We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Genetic Loci Significantly Associated with Anorexia Nervosa

By LabMedica International staff writers
Posted on 22 Jul 2019
Print article
Image: A new study identified eight genetic variants linked to anorexia nervosa, and suggests that the genetic origins of the disorder are both metabolic and psychiatric (Photo courtesy of Medical Xpress).
Image: A new study identified eight genetic variants linked to anorexia nervosa, and suggests that the genetic origins of the disorder are both metabolic and psychiatric (Photo courtesy of Medical Xpress).
Data accumulated by a large-scale genome-wide association study suggested that anorexia nervosa should be redefined as a “metabo-psychiatric disorder”, since at least eight genetic loci were identified as being significantly associated with the syndrome.

Anorexia nervosa is a life-impairing mental illness, affecting 0.9–4% of women and 0.3% of men, which is characterized by dangerously low body weight, an intense fear of gaining weight, and a lack of recognition of the seriousness of the low body weight.

To better understand the role of genetics in anorexia, investigators at the University of North Carolina (Chapel Hill, USA) and collaborators from over 100 institutions worldwide conducted a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls. The investigators combined data collected by the Anorexia Nervosa Genetics Initiative (ANGI) and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) from individuals of European ancestry from 17 countries across North America, Europe, and Australasia.

Results pointed to eight significant genetic loci linked to anorexia nervosa. The genetic architecture of anorexia nervosa reflected its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index.

The eight loci overlapped other psychiatric disorders such as obsessive-compulsive disorder, depression, anxiety and schizophrenia. The loci associated with anorexia nervosa also influenced physical activity, which might explain the hyperactivity often associated with the disorder.

"Until now, our focus has been on the psychological aspects of anorexia nervosa such as the patients' drive for thinness. Our findings strongly encourage us to also shine the torch on the role of metabolism to help understand why individuals with anorexia frequently drop back to dangerously low weights, even after therapeutic renourishment. A failure to consider the role of metabolism may have contributed to the poor track record among health professionals in treating this illness," said senior author Dr. Cynthia M. Bulik, professor of psychiatry in the University of North Carolina.

The study was published in the July 15, 2019, online edition of the journal Nature Genetics.

Related Links:
University of North Carolina

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
HLX
Complement 3 (C3) Test
GPP-100 C3 Kit
New
Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV

Print article

Channels

Clinical Chemistry

view channel
Image: The new versatile assay has the ability to measure both total and bioavailable cortisol from serum (Photo courtesy of Aarhus University)

Highly Reliable Cell-Based Assay Enables Accurate Diagnosis of Endocrine Diseases

The conventional methods for measuring free cortisol, the body's stress hormone, from blood or saliva are quite demanding and require sample processing. The most common method, therefore, involves collecting... Read more

Molecular Diagnostics

view channel
Image: The simple blood test can measure changes in cellular metabolism arising from pancreatic cancer (Photo courtesy of Metabolomycs)

Groundbreaking Blood Test Offers Early Pancreatic Cancer Diagnosis

Pancreatic cancer ranks as the third leading cause of cancer-related deaths, primarily due to its late detection. Early discovery of the disease, while it's still treatable, could significantly impact... Read more

Hematology

view channel
Image: The Gazelle Hb Variant Test (Photo courtesy of Hemex Health)

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Hemoglobin disorders rank as some of the most prevalent monogenic diseases globally. Among various hemoglobin disorders, beta thalassemia, a hereditary blood disorder, affects about 1.5% of the world's... Read more

Pathology

view channel
Image: The photoacoustic spectral response sensing instrument is based on low-cost laser diodes (Photo courtesy of Khan et al., doi 10.1117/1.JBO.29.1.017002)

Compact Photoacoustic Sensing Instrument Enhances Biomedical Tissue Diagnosis

The pursuit of precise and efficient diagnostic methods is a top priority in the constantly evolving field of biomedical sciences. A promising development in this area is the photoacoustic (PA) technique.... Read more

Industry

view channel
Image: The companies will develop genetic testing systems based on capillary electrophoresis sequencers (Photo courtesy of 123RF)

Sysmex and Hitachi Collaborate on Development of New Genetic Testing Systems

Sysmex Corporation (Kobe, Japan) and Hitachi High-Tech Corporation (Tokyo, Japan) have entered into a collaboration for the development of genetic testing systems using capillary electrophoresis sequencers... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.