We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Siemens Healthineers - Laboratory Diagnostics

Provides advanced laboratory diagnostics solutions for the medical industry read more Featured Products: More products

Download Mobile App




Serum Creatinine-to-Cystatin C Ratio Predicts AKI Mortality

By LabMedica International staff writers
Posted on 05 Nov 2020
Acute kidney injury (AKI) is a common and serious complication among critically ill patients and often requires continuous renal replacement therapy (CRRT). More...
Owing to the high mortality risk associated with kidney injury development, identifying effective risk factors for outcome is imperative in AKI patients being treated with CRRT.

Creatinine is mainly released from muscle tissue, and therefore its serum concentration is influenced by whole body muscle mass. Cystatin C, on the other hand, is universally produced by nucleated cells. Both creatinine and cystatin are commonly measured to estimate kidney function. Under situations of kidney injury, creatinine and cystatin C exhibit variable kinetics and their levels may vary rapidly.

Nephrologists at Yonsei University College of Medicine (Seoul, Republic of Korea) studied 1,588 patients who underwent CRRT in a single tertiary center intensive care unit between August 2009 and June 2019. The mean age was 64.7 ± 14.5 years and 635 patients (40.0%) were female. Among all subjects, 886 (55.8%) had hypertension and 597 (37.6%) were being treated for diabetes mellitus.

The scientists collected laboratory data included complete blood cell counts, serum blood urea nitrogen (BUN) levels, creatinine and cystatin C, albumin, and electrolytes. Serum creatinine levels were determined using an isotope dilution mass spectrometry-traceable method at a central laboratory, and cystatin C levels were measured by immunonephelometry, with calibration against the reference. The ratio of creatinine (mg/dL) to cystatin C (mg/L) was calculated from values measured concomitantly at baseline.

The investigators reported that the range of creatinine:cystatin C ratio was 0.08-10.48. The 30- and 90-day mortality rates were significantly lower for the higher creatinine:cystatin C ratio groups. Multivariable Cox proportional hazards regression analyses revealed that the mortality risk decreased successively across quartiles of increasing creatinine:cystatin C ratio. When creatinine:cystatin C ratio was evaluated using cubic spline analyses, the risks for both 30- and 90-day mortality were lower with higher creatinine:cystatin C ratios. These associations remained significant even after adjustment for confounding variables. A total of 954 (60.1%) and 1,055 (66.4%) deaths occurred within 30 and 90 days of CRRT initiation, respectively.

The authors concluded that the creatinine:cystatin C ratio is associated with survival in ICU patients with AKI undergoing CRRT. This ratio may be used as a practical prognosis risk American Journal of Kidney Diseases.




Gold Member
Quantitative POC Immunoassay Analyzer
EASY READER+
Collection and Transport System
PurSafe Plus®
New
Blood Glucose Test Strip
AutoSense Test
New
Capillary Blood Collection Tube
IMPROMINI M3
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Pathology

view channel
Image: Erythrocyte Sedimentation Rate Sample Stability (Photo courtesy of ALCOR Scientific)

ESR Testing Breakthrough Extends Blood Sample Stability from 4 to 28 Hours

Erythrocyte sedimentation rate (ESR) is one of the most widely ordered blood tests worldwide, helping clinicians detect and monitor infections, autoimmune conditions, cancers, and other diseases.... Read more

Technology

view channel
Image: Conceptual design of the CORAL capsule for microbial sampling in the small intestine (H. Mohammed et al., Device (2025). DOI: 10.1016/j.device.2025.100904)

Coral-Inspired Capsule Samples Hidden Bacteria from Small Intestine

The gut microbiome has been linked to conditions ranging from immune disorders to mental health, yet conventional stool tests often fail to capture bacterial populations in the small intestine.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.