We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




A Simple Blood Test Detects Suicidal Tendencies in Individuals with Major Depressive Disorder

By LabMedica International staff writers
Posted on 06 May 2022
Print article
Image: Suicidal tendencies among people with depression and unhappiness may be detected by a simple blood test (Photo courtesy of 123rf.com)
Image: Suicidal tendencies among people with depression and unhappiness may be detected by a simple blood test (Photo courtesy of 123rf.com)

A gene expression signature found in blood and brain tissue from individuals with major depressive disorder seemed to be associated with the likelihood of development of suicidal behavior.

Suicide is a serious global public health problem that accounts for close to 800,000 deaths per year, and since major depressive disorder (MDD) is the most common diagnosis among suicides, identifying those at the highest risk for suicide is a pressing challenge.

To meet this challenge, investigators at the University of California, Irvine (USA) collected blood and dorsolateral prefrontal cortex (DLPFC) samples from MDD patients who died by suicide (MDD-S), MDDs who died by other means (MDD-NS), and non-psychiatric controls. Gene expression was analyzed using RNA and the NanoString (Seattle, WA, USA) platform.

Results revealed 14 genes in the blood samples that significantly differentiated MDD-S versus MDD-NS. The top six genes differentially expressed in blood were: PER3, MTPAP, SLC25A26, CD19, SOX9, and GAR1. Additionally, four genes showed significant changes in brain and blood between MDD-S and MDD-NS; SOX9 was decreased and PER3 was increased in MDD-S in both tissues, while CD19 and TERF1 were increased in blood but decreased in DLPFC. These changes in gene expression reflected stress response, including polyamine metabolism, circadian rhythm, immune dysregulation, and telomere maintenance.

“These blood biomarkers are an important step toward developing blood tests to identify patients with imminent risk of ending their lives,” said senior author Dr. Adolfo Sequeira, associate researcher in the department of psychiatry and human behavior at the University of California, Irvine. “To our knowledge, this is the first study to analyze blood and brain samples in a well-defined population of MDDs demonstrating significant differences in gene expression associated with completed suicide.”

The study was published in the April 14, 2022, online edition of the journal Translational Psychiatry.

Related Links:
University of California, Irvine 
NanoString

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
MAG and HEATMAG
POCT Fluorescent Immunoassay Analyzer
FIA Go
New
Gold Member
Plasma Control
Plasma Control Level 1

Print article

Channels

Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Immunology

view channel
Image: The AI predictive model identifies the most potent cancer killing immune cells for use in immunotherapies (Photo courtesy of Shutterstock)

AI Predicts Tumor-Killing Cells with High Accuracy

Cellular immunotherapy involves extracting immune cells from a patient's tumor, potentially enhancing their cancer-fighting capabilities through engineering, and then expanding and reintroducing them into the body.... Read more

Microbiology

view channel
Image: The T-SPOT.TB test is now paired with the Auto-Pure 2400 liquid handling platform for accurate TB testing (Photo courtesy of Shutterstock)

Integrated Solution Ushers New Era of Automated Tuberculosis Testing

Tuberculosis (TB) is responsible for 1.3 million deaths every year, positioning it as one of the top killers globally due to a single infectious agent. In 2022, around 10.6 million people were diagnosed... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.