of the European population, with symptoms and progression that vary widely. Although viral components of the microbiome... Read more

Pathology

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Urine Specimen Collection System Improves Diagnostic Accuracy and Efficiency
AI-Powered 3D Scanning System Speeds Cancer Screening
Single Sample Classifier Predicts Cancer-Associated Fibroblast Subtypes in Patient...
Image: The noninvasive technology aims to improve melanoma screening outcomes (Photo courtesy of 123RF)

Molecular Imaging to Reduce Need for Melanoma Biopsies

Melanoma is the deadliest form of skin cancer and accounts for the vast majority of skin cancer-related deaths. Because early melanomas can closely resemble benign moles, clinicians often rely on visual... Read more

Technology

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Blood Test “Clocks” Predict Start of Alzheimer’s Symptoms
AI-Powered Biomarker Predicts Liver Cancer Risk
Robotic Technology Unveiled for Automated Diagnostic Blood Draws
Image: The machine learning tool generates a patient-specific probability score for periprosthetic joint infection (Photo courtesy of Zimmer Biomet)

AI-Driven Diagnostic Demonstrates High Accuracy in Detecting Periprosthetic Joint Infection

Periprosthetic joint infection (PJI) is a rare but serious complication affecting 1% to 2% of primary joint replacement surgeries. The condition occurs when bacteria or fungi infect tissues around an implanted... Read more

Industry

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QuidelOrtho Collaborates with Lifotronic to Expand Global Immunoassay Portfolio
WHX Labs in Dubai spotlights leadership skills shaping next-generation laboratories...
New Collaboration Brings Automated Mass Spectrometry to Routine Laboratory Testi...
Image: The initiative aims to speed next-generation diagnostic development during early pathogen emergence (photo courtesy of 123RF)

Cepheid Joins CDC Initiative to Strengthen U.S. Pandemic Testing Preparednesss

Cepheid (Sunnyvale, CA, USA) has been selected by the U.S. Centers for Disease Control and Prevention (CDC) as one of four national collaborators in a federal initiative to speed rapid diagnostic technologies... Read more

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