We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

Researchers Use Physics Technology to Develop Rapid Antigen COVID-19 Test

By LabMedica International staff writers
Posted on 10 Nov 2020
Print article
Image: Researchers Use Physics Technology to Develop Rapid Antigen COVID-19 Test (Photo courtesy of MIT)
Image: Researchers Use Physics Technology to Develop Rapid Antigen COVID-19 Test (Photo courtesy of MIT)
Researchers have adapted technology that is typically used for physics applications to create a rapid antigen COVID test that has been able to detect viral proteins in minutes with high accuracy.

Currently, PCR-, antigen-, and antibody-based technologies have been at the forefront in the development of COVID testing. However, scientists are looking into other technologies not usually used in the life sciences in order to improve the detection of the virus. Researchers from the Department of Materials Science and Engineering at the Massachusetts Institute of Technology (Cambridge, MA, USA) have developed a test called TriboSense One that does not have an optical readout for detecting viruses like many current tests on the market, but instead provides a mechanical readout to assess the strength of biomolecular interactions, looking at friction to detect a sample's molecular interactions and confirm the presence of the virus in very small concentrations.

The instrument measures how molecules in saliva affect the motion of sensing beads with magnetic properties to determine whether SARS-CoV-2 viruses are present or not. The beads and the saliva are mixed together during sample prep. Currently, the test detects the spike protein of the virus, but the magnetic sensing particles can also be customized to stick to different types of proteins, for example the nucleocapsid protein of SARS-CoV-2, which the researchers are also pursuing. Once the saliva sample is collected, the consumer's job is quite simple, consisting mostly of pipetting the sample into the solution. The technology was originally created to measure protein-protein, protein-DNA, DNA-DNA and other biomolecular interactions. Eventually, the team wants to expand testing to other diseases, but the focus now is on COVID-19. The testing system could potentially benefit point-of-care settings because of its small size and portability. The test is also inexpensive; while it costs around USD 5-6 right now, at scale it could even cost as little as USD 3.

"We had to go from scratch," said MIT Professor Alfredo Alexander-Katz. "We had never worked on viruses … and we adapted the technology to be able to do this."

Related Links:
Massachusetts Institute of Technology

Gold Supplier
SARS-CoV-2 Assay
SARS-CoV-2 Antibody Test
EliA SARS-CoV-2-Sp1 IgG test
Silver Supplier
Nucleic Acid Extractor
Gold Supplier
Influenza A&B Test
SGTi-flex Influenza A&B

Print article


Molecular Diagnostics

view channel
Image: Micrograph of a colorectal adenocarcinoma (Photo courtesy of Wikimedia Commons)

Plasma or Urine Liquid Biopsy Tests May Guide Colorectal Cancer Treatment

A recent paper suggested that liquid biopsy examination of blood or urine could aid in evaluating the effectiveness of therapy for colorectal cancers that had begun to metastasize beyond the site of the... Read more


view channel
Image: Sysmex CN-Series automated blood coagulation analyzer (Photo courtesy of Sysmex Corporation)

Siemens and Sysmex Extend Agreement to Provide One of the Largest Portfolios of Hemostasis Testing Systems and Reagents

Siemens Healthineers (Erlangen, Germany) and Sysmex Corporation (Kobe, Japan) have renewed their long-standing global supply, distributorship, sales and service agreement for a broad portfolio of hemostasis... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.