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Hematology

Image: Acute lymphoblastic leukemia: bone marrow aspirate smear reveals increased blasts which are small to medium in size with high nuclear-to-cytoplasmic ratios, round to irregular nuclei, smooth chromatin, and scant basophilic agranular cytoplasm. Some background maturing myeloid cells are also present in this case (Photo courtesy of Karen M. Chisholm, MD, PhD)

Acute Lymphoblastic Leukemia Risk Linked to Genetically Mediated Increase in Lymphocytes

Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated. More...
15 Sep 2021
Image: The Mission Ultra Hb Testing System portable point-of-care testing device detects anemia (Photo courtesy of ACON Laboratories)

Point-of-Care Testing Device Evaluated for Anemia Detection

Anemia is a serious public health problem worldwide. Several methods are commonly used to assess an individuals’ hemoglobin (Hb) and hematocrit (Hct) levels, including automated hematology analyzers, microhematocrit centrifuge, gravimetric copper sulfate method, cyanmethemoglobin method, and color code Hb estimation. More...
14 Sep 2021
Image: The Princeton Applied Research ParstatMC multi-potentiostat was used to identify redox potential as a feasible marker for banked blood quality (Photo courtesy of Ametek)

Redox Potential Used as a Feasible Marker for Banked Blood Quality

Stored red blood cells (RBCs) may undergo oxidative stress over time, with functional changes affecting oxygen delivery. Central to these changes are oxidation-reduction (redox) reactions and redox potential (RP) that must be maintained for cell function. More...
09 Sep 2021
Image: The HemoCue Hb 201+ System Analyzer has become a standard in hemoglobin point-of-care testing (Photo courtesy of HemoCue AB)

Dengue Patients’ Hemoglobin Concentrations Compared by POC and CBC

Dengue is a mosquito-borne viral infection that is mainly found in tropical and sub-tropical climates. The natural history of dengue has the unique characteristic of plasma leakage that results in hemoconcentration as well as vasculopathy and thrombocytopenia that result in bleeding. More...
06 Sep 2021
Image: Blood film showing eosinophilic leukocytes (single cell arrowed) surrounded by red blood cells. About 50% of people with severe asthma may have elevated levels of eosinophils in their blood (Photo courtesy of Jane Liesveld, MD)

Exhaled Nitric Oxide and Eosinophil Count Diagnose Eosinophilic Asthma

Eosinophilic asthma is now recognized as an important subphenotype of asthma based on the pattern of inflammatory cellular infiltrate in the airway. Eosinophilic asthma can be associated with increased asthma severity, atopy, late-onset disease, and steroid refractoriness. More...
01 Sep 2021
Image: The STANDARD G6PD Test is a handheld device that delivers results in two minutes and provides a quantitative measure of G6PD activity, including in heterozygous women (Photo courtesy of SD BIOSENSOR/PATH)

Point-of-Care Diagnostic to Identify G6PD Deficiency Evaluated

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited condition in which patients are excessively susceptible to the development of hemolytic anemia. Affected people lack the ability to tolerate biochemical oxidative stress, and red cell hemolysis is the most important clinical consequence. More...
31 Aug 2021
Image: The Sysmex DI-60 is an automated, cell-locating image analysis system. It is connected directly to the analyzer track and therefore eliminates the need for manual intervention in the hematology workflow in the imaging cycle (Photo courtesy of Sysmex Corporation)

Fluorescent Lymphocytes and Smudge Cells Explored in Infectious Mononucleosis

Infectious mononucleosis (also known as Glandular fever) is an infection most commonly caused by the Epstein-Barr virus (EBV), which is a human herpes virus. Glandular fever is not particularly contagious. It is spread mainly through contact with saliva, such as through kissing, or sharing food and drink utensils. More...
30 Aug 2021


The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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