We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics - An LGC Company

Download Mobile App





Finger-Prick Blood Test Identifies Immunity to COVID-19

By LabMedica International staff writers
Posted on 26 Sep 2022
Print article
Image: A finger-prick blood test can identify people most at risk of being reinfected with COVID-19 (Photo courtesy of ImmunoServ)
Image: A finger-prick blood test can identify people most at risk of being reinfected with COVID-19 (Photo courtesy of ImmunoServ)

Recent efforts to identify those least protected from COVID-19 reinfection have focused on quantifying antibodies recognizing the surface spike protein of SARS-CoV2. Although measuring antibodies on a larger scale in a population is relatively easy, the levels do not give the full picture of protection from re-infection, especially as variants of SARS-CoV-2 emerge. Now, a simple finger-prick test that measures the presence of immune T cells which can recognize SARS-CoV-2 will help determine which individuals are most vulnerable, and who might need more focused interventions such as repeated booster vaccinations.

Over 300 volunteers were recruited from across the UK in early 2022 to assess the novel test developed by ImmunoServ Ltd. (Cardiff, UK) in close collaboration with Cardiff University (Cardiff, UK). The test used a simple finger-prick blood sample collected at home and sent to a laboratory by post allowing anyone within the UK to be part of the study. Individuals with the largest T cell response to the virus were best protected from COVID-19 over the following three months, regardless of their levels of antibodies to the virus.

The study highlighted the potential for more accurate assessment of an individual’s immunity to COVID-19. The new test brings the focus away from ‘just measured’ antibody responses to take into account T cell mediated immunity. The Cardiff team say their work highlights the need to assess how long immune responses persist in the population, with uncertainty around whether repeated booster vaccinations will be required in future, and who will need them.

“Many individuals worry about their risk of contracting COVID-19, whether they have been previously vaccinated or not,” said Dr. Martin Scurr, lead author of the study. “Our test identified that it is the level of T cell response induced by prior vaccination or infection that associated with the risk of that individual contracting COVID-19 in the months following the blood test.”

“Long-term immunity screening using such a test would allow us to monitor longevity of responses that prevent COVID-19 and identify the most vulnerable members of our society who may need earlier booster vaccinations,” added Andrew Godkin, Professor of Experimental Medicine and Immunology at Cardiff University and co-senior author of the work.

Related Links:
ImmunoServ Ltd. 
Cardiff University 

Gold Supplier
Negative Third-Party QC for IgM Antibodies to SARS-C0V-2
Multichem ID-COVID19Neg
New
Microarray Hybridization Station
CapitalBio BioMixer II
New
Clinical Centrifuge
CAPPRondo
New
POC Quantitative Immunoassay Platform
ProciseDx Instrument

Print article
SUGENTECH INC.

Channels

Clinical Chem.

view channel
Image: Equivalence of Genetically Elevated LDL and Lipoprotein(a) on Myocardial Infarction (Photo courtesy of Viborg Regional Hospital)

Familial Hypercholesterolemia Patients With ACD Have Elevated Lipoprotein(a)

Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL cholesterol), in the blood and early cardiovascular... Read more

Molecular Diagnostics

view channel
Image: A cheap blood test could improve diagnosis of myocarditis (Photo courtesy of Queen Mary University of London)

First-Ever Blood Test Could Detect Deadly Heart Inflammation Within Hours

Myocarditis, or inflammation of the heart muscle, is a difficult condition to diagnose. Symptoms include a temperature, fatigue, chest pain and shortness of breath, which can all be easily mistaken for... Read more

Microbiology

view channel
Image: Ring-form trophozoites of Plasmodium vivax in a thin blood smear (Photo courtesy of Centers for Disease Control and Prevention)

Immune Regulators Predict Severity of Plasmodium vivax Malaria

Cytokines and chemokines are immune response molecules that display diverse functions, such as inflammation and immune regulation. In Plasmodium vivax infections, the uncontrolled production of these molecules... Read more

Pathology

view channel
Image: Breast cancer spread uncovered by new molecular microscopy (Photo courtesy of Wellcome Sanger Institute)

New Molecular Microscopy Tool Uncovers Breast Cancer Spread

Breast cancer commonly starts when cells start to grow uncontrollably, often due to mutations in the cells. Overtime the tumor becomes a patchwork of cells, called cancer clones, each with different mutations.... Read more

Industry

view channel
Image: With Cell IDx’s acquisition, Leica Biosystems will be moving its multiplexing menu forward (Photo courtesy of Leica Biosystems)

Leica Biosystems Acquires Cell IDx, Expanding Offerings in Multiplexed Tissue Profiling

Leica Biosystems, a technology leader in automated staining and brightfield and fluorescent imaging (Nussloch, Germany), has acquired Cell IDx, Inc. (San Diego, CA, USA), which provides multiplex staining... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.