We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Immundiagnostik AG

Immundiagnostik AG s a globally operating diagnostics company that focuses on the development and production of innov... read more Featured Products: More products

Download Mobile App





Immundiagnostik AG Presents New PCR Test MutaPLEX RespiraScreen4_Diff_seqc at MEDICA 2022

By LabMedica International staff writers
Posted on 16 Nov 2022
Print article
Image: Immundiagnostik is exhibiting at this year’s MEDICA (Photo courtesy of Immundiagnostik)
Image: Immundiagnostik is exhibiting at this year’s MEDICA (Photo courtesy of Immundiagnostik)

Immundiagnostik AG (Bensheim, Germany) is presenting its new PCR test MutaPLEX RespiraScreen4_Diff_seqc for the first time at this year's MEDICA, the world's largest annual medical technology trade fair, which is taking place from 14-17 November in Düsseldorf, Germany. The test kit developed by Immundiagnostik is a further development of the existing products MutaPLEX RespiraScreen1 and MutaPLEX Coronavirus and represents a comprehensive real-time PCR diagnostic tool that efficiently, conveniently and reliably masters the expected respiratory diagnostic challenge in every new winter season.

The MutaPLEX RespiraScreen4_Diff_seqc real-time PCR test can be used to detect three different respiratory pathogens highly efficiently in just one approach: Coronavirus, Influenza Virus and RSV=Respiratory Syntial Virus. The innovative combination of two basic PCR techniques, namely qualitative amplification followed by melting curve analysis, allows the respective pathogens to be detected and differentiated in the same experiment. This means that in case of positivity (i.e. in the first step "amplification") in the case of coronavirus two different CoV-2 genes (S=Spike & E=Envelope) are specifically detected and in the case of influenza and RSV respectively the subtypes A and subtypes B are specifically detected. In all three cases, the distinction is made in the second step of the "melting curve analysis".

In addition, the entire diagnostic process is rounded off by the verification of the original sample collection by means of the detection of a human housekeeping gene. In times of pandemic coronalage, which has been ongoing for more than two years now, this is still essential, as the collection of respiratory pathogens from the nasal or oral/pharyngeal region may be suboptimal, resulting in inefficient sample collection. In these rare but not excludable cases, false-negative results in subsequent PCR diagnostics in the laboratory/testing center are inevitably the consequence.

Amplification of the human housekeeping gene on a separate detection channel of the real-time PCR instrument used provides an excellent means of controlling this situation. Detection of the human housekeeping gene provides assurance not only to the processing laboratory, but also to the specimen-submitting physician (and, not least, to the specimen-taking staff of the testing center) that the clinical source material collected and transferred to the laboratory met the requirements of correct specimen collection via swab smear. If the household gene amplification is strongly reduced or missing, the PCR result is not valid and a diagnosis of the patient sample is not possible. As a consequence, a new sample must be requested.

Related Links:
Immundiagnostik AG

Gold Member
C-Reactive Protein Reagent
CRP Ultra Wide Range Reagent Kit
Antipsychotic TDM AssaysSaladax Antipsychotic Assays
New
Thyroxine ELISA
T4 ELISA
New
Centrifuge
Centrifuge 5430/ 5430 R

Print article

Channels

Clinical Chemistry

view channel
Image: Rapid and non-invasive analysis of paracetamol overdose using paper arrow-mass spectrometry (Photo courtesy of Dr Simon Maher/University of Liverpool)

New Saliva Test Rapidly Identifies Paracetamol Overdose

Paracetamol is the most widely used medication worldwide, and its easy availability contributes to its frequent misuse and overdose. Overdosing on paracetamol can lead to liver toxicity, requiring hospitalization.... Read more

Molecular Diagnostics

view channel
Image: The study found previously undetected cancers in pregnant women with abnormal prenatal cfDNA test results (Photo courtesy of NIH)

Abnormal Prenatal Blood Test Results Could Indicate Hidden Maternal Cancers

Researchers have discovered previously undiagnosed cancers in 48.6% of pregnant individuals who received abnormal results from prenatal cell-free DNA (cfDNA) testing, which is typically used to screen... Read more

Hematology

view channel
Image: RHD screening just got easier with single exon NIPT testing (Photo courtesy of Devyser)

Non-Invasive Test Solution Determines Fetal RhD Status from Maternal Plasma

RhD (rhesus D) is a blood group type that can trigger immune responses. Individuals who lack RhD on their red blood cells are classified as RhD-negative. These individuals may produce antibodies against... Read more

Immunology

view channel
Image: Concept for the device. Memory B cells able to bind influenza virus remain stuck to channels despite shear forces (Photo courtesy of Steven George/UC Davis)

Microfluidic Chip-Based Device to Measure Viral Immunity

Each winter, a new variant of influenza emerges, posing a challenge for immunity. People who have previously been infected or vaccinated against the flu may have some level of protection, but how well... Read more

Microbiology

view channel
Image: A new test finds bacteria in liquids and indicate their presence by changing color (Photo courtesy of Georgia Kirkos/McMaster University)

New Hands-Free Rapid Test Detects Bacteria in Fluids

Bacteriophages, the most abundant form of life on Earth, are specialized to target and destroy specific types of bacteria. Their natural ability to fight bacteria has long been harnessed to treat infections.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.