We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics

Download Mobile App




Genome Analysis Predicts Likelihood of Neurodisability in Oxygen-Deprived Newborns

By LabMedica International staff writers
Posted on 11 Aug 2020
Print article
Structure of the RGS1 protein (Photo courtesy of Wikimedia Commons)
Structure of the RGS1 protein (Photo courtesy of Wikimedia Commons)
A genomics-based blood test can predict likelihood that a baby suffering hypoxia at birth will suffer serious nervous disorders such as cerebral palsy or epilepsy at a later stage of development.

Hypoxic ischemic encephalopathy has many causes and is essentially the reduction in the supply of blood or oxygen to a baby's brain before, during, or even after birth. It is a major cause of death and disability, occurring in approximately two to three per 1000 births and causing around 20% of all cases of cerebral palsy.

Brain hypothermia, induced by cooling a baby to around 33 degrees Celsius for three days after birth, is a treatment for hypoxic ischemic encephalopathy. It has recently been proven to be the only medical intervention which reduces brain damage, and improves an infant's chance of survival and reduced disability.

Since a rapid and early diagnostic test to identify the encephalopathic babies at risk of adverse outcome has been lacking, investigators at Imperial College London (United Kingdom) have developed one.

The investigators theorized that a whole blood transcriptomic signature measured soon after birth would predict adverse neurodevelopmental outcome eighteen months after neonatal encephalopathy. To test this hypothesis, they performed next generation sequencing (NGS) on whole blood ribonucleic acid obtained within six hours of birth from the first 47 encephalopathic babies recruited to the Hypothermia for Encephalopathy in Low and middle-income countries (HELIX) trial. The study was conducted in Indian hospitals, where there are around 0.5-1.0 million cases of birth asphyxia per year. Blood was taken within six hours after birth, and the infants were followed until 18 months of age to identify those who developed neurodisabilities. Two infants with blood culture positive sepsis were excluded, and the data from remaining 45 were analyzed.

Results revealed that a total of 855 genes were significantly differentially expressed between the good and adverse outcome groups, of which Regulator of G-protein Signaling 1 (RGS1) and Structural Maintenance of Chromosomes Protein 4 (SMC4) were the most significant. Biological pathway analysis adjusted for gender, treatment (cooling therapy versus usual care), and estimated blood leukocyte proportions revealed over-representation of genes from pathways related to melatonin and polo-like kinase in babies with adverse outcome.

Senior author Dr. Sudhin Thayyil, professor of perinatal neuroscience at Imperial College London, said, "The results from these blood tests will allow us to gain more insight into disease mechanisms that are responsible for brain injury and allow us to develop new therapeutic interventions or improve those which are already available."

The study was published in the August 4, 2020, online edition of the journal Scientific Reports.


Related Links:

Imperial College London

Gold Supplier
Blood Glucose Laboratory Analyzer
Nova Primary
New
Reagent Strips
ETEST
New
COVID-19 IgG/IgM Test
Accu-Tell COVID-19 IgG/IgM
New
SARS-CoV-2/Influenza A+B/RSV/Adenovirus/M.Pneumoniae Antigen Combo Rapid Test
SARS-CoV-2/Influenza A+B/RSV/Adenovirus/M.Pneumoniae Antigen Combo Rapid Test

Print article
Mayo Medical Laboratories
BIOHIT  Healthcare OY

Channels

Molecular Diagnostics

view channel
Image: Photograph of the novel capsule-based smell test (Photo courtesy of Queen Mary University of London)

A Novel Capsule-Based Smell Test for Diagnosis of Neurological and Respiratory Diseases

To aid in diagnosing diseases where loss of the sense of smell is a symptom, such as in chronic neurological conditions like Parkinson's and Alzheimer's diseases and in acute respiratory infections such... Read more

Pathology

view channel
Image: The Hamamatsu Photonics Nanozoomer 1 Digital Slide Scanner (Photo courtesy of University of Adelaide)

Genetic Background and Clinicopathologic Features Established for Adult-Onset Nephronophthisis

Nephronophthisis (NPH) is a genetic disorder of the kidneys which mainly affects children. It is classified as a medullary cystic kidney disease. The disorder is inherited in an autosomal recessive fashion... Read more

Industry

view channel
Image: DxA 5000 Fit (Photo courtesy of Beckman Coulter)

Beckman Coulter Becomes First Diagnostics Company to Offer Workflow Automation Specifically for Mid-Volume Laboratories

Beckman Coulter (Brea, CA, USA) has announced the global launch of the DxA 5000 Fit, a workflow-automation solution designed to fit into medium-sized labs that run fewer than 5,000 tests a day.... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.