We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App





Breaching the Blood-Brain Barrier

By CLN Stat
Posted on 27 Jun 2018
A late-breaking session at the AACC 70th Annual Scientific Meeting & Clinical Lab Expo in Chicago will highlight the uses and implications of the first chemical biomarker test cleared by the U.S. More...
Food and Drug Administration for detecting mild traumatic brain injury (mTBI) or concussion. It will also examine other TBI biomarkers.

“TBI is a very large problem in both civilian and military occupations and activities,” session moderator Robert Christenson, PhD, professor of pathology and professor of medical and research technology at the University of Maryland School of Medicine in Baltimore, told CLN Stat. “Blood is a simple specimen to obtain, and a biomarker would be of great value for rapid rule-out or rule-in of TBI. This would be from economic and, most importantly, patient health reasons,” said Christenson, who is co-presenting with Frank Peacock, MD, professor of emergency medicine at Baylor College of Medicine in Houston, and Robert Welch, MD, director of clinical research at Wayne State University School of Medicine in Detroit.

In his presentation, Christenson plans to cover the interpretation of brain biomarker tests. The speakers also will describe the characteristics of an ideal TBI marker, as well as the evidence for proposed biomarkers that have already been explored. Another discussion will address the seminal trial of the newly cleared test, called Brain Trauma Indicator (BTI), and detail how BTI might be used in emergency department settings.

Detecting TBI in blood is not without its challenges, Christenson emphasized. A blood-brain barrier exists between the blood compartment and the brain compartment. “To determine what brain-specific biomarkers are of high enough concentration to leak over to the blood compartment and be detected in a reasonable time frame after injury has been challenging. There are both biological and technical measurement considerations,” he said.

Clinical laboratorians from all aspects of testing and reimbursement need to understand the inner workings of brain biomarkers, and in particular what the BTI test is—and what it’s not, Christenson indicated. “Interpretation of the test results will also be critical for laboratorians to know, as they will be asked questions about test results by clinicians,” he added.

Participants of this session will be able to:

1. Identify strategies for identifying, quantifying, and validating potential TBI biomarkers;
2. Discuss the algorithm for interpreting the Brain Trauma Index; and
3. List ways that TBI biomarkers can benefit patients and decrease healthcare costs.

Register now for the AACC 70th Annual Scientific Meeting & Clinical Lab Expo in Chicago to attend this informative session on August 2. Attendees will receive 1.5 CE hours.



Visit AACC 2018 >>



Gold Member
Flocked Fiber Swabs
Puritan® Patented HydraFlock®
Serological Pipet Controller
PIPETBOY GENIUS
New
ESR Analyzer
TEST1 2.0
New
Gold Member
Hematology Analyzer
Medonic M32B
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Molecular Diagnostics

view channel
Image: A diagnostic test can distinguish patients with head and neck squamous cell carcinoma who can be cured with surgery alone (Photo courtesy of University of Turku)

Novel Diagnostic Tool to Revolutionize Treatment Guidance of Head and Neck Cancer

Head and neck squamous cell carcinoma (HNSCC) is a solid tumor type commonly treated with surgery. However, there has been no clinically available method to determine which patients can be cured with surgery... Read more

Hematology

view channel
Image: The microfluidic device for passive separation of platelet-rich plasma from whole blood (Photo courtesy of University of the Basque Country)

Portable and Disposable Device Obtains Platelet-Rich Plasma Without Complex Equipment

Platelet-rich plasma (PRP) plays a crucial role in regenerative medicine due to its ability to accelerate healing and repair tissue. However, obtaining PRP traditionally requires expensive centrifugation... Read more

Immunology

view channel
Image: The 3D paper-based analytical device has shown high clinical accuracy for adult-onset immunodeficiency (Photo courtesy of National Taiwan University)

Paper-Based Device Accurately Detects Immune Defects in 10 Minutes

Patients with hidden immune defects are especially vulnerable to severe and persistent infections, often due to autoantibodies that block interferon-gamma (IFN-γ), a key molecule in immune defense.... Read more

Microbiology

view channel
Image: The groundbreaking salmonella antimicrobial resistance prediction platform has demonstrated 95% accuracy (Photo courtesy of Yujie You et al., DOI: 10.1016/j.eng.2025.01.013)

New Platform Leverages AI and Quantum Computing to Predict Salmonella Antimicrobial Resistance

Antimicrobial-resistant Salmonella strains are a growing public health concern due to the overuse of antimicrobials and the rise of genetic mutations. Accurate prediction of resistance is crucial for effective... Read more

Technology

view channel
Image: The Check4 gene-detection platform (Photo courtesy of IdentifySensors)

Electronic Biosensors Used to Detect Pathogens Can Rapidly Detect Cancer Cells

A major challenge in healthcare is the early and affordable detection of serious diseases such as cancer. Early diagnosis remains difficult due to the complexity of identifying specific genetic markers... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.