We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




New RNA Molecules Can Help Predict Bowel Cancer Recurrence

By LabMedica International staff writers
Posted on 01 Nov 2024

Colorectal cancer accounts for 10% of all cancer-related deaths worldwide and was ranked as the second most common cause of cancer death in the United States in 2022. More...

Currently, clinicians face diagnostic challenges due to the absence of effective prognostic markers to determine whether a patient with early-stage bowel cancer should only undergo tumor removal or require additional chemotherapy, particularly if the cancer exhibits aggressive characteristics that might lead to a relapse later in life. Now, researchers have identified new RNA molecules that could aid doctors in predicting the likelihood of bowel cancer recurrence. This advancement could allow healthcare professionals to categorize early-stage colorectal cancer patients into groups based on their risk of developing metastasis and disease recurrence, ultimately improving treatment outcomes. High-risk patients could receive further chemotherapy, while those at lower risk could avoid unnecessary overtreatment.

In a study conducted by the University of Otago (Dunedin, New Zealand), researchers examined patient tissues from the Dunedin Colorectal Cancer Cohort to identify three long noncoding RNAs (lncRNAs) that were present exclusively in cancer cells and absent in any healthy tissues. The researchers found that elevated levels of these lncRNAs correlated with poorer patient outcomes, suggesting their potential as prognostic indicators. This study, published in npj Precision Oncology, holds particular significance for regions with high rates of bowel cancer, highlighting the urgent need for clinical advancements in managing this disease.

“We used some exciting technologies to do this research, including spatial transcriptomics – using a picture of the tumor like a map to see exactly where genes are turned off or on – and AI, to help us predict what types of cells are present in the tumors,” said lead author Holly Pinkney, PhD candidate in the Department of Biochemistry. “The development of new technologies, such as the spatial mapping of tumors or AI to make predictions about different parts of the tumor, are important for helping us do this research and highlight how new scientific developments can be harnessed for cancer research.”


Gold Member
Hematology Analyzer
Medonic M32B
Portable Electronic Pipette
Mini 96
New
Silver Member
PCR Plates
Diamond Shell PCR Plates
Gold Member
Hematology System
Medonic M16C
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New evidence shows viscoelastic testing can improve assessment of blood clotting during postpartum hemorrhage (Photo courtesy of 123RF)

Viscoelastic Testing Could Improve Treatment of Maternal Hemorrhage

Postpartum hemorrhage, severe bleeding after childbirth, remains one of the leading causes of maternal mortality worldwide, yet many of these deaths are preventable. Standard care can be hindered by delays... Read more

Immunology

view channel
Image: The CloneSeq-SV approach can allow researchers to study how cells within high-grade serous ovarian cancer change over time (Photo courtesy of MSK)

Blood Test Tracks Treatment Resistance in High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is often diagnosed at an advanced stage because it spreads microscopically throughout the abdomen, and although initial surgery and chemotherapy can work, most... Read more

Industry

view channel
Image: The collaboration aims to improve access to Hb variant testing with the Gazelle POC diagnostic platform (Photo courtesy of Hemex Health)

Terumo BCT and Hemex Health Collaborate to Improve Access to Testing for Hemoglobin Disorders

Millions of people worldwide living with sickle cell disease and other hemoglobin disorders experience delayed diagnosis and limited access to effective care, particularly in regions where testing is scarce.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.