Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Artificial Intelligence Test Determines Risk of Bowel Cancer Recurrence After Surgery

By LabMedica International staff writers
Posted on 02 Aug 2024

Bowel cancer, commonly referred to as colorectal cancer, can develop anywhere in the large bowel, including the colon and rectum. More...

It ranks among the most prevalent cancers globally, with 1.9 million new cases recorded in 2020. The current protocols for determining the need for chemotherapy for patients with early-stage bowel cancer are not consistently reliable. As a result, some patients receive chemotherapy unnecessarily, while others who might benefit from it do not receive it and may face cancer recurrence. This decision is particularly challenging for stage II colon cancer, where the risk of recurrence post-surgery is generally lower. Now, a new artificial intelligence (AI) test can predict the risk of recurrence in bowel cancers, potentially helping patients avoid unnecessary chemotherapy. This test employs an AI algorithm to measure the concentration of immune cells known as CD3 in tumors at the early stages of bowel cancer.

Previous studies have indicated that bowel and rectal tumors with a higher presence of CD3 immune cells have a reduced likelihood of recurrence after surgical removal. This is attributed to the ability of CD3 cells to combat cancer, aiding the body's response to the disease. In the latest study by researchers at the University of Leeds (West Yorkshire, UK), the CD3 Score test effectively identified which stage II cancers were more prone to recurrence within five years post-surgery. This information could aid clinicians in determining the need for additional treatments, such as chemotherapy. The study analyzed tissue samples from 868 bowel tumors classified as stage II and III to quantify the CD3 cells present within the tumors.

The AI algorithm developed by the research team calculated a 'CD3 Score' based on the distribution of CD3 cells throughout the tumor. Tumors assigned a high-risk CD3 Score displayed fewer immune cells, whereas those with a low-risk score exhibited a higher number of immune cells. Tumors categorized with a high-risk CD3 Score were three times more likely to recur within five years of surgery compared to those with a low-risk score. Although chemotherapy reduced recurrence rates in both groups, the study further revealed that patients with fewer immune cells gained the most from chemotherapy. These findings, published in the Journal of Clinical Oncology, could assist doctors in making informed decisions about administering chemotherapy following bowel cancer surgery.

“This has the potential to be the most important test patients with early-stage bowel cancer ask for. It’s fast, accurate and simple, and we hope it will make conversations about chemotherapy after surgery much more straightforward for patients and their doctors,” said lead author Dr. Christopher Williams, Cancer Research UK Clinical Trials Research Fellow in the University of Leeds’ School of Medicine.

Related Links:
University of Leeds


Gold Member
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
Portable Electronic Pipette
Mini 96
New
Gold Member
Automatic Hematology Analyzer
DH-800 Series
New
Clinical Chemistry System
P780
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Immunology

view channel
Image: The VENTANA HER2 (4B5) test is now CE-IVDR approved (Photo courtesy of Roche)

Companion Diagnostic Test Identifies HER2-Ultralow Breast Cancer and Biliary Tract Cancer Patients

Breast cancer is the most common cancer in Europe, with more than 564,000 new cases and 145,000 deaths annually. Metastatic breast cancer is rising in younger populations and remains the leading cause... Read more

Technology

view channel
Image: Conceptual design of the CORAL capsule for microbial sampling in the small intestine (H. Mohammed et al., Device (2025). DOI: 10.1016/j.device.2025.100904)

Coral-Inspired Capsule Samples Hidden Bacteria from Small Intestine

The gut microbiome has been linked to conditions ranging from immune disorders to mental health, yet conventional stool tests often fail to capture bacterial populations in the small intestine.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.