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Image: A catalog of deletions (4,489) observed in brain samples derived from both healthy subjects and subjects with psychiatric disorders. The burden of deletions accumulates in various brain regions during aging. Many deletions play a major role in classical mitochondrial disorders, and deletion burden is viewed as an indicator of long lasting mitochondrial oxidative stress. Each colored ribbon is composed of individual lines showing the relative amount of deletions in brain samples in the catalog (Photo courtesy of the University of California, Irvine).

New Technique Detects Breaks in Mitochondrial DNA

The Splice-Break pipeline is a recently described technique that can detect and quantify mitochondrial DNA (mtDNA) deletions at a high level of resolution. More...
22 Apr 2019
Image: A color photograph of a kidney stone – eight millimeters in length (Photo courtesy of Wikimedia Commons).

Genome Study Identifies Kidney Disease Risk Factor Genes

A large genome-wide association study identified 14 variants, including nine new variants, at different genetic loci that were linked to the development of urolithiasis (kidney stone disease). More...
22 Apr 2019
Image: A diagram of the epidermal growth factor receptor (EGFR) (rainbow colored, N-terminus = blue, C-terminus = red) complexed its ligand epidermal growth factor (magenta) (Photo courtesy of Wikimedia Commons).

Targeting MicroRNA Blocks Drug Tolerance in Some Cancers

Cancer researchers have suggested that by exploiting the link between a specific microRNA and the tricarboxylic acid energy-producing cycle it may be possible to prevent or reverse the development of drug tolerance or resistance by non-small-cell lung carcinomas. More...
15 Apr 2019
Image: Researchers identified an RNA signature in the blood of pregnant lupus patients that could help predict the development of preeclampsia (Photo courtesy of Medical Xpress).

Profiling of Blood Transcriptome Predicts Complications in Pregnancies

Researchers have proposed profiling of the blood transcriptome as a method to predict complications in pregnancy that might be experienced by women with systemic lupus erythematosus. More...
15 Apr 2019
Image: The wearable CTC collection device measures roughly 2 x 2.75 x 1 inches (5.08 x 6.98 x 2.54 cm), with the cancer-cell-capturing chip mounted on top. The catheter connecting to the patient runs through the hole in the top left corner (Photo courtesy of Dr. Tae Hyun Kim).

Prototype CTC Collection Device Tested Successfully in Model

A novel, wearable device for continuous isolation of circulating tumor cells (CTCs) from a peripheral vein was tested successfully in a dog model of human cancer. More...
08 Apr 2019
Image: The cells that line the gut of an ulcerative colitis patient are inflamed and filled with PAI-1 protein (shown in red), which is linked to blood clotting. Nuclei are shown in blue, and other intestinal cells are marked in green (Photo courtesy of Gerard Kaiko, Washington University School of Medicine).

Experimental Treatment Eases Symptoms of IBD in Model

A recent paper described the use of an experimental enzyme inhibitor to treat and relieve symptoms of inflammatory bowel disease (IBD) in a mouse model. More...
01 Apr 2019
Image: The lack of dystrophin, shown in red, in an unedited human heart muscle cell with DMD (left) and the restoration of dystrophin in a CRISPR-edited human heart muscle cell (right) (Photo courtesy of the University of Texas Southwestern Medical Center).

MD Mouse Model Used to Tweak Gene-Editing Protocols

A new mouse model of Duchenne muscular dystrophy (DMD) that carries the exon 44 deletion mutation was used to develop strategies for correction of this mutation employing CRISPR/Cas9 to edit surrounding exons, which restores the dystrophin open reading frame. More...
25 Mar 2019

BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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