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Molecular Diagnostics

Image: Abnormal accumulation of tau protein in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who had died with Alzheimer\'s disease. Tau protein was stained brown using immunohistochemistry. The bar represents a distance of 25 microns (0.025 millimeters). (Photo courtesy of Wikimedia Commons)

Memory Loss in Alzheimer’s Disease Linked to Both Amyloid Plaques and Tau Tangles

 A team of neurodegenerative disease researchers has linked the APOE-epsilon-4 gene to increased formation of toxic tau protein aggregates (tangles) as well as amyloid-beta plaques in individuals with Alzheimer’s disease (AD). More...
31 Dec 2019
Image: Representation of the structure of apolipoprotein(a), a unique protein component of lipoprotein(a) (Photo courtesy of Wikimedia Commons)

Elevated Levels of Lipoprotein(a) Increase Cardiovascular Disease Risk in Patients with Type I Diabetes

 Results obtained by a team of Swedish researchers indicated that individuals with type I diabetes were at greater risk of developing cardiovascular disease (CVD) if they had elevated levels of lipoprotein(a) in their blood. More...
30 Dec 2019
Image: Each dot seen in this PRAM image represents one microRNA that has bound to the sensor (Photo courtesy of Nantao Li, University of Illinois)

Novel Liquid Biopsy Method for Detection of Cancer MicroRNA Biomarkers

 The potential usefulness of the “liquid biopsy” approach for detection of cancer biomarkers in the blood has been increased by the development of a method for capturing and counting cancer-associated microRNAs. More...
30 Dec 2019
Image: The cancer screening platform was a  multitarget stool DNA test (MT-sDNA), that uses multiple biomarkers to ensure the highest levels of sensitivity (Photo courtesy of Exact Sciences Laboratory)

Stool DNA Test Helps Detect Precancerous Lesions

 Colorectal cancer (CRC) is the third most common cancer and is one of the leading causes of cancer-related mortality. Although CRC incidence is increasing, a decrease in mortality has been observed due to the implementation of CRC screening and improved therapies. More...
27 Dec 2019
Image: FoundationOne Heme next-generation sequencing test can be used to assess routine cancer specimens for all genes that are currently known to be somatically altered and unambiguous drivers of oncogenesis in hematologic malignancies and sarcomas (Photo courtesy of Foundation Medicine)

Germline Genetic Testing Assesses Inherited Risk for Myeloid Malignancies

 Inherited risk for hematologic malignancies was historically thought to be relatively rare; however, the increased use of next-generation sequencing has identified more patients with germline genetic mutations that are known to increase cancer risk. More...
26 Dec 2019
Image: The test tube on the left shows a real positive result from water sampled in Costa Rica. The middle tube is a negative control. The tube on the right is a positive control (Photo courtesy of Dr. Julius B. Lucks, Northwestern University)

Novel Biotech-Based Field or Lab Assay for Detection of Fluoride

 A simple, yet sophisticated biotech-based assay for the detection of fluoride levels was successfully tested in the laboratory and in the field. More...
26 Dec 2019
Image: Acoustofluidic exosome isolation chip for salivary exosome isolation. The microfluidic channel is shown by red dye solution and the coin demonstrates the size of the chip. Two pairs of gold interdigital transducers are deposited along the channel, which separates particles according to size (Photo courtesy of The Journal of Molecular Diagnostics)

A Rapid Method for Isolating Viral DNA-enriched Salivary Exosomes for Diagnosis and Monitoring of Oropharyngeal Cancer

 A novel method, based on the combination of microfluidics and acoustics, for concentrating exosomes containing viral DNA from the saliva of oropharyngeal cancer patients was found to be 15 times more sensitive than the current gold standard differential centrifugation method. More...
24 Dec 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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