We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Projects Promote Use of Placental Cells in Bone Marrow Disorder Therapeutics

By LabMedica International staff writers
Posted on 06 Mar 2016
An Israeli biotechnology company will be collaborating with Japanese researchers and American health authorities to complete development of a novel cell-based therapeutic approach for treatment of Acute Radiation Syndrome (ARS) and other conditions that prevent the bone marrow from making new blood cells.

The Israeli biotechnology company Pluristem Therapeutics (Haifa, Israel) utilizes placental cells obtained following scheduled caesarean section births. More...
These cells are expanded in the company's state-of-the-art manufacturing facility following current Good Manufacturing Practices (GMP) in proprietary bioreactor systems that create a three-dimensional microenvironment. This three-dimensional technology allows for the controlled, large-scale growth of cells implementing an optimized, standardized, scaled-up, and fully automated operation. This process enables mass-production of PLacental eXpanded (PLX) cells with batch-to-batch consistency for a fraction of the cost of traditionally expanding cells using culture dishes.

Pluristem recently announced that the [US] National Institute of Allergy and Infectious Diseases (Bethesda, MD, USA) was set to begin studies in large animals to establish dosing protocols for Pluristem’s PLX-R18 cells as a medical counter measure in the treatment of the hematological components of ARS. PLX-R18 is Pluristem’s second cell therapy product in development. It is designed to treat bone marrow that is unable to produce enough blood cells due to a variety of causes including ARS, certain cancers or cancer treatments, or immune-mediated bone marrow failure. A recent study showed that administration of PLX-R18 resulted in a statistically significant improvement in the recovery of white blood cell, red blood cell, and platelet levels in animals exposed to high levels of radiation.

In addition to the American project, Plutistem has signed a memorandum of understanding with Fukushima Medical University (Japan) to develop PLX-R18 for the treatment of ARS and for morbidities following radiotherapy in cancer patients.

“We are very pleased to receive the support and collaboration of the NIH ([US] National Institutes of Health) for the development of PLX-R18 as a medical countermeasure in the treatment of ARS, which is the first indication we are targeting in the defense technology space,” said Zami Aberman, chairman and CEO of Pluristem Therapeutics.

Related Links:

Pluristem Therapeutics
[US] National Institute of Allergy and Infectious Diseases
Fukushima Medical University



Gold Member
Blood Gas Analyzer
Stat Profile pHOx
Portable Electronic Pipette
Mini 96
New
Anterior Nasal Specimen Collection Swabs
53-1195-TFS, 53-0100-TFS, 53-0101-TFS, 53-4582-TFS
New
Autoimmune Liver Diseases Assay
Microblot-Array Liver Profile Kit
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Immunology

view channel
Image: The VENTANA HER2 (4B5) test is now CE-IVDR approved (Photo courtesy of Roche)

Companion Diagnostic Test Identifies HER2-Ultralow Breast Cancer and Biliary Tract Cancer Patients

Breast cancer is the most common cancer in Europe, with more than 564,000 new cases and 145,000 deaths annually. Metastatic breast cancer is rising in younger populations and remains the leading cause... Read more

Technology

view channel
Image: Conceptual design of the CORAL capsule for microbial sampling in the small intestine (H. Mohammed et al., Device (2025). DOI: 10.1016/j.device.2025.100904)

Coral-Inspired Capsule Samples Hidden Bacteria from Small Intestine

The gut microbiome has been linked to conditions ranging from immune disorders to mental health, yet conventional stool tests often fail to capture bacterial populations in the small intestine.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.