We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Noninvasive Prenatal Test Diagnoses Hemolytic Disease of Fetus and Newborn

By LabMedica International staff writers
Posted on 05 Oct 2022
Print article
Image: Fetal antigen NIPT may help streamline management of most alloimmunized pregnant patients (Photo courtesy of BillionToOne)
Image: Fetal antigen NIPT may help streamline management of most alloimmunized pregnant patients (Photo courtesy of BillionToOne)

Alloimmunization occurs in about 1% of pregnancies and is when the pregnant patient makes RBC antibodies as a result of foreign blood mixing. These antibodies can cross the placenta and attack the unborn baby. Hemolytic Disease of the Fetus and Newborn (HDFN), a rare but potentially deadly resulting condition, can have devastating effects on the fetus including anemia, hyperbilirubinemia, and death. Due to the potential severity of HDFN and the previous lack of non-invasive risk assessment tools, alloimmunized patients are typically monitored closely until delivery, sometimes via weekly blood titers and ultrasounds. This close monitoring determines if an early term delivery or an intrauterine transfusion may be indicated for the pregnancy. Now, a new fetal antigen single-gene non-invasive prenatal test (sgNIPT) for pregnant patients who are alloimmunized with C, c, D, E, Duffy (Fya), or Kell (K) red blood cell (RBC) antibodies looks for the presence of the genetic variants that code for the corresponding fetal antigens.

BillionToOne, Inc. (Palo Alto, CA, USA) has launched UNITY fetal antigen sgNIPT, a new addition to UNITY Screen, that is available at 10+ weeks gestation, and may streamline management for most pregnancies thought to be at risk for HDFN. The UNITY fetal antigen NIPT report will show if the fetal antigen of interest is detected or not detected, providing stronger clinical conviction for those patients who require rigorous monitoring. Importantly, it is expected that up to 65% alloimmunized pregnant patients will not be carrying fetuses that express the antigen(s) of interest. This may drastically minimize unnecessary healthcare resources, decrease monitoring visits, and, most importantly, reduce unnecessary anxiety for many families. Analytical validation data show the test sensitivity and specificity is >99.9%.

"We are thrilled to launch our UNITY fetal antigen sgNIPT. While HDFN only affects 1% of US pregnancies, it can have dire consequences, and the extra, and often unnecessary, monitoring can be a significant source of anxiety for patients," said Oguzhan Atay, BillionToOne CEO. "This is yet another example of our powerful Quantitative Counting Templates (QCT) technology and its application to single-gene NIPT fulfilling a previously unmet medical need. Providing up to 65% of alloimmunized patients with greater peace of mind that their babies are low risk is the type of patient-oriented product we always strive for."

Related Links:
BillionToOne, Inc. 

Gold Supplier
Rheumatoid Factors (RF) Test
Rheumatoid Factors (RF)
COVID-19 Test Cassette
Fecal Occult Blood Test
Fecal Occult Blood (iFOB) Neo
C-Reactive Protein Test
PLUS CRP Turbilatex

Print article


Clinical Chem.

view channel
Image: Equivalence of Genetically Elevated LDL and Lipoprotein(a) on Myocardial Infarction (Photo courtesy of Viborg Regional Hospital)

Familial Hypercholesterolemia Patients With ACD Have Elevated Lipoprotein(a)

Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL cholesterol), in the blood and early cardiovascular... Read more

Molecular Diagnostics

view channel
Image: A cheap blood test could improve diagnosis of myocarditis (Photo courtesy of Queen Mary University of London)

First-Ever Blood Test Could Detect Deadly Heart Inflammation Within Hours

Myocarditis, or inflammation of the heart muscle, is a difficult condition to diagnose. Symptoms include a temperature, fatigue, chest pain and shortness of breath, which can all be easily mistaken for... Read more


view channel
Image: Ring-form trophozoites of Plasmodium vivax in a thin blood smear (Photo courtesy of Centers for Disease Control and Prevention)

Immune Regulators Predict Severity of Plasmodium vivax Malaria

Cytokines and chemokines are immune response molecules that display diverse functions, such as inflammation and immune regulation. In Plasmodium vivax infections, the uncontrolled production of these molecules... Read more


view channel
Image: Breast cancer spread uncovered by new molecular microscopy (Photo courtesy of Wellcome Sanger Institute)

New Molecular Microscopy Tool Uncovers Breast Cancer Spread

Breast cancer commonly starts when cells start to grow uncontrollably, often due to mutations in the cells. Overtime the tumor becomes a patchwork of cells, called cancer clones, each with different mutations.... Read more


view channel
Image: With Cell IDx’s acquisition, Leica Biosystems will be moving its multiplexing menu forward (Photo courtesy of Leica Biosystems)

Leica Biosystems Acquires Cell IDx, Expanding Offerings in Multiplexed Tissue Profiling

Leica Biosystems, a technology leader in automated staining and brightfield and fluorescent imaging (Nussloch, Germany), has acquired Cell IDx, Inc. (San Diego, CA, USA), which provides multiplex staining... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.