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Molecular Diagnostics

Image: Scanning electron micrograph of carbapenem-resistant Enterobacteriaceae bacteria (Photo courtesy of Stephanie Rossow, Centers for Disease Control and Prevention/Antibiotic Resistance Coordination & Strategy Unit)

A Rapid Method for Selecting the Proper Antibiotic to Treat Multidrug Resistant Bacteria

 A new diagnostic approach allows physicians to accurately identify bacterial pathogens and identify the most appropriate antibiotic within a period of hours rather than days. More...
12 Dec 2019
Image: Trypanosoma cruzi amastigotes in heart tissue from a patient with Chagas disease (Photo courtesy of the CDC)

Chronic Comorbidities Are Prevalent Among People with Chagas Disease

 Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. More...
12 Dec 2019
Image: Biopsy of small bowel showing celiac disease manifested by blunting of villi, crypt hypertrophy, and lymphocyte infiltration of crypts (Photo courtesy of Wikimedia Commons)

A One-step Rapid Point-of-Care Assay for Diagnosis of Celiac Disease

 A spectrophotometric assay has been developed that shows strong potential for use as a point-of-care (POC) assay for the rapid detection of celiac disease antibodies. More...
12 Dec 2019
Image: The ARCHITECT Anti-HCV assay is a fully automated high throughput chemiluminescent microparticle immunoassay (CMIA) for the detection of antibodies to structural and nonstructural proteins of the hepatitis C virus (HCV) (Photo courtesy of Abbot Diagnostics)

Diagnosis and Monitoring of Patients with Hepatitis C Virus

 The global prevalence of people with hepatitis C virus (HCV) antibodies (anti-HCV-positive) is estimated to be 115 million, and 80 million of them have an active infection (anti-HCV-positive and HCV-RNA-positive). More...
11 Dec 2019
Image: Peripheral blood smear showing chronic lymphocytic leukemia (CLL). A large lymphocyte (arrow) has a notched nucleus and demonstrates the variable appearance of some of the lymphocytes in CLL (Photo courtesy of Peter Maslak)

TP53 Gene Promoter Methylation Impacts Chronic Lymphocytic Leukemia

 Chronic lymphocytic leukemia (CLL) is a clonal disorder that results in the accumulation of morphologically mature-looking and immunologically incompetent lymphoid cells in the bone marrow, peripheral blood, and lymphatic tissues. More...
11 Dec 2019
Image: HbA1c Advanced Clinical Chemistry Diabetes Assay: to diagnose maturity-onset diabetes of the young (MODY), screening for at least three autoantibodies and HbA1c testing should takes place in all youth at the time of diabetes diagnosis (Photo courtesy of Beckman Coulter)

Three Factors Distinguish MODY, a Rare Diabetes, in Youth

 Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. MODY is a monogenic, dominantly inherited form of diabetes that typically arises in adolescence or young adulthood, and accounts for 1%-4% of cases of pediatric diabetes. More...
10 Dec 2019
Image: Single-cell RNA-seq reveals cellular heterogeneity that is masked by bulk RNA-seq methods (Photo courtesy of 10x Genomics)

Alzheimer's Disease Gene Expression Varies by Brain Cell Type

 Genetic variants in apolipoprotein E (APOE) and other genes have been implicated in late-onset Alzheimer's disease through genome-wide association studies and other analyses. More...
09 Dec 2019

Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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