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Image: Results of a LAMP test showing positive samples that emit green fluorescence (Photo courtesy of Foundation for Innovative New Diagnostics).

TB-LAMP Assay Evaluated in Reference Labs

Smear microscopy, the first line in tuberculosis (TB) detection, has a low and variable sensitivity of 30% to 70%. Read more
19 Apr 2018 | Microbiology
Image: Computer-generated illustration of Mycobacterium tuberculosis bacteria, Ziehl-Neelsen stain. Acid-fast bacilli stain red and the background is blue (Photo courtesy of Microbiology Pictures).

Blood Test Predicts Onset of TB in Advance

Tuberculosis, caused by infection with Mycobacterium tuberculosis (TB), is the world's leading cause of death brought on by a single pathogen. Read more
18 Apr 2018 | Microbiology
Image: The Synergy H1 Hybrid Multi-Mode Microplate Reader (Photo courtesy of BioTek).

Vitamin D Blood Test May Speed Pediatric Bipolar Diagnosis

Major mood disorders (MMD), specifically bipolar disorder (BD) and major depressive disorder (MDD), are some of the most prevalent albeit under-diagnosed health problems in children and adolescents. Read more
18 Apr 2018 | Clinical Chemistry
Image: A diagram comparing normal and diseased in irritable bowel syndrome (Photo courtesy of HealthNormal).

Genetic Link to IBS Identified in Women

Irritable bowel syndrome is the most common gastrointestinal disorder. More than 10% of the population suffers from recurrent symptoms including abdominal pain, gas, diarrhea and constipation and it is more common in women than men. Read more
18 Apr 2018 | Molecular Diagnostics
Image: A diagram of various stents used in angioplasty (Photo courtesy of Open Biomedical Initiative).

Genetic Test May Improve Post-Stent Treatment Outcome

A test for specific genetic mutations successfully informed blood-thinner treatment selection following stent placement to open clogged blood vessels, leading to significantly fewer complications. Read more
17 Apr 2018 | Molecular Diagnostics
Image: Determination of the amyloid‐beta (Aβ) secondary structure distribution in blood plasma by an immuno‐IR‐sensor correlates with PET scanning and CSF markers in Alzheimer\'s disease (AD) patients, with potentials to be an accurate, simple, and minimally invasive biomarker for early AD detection (Photo courtesy of Ruhr University Bochum).

Amyloid Blood Biomarker Detects Alzheimer's Disease

There is, as yet, no cure for Alzheimer's disease. It is often argued that progress in drug research has been hampered by the fact that the disease can only be diagnosed when it is too late for an effective intervention. Read more
17 Apr 2018 | Clinical Chemistry
Image: Using darkfield microscopy technique, this photomicrograph, magnified ×400, reveals the presence of spirochete, or \"corkscrew-shaped\" bacteria known as Borrelia burgdorferi, which is the pathogen that causes Lyme disease (Photo courtesy of the CDC).

New POC Test Quickly Detects Lyme Neuroborreliosis

The clinical pictures of borreliosis vary from local skin infection to infections of the central nervous system, joints or the heart. Read more
17 Apr 2018 | Microbiology
Image: The Vivascope 2500 confocal scanning microscopic view of lymph node metastases from thyroid carcinoma are papillary structures made up of scanty bright spots floating in a dark background (left) (Photo courtesy of IRCSS Santa Maria Nuova Hospital).

Confocal Fluorescence Microscopy Used for Rapid Tissue Evaluation

Optical imaging techniques are currently available for imaging tissues without the need for any type of extensive tissue preparation. Read more
16 Apr 2018 | Pathology
Image: A new study showed a one-time measurement of branched chain amino acids in the blood stream predicted future risk of CV events in women (Photo courtesy of iStock).

Amino Acids Can Predict CV Disease Risk in Women

Results of a recent study supported the hypothesis that plasma BCAAs (branched-chain amino acids) were positively associated with cardiovascular disease (CVD) risk and were linked to an intermediate diagnosis of type II diabetes (T2D). Read more
16 Apr 2018 | Molecular Diagnostics
Image: The Genedrive PCR diagnostics platform (Photo courtesy of Genedrive).

Rapid Test Developed for Hepatitis C Infections

A rapid, point-of-care PCR-based diagnostic test will allow for the detection of occult hepatitis C virus (HCV) infections under both laboratory and field conditions. Read more
16 Apr 2018 | Molecular Diagnostics
Image: A diagram of two different forms of heart failure compared with a normal heart (Photo courtesy of The Medical University of South Carolina).

CV Biomarkers Associated with Incident Heart Failure

Nearly half of all patients with heart failure have preserved ejection fraction as opposed to reduced ejection fraction, yet associations of biomarkers with future heart failure subtype are incompletely understood. Read more
12 Apr 2018 | Clinical Chemistry

Channels

Clinical Chemistry

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Biomarker Assay Recommended for Heart Failure Diagnosis
CKD May Occur Before Diabetes Diagnosis
New Heart Attack Test Better Informs Underlying Condition
Image: The Dexcom 6 is an integrated continuous glucose monitoring (iCGM) system for determining blood glucose (Photo courtesy of DEXCOM).

Interoperable Glucose Monitoring System Authorized

An integrated continuous glucose monitoring (iCGM) system for determining blood glucose levels in children aged two years and older and adults with diabetes has been authorized. This is the first type... Read more

Molecular Diagnostics

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Aggressive Meningioma Linked to Transcription Factor Activity
Genomic Test Detects Lynch Syndrome in Colorectal Cancer
Potential Genetic Link Identified in SIDS
Image: The MinION is the only portable real-time device for DNA and RNA sequencing (Photo courtesy of Oxford Nanopore Technologies).

Nanopore Method Developed for Genetic Screening

Rapid sequencing of short DNA reads may be useful for a wide range of clinical applications including targeted mutation analysis, cancer-panel testing, and aneuploidy screening. Fast, point-of-care preimplantation... Read more

Hematology

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Flow Cytometry Detects Myelodysplasia in Peripheral Blood
Telomere Length Test Influences Treatment Decisions
Multiple Myeloma Risk Genes Revealed
Image: The Architect i2000SR immunoassay analyzer (Photo courtesy of Abbott Diagnostics).

Chronic Fatigue Syndrome Linked to Thyroid Levels

Chronic fatigue syndrome (CFS) is a common disease marked by lengthy spells of weakness, fatigue and depression. Its diagnosis is predominantly based on symptoms and on ruling out any underlying medical... Read more

Immunology

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Helicobacter Pylori Immunoassays Evaluated for Efficacy
ELISA Methods Developed for Analyzing Immunotherapy
Immune Signature Predicts Asthma Susceptibility
Image: A transmission electron micrograph (TEM) of a number of Lassa virus virions adjacent to some cell debris (Photo courtesy of C. S. Goldsmith/CDC).

Immunoassay Developed for Lassa Fever Virus

Lassa fever is a type of viral hemorrhagic fever and is endemic in several West African countries. However, only few hospitals and laboratories in the region have the capacity to conduct molecular or serological... Read more

Microbiology

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Rapid Hepatitis C Virus POC Test Evaluated
Unusual Blood Clots Characterized in Leprosy Patients
New Dipstick Rapidly Detects Cholera in Acute Diarrhea
Image: The Malaria Ag P.f test is 10 times more sensitive than current malaria rapid diagnostic tests for the detection of Plasmodium falciparum HRP-II antigen (Photo courtesy of Alere).

Ultra-Sensitive Rapid Test Evaluated for Malaria

In low prevalence regions, subpatent Plasmodium falciparum malaria infections have become an issue of increasing concern. As malaria endemic countries shift from control to elimination, the proportion... Read more

Pathology

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Gut Microbiome Analysis Predicts Hospitalizations in Cirrhosis
Liquid Biopsy Can Rule Out Early-Stage Lung Cancer
Cervical Fluid Test Developed for Gynecological Cancers
Image: The use of the WATS3D biopsy is an adjunct to forceps biopsy, identified a patient with abnormality in the esophagus (Photo courtesy of CDx Diagnostics).

Sampling Device Increases Detection of Barrett’s Esophagus

Esophageal adenocarcinoma, one of the most fatal and fastest growing cancers in the USA, can be prevented if detected at a precancerous stage. In Barrett’s esophagus (BE), esophageal squamous mucosa is... Read more

Lab Tech.

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Device Leads to Lower Blood Culture Contamination Rates
Nanowire Technology Developed to Detect Cancer Biomarkers in Urine
Spinal Tap Needle Impacts Risk of Complications
Image: The μCENSE chip with the benchtop centrifugal platform in the background (Photo courtesy of Dr. Joo Chuan Yeo, PhD).

Liquid Biopsy Platform Isolates Circulating Disease Biomarkers

A new platform has been created with the potential to extract tiny circulating biomarkers of disease from patient blood. This simple, fast and convenient technique could help realize liquid biopsy diagnostics,... Read more

Industry News

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Randox and Bosch Partner to Launch Molecular Diagnostics Platform
Immunofluorescence Assay Market Worth USD 2 Billion by 2023
Siemens Healthineers AG IPO Planned for First Half of 2018
Image: Danaher Corporation has entered into a definitive agreement to acquire Integrated DNA Technologies (Photo courtesy of iStock).

Danaher Acquires Integrated DNA Technologies

Danaher Corporation (Washington, D.C, USA) has entered into a definitive agreement to acquire Integrated DNA Technologies (IDT) (Skokie, IL, USA), a privately held provider of high-value consumables for... Read more

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