We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Glioma Risk Lower with Elevated Blood Sugar

By LabMedica International staff writers
Posted on 16 May 2017
Print article
Image: New research suggests that there may be a link between blood sugar and glioma (Photo courtesy of MNT).
Image: New research suggests that there may be a link between blood sugar and glioma (Photo courtesy of MNT).
While many cancers are more common among those with diabetes, cancerous brain tumors called gliomas are less common among those with elevated blood sugar and diabetes.

Glioma is a heterogeneous primary brain tumor for which there is no treatment that ensures long-term survival and patients diagnosed with the most common adult form of this tumor, glioblastoma, survive on average only 14 months.

An international team of scientists led by those at the Ohio State University evaluated blood sugar and diabetes data and its relationship to subsequent development of brain cancer and found that those with elevated blood sugar and diabetes had a lower risk of developing glioma. They used data from the Apolipoprotein MOrtality RISk (AMORIS) (n = 528,580) and the Metabolic syndrome and Cancer project (Me-Can) cohorts (n = 269,365). They identified individuals who were followed for a maximum of 15 years after their first blood glucose test until glioma diagnosis, death, emigration or the end of follow-up.

They conducted an exploratory analysis of the 51 glioma cases using the Me-Can data set with multiple measurements to determine whether glucose values equal to or less than 7.0 mmol/L varied with the number of measurements or time between the blood glucose test and glioma diagnosis. They found that fasting and non-fasting glucose dose-response relationships were similar allowing them to combine data from these two groups.

They found that the relative proportions of male and female total glioma cases differ between the cohorts (in AMORIS 65% are men; in Me-Can 52%), as does fasting status (in AMORIS 61% of blood was drawn when total glioma cases were fasting; in Me-Can all blood samples were collected from fasting participants). Pre-diagnostic blood glucose levels were inversely related to glioma risk and pre-diagnostic diabetes. During the year before diagnosis, blood glucose was inversely associated with glioma in the AMORIS but not the Me-Can cohort. This AMORIS result is consistent with their hypothesis that excess glucose consumption by the preclinical tumor accounts for the inverse association between blood glucose and glioma.

Judith Schwartzbaum, PhD, a professor and lead author of the study said, “Diabetes and elevated blood sugar increase the risk of cancer at several sites including the colon, breast and bladder. But in this case, these rare malignant brain tumors are more common among people who have normal levels of blood glucose than those with high blood sugar or diabetes.” The study was published on May 3, 2017, in the journal Scientific Reports.

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Systemic Autoimmune Testing Assay
BioPlex 2200 ANA Screen with MDSS

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Molecular Diagnostics

view channel
Image: The study showed the blood-based cancer screening test detects 83% of people with colorectal cancer with specificity of 90% (Photo courtesy of Guardant Health)

Blood Test Shows 83% Accuracy for Detecting Colorectal Cancer

Colorectal cancer is the second biggest cause of cancer deaths among adults in the U.S., with forecasts suggesting 53,010 people might die from it in 2024. While fewer older adults are dying from this... Read more

Hematology

view channel
Image: The Gazelle Hb Variant Test (Photo courtesy of Hemex Health)

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Hemoglobin disorders rank as some of the most prevalent monogenic diseases globally. Among various hemoglobin disorders, beta thalassemia, a hereditary blood disorder, affects about 1.5% of the world's... Read more

Microbiology

view channel
Image: The new platform is designed to perform blood-based diagnoses of nontuberculosis mycobacteria (Photo courtesy of 123RF)

New Blood Test Cuts Diagnosis Time for Nontuberculous Mycobacteria Infections from Months to Hours

Breathing in nontuberculous mycobacteria (NTM) is a common experience for many people. These bacteria are present in water systems, soil, and dust all over the world and usually don't cause any problems.... Read more

Industry

view channel
Image: These new assays are being developed for use on the recently introduced DxI 9000 Immunoassay Analyzer (Photo courtesy of Beckman Coulter)

Beckman Coulter and Fujirebio Expand Partnership on Neurodegenerative Disease Diagnostics

Beckman Coulter Diagnostics (Brea, CA, USA) and Fujirebio Diagnostics (Tokyo, Japan) have expanded their partnership focused on the development, manufacturing and clinical adoption of neurodegenerative... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.