We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us


Cytovale is a medical diagnostics company focused on providing a more rapid and insightful way to diagnose fast-movin... read more Featured Products: More products

Download Mobile App


15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024
25 Apr 2024 - 27 Apr 2024

Sepsis Test Could Save Lives in Emergency Departments, Study Suggests

By LabMedica International staff writers
Posted on 29 Sep 2023
Print article
Image: The new blood test could prevent some of the 350,000 sepsis deaths in the U.S. annually (Photo courtesy of Cytovale)
Image: The new blood test could prevent some of the 350,000 sepsis deaths in the U.S. annually (Photo courtesy of Cytovale)

Sepsis poses a severe, life-endangering illness that arises when an infection triggers a body-wide chain reaction, potentially causing multiple organs to fail quickly. Prompt and accurate diagnosis is crucial for survival, especially for high-risk groups like older adults and individuals with chronic conditions such as kidney disease or cancer. When these at-risk patients arrive at a hospital's emergency department, healthcare professionals assess them for signs of sepsis. Since there's no definitive test for diagnosing sepsis, doctors rely on their expertise to recognize a mix of infection and inflammation indicative of the condition.

An interdisciplinary team of researchers led by Penn State (University Park, PA, USA) has now found that Cytovale’s (San Francisco, CA, USA) IntelliSep blood test for sepsis could save lives and money. The IntelliSep test evaluates changes in a person's white blood cells, quickly determining if the patient is at a high risk for sepsis. The study examined the financial implications of implementing IntelliSep in emergency departments by analyzing its cost-effectiveness for patients suspected of having sepsis.

For their analysis, the researchers used earlier IntelliSep test data and compared it with another test that gauges patients' procalcitonin levels, an indicator of sepsis. Procalcitonin which serves as a biomarker is released by the body during an infection and can be measured with a simple blood test. While procalcitonin levels can offer clues for sepsis diagnosis, they only reveal the presence of an infection and not the accompanying inflammation specific to sepsis. The team noted that procalcitonin tests are not part of standard clinical guidelines, and healthcare providers haven't broadly embraced them over clinical judgment.

The study showed that IntelliSep outperformed procalcitonin testing. Using IntelliSep could lead to a survival rate of over 95% in patients, costing less than USD 4,000 per individual for treatment. These figures represent both a slightly higher survival rate and a lower cost compared to using procalcitonin tests. The primary source of the cost reduction was a more accurate diagnosis of sepsis, the researchers pointed out. Patients with undetected sepsis can be expensive to treat and are at a substantially higher risk of death. However, the research team clarified that IntelliSep is not a replacement for quality clinical care; rather, it should serve as an additional tool to assist clinicians in diagnosing sepsis.

“For patients who have sepsis, getting sent home from the hospital is very serious because they can suffer multiple-organ failure within hours,” said Christopher Hollenbeak, professor of health policy and administration in the Penn State College of Health and Human Development, who led the research. “Every year, there are patients who enter the emergency department of a hospital, present with a limited number of sepsis symptoms and are sent home. This test could save many of those people’s lives.”

Related Links:
Penn State 

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
Plasma Control
Plasma Control Level 1

Print article


Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more

Molecular Diagnostics

view channel
Image: AI analysis of DNA fragmentomes and protein biomarkers noninvasively detects ovarian cancer (Photo courtesy of Adobe Stock)

Blood-Based Machine Learning Assay Noninvasively Detects Ovarian Cancer

Ovarian cancer is one of the most common causes of cancer deaths among women and has a five-year survival rate of around 50%. The disease is particularly lethal because it often doesn't cause symptoms... Read more


view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more


view channel
Image: The groundbreaking treatment approach has shown promise in hard-to-treat cancers (Photo courtesy of 123RF)

Genetic Testing Combined With Personalized Drug Screening On Tumor Samples to Revolutionize Cancer Treatment

Cancer treatment typically adheres to a standard of care—established, statistically validated regimens that are effective for the majority of patients. However, the disease’s inherent variability means... Read more


view channel
Image: ‘Virtual biopsy’ allows clinicians to analyze skin noninvasively (Photo courtesy of Stanford Medicine)

Virtual Skin Biopsy Determines Presence of Cancerous Cells

When dermatologists spot an unusual mark on a patient's skin, they face a choice: monitor it for some time or remove it for biopsy. Similarly, when removing breast tumors, surgeons must send excised tissues... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.