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Pathology

Image: A melanoma on a patient\'s skin (Photo courtesy of the National Cancer Institute).

Fine-Tuned Microscopy Offers Breakthrough Resolution of Melanoma

Researchers have refined a classic Raman-based technique and succeeded in imaging the two dominant melanin molecules, which could lead to new understandings and, critically, early detection of melanoma. More...
17 Mar 2017
Image: The pituitary-specific transcription factor PIT-1 plays an essential role in producing growth hormone (GH), thyroid stimulation hormone (TSH), and prolactin (PRL). Researchers have discovered that a thymoma was detected in examined cases of “anti-PIT-1 antibody syndrome”. PIT-1 expression was abnormally increased within the thymoma and this likely evoked the immune tolerance breakdown and hypopituitarism that occurs in patients with this autoimmune disorder (Photo courtesy of Kobe University).

Autoimmune Disease Trigger Associated with Thymoma Tumors

Researchers have discovered that a newly-identified autoimmune endocrine disease – “Anti-PIT-1 antibody syndrome” – that leads to hypopituitarism is likely caused by overexpression of PIT-1 in the thymoma type of tumor originating from the thymic gland. More...
16 Mar 2017
Mayo Medical Laboratories
Image: A structural model of amyloid precursor protein (APP) (Photo courtesy of Wikimedia Commons).

Study Identifies Gene Variants Linked to AD in African Americans

In what may have been the first comprehensive screening of rare coding variants in an African American population, researchers identified several rare gene variants linked to the development of early onset Alzheimer's disease (AD). More...
08 Mar 2017
Image: A histopathogic image of pancreatic adenocarcinoma arising in the pancreas head region (Photo courtesy of Wikimedia Commons).

Diagnosing Pancreatic Cancer Early Enough for Surgical Treatment

A team of pancreatic cancer researchers has found that by combining measurement of two blood biomarker proteins with determination of the current gold standard biomarker, CA 19-9, it was possible to detect pancreatic cancer at an early enough stage to save patients with surgery. More...
08 Mar 2017
Image: A diagram showing lung cancer’s “field of injury” extends well beyond the tumor. New research demonstrates genetic changes in nasal cells of patients who went on to develop lung cancer (Photo courtesy of Avrum Spira, Boston University Medical Center).

Samples Reveal Gene Expression Pattern Diagnostic for Lung Cancer

Differences in gene expression that can be detected in nasal tissue from smokers or nonsmokers suggest that it may be possible to diagnose lung cancer from samples collected on nasal swabs. More...
08 Mar 2017
CELLAVISION AB
Image: A scanning electron micrograph (SEM) of dividing colorectal cancer cells (Photo courtesy of MNT).

Panel Establishes Biomarker Guidelines for CRC Diagnostics

After reviewing more than 4,000 articles, an expert panel has issued recommendations for testing diagnostic biomarkers in patients with early and advanced colorectal cancer. More...
07 Mar 2017
Image: The HiSeq 2500 high-throughput sequencing system (Photo courtesy of Illumina).

Novel Biomarkers Found for Bowel Cancer Treatment

Bowel cancer is the third most common form of cancer in the world and 95% of cases are colorectal carcinomas and at an advanced stage they are one of the most common causes of death, as only some patients respond to drug treatment. More...
03 Mar 2017

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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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