We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Microbial Sensor Identifies Bacterial Infections and Also Creates Blood Stem Cells

By LabMedica International staff writers
Posted on 26 Dec 2023
Print article
Image: Blood stem cells forming in the trunk of a zebrafish embryo (Photo courtesy of Xiaoyi Cheng)
Image: Blood stem cells forming in the trunk of a zebrafish embryo (Photo courtesy of Xiaoyi Cheng)

A new study has revealed that a microbial sensor, known as Nod1, crucial in detecting and combating bacterial infections, also significantly influences the formation of blood stem cells. This discovery could revolutionize the process of generating patient-specific blood stem cells, potentially eliminating the need for bone marrow transplants. Previous research indicated that while inflammatory signals typically trigger immune responses, they serve a different purpose during the early stages of embryonic development, particularly in the formation of vascular systems and blood. The activation of the microbial sensor in embryos prompts the transformation of vascular endothelial cells into blood stem cells, creating the potential for the development of a new method to replicate this process in a laboratory setting using a patient's own blood.

Stem cells are critical for the body's development and repair, continuously dividing to maintain their population and generate specialized cells. Embryonic pluripotent stem cells have the capability to form any cell type required by the body, while adult stem cells are more specialized. Hematopoietic stem cells, or blood stem cells, are responsible for producing all the components of blood. These essential cells are formed before birth within the embryo. Researchers at Iowa State University (Ames, IA, USA) discovered that the immune receptor Nod1 activates in an embryo before endothelial cells begin their transition into becoming stem cells, essentially preparing them for this transformation.

The team focused on Nod1 by examining data from human embryos and conducting studies on zebrafish, which share a significant portion of their genetic makeup with humans. They observed that the formation of blood stem cells corresponded with the levels of Nod1, as they manipulated its activity. Further experiments with human induced pluripotent stem cells, adult cells reprogrammed to an embryonic stem cell-like state, reinforced the importance of Nod1 in blood development. The absence of Nod1 led to reduced blood production, similar to the results observed in zebrafish.

Understanding Nod1's critical role in blood stem cell development is a significant step forward for scientists aiming to create a method to produce blood stem cells from human samples. This breakthrough could lead to a transformative new treatment for patients with blood disorders, allowing them to receive transfusions of blood stem cells derived from their own tissues. This approach could potentially eliminate the risks associated with graft-versus-host disease, a severe complication that occurs when the body's immune system attacks the transplanted cells. The research team continues to unravel the intricate process of blood stem cell development, focusing on the timing and expression of various signals crucial for creating a viable method for generating blood stem cells.

“My group at Iowa State University will continue working towards a life without blood disorders. I believe our investigations will pave the road to finally create therapeutic-grade blood stem cells to cure blood disorder patients,” said Raquel Espin Palazon, an assistant professor of genetics, development and cell biology at Iowa State University who led the research team.

Related Links:
Iowa State University

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
HLX
Complement 3 (C3) Test
GPP-100 C3 Kit
Gold Member
Xylazine Immunoassay Test
Xylazine ELISA

Print article

Channels

Molecular Diagnostics

view channel
Image: Prostate cancer cell image taken using a scanning electron microscope (Photo courtesy of LRI EM Unit)

New Discoveries of Prostate Cancer Evolution Pave Way for Genetic Test

Prostate cancer ranks as one of the most common cancers affecting men, and while it accounts for a significant number of male cancer fatalities, many men live with it rather than die from it.... Read more

Hematology

view channel
Image: The Gazelle Hb Variant Test (Photo courtesy of Hemex Health)

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Hemoglobin disorders rank as some of the most prevalent monogenic diseases globally. Among various hemoglobin disorders, beta thalassemia, a hereditary blood disorder, affects about 1.5% of the world's... Read more

Pathology

view channel
Image: The photoacoustic spectral response sensing instrument is based on low-cost laser diodes (Photo courtesy of Khan et al., doi 10.1117/1.JBO.29.1.017002)

Compact Photoacoustic Sensing Instrument Enhances Biomedical Tissue Diagnosis

The pursuit of precise and efficient diagnostic methods is a top priority in the constantly evolving field of biomedical sciences. A promising development in this area is the photoacoustic (PA) technique.... Read more

Industry

view channel
Image: The companies will develop genetic testing systems based on capillary electrophoresis sequencers (Photo courtesy of 123RF)

Sysmex and Hitachi Collaborate on Development of New Genetic Testing Systems

Sysmex Corporation (Kobe, Japan) and Hitachi High-Tech Corporation (Tokyo, Japan) have entered into a collaboration for the development of genetic testing systems using capillary electrophoresis sequencers... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.