We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




In Vitro System Developed for Studying Lung Fibrosis

By LabMedica International staff writers
Posted on 05 Jun 2018
A novel lung-on-a-chip device was tested in a proof-of-principle study with results suggesting that this technology could be used to evaluate a variety of potential treatments for lung fibrosis.

Fibrosis is a severe health problem characterized by progressive stiffening of tissues, which causes organ malfunction and failure. More...
A major bottleneck in developing new anti-fibrosis therapies is the lack of in vitro models that recapitulate dynamic changes in tissue mechanics during fibrogenesis.

To help overcome the lack of in vitro model systems for fibrosis, investigators at the University at Buffalo (NY, USA) created membranous human lung microtissues to model key biomechanical events occurred during lung fibrogenesis.

The investigators used microlithography to print microscale pillars of silicon-based organic polymer onto flexible plastic chips. Lung tissue cultured on top of the pillars behaved like functional alveoli. Fibrosis was induced by introducing a protein that caused healthy lung cells to become diseased, leading to the contraction and stiffening of the lung tissue.

The investigators reported in the May 25, 2018, online edition of the journal Nature Communications that by demonstrating these capabilities they had provided proof-of-principle evidence for using this fibrotic tissue array for multi-parameter, phenotypic analysis of the therapeutic efficacy of two anti-fibrosis drugs recently approved by the [U.S.] Food and Drug Administration. The test system confirmed that treatment with either Pirfenidone or Nintedanib reduced tissue contractility and prevented tissue stiffening and decline in tissue compliance.

"Obviously it is not an entire lung, but the technology can mimic the damaging effects of lung fibrosis. Ultimately, it could change how we test new drugs, making the process quicker and less expensive," said senior author Dr. Ruogang Zhao, assistant professor of biomedical engineering at the University at Buffalo.

Related Links:
University at Buffalo


New
Gold Member
Quality Control Material
iPLEX Pro Exome QC Panel
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Silver Member
Fibrinolysis Assay
HemosIL Fibrinolysis Assay Panel
New
Automated PCR System
OnePCR
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Molecular Diagnostics

view channel
Image: The RNA-seq based diagnostic test for pediatric leukemia ensures better outcomes for children with this common cancer (Photo courtesy of Qlucore)

RNA-Seq Based Diagnostic Test Enhances Diagnostic Accuracy of Pediatric Leukemia

A new unique test is set to reshape the way Acute Lymphoblastic Leukemia (BCP-ALL) samples can be analyzed. Qlucore (Lund, Sweden) has launched the first CE-marked RNA-seq based diagnostic test for pediatric... Read more

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.