We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

BODITECH

Boditech Med Inc. develops products for in-vitro diagnostics and diagnostic reagents. Its products include automatic ... read more Featured Products: More products

Download Mobile App




Biomarkers Evaluated for Severity of Diabetic Kidney Disease

By LabMedica International staff writers
Posted on 24 Aug 2020
Type 2 diabetic mellitus (T2DM) is a chronic metabolic disorder with multiple complications, including diabetic retinopathy, diabetic neuropathy, diabetic kidney disease (DKD) as well as cardiovascular diseases. More...
T2DM is related to an exacerbated systematic inflammation.

Among all plasma inflammatory biomarkers, erythrocyte sedimentation rate (ESR) and high-sensitivity C-reactive protein (hsCRP) are the mostly commonly used laboratory tests for identifying systematic inflammation. Both ESR and hsCRP are important markers in various inflammation-related diseases.

A team of endocrinologists at Huashan Hospital (Shanghai, China) conducted a cross-sectional study in 1,210 patients with T2DM, among whom 265 had DKD. The severity of DKD was assessed by estimated-glomerular filtration rate (eGFR) and urinary albumin creatinine ratio (ACR). The relationship between ESR, hsCRP and DKD was analyzed by multivariate logistic analysis. The relationship between ESR and eGFR, ESR or ACR was analyzed by multivariate linear regression.

Fasting blood sample was collected to measure fasting plasma glucose (FBG), glycated hemoglobin (HbA1c), hsCRP, serum albumin (ALB), globulin (GLB), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL) and low-density lipoprotein cholesterol (LDL), serum creatinine (SCr), and ESR. ESR was measured using ESR-30 fully automatic dynamic analyzer (Xunda Medical Instrument Co., Ltd., Shanghai, China). FBG, TC, TG, HDL, LDL, ALB, total protein, SCr was quantified by Beckman AU5800 (Beckman Coulter Inc., Brea, CA, USA). HsCRP was detected by iCHROMA reader (Boditech Med Inc, Chungcheon-si, South Korea).

The scientists reported that ESR (23.0 mm/h [12.0 ~ 41.5] versus 12.0 mm/h [7.0 ~ 22.0], and hsCRP (3.60 mg/L [2.20 ~ 7.65] versus 2.90 mg/L [1.80 ~ 5.60],) values were significantly higher in patients with DKD than those without. Patients with higher ESR or hsCRP had lower eGFR and higher urinary albumin creatinine ratio (ACR). After adjusted for gender, age, hemoglobin, plasma proteins, HbA1c, lipid profiles, and the usage of renin-angiotensin system inhibitors, ESR but not hsCRP was independently associated with the rate and severity of DKD in patients with T2DM.

The authors concluded that their study underlined the role of inflammation in DKD. The study found that, both ESR and hsCRP correlated with DKD in T2DM, of which ESR was an independent risk factor for DKD and positively associated with severity of DKD. The study was published on July 13, 2020 in the journal BMC Endocrine Disorders




New
Gold Member
Quality Control Material
iPLEX Pro Exome QC Panel
Serological Pipet Controller
PIPETBOY GENIUS
New
Gold Member
Blood Gas Analyzer
Stat Profile pHOx
New
Legionella Pneumophila Test
CHORUS Legionella Urinary Antigen
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.