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Immunology

Image: Autoantibody order, timing helps predict genetically susceptible children most likely to get type 1 diabetes (Photo courtesy of the Morsani College of Medicine).

Autoantibody Timing Predicts Genetically At-Risk Children for Diabetes

While antibodies are molecules produced by the body's immune system to detect and destroy specific viruses, bacteria and other harmful substances, autoantibodies are antibodies that target a person's own healthy tissue. In the case of type 1 diabetes (T1D), a misdirected autoimmune response attacks the pancreas and gradually destroys the organ's insulin-producing beta cells. More...
11 Nov 2020
Image: The Buhlmann fCal Turbo turbidimetric immunoassay measures fecal calprotectin in stool specimens (Photo courtesy of Buhlmann Diagnostics).

Novel Fecal Calprotectin Test Validated in Pediatric Population

Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are increasingly prevalent disorders with overlapping clinical presentations. Distinguishing between these two classes of disease is important, as while IBS is an idiopathic functional disorder, IBD is characterized by chronic inflammation and tissue destruction. More...
10 Nov 2020
Image: The iFlash 1800 chemiluminescence immunoassay analyzer (Photo courtesy of Shenzhen YHLO Biotech).

Serum-IgG Responses in Patients with Mild and Severe COVID-19

The coronavirus disease 2019 (COVID-19) pandemic continues, causing considerable morbidity and mortality worldwide. The severity of COVID-19 ranges from asymptomatic to fatal pneumonitis, with mildly symptomatic patients accounting for approximately 80% of all cases according to current understanding. More...
04 Nov 2020
Image: Serological test performed at the rabies laboratory. The Bio-Rad Platelia Rabies II ELISA kit is one of the diagnostic assays that are routinely conducted for the determination of antibodies against the rabies virus (Photo courtesy of Korean Animal and Plant Quarantine Agency).

Antibodies Against Rabies Detected in Human Dried Blood Spots

Rabies is a viral disease that causes inflammation of the brain in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. Although preventable by vaccination for more than a century, rabies virus still causes numerous fatalities every year. More...
03 Nov 2020
Image: Mutations in cell free DNA (cfDNA) or cells in the peripheral blood along with anemia or thrombocytopenia are the hallmark of myelodysplastic syndrome (MDS). The diagnosis of MDS is confirmed when mutations in hematopoietic cells are detected at relatively high levels (Photo courtesy of Genomic Testing Cooperative).

Inherited Causes of Clonal Hematopoiesis in Multiplicity of Whole Genomes

The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating hematopoietic stem cell populations has recently been associated with both hematological cancer and coronary heart disease, and this phenomenon is termed clonal hematopoiesis of indeterminate potential (CHIP). More...
29 Oct 2020
Image: Scientists have greatly boosted the amount of information that can be obtained using Seq-Well S3, a technique for rapidly sequencing RNA from single cells (Photo courtesy of MIT).

Novel Method Reclaims Resolution of Single-Cell RNA-Seq

Single-cell RNA sequencing (scRNA-seq) is a powerful tool to characterize cells. Current scRNA-seq platforms, despite offering high throughput, are inefficient and provide low resolution among distinct cell states and molecular features. More...
28 Oct 2020
Image: The EUROPattern Microscope Live: Ultrafast fluorescence microscopy that automatically detects anti-neutrophil cytoplasmic antibodies (Photo courtesy of EUROIMMUN AG).

Methods for Automated Anti-Neutrophil Cytoplasmic Antibodies Compared

The detection of anti-neutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence assays (IFA) is of diagnostic importance in vasculitis and some other inflammatory diseases. More...
21 Oct 2020


The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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