We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Distinctive mRNA Signatures May Prove Diagnostic for Cancer-Related AIS

By LabMedica International staff writers
Posted on 22 Sep 2019
A recently published paper described a distinctive molecular signature present in blood mRNA expression profiles of patients with cancer-related acute ischemic stroke (AIS) that could potentially lead to earlier diagnosis of cancer in these patients.

Cancer is commonly diagnosed in patients with AIS. More...
Since blood mRNA profiles can distinguish AIS mechanisms, a team of cancer investigators from several institutions including Weill Cornell Medical College (New York, NY, USA) and the University of California, Davis (USA) hypothesized that cancer-related AIS would have a distinctive gene expression profile.

To test this theory, the investigators evaluated four groups of 10 subjects prospectively enrolled at three centers from 2009 to 2018. This population included the group of interest with active solid tumor cancer and AIS and three control groups with active cancer only, AIS only, or vascular risk factors only. Subjects in the AIS-only and cancer-only groups were matched to subjects in the cancer-stroke group by age, sex, and cancer type (if applicable). Subjects in the vascular risk factor group were matched to subjects in the cancer-stroke and stroke-only groups by age, sex, and vascular risk factors. Blood was drawn 72 to 120 hours after stroke, and total RNA was analyzed using 3′ mRNA sequencing.

Results revealed that more than half of strokes in the cancer-stroke group were not caused by traditional risk factors. In total, more than 12,000 genes were analyzed and comparing the cancer-stroke group to the stroke-only group and after accounting for cancer-only genes, 438 genes were found to be differentially expressed. These genes were linked to upregulation of multiple genes/pathways implicated in autophagy signaling, immunity/inflammation, and gene regulation, including interleukin-1, interferon, relaxin, mammalian target of rapamycin signaling, SQSTMI1 (sequestosome-1), and CREB1 (cAMP response element binding protein-1).

"We clearly see that cancer-stroke patients have a unique gene expression profile," said first author Dr Babak Navi, chief of stroke and hospital neurology at Weill Cornell Medical College. "No one before had differentiated gene expression between patients with cancer, stroke, or both. A blood test would be easier, safer, and less expensive than a CT or PET scan to diagnose cancer."

The report was published in the September 12, 2019, online edition of the journal Stroke.

Related Links:
Weill Cornell Medical College
University of California, Davis


Gold Member
Veterinary Hematology Analyzer
Exigo H400
Serological Pipet Controller
PIPETBOY GENIUS
New
Droplet Digital PCR System
QX600 AutoDG
New
C-Reactive Protein Rapid Test
Afinion CRP
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: The tip optofluidic immunoassay platform enables rapid, multiplexed antibody profiling using only 1 μL of fingertip blood (Photo courtesy of hLife, DOI:10.1016/j.hlife.2025.04.005)

POC Diagnostic Platform Performs Immune Analysis Using One Drop of Fingertip Blood

As new COVID-19 variants continue to emerge and individuals accumulate complex histories of vaccination and infection, there is an urgent need for diagnostic tools that can quickly and accurately assess... Read more

Pathology

view channel
Image: The new technology combines a rapid hemoglobin test with a smartphone app (Photo courtesy of 123RF)

Smartphone-Based Rapid Hemoglobin Test Accurately Detects Colorectal Cancer

Despite the availability of colorectal cancer screening programs, participation remains low, especially for fecal immunochemical tests (FIT), a non-invasive method to detect hidden blood in the stool.... Read more

Technology

view channel
Image: The machine learning-based method delivers near-perfect survival estimates for PAC patients (Photo courtesy of Shutterstock)

AI Method Predicts Overall Survival Rate of Prostate Cancer Patients

Prostate adenocarcinoma (PAC) accounts for 99% of prostate cancer diagnoses and is the second most common cancer in men globally after skin cancer. With more than 3.3 million men in the United States diagnosed... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.