We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App

Urine Metabolite Test Can Predict Diabetic Kidney Failure 5-10 Years Early

By LabMedica International staff writers
Posted on 25 Aug 2023
Print article
Image: Metabolite in urine can predict diabetic kidney failure 5-10 years early (Photo courtesy of Tom Schoumakers, Shutterstock.com)
Image: Metabolite in urine can predict diabetic kidney failure 5-10 years early (Photo courtesy of Tom Schoumakers, Shutterstock.com)

Until now, the presence of protein (albumin) in the urine has been the key indicator for kidney disease. However, nearly half of diabetes patients who experience kidney failure do not exhibit substantial protein levels in their urine. Now, in the first-ever study, researchers have identified a new predictive marker in the urine that identifies these patients at an early stage. This discovery holds significant implications, given that 90% of diabetes patients with low levels of albumin in their urine remain at heightened risk.

Researchers from UT Health San Antonio (San Antonio, TX, USA) have discovered that the levels of adenine, a metabolite originating in the kidney, serve as predictive and causative biomarkers for impending progressive kidney failure in diabetes patients. Metabolites are small molecules generated in response to metabolism. They can either drive cells towards a healthy state or a disease state. This breakthrough opens avenues for clinical testing to identify, five to ten years prior to kidney failure, patients who are at risk. Importantly, the research team identified a specific small molecule that can inhibit the main pathway of endogenous adenine production in the body. This therapeutic drug decreased kidney adenine levels in mice with type 2 diabetes.

The researchers studied over 1,200 diabetes patients across three global research cohorts, consistently finding a correlation between elevated urine adenine levels and a heightened risk of kidney failure. UT Health San Antonio has perfected a spatial metabolomics technique on kidney biopsies from human patients that enables the identification of adenine and other small molecule locations within kidney tissues. The team detected endogenous adenine around scarred blood vessels in the kidney and around tubular-shaped kidney cells that were undergoing destruction. The finding that elevated adenine levels are also linked to all-cause mortality in study participants implies that the metabolite may influence other bodily regions. Although the measurement of urine adenine presents challenges, the Center for Precision Medicine at UT Health San Antonio has devised a robust and sensitive method to accurately measure urine adenine levels in patients.

“It’s a very difficult technique, and it took us several years to develop a method where we combine high resolution of the geography of the kidney with mass spectrometry analysis to look at the metabolites,” said the senior study author, Kumar Sharma, MD. “What we’re hoping is that by identifying patients early in their course and with new therapies targeting adenine and kidney scarring, we can block kidney disease or extend the life of the kidney much longer.”

Related Links:
UT Health San Antonio 

Platinum Supplier
Automatic Nucleic Acid Workstation
Gold Supplier
Automated, Random Access Chemistry Analyzer
LIDA 300
Silver Supplier
Real-time Fluorescence Quantitative PCR Analyzer
Concentrated Anionic Detergent

Print article


Clinical Chemistry

view channel
Image: The new assays are designed to run on the B•R•A•H•M•S KRYPTOR compact PLUS clinical chemistry analyzer (Photo courtesy of Thermo Fisher)

Breakthrough Immunoassays to Aid in Risk Assessment of Preeclampsia

Preeclampsia is a life-threatening blood pressure condition that can arise during pregnancy and the postpartum phase. This severe pregnancy complication is a primary cause of maternal and fetal mortality... Read more


view channel
Image: The US FDA has cleared HemoScreen point of care CBC for direct capillary sampling (Photo courtesy of PixCell Medical)

Point of Care CBC Analyzer with Direct Capillary Sampling Enhances Ease-of-Use and Testing Throughput

The world’s only 5-part differential Complete Blood Count (CBC) analyzer that is FDA-cleared, CE-marked, and TGA-approved for point-of-care use has now been granted FDA 510(k) clearance for direct capillary... Read more


view channel
Image: Immune cells present long before infection predict flu symptoms (Photo courtesy of Shutterstock.com)

Single Blood Draw to Detect Immune Cells Present Months before Flu Infection Can Predict Symptoms

For decades, if not centuries, scientists have struggled to solve the mystery of why certain individuals fall ill to infections while others remain unaffected. In an impressive development, researchers... Read more


view channel
Image: The rapid diagnostic test could pinpoint the correct antibiotic for infection treatment in under an hour (Photo courtesy of Microplate Dx)

Point-of-Care Device to Reduce Antibiotic Susceptibility Testing Time from Days to Minutes

Antimicrobial resistance (AMR) is a significant global health issue, currently leading to over 1.27 million deaths worldwide each year. By 2050, AMR could be causing up to 10 million deaths annually, surpassing... Read more


view channel
Image: The Tasso+ device has received CE Mark certification (Photo courtesy of Tasso)

Groundbreaking Blood Lancing Device Obtains Microliter Capillary Whole Blood Samples Painlessly

A convenient, virtually pain-free blood lancet that collects whole liquid blood samples has received CE Mark designation, making the patient-centric, high-volume blood collection solution available in... Read more


view channel
Image: A new electrochemical device can quickly and inexpensively identify people at greatest risk for osteoporosis (Photo courtesy of ACS Central Science, 2023)

Electrochemical Device Identifies People at Higher Risk for Osteoporosis Using Single Blood Drop

With the global increase in life expectancy, the incidence of age-related conditions like osteoporosis is increasing. Osteoporosis, affecting around 200 million individuals worldwide, has a higher incidence... Read more


view channel
Image: The global fully automatic electrolyte analyzers market is projected to reach close to USD 0.77 billion by 2032 (Photo courtesy of 123RF)

Global Fully Automatic Electrolyte Analyzers Market Driven by Surge in Demand for Point-of-Care Testing

Fully automatic electrolyte analyzers can measure the levels of electrolytes in various bodily fluids like blood and plasma. Electrolytes are ions that have an electrical charge and are essential for multiple... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.