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In Other News

Image: The Vidas BRAHMS procalcitonin assay is performed on the benchtop Vidas multiparametric immunoassay instrument (Photo courtesy of bioMérieux).

Procalcitonin Guides Use of Antibiotics for Respiratory Infections

The overuse of antibiotic agents is a public health problem associated with increased health care costs and antibiotic resistance. Read more
12 Jun 2018 | Clinical Chemistry
Image: The NextSeq 500 desktop sequencing platform (Photo courtesy of Illumina).

Molecular Test Developed for Nasopharyngeal Carcinoma

The prevalence of nasopharyngeal carcinoma (NPC) is higher in Southeast Asia than other parts of the world, around 35 cases per 100,000. Read more
12 Jun 2018 | Molecular Diagnostics
Image: The LightCycler 96 real-time PCR system (Photo courtesy of Roche Diagnostics).

RT-PCR Assay Developed to Detect Bloodstream Infections

Rapid detection and identification of a causative pathogen is essential in the treatment of critically ill patients with blood stream infection (BSI), since timely initiation of adequate antibiotic treatment is associated with decreased morbidity, mortality, and possibly reduced healthcare costs. Read more
11 Jun 2018 | Molecular Diagnostics
Image: The Measles-Rubella Box (MRBox) is a low-cost, portable technology to detect measles and rubella infection status and immunity, for use in developing nations (Photo courtesy of University of Toronto).

Portable Device Rapidly Detects Measles and Rubella

Serosurveys are useful for assessing population susceptibility to vaccine-preventable disease outbreaks. Read more
11 Jun 2018 | Immunology
Image: An intubated baby that was born prematurely 26 weeks, six days gestation, weighing 990 grams. Photograph was taken approximately 24 hours after birth (Photo courtesy of Wikimedia Commons).

Assay Detects CP Risk in Premature Babies

MicroRNA sequencing has been used for early diagnosis of premature babies with abnormal muscle tone and/or intraventricular hemorrhage (IVH) - symptoms that are considered to be indicators for risk of cerebral palsy. Read more
11 Jun 2018 | Molecular Diagnostics
Image: The microfluidic chip developed to detect proteins (Photo courtesy of National Chung Cheng University).

Chip Developed to Detect Cancer in 30 Minutes

A compact microfluidic chip with integrated impedance biosensor for protein pre-concentration and detection has been developed. Read more
07 Jun 2018 | Lab Tech.
Image: The ABI 7300 real-time PCR system (Photo courtesy of Applied Biosystems).

Leprosy Neural Impairment Diagnosis Evaluated by Tests

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an obligate intracellular parasite with a predilection for infecting peripheral nerves and skin. Read more
07 Jun 2018 | Microbiology
Image: The relationship between delay in initial lactate measurement and the probability of in-hospital mortality for patients meeting SEP-1 criteria, stratified by level of initial lactate value (mmol/L) and adjusted for patient location, eCART score, and lactate value (Photo courtesy of University of Chicago).

Earlier Measurements Offer Quicker Treatment for Sepsis

Sepsis remains a significant cause of morbidity and mortality in the USA, leading to the implementation of the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1). Read more
07 Jun 2018 | Clinical Chemistry
Image: The TruSight Cardio Sequencing kit uses next-generation sequencing (NGS) to provide comprehensive coverage of 174 genes with known associations to 17 inherited cardiac conditions, including cardiomyopathies, arrhythmias, aortopathies, and more (Photo courtesy of Illumina).

Link Found Between Alcohol, Genes and Heart Failure

Alcoholic cardiomyopathy (ACM) is caused by chronic and excessive alcohol intake. Although moderate levels of alcohol consumption may have some beneficial cardiovascular effects, prolonged and excessive consumption can lead to deleterious consequences including cardiac arrhythmias and a dilated cardiomyopathy (DCM) phenotype. Read more
07 Jun 2018 | Molecular Diagnostics
Image: A microsatellite analysis of a patient with balanced chromosomal rearrangements (Photo courtesy of Human Genetics).

Chromosome Study Leads to Counseling Pregnant Women

Fetuses with a so-called new balanced chromosomal aberration have a higher risk of developing brain disorders such as autism and mental retardation than previously anticipated and the risk is 20% for fetuses with these types of aberrations. Read more
06 Jun 2018 | Molecular Diagnostics
Image: The Infinium Methylation EPIC kit (Photo courtesy of Illumina).

Mutations Missed in Congenital Disease Screening

A type of genetic aberration has been identified as the cause of certain neurodevelopmental disorders and congenital diseases, such as autism and congenital heart disease, which are undetectable by conventional genetic testing. Read more
06 Jun 2018 | Molecular Diagnostics

Channels

Clinical Chemistry

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Troponin Assays Evaluated for Acute MI
Serum Biomarkers Improve Preeclampsia Screening
New Acquisition Method Expands MS Range and Sampling Depth
Image: The Access 2 benchtop immunoassay system (Photo courtesy of Beckman Coulter Diagnostics).

Vitamin D Levels Associated with Type 2 Diabetes

The incidence of type 2 diabetes has increased substantially in both high-income and low- and middle-income countries in recent decades. Observational studies have reported that higher plasma 25-hydroxyvitamin... Read more

Molecular Diagnostics

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New Test More Accurate for Determining Prostate Cancer Risk
Electronic Chip Captures Pancreatic Cancer Exosomes for Analysis
Genome Sequencing Increases Sensitivity of Carrier Screens
Image: A micrograph showing cirrhosis of the liver. The tissue in this example is stained with a trichrome stain, in which fibrosis is colored blue. The red areas are the nodular liver tissue (Photo courtesy of Wikimedia Commons).

Fluorescent-Polymer Sensor Test Detects Liver Fibrosis

A novel method has been developed that can detect liver fibrosis from a blood sample in 30-45 minutes. Liver disease is the fifth most common cause of premature death in the Western world, with the... Read more

Hematology

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NIV Test Developed for Fetal Rhesus Factor
Sequencing Enables Precise Match for Blood Transfusions
Early Sepsis Indicator Alerts Emergency Department Clinicians
Image: The BD Vacutainer UltraTouch push button blood collection set (Photo courtesy of Becton Dickinson).

Novel Device Contributes to Positive Phlebotomy Experience

Phlebotomy is a necessary procedure that may be a source of pain, stress and anxiety for some patients. While smaller gauge needles are known to lessen patient discomfort, they are often associated with... Read more

Immunology

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Method Developed to Detect AFP and GP73 Simultaneously
Protein Biomarker Found for Early-Stage Lung Cancer
Specific Biomarker Discovered for Rheumatoid Arthritis
Image: A pregnant woman with a stethoscope placed to her stomach. Scientists have developed a test to predict a woman\'s risk of preterm birth (Photo courtesy of University of California - San Francisco).

New Test Predicts Risk of Preterm Birth

A test has been developed to predict a woman's risk of preterm birth when she is between 15 and 20 weeks pregnant, which may enable doctors to treat them early and prevent severe complications later in... Read more

Microbiology

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Blood Type Linked to Severity of Diarrhea
Study Shows Labs Should Specify HPV Assay Used
Near-Patient Hepatitis C Assay Validated
Image: The HiSeq 2500 system is a powerful high-throughput sequencing system (Photo courtesy of Illumina).

American Gut Project Reports Microbiome Results

Although much work has linked the human microbiome to specific phenotypes and lifestyle variables, data from different projects have been challenging to integrate and the extent of microbial and molecular... Read more

Pathology

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Cell Block Prep Method Modified for Molecular Studies
Breath and Urine Tests Detect Early Breast Cancer
Biomarkers Identified for Irritable Bowel Syndrome
Image: A photomicrograph of breast cancer cells in purple surrounded by healthy tissue in pink (Photo courtesy of US National Institute of Health).

Hereditary Breast Cancer Tests Double Detection Rate

Germline genetic testing in patients newly diagnosed with cancer has the potential to reduce disease burden through secondary prevention and targeted therapies. There is a prerequisite to understand how... Read more

Lab Tech.

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Smart Phone Reader Detects Common Pathogens
Beckman Coulter Announces CE Mark for Hematology Analyzer
Smartphone Microscopes Transformed into Lab Devices
Image: A diagram of simplifying disease diagnosis using topically applied nanotechnology could change the way skin diseases such as abnormal scars are diagnosed and managed (Photo courtesy of Nanyang Technological University).

Topical Nanotechnology Simplifies Skin Disease Diagnosis

Tissue biopsies are necessary for the accurate diagnosis of skin diseases, but their application is limited by the pain, inconvenience, and morbidity experienced by patients, as well as risks of scarring... Read more

Industry News

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Siemens Healthineers Launches Thermocycler with AI-Powered Software
Google Builds AR Microscope for Cancer Detection
AI-Based Cancer Diagnosis System Eliminates Errors
Image: The global PCR market is projected to surpass USD 7.4 billion by 2025 (Photo courtesy of iStock).

Global PCR Market to Surpass USD 7 Billion by 2025

The global polymerase chain reaction market (PCR) was valued at USD 3.7 billion in 2017 and is projected to grow at a CAGR of 8.8% over the forecast period (2017 – 2025) to surpass USD 7.... Read more

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