We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Roche Diagnostics

Develops, manufactures, and markets a wide range of in vitro diagnostic systems, instruments, reagents, and tests read more Featured Products: More products

Download Mobile App




Plasma-Based S100B Testing for Management of Traumatic Brain Injury

By LabMedica International staff writers
Posted on 24 May 2021
Traumatic brain injury (TBI) usually results from a violent blow or jolt to the head or body. More...
An object that penetrates brain tissue, such as a bullet or shattered piece of skull, also can cause traumatic brain injury. Mild traumatic brain injury may affect the brain cells temporarily.

Serum biomarker S100B has been explored for its potential benefit to improve clinical decision-making in the management of patients suffering from TBI, especially as a pre-head computed-tomography screening test for patients with mild TBI. Although being already included into some guidelines, its implementation into standard care is still lacking.

Clinical Laboratorians at the University Medicine Mannheim (Mannheim, Germany) and their colleagues conducted retrospective study and compared, serum and lithium heparin blood samples from a total of 136 patients were analyzed for S100B concentrations. Specifically, 85 blood samples of stage I to IV melanoma patients were obtained during regular follow-up visits and additionally, they enrolled 51 consecutive patients presenting with TBI.

Serum samples were collected for the determination of S100B when clinically indicated together with lithium heparin blood for analysis of standard clinical chemistry analytes. S100B concentrations were determined using the Elecys S100 (Roche Diagnostics, Mannheim, Germany) assay on a Roche Cobas e411 instrument. The test is specified by the manufacturer for serum samples with a cut-off of 0.105 ng/mL and a linearity range of 0.005 – 39 ng/mL. Both S100B plasma and serum levels were tested for potential confounding variables.

The scientists reported that overall, S100B levels between both blood constituents correlated very well. The suitability of S100B testing from plasma was verified according to ISO15189 requirements. Using a cut-off of 0.105ng/ml, a sensitivity and negative predictive value of 100% were obtained for identifying patients with pathologic CT scans. Importantly, plasma-based testing reduced the turnaround time (TAT) to 26 minutes allowing for quicker clinical decision-making. The clinical utility of integrating S100B in TBI management was highlighted by two case reports.

The authors concluded that their study demonstrated the commutability of serum- and heparin-plasma-based S100B testing for TBI patients requiring rapid exclusion of organic brain damage. The analytical reliability of S100B testing from plasma was further proved by verification studies. The study was published on May 12, 2021 in the journal Practical Laboratory Medicine.

Related Links:
University Medicine Mannheim
Roche Diagnostics



Gold Member
Flocked Fiber Swabs
Puritan® Patented HydraFlock®
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Gold Member
Quality Control Material
iPLEX Pro Exome QC Panel
New
Silver Member
Quality Control Material
NATtrol Chlamydia trachomatis Positive Control
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.