We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

First of Its Kind Technology Detects Glucose in Human Saliva

By LabMedica International staff writers
Posted on 30 Nov 2023
Print article
Image: Saliva could one day replace blood to monitor people’s health (Photo courtesy of 123RF)
Image: Saliva could one day replace blood to monitor people’s health (Photo courtesy of 123RF)

Blood tests are vital for assessing health, but they often involve uncomfortable procedures, including frequent finger pricks or blood draws by a phlebotomist. Saliva, which shares many biomarkers with blood, has been considered as an alternative for monitoring health indicators like glucose levels. Traditional analysis of saliva for small molecules often requires lab equipment. Now, a new device capable of detecting glucose and adenosine monophosphate (AMP) in saliva with high sensitivity could simplify home health monitoring and eliminate the discomfort of traditional methods.

At the Université de Sherbrooke in Québec, Canada, researchers have adapted electrochemical aptamer-based (E-AB) biosensors, previously used for testing blood samples, to work with saliva. These biosensors generate an electrochemical signal when a custom-designed DNA or RNA aptamer binds to a specific target molecule. Focusing on glucose and AMP—a biomarker linked to gum disease—the team modified existing DNA aptamers to enhance their sensitivity and mounted them on gold electrodes to create the E-AB biosensors. Saliva samples were gathered from participants and combined for testing. The innovative aspect of this approach lies in its simplicity: the biosensors can be directly immersed in saliva without any additional preparation or reagents, making it feasible for at-home patient use.

The researchers observed that their devices could deliver results in just 30 seconds, remained effective in pure saliva for up to three days, and maintained their sensitivity for a week with proper washing after each use. The glucose sensor demonstrated high specificity for its target, and both AMP and glucose sensors could detect these biomarkers at concentrations lower than those usually present in saliva. This breakthrough, particularly in glucose detection in human saliva, holds promise for making health monitoring less invasive and more manageable for individuals with chronic conditions like diabetes.

Related Links:
Université de Sherbrooke

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
Complement 3 (C3) Test
GPP-100 C3 Kit
Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV

Print article


Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more


view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more


view channel
Image: The AI predictive model identifies the most potent cancer killing immune cells for use in immunotherapies (Photo courtesy of Shutterstock)

AI Predicts Tumor-Killing Cells with High Accuracy

Cellular immunotherapy involves extracting immune cells from a patient's tumor, potentially enhancing their cancer-fighting capabilities through engineering, and then expanding and reintroducing them into the body.... Read more


view channel
Image: The T-SPOT.TB test is now paired with the Auto-Pure 2400 liquid handling platform for accurate TB testing (Photo courtesy of Shutterstock)

Integrated Solution Ushers New Era of Automated Tuberculosis Testing

Tuberculosis (TB) is responsible for 1.3 million deaths every year, positioning it as one of the top killers globally due to a single infectious agent. In 2022, around 10.6 million people were diagnosed... Read more


view channel
Image: The new AI tool can help beat brain tumors (Photo courtesy of Crystal Light/Shutterstock)

New AI Tool Classifies Brain Tumors More Quickly and Accurately

Precision in diagnosing and categorizing tumors is essential for delivering effective treatment to patients. Currently, the gold standard for identifying various types of brain tumors involves DNA methylation-based... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.