We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




CKD May Occur Before Diabetes Diagnosis

By LabMedica International staff writers
Posted on 28 Mar 2018
Doctors have long known that patients with diabetes are at risk for kidney disease, and while chronic kidney disease (CKD) is regularly evaluated among patients with diabetes, kidney function may be significantly impaired before diabetes is diagnosed.

Approximately 10% of the general population in the USA, more than 20 million people, has chronic kidney disease (CKD), and this condition is especially prevalent among patients with diabetes mellitus (DM). More...
Specifically, an estimated one-third of adults with DM have CKD, and DM is the leading cause of CKD and end stage renal disease.

Scientists working with the University of Tennessee Health Science Center (Memphis, TN, USA) assessed the risk of kidney damage from undiagnosed diabetes, and looked at data on 36,794 veterans who were diagnosed with diabetes between 2003 and 2013. They found that 31.6% of these veterans had evidence of CKD prior to the diabetes diagnosis, based on estimated glomerular filtration rate (eGFR) and urine-albumin-creatine ratios, two common measures of kidney function. Veterans with higher age, hemoglobin A1C, blood pressure, and body mass index (BMI) also had a greater risk of CKD. All of these factors are themselves risk factors for diabetes. Those with cerebrovascular disease, congestive heart failure, or peripheral artery disease, conditions that are frequently seen alongside diabetes had higher kidney disease risk as well.

The study also revealed disparities in the rates of CKD based on race. Asian Americans and African Americans had higher rates of chronic kidney disease than whites. However, the proportion of patients who were minorities decreased as disease severity increased. The results suggest that kidney damage often occurs before diabetes is diagnosed. The authors propose two possible reasons for this early kidney damage: Type 2 diabetes can be undiagnosed for a long time, meaning the kidneys are being damaged without the patient or doctors being aware, or, kidney damage could come from other conditions common in the population at risk for diabetes. The results highlight an opportunity for broadening screening among patients with increased risk of CKD. More screening of at-risk populations could lead to earlier identification of diabetes, which could in turn prevent organ damage.

Csaba P. Kovesdy, MD, FASN, a professor of Medical Nephrology and senior author of the study, said, “Chronic kidney disease is silent, so patients can develop even advanced stages of chronic kidney disease before noticing anything. The only way to detect it in most affected individuals is through laboratory measurement, i.e., serum creatinine and urine albumin. Serum creatinine is measured very frequently among veterans, but an abnormal value would only diagnose stage 3 and above of chronic kidney disease. Urine albumin screening would be a way to identify early stages, but the use of this screening test is mostly limited to diabetics.” The study was published on February 9, 2018, in the journal Public Library of Science ONE.

Related Links:
University of Tennessee Health Science Center


New
Gold Member
Quality Control Material
iPLEX Pro Exome QC Panel
Serological Pipet Controller
PIPETBOY GENIUS
New
Staining Management Software
DakoLink
New
Silver Member
Autoimmune Hepatitis Test
LKM-1-Ab ELISA
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: An “evolutionary” approach to treating metastatic breast cancer could allow therapy choices to be adapted as patients’ cancer changes (Photo courtesy of 123RF)

Evolutionary Clinical Trial to Identify Novel Biomarker-Driven Therapies for Metastatic Breast Cancer

Metastatic breast cancer, which occurs when cancer spreads from the breast to other parts of the body, is one of the most difficult cancers to treat. Nearly 90% of patients with metastatic cancer will... Read more

Pathology

view channel
Image: A real-time trial has shown that AI could speed cancer care (Photo courtesy of Campanella, et al., Nature Medicine)

AI Accurately Predicts Genetic Mutations from Routine Pathology Slides for Faster Cancer Care

Current cancer treatment decisions are often guided by genetic testing, which can be expensive, time-consuming, and not always available at leading hospitals. For patients with lung adenocarcinoma, a critical... Read more

Technology

view channel
Image: Researchers Dr. Lee Eun Sook and Dr. Lee Jinhyung examine the imprinting equipment used for nanodisk synthesis (Photo courtesy of KRISS)

Multifunctional Nanomaterial Simultaneously Performs Cancer Diagnosis, Treatment, and Immune Activation

Cancer treatments, including surgery, radiation therapy, and chemotherapy, have significant limitations. These treatments not only target cancerous areas but also damage healthy tissues, causing side effects... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.