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Hematology

Image: The High Mobility Group Box protein 1 (HMGB1) quantitative enzyme-linked immunosorbent assay kit (Photo courtesy of Shino-Test Corporation).

Serum HMGB1 Levels Reflect Clinical Features of HLH

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome. Hypercytokinemia secreted from dysregulated hyperactivated monocytes, macrophages, T cells and NK cells has been reported to play a major role in HLH. More...
17 Sep 2019
Image: Risk stratification integrating genetic data for factor VIII inhibitor development in patients with severe hemophilia (Photo courtesy of Paris-Saclay University).

Genetics Affect Risk of Developing Factor VIII Inhibitors

For severe hemophilia A (HA) patients, the current standard of care includes regular prophylactic infusions of factor VIII (FVIII) products in order to prevent spontaneous bleeds or on demand infusions to treat bleeds. More...
06 Sep 2019
Image: The Ortho ProVue automated blood bank analyzer (Photo courtesy of Ortho Clinical Diagnostics).

Clinical Specificity of RBC Alloantibodies Studied in Pregnant Women

Maternal red cell immunoglobulin G (IgG) antibodies can cross the placenta and cause hemolysis of fetal red cells in case of antigenic differences between maternal and fetal red blood cells (RBCs), leading to hemolytic disease of the fetus and newborn (HDFN). More...
05 Sep 2019
Image: A peripheral blood smear from a patient with iron deficiency anemia: significant hypochromia and microcytosis is seen, as well as moderate variation in size and shape of the red cells (Photo courtesy of American Society of Hematology).

Toolkit Developed for Iron Deficiency in Pregnancy

The risk of iron deficiency (ID) increases during pregnancy due to an increase in maternal iron requirements to accommodate the expansion of maternal red blood cell (RBC) mass, development of the placenta and fetus, and the loss of blood associated with labor and delivery. More...
04 Sep 2019
Image: The BC-5800 hematology autoanalyzer (Photo courtesy of Mindray).

Platelet Volume Related to Geriatric Patient In-Hospital Mortality

Treatment of acute coronary syndrome involves inhibition of platelet activity and thrombus formation. Platelets play a significant part during myocardial infarction by enhancing microvascular obstruction and secreting vasoactive peptides. More...
28 Aug 2019
Image: The BC-6800 benchtop automatic hematology analyzer (Photo courtesy of Mindray).

Hematology Analyzer Screens for Malaria in Clinical Setting

Malaria is a vector-borne infectious disease that continues to have high morbidity and mortality globally. Diagnosis based only on clinical symptoms has very low specificity as there is no combination of symptoms that reliably distinguishes malaria from other causes of fever or influenza. More...
14 Aug 2019
Image: A blood smear from a patient with non-Hodgkin lymphoma showing very large lymphocytes (Photo courtesy of Venngage).

BRCA2 Mutations Linked to Pediatric Non-Hodgkin Lymphoma Risk

Inherited mutations in BRCA1 and BRCA2 genes are most typically associated with an increased risk of developing breast and ovarian cancer. BRCA2 was the third most frequently mutated gene (14 occurrences) among 3,006 survivors of childhood cancer, with the highest number observed among survivors of lymphoma. More...
09 Aug 2019


The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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