Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Paper-Based Device Accurately Detects Immune Defects in 10 Minutes

By LabMedica International staff writers
Posted on 22 Jul 2025

Patients with hidden immune defects are especially vulnerable to severe and persistent infections, often due to autoantibodies that block interferon-gamma (IFN-γ), a key molecule in immune defense. More...

These autoantibodies can go undetected for extended periods, making diagnosis difficult and delaying critical treatment. Traditional testing methods can be slow, expensive, and insensitive to trace levels of harmful antibodies, especially in the early stages of illness. Now, researchers have developed a rapid, highly sensitive paper-based test that enables one-step detection of these autoantibodies in under 10 minutes.

The paper-based diagnostic device called the 3D-osPAD (3D origami signal-amplified paper-based analytical device) has been developed by scientists at National Taiwan University (Taipei, Taiwan) and uses a folded 3D paper structure combined with gold nanoparticle signal amplification to enhance detection. All necessary reagents are preloaded within layered compartments, which allows the assay to initiate automatically once a small drop of diluted blood serum is added. The design enables a one-step, streamlined process that does not require expensive laboratory equipment or specialized training, making it accessible for both hospital and remote clinical settings. This technological innovation significantly improves test sensitivity achieving a tenfold increase over conventional detection methods while delivering results in just 10 minutes.

In the study published in Biosensors and Bioelectronics, the 3D-osPAD was clinically validated and demonstrated 100% sensitivity and specificity in accurately identifying patients with adult-onset immunodeficiency caused by anti-IFN-γ autoantibodies. In addition to its clinical accuracy, the portable and user-friendly design of the test supports applications in rapid diagnosis, treatment planning, and recovery monitoring. The researchers plan to further develop similar user-friendly and highly sensitive analytical tools for on-site diagnostics, especially in resource-limited environments.

Related Links:
National Taiwan University


New
Gold Member
Hybrid Pipette
SWITCH
Portable Electronic Pipette
Mini 96
HBV DNA Test
GENERIC HBV VIRAL LOAD VER 2.0
Gram-Negative Blood Culture Assay
LIAISON PLEX Gram-Negative Blood Culture Assay
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New evidence shows viscoelastic testing can improve assessment of blood clotting during postpartum hemorrhage (Photo courtesy of 123RF)

Viscoelastic Testing Could Improve Treatment of Maternal Hemorrhage

Postpartum hemorrhage, severe bleeding after childbirth, remains one of the leading causes of maternal mortality worldwide, yet many of these deaths are preventable. Standard care can be hindered by delays... Read more

Technology

view channel
Image: The SWITCH hybrid pipette is designed to simplify and accelerate pipetting tasks (Photo courtesy of INTEGRA)

Hybrid Pipette Combines Manual Control with Fast Electronic Aliquoting

Manual pipettes offer the control needed for delicate tasks such as mixing or supernatant removal, but typically fall short in repetitive workflows like aliquoting. Electronic pipettes solve this problem... Read more

Industry

view channel
Image: The partnership between OGT and QIAGEN unlocks a complete sample to report workflow for SureSeq NGS panels (Photo courtesy of OGT)

Qiagen and Oxford Gene Technology Partner on Sequencing Panel Interpretation

In clinical research, next-generation sequencing (NGS) panels provide essential insights for genetic analysis, but many laboratories face challenges in transforming raw sequencing data into clinically... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.