We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

First-of-Its-Kind Infectious Disease Diagnostic Platform to Deliver Rapid Antibiotic Treatment Guidance

By LabMedica International staff writers
Posted on 03 May 2023
Print article
Image: Pattern’s single-cell microbiology platform could revolutionize bacterial testing (Photo courtesy of Freepix)
Image: Pattern’s single-cell microbiology platform could revolutionize bacterial testing (Photo courtesy of Freepix)

Annually, around 1.3 million lives and countless healthcare dollars are lost due to drug-resistant bacterial infections, highlighting the urgent need for faster diagnostic tools to facilitate targeted antibiotic treatment. Conventional culture-based tests may take up to four days to provide a definitive diagnosis for critically ill patients. Research indicates that patients with drug-resistant infections face a four to seven times higher risk of death if effective antibiotic treatment is delayed by even 24 hours. Now, a revolutionary phenotypic test platform for infectious diseases has the potential to quickly identify the infection-causing pathogen and offer precise guidance on the most suitable antibiotic for treatment.

Pattern Bioscience, Inc. (Austin, TX, USA), an innovator in rapid diagnosis and antibiotic susceptibility testing (AST) for bacterial infections, is pioneering the use of single-cell microbiology to rapidly diagnose drug-resistant bacterial infections and identify effective treatments. The company's unique single-cell microbiology technology represents the first culture-free, rapid phenotypic testing platform capable of delivering clinically actionable results in a timeframe that allows healthcare professionals to administer timely, life-saving treatments to patients, significantly improving outcomes.

By employing single-cell analysis of microorganisms in conjunction with machine learning, Pattern's innovative technology can produce clinically actionable information that identifies the responsible pathogen and assesses its antibiotic susceptibility within hours, as opposed to the days needed for standard culture-based tests. Pattern's proprietary single-cell analysis technology accelerates testing by directly measuring the live response of each pathogenic cell, eliminating the need for lengthy culture procedures. Phenotypic pattern recognition encompasses every resistance mechanism, whether known or unknown, existing or emerging, simple or complex, genetic, or epigenetic. Evaluating the phenotypic bacterial response to antibiotics ensures that the clinical validity of the current gold standard is upheld for rapid testing.

Traditional lab tests require days to complete, as they depend on the time-intensive growth and average response of millions of bacteria to potential antibiotic treatments. Pattern's technology, on the other hand, allows for testing directly from non-sterile specimens, improving upon the qualities that have established traditional culture as the gold standard for bacterial diagnosis. The company's first test, which has been granted US FDA Breakthrough Device Designation, targets hospitalized patients with pneumonia. In the future, Pattern's technology is expected to support a comprehensive range of other tests.

“We believe our technology will significantly impact patient outcomes and help tackle the growing challenge of antibiotic resistance,” said Nick Arab, co-founder and CEO of Pattern Bioscience.

Related Links:
Pattern Bioscience, Inc. 

Gold Supplier
Virus Detection System
UHF RFID Tag and Inlay
IFA Automation Solution
dIFine 30 System

Print article


Clinical Chem.

view channel
Image: Electrochemical cells etched by laser on wooden tongue depressor measure glucose and nitrite in saliva (Photo courtesy of Analytical Chemistry)

Biosensor-Fabricated Wooden Tongue Depressor Measures Glucose and Nitrite in Saliva

Physicians often use tongue depressors to examine a patient's mouth and throat. However, it is hard to imagine that this simple wooden tool could actively assess a patient's health. This idea has led to... Read more

Molecular Diagnostics

view channel
Image: A portable smartphone-based POC device for use with EXTRA-CRISPR method for cancer diagnostics (Photo courtesy of UF Health)

CRISPR-Powered Method for Non-Invasive Blood Tests to Help Diagnose Early Stage Cancer

MicroRNAs, tiny RNA molecules that regulate gene expression, have been identified as potential cancer biomarkers in human fluids like blood. Extracellular vesicles, tiny particles actively discharged by... Read more


view channel
Image: The Atellica HEMA 570 and 580 hematology analyzers remove workflow barriers (Photo courtesy of Siemens)

Next-Gen Hematology Analyzers Eliminate Workflow Roadblocks and Achieve Fast Throughput

Hematology testing is a critical aspect of patient care, utilized to establish a patient's health baseline, track treatment progress, or guide timely modifications to care. However, increasing constraints... Read more


view channel
Image: Newly observed anti-FSP antibodies have also been found to predict immune-related adverse events (Photo courtesy of Calviri)

First Blood-Based Biomarkers Test to Predict Treatment Response in Cancer Patients

Every year worldwide, lung cancer afflicts over two million individuals and almost the same number of people succumb to the disease. This malignancy leads the charts in cancer-related mortalities, with... Read more


view channel
Image: The UNIQO 160 (CE-IVDR) advances diagnostic analysis for autoimmune diseases (Photo courtesy of EUROIMMUN)

Novel Automated IIFT System Enables Cutting-Edge Diagnostic Analysis

A newly-launched automated indirect immunofluorescence test (IIFT) system for autoimmune disease diagnostics offers an all-in-one solution to enhance the efficiency of the complete IIFT process, comprising... Read more


view channel
Electronic biosensor uses DNA aptamers for detecting biomarkers in whole blood samples (Photo courtesy of Freepik)

Electronic Biosensor Detects Biomarkers in Whole Blood Samples without Addition of Reagents

The absence of robust, reliable, and user-friendly bioanalytical tools for early and timely diagnosis of cardiovascular diseases, particularly sudden cardiac arrest, leads to preventable deaths and imposes... Read more


view channel
Image: The global hemostasis diagnostics market is expected to reach USD 3.95 billion by 2025 (Photo courtesy of Freepik)

Global Hemostasis Diagnostics Market Driven by Increase in Invasive Surgical Procedures

Injury or surgery naturally creates bleeding in living beings, which must be stopped to prevent excessive blood loss. The human body implements a protective mechanism known as hemostasis to stop excessive bleeding.... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.