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Clinical Chemistry

Image: Serum folate and B vitamins should be tested in certain patients than are being hospitalized (Photo courtesy of Toliopoulos Diagnostics/Roche).

Low Folate Levels Can Indicate Malnutrition in Hospital Patients

 Folate deficiency, also known as vitamin B9 deficiency, is a low level of folate and derivatives in the body. Signs of folate deficiency are often subtle. A low number of red blood cells (anemia) are a late finding in folate deficiency and folate deficiency anemia is the term given for this medical condition. More...
04 Mar 2020
Image: The Variant II Turbo Hemoglobin Testing System combines High Performance Liquid Chromatography (HPLC) precise and variant detection with fast throughput to provide a comprehensive solution for HbA1c testing (Photo courtesy of Bio-Rad).

Monogenic Hypercholesterolemia Increases Cardiovascular Disease Risk

 Monogenic familial hypercholesterolemia (FH) is associated with lifelong elevations in low-density lipoprotein cholesterol (LDL-C) levels and increased risk of atherosclerotic cardiovascular disease (CVD). More...
03 Mar 2020
DIASOURCE (A Biovendor Company)
Image: The penKid assay allows the measurement of actual kidney function with a simple blood draw. Being non-inferior to the gold standard, rising and decreasing penKid values reveal worsening and improving of kidney function independent from inflammation or any other comorbidity, allowing the inclusion of all critical ill patients (Photo courtesy of SphingoTec GmbH).

Proenkephalin Assesses True Glomerular Filtration Rate Accurately

 The assessment of renal function in clinical practice remains challenging. Using creatinine to assess the glomerular filtration rate (GFR) is notoriously inaccurate, and determination of the true GFR, such as using inulin or iohexol, is laborious and not feasible in daily practice. More...
02 Mar 2020
Image: The Quanterix SR-X Ultra-Sensitive Biomarker Detection System uses single molecular array technology (SIMOA) (Photo courtesy of Quanterix Corporation).

Blood Biomarkers Associated with Acute Sport-Related Concussion

 During the past decade, several candidate biomarkers have emerged as potential diagnostic markers of traumatic brain injury (TBI) and an estimated 90% of brain injuries are classified as mild TBI. More...
27 Feb 2020
Image: Illumina microarrays are a robust system that allow investigators to find variants in simple nucleotide polymorphisms (SNPs). The microarrays are subsequently scanned in the iScan system (Photo courtesy of LABSERGEN LANGEBIO).

Genetic Risk Factors Found in Gestational Diabetes

 Gestational diabetes mellitus (GDM) is a common pregnancy complication affecting 6%–15% of pregnancies globally. Although the condition resolves after delivery in most cases, women with a history of GDM have a more than sevenfold increased risk of developing type 2 diabetes (T2D) compared with women with a normoglycemic pregnancy. More...
26 Feb 2020
Image: Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson`s disease (Photo courtesy of Marvin101).

Technology Discriminates Parkinson’s Disease from Multiple System Atrophy

 It is challenging to distinguish between Parkinson’s Disease and Multiple System Atrophy (MSA) because the early signs are similar, disturbances in movement, tremors, uncontrollable movements during sleep, impaired speech, but the diseases progress differently and can require distinct treatment plans. More...
19 Feb 2020
Image: The ABX Pentra 400 is a compact clinical chemistry benchtop autoanalyzer (Photo courtesy of Horiba Medical).

Glycemic Markers Influenced by Chronic Kidney Disease

 Chronic kidney disease (CKD) is estimated to affect about 10% of the general adult population and is even more prevalent in diabetic patients. It is estimated that 20%–40% of individuals with diabetes have moderate to severe CKD, ranking diabetes as the leading cause of end-stage renal disease (ESRD) and an important risk factor for morbidity and mortality in dialysis patients. More...
18 Feb 2020
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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