We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
FUJIREBIO

Download Mobile App





Daily Rapid Lateral Flow COVID-19 Tests for Traced Contacts for Five Days Could Replace Requirement to Quarantine, Reveals Study

By LabMedica International staff writers
Posted on 25 Jan 2021
Print article
Image: Contact tracing app (Photo courtesy of Canva)
Image: Contact tracing app (Photo courtesy of Canva)
Additional testing with either a PCR or lateral flow antigen (LFA) test could potentially reduce the quarantine time of contacts of a confirmed case to seven days from the WHO recommended 14-day quarantine period without raising the risk of onward transmission, according to a new modeling study.

Researchers at the London School of Hygiene & Tropical Medicine (LSHTM; London, UK) conducted the study using mathematical modeling to estimate the effect of different quarantine and testing strategies on reducing onward transmission from traced secondary infections. The team simulated the levels of virus an infected person would be likely to produce at each stage of infection, alongside timing of symptom onset, test sensitivity and tracing and testing timings. The team estimate that completing the full 14-day recommended quarantine period for contacts of COVID-19 cases could prevent 59% of onward virus transmission. A similar proportion of onward transmission could potentially be prevented with only seven days of quarantine if a PCR or LFA test is performed on the final day of quarantine and people who receive a negative result are released.

The study estimates that the quarantine period could be replaced if traced contacts are required to take a daily LFA test for five days and those who do not receive any positive results are released, with 50% of onward virus transmission predicted to be prevented. If people adhere perfectly to self-isolation for the recommended 14 days after a positive test, and their close contacts taking a daily LFA test for five days and are then released on the final day if all tests are negative, the model estimates 80% of onward virus transmission could potentially be averted. Notably, the model is based on the assumption that the LFA test works at the higher level of sensitivity, detecting on average 76.8% of cases that tested positive in a PCR test.

“Our findings suggest that introducing testing of contacts in contact tracing may allow for a large reduction in the duration of quarantine,” said Billy Quilty, joint-lead author and Research Assistant at LSHTM. “Daily rapid tests for at least five days may allow for the quarantine requirement to be removed entirely, with self-isolation required only upon the onset of symptoms or a positive rapid test result. This strategy may allow for critical essential workers to continue working if exposed but not infected.”

Related Links:
London School of Hygiene & Tropical Medicine (LSHTM)

New
Gold Supplier
COVID-19 Test
ID NOW COVID-19
SARS-CoV-2 Antigen Test
ESPLINE SARS-CoV-2 Antigen Test
Coronavirus Test
COVID-19 Coronavirus Real Time PCR Kit
COVID-19 IgM/IgG Test
DPP COVID-19 IgM/IgG System

Print article

Channels

Molecular Diagnostics

view channel
Image: Histopathologic image from a patient with Li Fraumeni syndrome showing accumulation of mutant TP53 in tumoral cells (Photo courtesy of Thierry Soussi, PhD).

Clinical Germline Testing Evaluated for Pediatric Cancer Patients

Pediatric cancer is rare, with fewer than 10,000 solid tumors diagnosed in children annually in the USA. Previous studies interrogating germline predisposition broadly across pediatric cancer types have... Read more

Industry

view channel
Illustration

Mindray and Tencent AI Lab to Jointly Develop AI Products for Blood Disease Screening and In Vitro Diagnosis

Shenzhen Mindray Biomedical Electronics Co., Ltd. (Shenzhen, China) has signed an AI cooperation framework agreement with Tencent AI Lab (Shenzhen, China) to jointly develop AI products for blood cell... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.