We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Siemens Healthineers - Laboratory Diagnostics

Download Mobile App

PCR-Based Endometrial Cancer Detection Test to Prevent Missed Diagnoses

By LabMedica International staff writers
Posted on 31 Aug 2023
Print article
Image: The new molecular test is designed to use Pap Smear for early endometrial cancer detection (Photo courtesy of Freepik)
Image: The new molecular test is designed to use Pap Smear for early endometrial cancer detection (Photo courtesy of Freepik)

Endometrial cancer is the most frequently diagnosed gynecologic cancer. In 2020, around 417,367 individuals received an endometrial cancer diagnosis. One out 10 women experiencing abnormal bleeding during their lifetimes will need invasive specialist biopsy procedures to rule out endometrial cancer. Previous research has identified specific gene hypermethylation as a potential biomarker for endometrial cancer detection. This has now paved the way for a minimally invasive test that identifies methylated biomarkers, indicating gene repression linked to malignancy. By utilizing the widely accepted pap smear or HPV sampling approach, this molecular test offers huge potential as a supplementary tool for assisting in endometrial cancer diagnosis right at the clinic.

INEX Innovate (Singapore) has launched epiHERA, the company’s early endometrial cancer detection technology, powered by a cutting-edge PCR test that is designed to detect epigenetic changes in genes associated with the presence of endometrial cancer. The epiHERA testing process starts with a simple cervical swab, similar to the sample collection method employed in cervical cancer screening. Subsequent steps involve genomic DNA extraction and bisulfite conversion. The final phase of the test entails real-time PCR analysis, focusing on the hypermethylated CDO1 and CELF4 genes. This streamlined process takes about six hours to be completed.

epiHERA addresses a critical gap in existing diagnostics by promoting equitable access to testing for vulnerable women. Its innovative methodology streamlines sample collection, significantly reducing turnaround time from weeks to days. Leveraging the scalability of molecular PCR testing ensures widespread availability, thereby increasing epiHERA's impact in the field of women's health. epiHERA has shown promising results in validation studies. Researchers can now access epiHERA for validation within their unique population cohorts, facilitating diverse applications and a comprehensive understanding of its efficacy.

“The launch of epiHERA is a testament not only to a shift in endometrial cancer detection but also underscores INEX Innovate's unwavering dedication to innovative solutions that enable timely interventions and improved patient outcomes,” said Kane Black, CEO of INEX Innovate. “epiHERA is the latest test launched by our team as we continue our path to being Asia’s pre-eminent women’s life science platform, and has received significant interest from clinicians and lab operators in the region. The launch comes at an exciting time of growth for the company on the back of recent acquisitions in the area as we expand both technology pipelines and geographically across the region.”

Related Links:
INEX Innovate 

Platinum Supplier
Automatic Nucleic Acid Workstation
Gold Supplier
High-Density Lipoprotein Containing Cholesterol Assay
HDL-c direct FS
Semi Auto Biochemistry Analyzer
Handheld Electrolyte Analyzer
Seamaty SE1

Print article


Clinical Chemistry

view channel
Image: The new assays are designed to run on the B•R•A•H•M•S KRYPTOR compact PLUS clinical chemistry analyzer (Photo courtesy of Thermo Fisher)

Breakthrough Immunoassays to Aid in Risk Assessment of Preeclampsia

Preeclampsia is a life-threatening blood pressure condition that can arise during pregnancy and the postpartum phase. This severe pregnancy complication is a primary cause of maternal and fetal mortality... Read more


view channel
Image: The US FDA has cleared HemoScreen point of care CBC for direct capillary sampling (Photo courtesy of PixCell Medical)

Point of Care CBC Analyzer with Direct Capillary Sampling Enhances Ease-of-Use and Testing Throughput

The world’s only 5-part differential Complete Blood Count (CBC) analyzer that is FDA-cleared, CE-marked, and TGA-approved for point-of-care use has now been granted FDA 510(k) clearance for direct capillary... Read more


view channel
Image: Immune cells present long before infection predict flu symptoms (Photo courtesy of Shutterstock.com)

Single Blood Draw to Detect Immune Cells Present Months before Flu Infection Can Predict Symptoms

For decades, if not centuries, scientists have struggled to solve the mystery of why certain individuals fall ill to infections while others remain unaffected. In an impressive development, researchers... Read more


view channel
Image: The rapid diagnostic test could pinpoint the correct antibiotic for infection treatment in under an hour (Photo courtesy of Microplate Dx)

Point-of-Care Device to Reduce Antibiotic Susceptibility Testing Time from Days to Minutes

Antimicrobial resistance (AMR) is a significant global health issue, currently leading to over 1.27 million deaths worldwide each year. By 2050, AMR could be causing up to 10 million deaths annually, surpassing... Read more


view channel
Image: The Tasso+ device has received CE Mark certification (Photo courtesy of Tasso)

Groundbreaking Blood Lancing Device Obtains Microliter Capillary Whole Blood Samples Painlessly

A convenient, virtually pain-free blood lancet that collects whole liquid blood samples has received CE Mark designation, making the patient-centric, high-volume blood collection solution available in... Read more


view channel
Image: A new electrochemical device can quickly and inexpensively identify people at greatest risk for osteoporosis (Photo courtesy of ACS Central Science, 2023)

Electrochemical Device Identifies People at Higher Risk for Osteoporosis Using Single Blood Drop

With the global increase in life expectancy, the incidence of age-related conditions like osteoporosis is increasing. Osteoporosis, affecting around 200 million individuals worldwide, has a higher incidence... Read more


view channel
Image: The global fully automatic electrolyte analyzers market is projected to reach close to USD 0.77 billion by 2032 (Photo courtesy of 123RF)

Global Fully Automatic Electrolyte Analyzers Market Driven by Surge in Demand for Point-of-Care Testing

Fully automatic electrolyte analyzers can measure the levels of electrolytes in various bodily fluids like blood and plasma. Electrolytes are ions that have an electrical charge and are essential for multiple... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.