We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Single Metagenomic Next-Generation Sequencing Test Can Detect All Infectious Pathogens

By LabMedica International staff writers
Posted on 12 Nov 2024

Metagenomic next-generation sequencing (mNGS) is a comprehensive sequencing method that analyzes all nucleic acids (DNA and RNA) in a clinical sample at high depth, generating 10-20 million sequences per sample. More...

This approach can be applied to any type of clinical sample, including cerebrospinal fluid, plasma, respiratory secretions, urine, stool, or tissue. Now, mNGS offers the potential to diagnose a wide range of infectious agents—viruses, bacteria, fungi, and parasites—through a single test.

Researchers at the UCSF Center for Next-Gen Precision Diagnostics (San Francisco, CA, USA) have developed an mNGS test capable of detecting sequence reads for all pathogens, helping to identify the cause of an infection. Initially, the UCSF team developed an mNGS test to identify pathogens in cerebrospinal fluid for meningitis and encephalitis diagnosis. This was followed by the development of a clinical plasma mNGS test designed to detect DNA viruses, bacteria, fungi, and parasites responsible for sepsis and disseminated infections in other organs. To analyze mNGS data quickly for pathogen identification, the team employs SURPI+ (SURPI PLUS), a clinical bioinformatics software pipeline.

In research published in Nature Medicine, the team demonstrated that their mNGS test for cerebrospinal fluid accurately identified 86% of neurological infections. They are now working on validating clinical tests for detecting all microorganisms (bacteria, viruses, fungi, and parasites) causing pneumonia in respiratory fluids like bronchoalveolar lavage or tracheal aspirates. Additionally, in a related study published in Nature Communications, the team used mNGS to identify pneumonia-causing pathogens in respiratory fluids and automated the process to generate faster results.


Gold Member
Veterinary Hematology Analyzer
Exigo H400
Serological Pipet Controller
PIPETBOY GENIUS
New
Silver Member
Fibrinolysis Assay
HemosIL Fibrinolysis Assay Panel
New
Specimen Radiography System
TrueView 200 Pro
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: How the predictive test works (Photo courtesy of QMUL)

World’s First Clinical Test Predicts Best Rheumatoid Arthritis Treatment

Rheumatoid arthritis (RA) is a chronic condition affecting 1 in 100 people in the UK today, causing the immune system to attack its joints. Unlike osteoarthritis, which is caused by wear and tear, RA can... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.