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Molecular Diagnostics

Image: Histological sections of a moderately well differentiated squamous cell carcinoma of the lung showing infiltrating sheets and tongues of malignant squamous cells with whorls of keratin (Photo courtesy of Department of Health Western Australia).

Liquid Biopsy Lung Cancer Screening Method Developed

Genomic blood tests for cancer screening and early detection have become the focus of attention in the molecular diagnostic space, though most activity so far has been either toward pan-cancer screening tools, or in a few other specific tumor types like colorectal cancer, where tests hope to vie against colonoscopy and existing stool-based methods. More...
09 Apr 2020
Image: Structure of the phosphoglycerate dehydrogenase (PHGDH) enzyme (Photo courtesy of Wikimedia Commons)

Circulating RNA Biomarker Predicts Likelihood of Developing Alzheimer’s Disease

Elevated levels of a circulating RNA biomarker were found to be characteristic for individuals with Alzheimer’s disease (AD) and could be used to predicate whether an asymptomatic person would be likely to develop the disorder. More...
09 Apr 2020
Image: Photomicrograph of a vaginal epithelial clue cell coated with Gardnerella vaginalis (Photo courtesy of Universidad Autónoma de Zacatecas).

Potential Microbial Markers Identified for Cervical Pre-Cancer Progression

Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections. However, only a small percentage of high-risk (HR) HPV infections progress to cervical pre-cancer and cancer. The role of the cervicovaginal microbiome (CVM) in the natural history of HR-HPV has been investigated. More...
08 Apr 2020
Image: Cell-free DNA is isolated from blood samples drawn from a patient without cancer (top) or with cancer (bottom), and subjected to a targeted methylation sequencing assay. Sequencing results identifying methylated (red) or unmethylated (blue) CpG regions are fed into a machine-learning classifier that can identify the presence or absence of cancer, as well as identify the tissue of origin (Photo courtesy of Allen McCrodden, associate director, Creative Group of ProEd Communications)

Early Tumor Detection by Analysis of Circulating Free DNA Methylation Patterns

A blood test that analyzes patterns of methylation in circulating free DNA was shown to be capable of simultaneously detecting and localizing more than 50 types of cancer. More...
08 Apr 2020
Image: The Oxford Nanopore MinION device (Photo courtesy of Oxford Nanopore Technologies).

Deep Throat SARS-CoV-2 Viral Load Ascertained in Saliva Samples

Posterior oropharyngeal saliva samples are a non-invasive specimen more acceptable to patients and health-care workers. Unlike severe acute respiratory syndrome, patients with COVID-19 had the highest viral load near presentation, which could account for the fast-spreading nature of this epidemic. More...
06 Apr 2020
Image: The paper device for COVID-19 detection presents results that are visible to the naked eye: a green circle indicating positive and a blue circle negative (Photo courtesy of Cranfield University)

Rapid, Paper-Based Test Detects Coronavirus in Sewage and Wastewater

A team of British researchers has developed a rapid test to detect the COVID-19 virus, SARS-CoV-2, in sewage and wastewater as a means for gauging the level of infection within the community. More...
06 Apr 2020
Image: A new fluid analyzing platform allows for the isolation of circulating tumor cells (CTCs), which are formed during metastasis (Photo courtesy of NYU Abu Dhabi)

Hybrid Liquid Biopsy Platform Enables Tracking and Monitoring of Circulating Tumor Cells

By creating a hybrid microfluidic liquid biopsy platform that incorporates atomic force microscopy (AFM), cancer researchers have captured and characterized circulating tumor cells (CTCs), a technique which should prove useful in the diagnosis and prognosis of prostate cancer as well as other forms of cancer. More...
01 Apr 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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