We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us


Offers a complete system of hemostasis instrumentation and optimized reagent kits for research, as well as for routin... read more Featured Products: More products

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

D-Dimer and Thrombosis Risk in Adult Acute Lymphoblastic Leukemia

By LabMedica International staff writers
Posted on 07 Sep 2022
Print article
Image: The STA R MAX is a hemostasis analyzer for high-volume and reference laboratories performing routine and specialty assays (Photo courtesy of Stago)
Image: The STA R MAX is a hemostasis analyzer for high-volume and reference laboratories performing routine and specialty assays (Photo courtesy of Stago)

D-dimer is a marker of fibrinolysis harkening the presence of or risk for thrombosis, and it has been found to be a powerful predictor of thrombosis in solid cancers and acute myeloid leukemia (AML).

Patients with acute lymphoblastic leukemia (ALL) are at increased risk of thrombotic and/or bleeding events during early chemotherapy, especially when receiving asparaginase. Rates of venous thromboembolism (VTE) in ALL vary across studies, ranging from 1% to 36%, with the majority of studies reporting rates in the 5% to 20% range over a 1- to 3-year follow-up period.

A team of medical scientists led by The University of Chicago (Chicago, IL, USA) team identified 61 consecutive adult patients with newly diagnosed ALL from a single center between January 2008 and March 2020. They gathered demographic characteristics, treatment regimens, initial biomarkers including D-dimer, and assessing occurrence of venous or arterial thrombosis and bleeding in the first 100 days after diagnosis (index). The median age overall was 36 years (range, 18-84 years), with 52% female.

The D-dimer assay is ordered routinely at diagnosis of ALL at The University of Chicago Medical Center as a plasma assay and performed using photometric immunoassay analysis on a STA R Max analyzer (Diagnostica Stago, Inc, Parsippany, NJ, USA) within six hours of blood draw. Patients were stratified into two groups according to index D-dimer level using a cutoff of ≥4 µg/mL fibrinogen equivalent units (FEU) (high) and <4 µg/mL (low to moderate) based on previous work examining D-dimer and thrombosis in AML and the cutoff used in the disseminated intravascular coagulation (DIC) score.

The investigators reported that in the study cohort of patients with ALL, of whom 17 (28%) had high (≥4 µg/mL FEU) D-dimer levels at index, and 44 (72%) had low to moderate (<4 µg/mL FEU) index D-dimer levels. The 100-day cumulative incidence (95% confidence interval [CI]) of venous or arterial thrombosis in patients with high D-dimer (≥4 µg/mL) was 52.9% (95% CI, 26.4-73.8) compared with 13.8% (95% CI, 5.5-25.7) in patients with low to moderate D-dimer (<4 µg/mL), corresponding with a hazard ratio of 5.04 (95% CI, 1.79-14.22). When testing for potential confounders in a series of bivariate logistic regression models, the association between D-dimer and thrombosis remained after adjusting for body mass index, age, sex, asparaginase treatment, disseminated intravascular coagulation score, initial platelet level, and ALL phenotype.

The authors concluded that D-dimer levels at ALL diagnosis were associated with venous or arterial thrombosis at 100 days. Future studies should include D-dimer collated with other known risk factors to build a risk assessment model for thrombosis in patients newly diagnosed with ALL. The study was published on September 1, 2022 in the journal Blood Advances.

Related Links:
The University of Chicago 
Diagnostica Stago 

Platinum Supplier
Hormonal Test
Endocrine Array
1,5-AG Test
1,5-Anhydroglucitol Test Kit
Rapid Procalcitonin (PCT) Test
Dual-Channel Optical Coagulation Analyzer

Print article
IIR Middle East


Molecular Diagnostics

view channel
Image: Special blood test could determine if patient has early stage breast cancer and if the cancer is unlikely to return (Photo courtesy of USC)

Simple Blood Draw Could Revolutionize Early Breast Cancer Detection

Breast cancer is the most prevalent form of cancer in the world, affecting one in eight women over their lifetime. Since 1976 when the American Cancer Society endorsed mammography X-rays, the technique... Read more


view channel
Image: The global infectious disease IVD market is expected to hit USD 57 billion by 2030 (Photo courtesy of Pexels)

Global Infectious Disease IVD Market Dominated by Molecular Diagnostics Technology

The global infectious disease in vitro diagnostics (IVD) market stood at USD 113.7 billion in 2021 and is expected to grow at a CAGR of -7.41% from 2022 to 2030 to hit around USD 56.89 billion by 2030,... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.