We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Study Finds Need for Better Tests to Identify Candida Auris Susceptibility

By LabMedica International staff writers
Posted on 19 Jun 2023
Print article
Image: C. auris carries a high mortality rate, killing more than 1 in 3 people with infections (Photo courtesy of Freepik)
Image: C. auris carries a high mortality rate, killing more than 1 in 3 people with infections (Photo courtesy of Freepik)

Candida auris, a pathogenic yeast, has a high mortality rate, claiming the lives of over one-third of those infected. Infections commonly arise in healthcare settings where individuals are particularly susceptible, and the rates are increasing rapidly. Determining the appropriate antifungal treatment for a C. auris infection is a critical decision in clinical practice and relies on susceptibility testing. Unfortunately, many C. auris strains have developed resistance to available antifungals, necessitating the analysis of individual samples for treatment susceptibility. However, this process is costly and time-consuming due to the lack of FDA-approved, commercially available tests for C. auris. Consequently, hospital laboratories often send samples to specialized facilities for analysis. Now, a new study has revealed that commercially available antifungal tests exhibit poor performance for many treatments.

Researchers at Indiana University (Bloomington, IN, USA) examined the suitability of tests designed for other pathogenic yeast infections in assessing C. auris susceptibility. They employed four commercially available tests for pathogenic yeasts to evaluate the susceptibility of 50 C. auris isolates to existing antifungals. The results were mixed. Two tests accurately determined the effectiveness of echinocandins, an intravenous antifungal medication commonly used to treat C. auris. However, these same tests demonstrated poor performance when assessing fluconazole, an orally administered drug belonging to the triazole group, which currently represents the sole available treatment for C. auris. Additionally, some tests inaccurately reported resistance or susceptibility to a drug, providing misleading information.

Although certain tests performed adequately for specific drugs, the study highlights the absence of a comprehensive method for determining C. auris susceptibility to antifungals. The researchers emphasize the urgent need for FDA-approved, commercially available tests to facilitate clinical decisions and enhance patient care for those infected with this potentially fatal and frequently drug-resistant pathogen. The study findings were presented at ASM Microbe 2023, the annual meeting of the American Society for Microbiology.

Related Links:
Indiana University 

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
MAG and HEATMAG
POCT Fluorescent Immunoassay Analyzer
FIA Go
New
Gold Member
TORCH Panel Rapid Test
Rapid TORCH Panel Test

Print article

Channels

Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Immunology

view channel
Image: The AI predictive model identifies the most potent cancer killing immune cells for use in immunotherapies (Photo courtesy of Shutterstock)

AI Predicts Tumor-Killing Cells with High Accuracy

Cellular immunotherapy involves extracting immune cells from a patient's tumor, potentially enhancing their cancer-fighting capabilities through engineering, and then expanding and reintroducing them into the body.... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.