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Clinical Chem.

Image: ELISA kit for liver-type fatty acid–binding protein (L-FABP). The level of L-FABP present in urine reflects the level of renal tubular dysfunction (Photo courtesy of Sekisui Medical Co)

Urinary Biomarkers Predict Weaning From Acute Dialysis Therapy

Acute kidney injury is associated with a higher risk of chronic kidney disease (CKD), end-stage renal disease, and long-term adverse cardiovascular effects. Critically ill patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT) have a poor prognosis. More...
29 Nov 2022
Image: The NGAL Test is a tool for risk assessment of kidney damage (Photo courtesy of BioPorto)

AKI Biomarker Test Assesses Risk of Kidney Damage in Critically Ill Patients

Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker that rises rapidly in response to kidney injury, preceding changes in creatinine by as much as two to three days. By identifying patients at risk of AKI early, clinicians can take more appropriate action to manage fluid levels, avoid nephrotoxic agents, and potentially prevent permanent kidney damage. More...
29 Nov 2022
Image: Equivalence of Genetically Elevated LDL and Lipoprotein(a) on Myocardial Infarction (Photo courtesy of Viborg Regional Hospital)

Familial Hypercholesterolemia Patients With ACD Have Elevated Lipoprotein(a)

Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL cholesterol), in the blood and early cardiovascular disease. More...
22 Nov 2022
Image: Thermo Scientific BRAHMS KRYPTOR Compact Plus Automated Immune Analyzer (Photo courtesy of machinio)

Circulating Angiogenic Factor Levels Predict Hypertensive Disorders of Pregnancy

Preeclampsia is the most common hypertensive disorder associated with pregnancy. The severe form of the disease can lead to dangerously high blood pressure, organ failure, vision loss or even stroke. It affects approximately 5% of pregnant women and is a leading cause of maternal and fetal death and serious illness. More...
15 Nov 2022
Image: A Human Lipocalin-2/ neutrophil gelatinase-associated lipocalin (NGAL) sandwich ELISA kit (Photo courtesy of Epitope Diagnostics Inc.)

Urine Neutrophil Gelatinase-Associated Lipocalin Predicts Acute Kidney Injury

Despite the increasing heterogeneity of etiology, making a definitive and timely diagnosis of acute kidney injury (AKI) remains challenging. Currently, the diagnosis of AKI is still based on elevated serum creatinine concentration or decreased urinary excretion. However, increased serum creatinine and decreased urine volume usually occur 48 hours after renal injury. More...
15 Nov 2022
Image: A new sensor device can determine cholesterol levels in the blood (Photo courtesy of UrFU)

New Blood Cholesterol Testing System Is Cheaper, More Efficient, and Faster

Scientists have developed a new sensor device for determining cholesterol levels in the blood. The system does not use protein compounds, namely enzymes. Chemists replaced them with an inorganic analogue - copper chloride. This allowed to make the process of creating cholesterol meters cheaper, to make blood testing easier, faster and more accessible. More...
08 Nov 2022
Image: The POC device could facilitate monitoring of hereditary and hepatic metabolic disorders (Photo courtesy of UAB)

New Analyzer Monitors Blood Ammonium Levels at POC to Facilitate Quick Medical Decisions

Researchers have developed an analyzer that monitors the level of ammonium in the patient’s blood using a decentralized method at the POC, instead of sending blood samples to be analyzed in hospital laboratories, where traditional equipment is used. More...
04 Nov 2022

The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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