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Molecular Diagnostics

Image: These APOE gene alleles produce slightly different forms of the protein Apolipoprotein E (Photo courtesy of Genaro Gabriel Ortiz, MD, PhD, et al).

Alzheimer Disease Stratified by APOE Genotype

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and gradually worsens over time. It is the cause of 60% to 70% of cases of dementia. More...
27 Jun 2019
Image: A color hereditary cancer risk screening kit (Photo courtesy of Color Genomics).

Pathogenic Variant Carriers Missed by Current Genetic Testing

Current guidelines recommend genetic testing for people who have a personal or family history of cancer that indicates they might be at an increased risk of harboring a pathogenic familial variant, but this approach could miss people who lack any personal or family history. More...
27 Jun 2019
Image: Blue-stained dots are Chikungunya virus particles peppering the surface of an infected cell (Photo courtesy of Institute Pasteur/Thérèse Couderc).

RT-LAMP Used to Genotype and Diagnose Chikungunya

Chikungunya virus has re-emerged as an important pathogen causing several outbreaks in the world. As the clinical symptoms of chikungunya are similar to other mosquito-borne febrile diseases, the definitive diagnosis of the disease is based on the detection of viral genome from the patient blood. More...
27 Jun 2019
Image: A scanning electron photomicrograph of Candida albicans yeast cells (Photo courtesy of Science Photo Library).

Immune-Related Gene Implicated in Chronic Candida Infection Risk

Candida vaginitis is a frequent clinical diagnosis with up to 8% of women experiencing recurrent vulvovaginal candidiasis (RVVC) globally. RVVC is characterized by at least three episodes per year. More...
26 Jun 2019
Image: The HiSeq 2500 high-throughput sequencing system (Photo courtesy of Illumina).

Clinical Metagenomic Sequencing Improves Diagnosis of Neurological Infections

Metagenomic next-generation sequencing (NGS) is a promising approach for the diagnosis of infectious disease because a comprehensive spectrum of potential causes, viral, bacterial, fungal, and parasitic, can be identified by a single assay. More...
26 Jun 2019
Image: Identifying a metastatic colorectal cancer patient’s Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment (Photo courtesy of University of Southern California).

Identifying Colorectal Cancer Subtypes Improves Treatment Decisions

Colorectal cancer is the second leading cause of cancer death in the USA, and is expected to cause about 51,000 deaths in 2019, but until now, it was unclear which drugs were most effective for which patients. More...
25 Jun 2019
Image: A colorized electron micrograph showing malaria parasite (right, blue) attaching to a human red blood cell. The inset shows a detail of the attachment point at higher magnification (Photo courtesy of [U.S.]NIAID via Wikimedia Commons).

Blood Drop Assay Designed for Monitoring Antimalarial Drug Resistance

A new method for analyzing DNA directly in a drop of blood was designed for monitoring development of resistance to antimalarial drugs. More...
24 Jun 2019

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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.

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