We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App

Molecular Multiplex Panels Quickly Supplanting Conventional Pathogen Detection Methods, Finds Report

By LabMedica International staff writers
Posted on 28 Sep 2023
Print article
Image: AMP has published a report on the use of multiplex panels for diagnosing infectious diseases (Photo courtesy of AMP)
Image: AMP has published a report on the use of multiplex panels for diagnosing infectious diseases (Photo courtesy of AMP)

Multiplex molecular panels are increasingly being adopted in clinical labs for detecting a variety of microbial pathogens in different settings. While a lot of data exists on their effectiveness in identifying respiratory pathogens, there is scant information available for other types. Now, the latest review provides valuable insights into the use of multiplex PCR panels for detecting pathogens in the gastrointestinal system, central nervous system, lower respiratory tract, and joint specimens. The review not only explores new methods for detecting pathogens in alternative types of specimens but also outlines challenges related to the implementation of new tests and the costs involved.

The Association for Molecular Pathology (AMP, Rockville, MD, USA) has published a review of the benefits and challenges in utilizing multiplex PCR panels for detecting microbial pathogens from gastrointestinal, central nervous system, lower respiratory tract, and joint specimens. The manuscript, “Exploring the Utility of Multiplex Infectious Disease Panel Testing for Diagnosis of Infection in Different Body Sites: A Joint Report of the Association for Molecular Pathology, American Society for Microbiology (ASM), Infectious Diseases Society of America (IDSA), and Pan American Society for Clinical Virology (PASCV),” has been released online ahead of publication in The Journal of Molecular Diagnostics.

Despite the apparent benefits and growing adoption of PCR multiplex panels, several questions still remain unanswered. For example, how exhaustive should the panel be to realize the advantages previously described? Is it more useful to have extensive multi-target panels, or is a specific subset of organisms sufficient for routine testing? Additionally, what is contributing to better patient outcomes—quicker test results or a more systematic approach that balances costs and patient benefits? These issues require more investigation as our understanding of the clinical utility of PCR multiplex panels continues to develop.

“Molecular multiplex panels are quickly supplanting conventional pathogen detection methods,” said Michael A. Lewinski, PhD, Chair of the AMP Infectious Diseases Multiplex Working Group. “This new report offers a detailed snapshot of the various clinical and analytical benefits and challenges associated with these panels for diagnosis of infection in different body sites. We also raise a few questions that warrant further study.”

Related Links:

Platinum Supplier
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Gold Supplier
Real-Time PCR System
Gentier 96T
POCT Fluorescent Immunoassay Analyzer
Tick Borne Diseases Test
Savvygen Tick Borne

Print article


Clinical Chemistry

view channel
Image: A module with eight micro-devices, complete with microfluidic channels and drive motors (Photo courtesy of U.S Department of Energy)

Highly Sensitive pH Sensor to Aid Detection of Cancers and Vector-Borne Viruses

Understanding the acidity or alkalinity of substances through pH measurement is crucial in many fields, from environmental monitoring to healthcare product safety. In many cases, these measurements must... Read more

Molecular Diagnostics

view channel
Image: The PrismRA blood test helps target best treatments for patients with rheumatoid arthritis (Photo courtesy of Scipher Medicine)

Groundbreaking Rheumatoid Arthritis Blood Test Predicts Treatment Response

Rheumatoid arthritis (RA), an autoimmune disease affecting joints and other systems in the body, impacts millions globally. Typically, the initial biologic treatment involves anti-inflammatory drugs from... Read more


view channel
Image: The QScout hematology analyzer has received US FDA 510(k) clearance (Photo courtesy of Ad Astra Diagnostics)

First Rapid-Result Hematology Analyzer Reports Measures of Infection and Severity at POC

Sepsis, a critical medical condition that arises as an extreme response to infection, poses a significant health threat. It occurs when an infection triggers a widespread inflammatory response in the body.... Read more


view channel
Image: PointCheck is the world’s first device for non-invasive white cell monitoring (Photo courtesy of Leuko Labs)

World’s First Portable, Non-Invasive WBC Monitoring Device to Eliminate Need for Blood Draw

One of the toughest challenges for cancer patients undergoing chemotherapy is experiencing a low count of white blood cells, also known as neutropenia. These cells play a crucial role in warding off infections.... Read more


view channel
Image: AI methods used in satellite imaging can help researchers analyze tumor images (Photo courtesy of Karolinska Institutet)

AI Approach Combines Satellite Imaging and Ecology Techniques for Analysis of Tumor Tissue

Advancements in tumor imaging technology have significantly enhanced our ability to observe the minute details of tumors, but this also brings the challenge of interpreting vast amounts of data generated... Read more


view channel
Image: The acquisition significantly expands Medix Biochemica’s portfolio of IVD raw materials (Photo courtesy of ViroStat)

Medix Biochemica Acquires US-Based ViroStat to Expand Infectious Diseases Antibody Offering

Medix Biochemica (Espoo, Finland), a supplier of critical raw materials to the in vitro diagnostics (IVD) industry, has acquired ViroStat LLC (Portland, ME, USA), a provider of infectious disease antibodies... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.