We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Abbott Diagnostics

Download Mobile App





New Paper-Based Rapid Test for COVID-19 Awaiting FDA EUA Approval

By LabMedica International staff writers
Posted on 30 Mar 2020
Print article
Image: Illustration of a 2019-novel coronavirus (nCoV) virion (Photo courtesy of Alissa Eckert, MS/CDC).
Image: Illustration of a 2019-novel coronavirus (nCoV) virion (Photo courtesy of Alissa Eckert, MS/CDC).
E25Bio (Cambridge, MA, USA), a startup company spun out from MIT (Cambridge, MA, USA), is developing a new rapid paper-based diagnostic test for COVID-18 that can deliver results in under half an hour. The test is based on technology developed at MIT’s Institute for Medical Engineering and Science (IMES) and will be submitted to the FDA for “emergency use authorization,” granting temporary approval for using the device on patient samples during public health emergencies.

For the past several years, IMES researchers have been working on diagnostic devices that operate like a pregnancy test but are able to identify viral proteins from patient samples. The technology, known as lateral flow technology, has been used by the researchers to develop tests for various infectious diseases, including Ebola, dengue fever, and Zika virus. The tests comprise strips of paper coated with antibodies that bind to a specific viral protein. A second antibody is attached to specialized nanoparticles while the patient’s sample is added to a solution of those particles. After this, the test strip is dipped in this solution. In case the viral protein is present, it attaches to the antibodies on the paper strip as well as the nanoparticle-bound antibodies, and a colored spot is visible on the strip in about 20 minutes. In addition to delivering rapid results, paper tests can also be easily and inexpensively manufactured in large quantities

“Our hope is that, similar to other tests that we’ve developed, this will be usable on the day that symptoms develop,” said Lee Gehrke, the Hermann L.F. von Helmholtz Professor at IMES who developed the technology behind the test. “We don’t have to wait for antibodies to the virus to come up.”

Related Links:
E25Bio
MIT



Print article

Channels

Microbiology

view channel
Image: Stenotrophomonas maltophilia colonies on sheep blood agar. Cultivation 48 hours in an aerobic atmosphere, 37 °C (Photo courtesy of microbiologyinpictures).

Global Spread of the Multi-Resistant Pathogen Stenotrophomonas Maltophilia Revealed

Stenotrophomonas maltophilia strains occur in several natural and human associated ecosystems. The bacterium was long regarded as relatively unproblematic, but is now considered to be one of the most feared... Read more
Copyright © 2000-2020 Globetech Media. All rights reserved.