We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics - An LGC Company

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Blood Tests for Detecting Antioxidant and Inflammation Levels Could Diagnose Breast Cancer

By LabMedica International staff writers
Posted on 07 Apr 2022
Print article
Image: Antioxidant, inflammation levels may reveal new diagnostic tool for breast cancer (Photo courtesy of Pexels)
Image: Antioxidant, inflammation levels may reveal new diagnostic tool for breast cancer (Photo courtesy of Pexels)

Breast cancer is the most prevalent cancer in the world. Identifying new diagnostic techniques is of major importance to efforts that aim to minimize the disease’s devastating effects. Now, a new study that analyzes levels of antioxidants and stress markers in the blood could lead to a new diagnostic tool for breast cancer.

Researchers from the University of Lahore (Lahore, Pakistan) explored the role that inflammatory and stress markers may play in the development and progression of breast cancer. The research team examined blood samples from premenopausal women diagnosed with breast cancer. When compared to age-matched controls without cancer, the breast cancer patients had significantly increased levels of inflammatory markers.

Among the overexpressed markers were the pro-inflammatory protein interleukin-1, matrix metalloproteinase 9 - an enzyme that is overexpressed in several diseases - and heat shock protein 27. This protein acts as an antioxidant that typically prevents or reduces cell death. However, in some disease states - such as cancer - heat shock protein 27 has been found to be both protective and destructive. In addition, the breast cancer group had low levels of protective compounds such as vitamins A, C and D, catalase - an enzyme that protects cells from oxidative stress - and the antioxidants superoxide dismutase and glutathione.

“The breast cancer pathophysiology included an overbalance of oxidants or stress markers and an underbalance of antioxidants,” said Samina Malik, MBBS, MPhil, first author of the study. This proportion of pro- and anti-inflammatory components may play “a crucial role in the metastasis of breast cancer” and may be useful as a diagnostic marker for the disease, according to the researchers.

Related Links:
University of Lahore 

Gold Supplier
Clinical Chemistry Reagents
SEKURE Clinical Chemistry Reagents
New
Silver Supplier
Anti-Müllerian Hormone (AMH) ELISA Test
PCOCheck ELISA (CE)
New
SARS-CoV-2 IgG Antibodies Anti-S1 Assay
iRapid SARS-CoV-2 Quant "Neutralizing" Ab
New
Automated Pathology Workstation
NanoMtrx 100 & 300

Print article

Channels

Clinical Chem.

view channel
Image: The analysis pipeline used to investigate associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease (Photo courtesy of University College London)

Lipid Measurements Show Potential as Alzheimer’s Disease Biomarkers

Brain changes accompanying ageing are varied and can include pathologies that lead to cognitive impairment, the commonest of which is Alzheimer’s disease (AD). Identifying blood-based signatures of brain... Read more

Molecular Diagnostics

view channel
Image: This image depicts a DNA molecule that is methylated on both strands on the center cytosine. DNA methylation plays an important role for epigenetic gene regulation in development and cancer (Photo courtesy of Wikimedia Commons)

Study Supports Use of Methylated DNA Biomarkers for Cancer Diagnosis and Prognosis

A recent study added weight to the theory that methylated DNA biomarkers could be used for cancer diagnosis and prognosis. Methylation is a biological process by which methyl groups are added to a DNA molecule.... Read more

Industry

view channel
Image: QIAGEN has acquired a majority stake in enzymes provider BLIRT S.A. (Photo courtesy of QIAGEN)

Qiagen Acquires Enzymes Provider Blirt to Strengthen Sample Technologies Business

QIAGEN N.V. (Venlo, Netherlands) has signed agreements to acquire a 96% majority ownership stake in BLIRT S.A. (Gdansk, Poland), a manufacturer of recombinant enzymes for the life science industry.... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.