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Image: The High Mobility Group Box protein 1 (HMGB1) quantitative enzyme-linked immunosorbent assay kit (Photo courtesy of Shino-Test Corporation).

Serum HMGB1 Levels Reflect Clinical Features of HLH

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome. Hypercytokinemia secreted from dysregulated hyperactivated monocytes, macrophages, T cells and NK cells has been reported to play a major role in HLH. More...
17 Sep 2019
Image: A photomicrograph of an immunofluorescence assay (IFA) for Rickettsia (Photo courtesy of Fuller Laboratories).

Immunoassays Compared for Diagnosis of Acute Murine Typhus Infections

Murine typhus is a disease transmitted by fleas and is caused by intracellular gram-negative bacteria called Rickettsia typhi, and manifested clinically with acute fever, chills, muscle pain, nausea, vomiting, stomach pain, cough and rash. More...
10 Sep 2019
Image: NETosis Assay Kit: PMA induces neutrophil extracellular trap (NET) formation in human neutrophils (Photo courtesy of Cayman Chemical).

Differential Immune Responses Triggered against Salmonella enterica

Enteric fevers, caused by the Salmonella enterica serovars Typhi (ST), Paratyphi A (PA) and Paratyphi B (PB), are life-threatening illnesses exhibiting very similar clinical symptoms but with distinct epidemiologies, geographical distributions and susceptibilities to antimicrobial treatment. More...
06 Sep 2019
Image: Risk stratification integrating genetic data for factor VIII inhibitor development in patients with severe hemophilia (Photo courtesy of Paris-Saclay University).

Genetics Affect Risk of Developing Factor VIII Inhibitors

For severe hemophilia A (HA) patients, the current standard of care includes regular prophylactic infusions of factor VIII (FVIII) products in order to prevent spontaneous bleeds or on demand infusions to treat bleeds. More...
06 Sep 2019
Image: A collection of whole saliva by the Salivette (absorbent) method. (a) Saliva is collected by chewing a cotton wool swab. (b) The swab containing saliva is placed in the tube of Salivette. (c) Centrifugation of the assemblage. (d) Saliva is separated from the swab and is ready for analysis (Photo courtesy of Sarstedt).

Optimized Immunoassays Detect HBV in Oral Fluid Samples

It is estimated that there are 257 million chronic hepatitis B (HBV) carriers worldwide, which highlights the substantial health, social, and economic burden of HBV. Screening of infected, cured and vaccinated individuals is necessary to identify the presence of chronically infected reservoirs, immune and susceptible individuals. More...
05 Sep 2019
Image: Aspergillus (Photo courtesy of Kateryna Kon / Fotolia.com).

Novel ELISA Detects Invasive Aspergillosis

Aspergillus spp. is a ubiquitous sac fungus, which is found in soil or compost or on damp walls. Inhalation of spores can lead to severe infections in individuals with a weakened immune system. More...
05 Sep 2019
Image: The CFX96 Touch RT-PCR detection system (Photo courtesy of Bio-Rad Laboratories).

Enterovirus Antibodies Detected in Acute Flaccid Myelitis Patients

Neurotropic enteroviruses (EVs), such as poliovirus, have long been associated with paralytic disease. Acute flaccid myelitis (AFM) has caused motor paralysis in more than 560 children in the United States since 2014. More...
28 Aug 2019

The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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