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Molecular Diagnostics

Image: A scanning electron micrograph of two rod-shaped bacteria called Klebsiella pneumoniae that are resistant to treatment with the “last resort” antibiotic drug called carbapenem. In this image, the mustard-colored bacteria are interacting with the green-colored human white blood cells (Photo courtesy of National Institute of Allergy and Infectious Diseases).

Carbapenem-Resistant K. Pneumoniae Driven by Nosocomial Spread

Public health interventions to control the current epidemic of carbapenem-resistant Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and spread over a wide range of geographical scales. More...
15 Aug 2019
Image: The Mini8 Plus real time polymerase chain reaction (RT-PCR) thermocycler (Photo courtesy of Coyote Bioscience).

Direct Molecular Assay Developed for Zika Diagnosis

Zika virus (ZIKV), a mosquito-borne Flavivirus, is a positive single-stranded RNA virus with a nucleic acid length of about 10.7kb. This virus has been spreading rapidly and there have been large-scale outbreaks worldwide in recent years. ZIKV has drawn attention as it may cause severe symptoms while no specific medical treatment or vaccine is currently available. More...
14 Aug 2019
BIOHIT  Healthcare OY
Image: The structure of human hemoglobin with alpha and beta subunits in red and blue, respectively, and the iron-containing heme groups in green (Photo courtesy of Wikimedia Commons).

Abnormal Hemoglobin Levels Predict Risk of Developing Dementia

Both elevated and diminished levels of serum hemoglobin have been linked to an increased risk of developing various types of dementia including Alzheimer’s disease. More...
12 Aug 2019
Image: A circulating cancer cell (pink) attaches to carbon nanotube surface; white blood cells (blue) do not adhere and are later washed away (Photo courtesy of Curtis Sayers).

Liquid Biopsy Device Selectively Captures Circulating Tumor Cells

A new type of antigen-independent liquid biopsy captures device exploits the preferential attachment of circulating tumor cells (CTCs) to the surface of carbon nanotubes. More...
12 Aug 2019
Image: A micrograph showing amyloid beta (brown) in senile plaques of the cerebral cortex (upper left of image) and cerebral blood vessels (right of image) with immunostaining (Photo courtesy of Wikimedia Commons).

Amyloid Beta Blood Test Detects Asymptomatic Alzheimer’s Disease

An assay has been developed that determines the ratio of amyloid beta peptides in the blood and correlates with the accumulation of these Alzheimer’s disease risk factors in the brain. More...
12 Aug 2019
Image: A blood smear from a patient with non-Hodgkin lymphoma showing very large lymphocytes (Photo courtesy of Venngage).

BRCA2 Mutations Linked to Pediatric Non-Hodgkin Lymphoma Risk

Inherited mutations in BRCA1 and BRCA2 genes are most typically associated with an increased risk of developing breast and ovarian cancer. BRCA2 was the third most frequently mutated gene (14 occurrences) among 3,006 survivors of childhood cancer, with the highest number observed among survivors of lymphoma. More...
09 Aug 2019
Image: A photomicrograph showing tumor-infiltrating lymphocytes in colorectal carcinoma, which are suggestive of microsatellite instability, and may be seen in Lynch syndrome (Photo courtesy of Nephron).

Mutation Study Suggests Changes to Clinical Management

Lynch syndrome (LS) results from pathogenic variants in the mismatch repair (MMR) genes and is the most common hereditary cancer syndrome, affecting an estimated 1 in 300 individuals. More...
08 Aug 2019

Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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