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Clinical Chemistry

Image: The Thermo Fisher Scientific Orbitrap Velos mass spectrometer features dual-pressure linear ion trap technology that delivers increased sensitivity and dynamic range with ultimate robustness (Photo courtesy of University of Michigan)

Lipidomic Determinants Profiled for Human Diabetic Neuropathy

Peripheral neuropathy is a common complication of type 2 diabetes, ranging in prevalence from 10% to over 50% in various cohorts. Peripheral neuropathy symptoms manifest as a loss of sensation and pain in a length-dependent manner. Peripheral neuropathy in type 2 diabetes remains recalcitrant to effective treatment; glucose control only marginally prevents neuropathy onset and development. More...
05 Oct 2022
Image: Neutrophil gelatinase-associated lipocalin (NGAL) Duo Set ELISA (Photo courtesy of R&D Systems)

Synovial Fluid NGAL Accurately Diagnoses Prosthetic Joint Infection

Prosthetic joint infection (PJI) is a serious complication that is difficult to diagnose after joint arthroplasty and seriously affects the physical and mental health of patients. Current studies suggest that PJI is a relatively limited infectious disease, and the synovial fluid (SF) biomarkers more directly reflect the nature and extent of inflammation. More...
04 Oct 2022
Image: The Article Transfer Service is designed to help manuscripts find the right journal faster (Photo courtesy of Elsevier)

Article Submission Process Streamlined for Clinica Chimica Acta and Related Journals

An initiative by Elsevier BV (Amsterdam, Netherlands), one of the world's largest scientific publishers with around 300 journals including Clinica Chimica Acta, aims to help authors find the best journal match for their article, quickly and easily. More...
26 Sep 2022
Image: High-sensitivity cardiac troponin I: relying on the sex-specific 99th percentile upper reference limit of cardiac troponin may incorrectly suggest myocardial infarction (MI) in older adults with suspected heart attacks (Photo courtesy of Blood Tests in London)

Age Alters Diagnostic Performance of Cardiac Troponin

The guideline-recommended thresholds for increased high-sensitivity cardiac troponin I (hs-cTnI), indicating myocardial injury and potential infarction, performed at a similar sensitivity around 80% in people across age groups. More...
20 Sep 2022
Image: Blood sample for testosterone hormone test: Low Testosterone Levels Tied to More Severe COVID in Men (Photo courtesy of Rae Lynn Mitchell, MA)

Low Testosterone Levels Tied to More Severe COVID in Men

The COVID-19 pandemic has exacted a heavy toll on public health. Male sex is associated with severe COVID-19. It is not known whether the risk of hospitalization differs between men with hypogonadism, men with eugonadism, and those receiving testosterone therapy (TTh). More...
12 Sep 2022
mage: The AU560 automatic enzymatic analyzer (Photo courtesy of Sysmed Lab Europe)

Osteopontin and Osteoprotegerin Investigated In Peripheral Artery Disease

Peripheral artery disease (PAD) is one of the many complications of systemic atherosclerosis and it is accompanied by high rates of cardiovascular diseases (CVD) morbidity and mortality. PAD is a common condition in which narrowed arteries reduce blood flow to the arms or legs. More...
08 Sep 2022
Image: Results from STORK prenatal genetic test, shown in foreground (Photo courtesy of Columbia University Irving Medical Center).

Prenatal Test Reduces Time of Detecting Chromosomal Abnormalities

A newly developed prenatal test can determine if a fetus or embryo has the right number of chromosomes at a fraction of the time and cost of currently available clinical genetic tests.

More...
24 Aug 2022
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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