We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
ZeptoMetrix an Antylia scientific company

Download Mobile App

Simple Blood Test Simultaneously Measures 21 Biomarkers for Cardiovascular Disease

By LabMedica International staff writers
Posted on 20 Nov 2023
Print article
Image: Researchers have developed a new instrument for precision medicine in cardiovascular disease (Photo courtesy of Uppsala University)
Image: Researchers have developed a new instrument for precision medicine in cardiovascular disease (Photo courtesy of Uppsala University)

Cardiovascular diseases, which affect the heart and blood vessels, remain the leading cause of death globally. The medical management of these diseases often involves significant costs and risks of side effects. Consequently, there's a growing need for innovative tools that can enhance risk assessment, tailor treatment more precisely to individual needs, and monitor the effectiveness of therapies. Researchers have now created a new tool capable of simultaneously measuring 21 biomarkers related to cardiovascular disease using a simple blood test. This advancement aims to refine the prediction of cardiovascular complications and assist in the customization of patient treatment, while also simplifying the process of monitoring treatment outcomes.

Developed by a team of researchers at Uppsala University (Uppsala, Sweden), this new instrument is based on analyses of 368 proteins in the blood samples of over 10,000 patients involved in international cardiovascular disease and atrial fibrillation treatment studies. The researchers have identified 21 circulating proteins, forming the CVD-21 panel, that serve as biomarkers. These biomarkers are indicative of various functional disturbances that affect the progression of cardiovascular disease and the effectiveness or risks associated with different treatments. The CVD-21 tool employs Proximity Extension Assay (PEA), a molecular biology technology honed in Uppsala, allowing for the measurement of protein levels down to very low concentrations and requiring only minimal volumes of blood plasma.

The utility of the CVD-21 instrument was assessed using blood samples and clinical data from 4,224 patients with chronic coronary disease. In terms of risk assessment accuracy for various cardiovascular complications, the combination of CVD-21 and the protein troponin T was found to be as effective as a model based on a few traditional risk markers for cardiovascular disease. Additionally, the instrument helped identify nine novel biomarkers with predictive value for different cardiovascular events, such as myocardial infarction, cardiovascular death, and hospitalization due to heart failure. These new biomarkers offer insights into diverse disease processes and contribute to a deeper understanding of the root causes of cardiovascular diseases. Risk assessment based on these biomarkers was also more accurate than the assessments relying solely on clinical variables, which are currently the standard in routine clinical practice.

Looking forward, instruments like the CVD-21 could significantly aid in making informed decisions regarding cardiovascular diseases and other medical conditions. They could enable the categorization of patients with cardiovascular disease into more precise sub-groups than currently possible, leading to treatment strategies that are more individualized and effective.

“Our biomarker-based instrument provides information about many proteins with known or unknown functions at the same time and has been developed for research and future application in care for cardiovascular diseases,” said Agneta Siegbahn, Professor of Clinical Coagulation Science at Uppsala University. “Our study shows that concentrations of biomarkers can reveal various signatures associated with heart complications. The development of CVD-21 is a first step that involves simultaneously quantifying many cardiovascular processes in a single drop of blood.”

Related Links:
Uppsala University 

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
Plasma Control
Plasma Control Level 1

Print article


Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more


view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more


view channel
Image: The AI predictive model identifies the most potent cancer killing immune cells for use in immunotherapies (Photo courtesy of Shutterstock)

AI Predicts Tumor-Killing Cells with High Accuracy

Cellular immunotherapy involves extracting immune cells from a patient's tumor, potentially enhancing their cancer-fighting capabilities through engineering, and then expanding and reintroducing them into the body.... Read more


view channel
Image: The T-SPOT.TB test is now paired with the Auto-Pure 2400 liquid handling platform for accurate TB testing (Photo courtesy of Shutterstock)

Integrated Solution Ushers New Era of Automated Tuberculosis Testing

Tuberculosis (TB) is responsible for 1.3 million deaths every year, positioning it as one of the top killers globally due to a single infectious agent. In 2022, around 10.6 million people were diagnosed... Read more


view channel
Image: The new AI tool can help beat brain tumors (Photo courtesy of Crystal Light/Shutterstock)

New AI Tool Classifies Brain Tumors More Quickly and Accurately

Precision in diagnosing and categorizing tumors is essential for delivering effective treatment to patients. Currently, the gold standard for identifying various types of brain tumors involves DNA methylation-based... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.