We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Events

09 Apr 2024 - 12 Apr 2024
15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024

Neutrophil‐Lymphocyte Ratio and Lactate Predict Mortality in Septic Patients

By LabMedica International staff writers
Posted on 23 Jul 2019
Print article
Image: The ABL800 FLEX blood gas analyzer (Photo courtesy of Radiometer Medical).
Image: The ABL800 FLEX blood gas analyzer (Photo courtesy of Radiometer Medical).
Sepsis is the primary cause of death from infection. It is also one of the leading causes of intensive care unit (ICU) mortality, despite early administration of antibiotics and hemodynamic management.

Plasma biomarkers may have diagnostic, prognostic, and theranostic values, all of which are important factors influencing outcomes in patients with sepsis. White blood cell (WBC) enumeration has been identified as an important systemic inflammation marker. The neutrophil‐to‐lymphocyte ratio (NLR) is a rapid and simple parameter of systemic inflammation and stress.

Scientists at the Changai Hospital (Shanghai, China) and their colleagues conducted a prospective, observational study that included 63 nonsurgical and non-trauma adult patients with sepsis admitted to the Department of Critical Care Medicine from September 2016 to October 2018. Baseline characteristics of the patients including demographics (age and gender), comorbidities (cardiovascular disease, chronic lung disease, and diabetes, among others), and primary diagnosis were recorded. In addition, healthy subjects were assigned to a control group.

The team collected blood samples within 24 hours after diagnosis. Routine blood tests, blood gas analysis, and procalcitonin (PCT) concentrations were conducted in the hospital's central laboratory. Routine blood tests, including neutrophil count and lymphocyte count performed on a blood analyzer, XN9000, C-reactive protein (CRP) estimated by scattering nephelometry, and plasma PCT concentrations were measured using a time‐resolved amplified cryptate emission technology assay. Plasma lactate was evaluated on an ABL800 Flex.

The scientists reported that NLR and plasma lactate levels of the patients were significantly higher than those of control subjects: 19.44 (14.3‐34.53) versus 14.09 (8.17‐28.99), and 3.7 (3‐6.6) versus 2.72 (2.13‐4.3) ng/mL, respectively. There were no statistical differences in the concentrations of PCT and CRP between non-survivors and survivors. With an optimal cutoff of 14.08, the sensitivity and specificity of NLR for prediction of 28‐day mortality were 78.3% and 50%, respectively. The sensitivity and specificity of plasma lactate level to predict 28‐day mortality, at an optimal cutoff value of 2.99 mmol/L, were 82.6% and 55%, respectively.

The authors concluded that elevated NLR and lactate levels showed significant association with increased mortality in patients with sepsis. NLR and lactate may be important prognostic biomarkers to optimize treatment and manage patients. The study was published on July 2, 2019, in the Journal of Clinical Laboratory Analysis.

Related Links:
Changai Hospital

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
GREENCARE A1c
POCT Fluorescent Immunoassay Analyzer
FIA Go
New
Gold Member
Magnetic Bead Separation Modules
MAG and HEATMAG

Print article

Channels

Molecular Diagnostics

view channel
Image: MOF materials efficiently enrich cfDNA and cfRNA in blood through simple operational process (Photo courtesy of Science China Press)

Blood Circulating Nucleic Acid Enrichment Technique Enables Non-Invasive Liver Cancer Diagnosis

The ability to diagnose diseases early can significantly enhance the effectiveness of clinical treatments and improve survival rates. One promising approach for non-invasive early diagnosis is the use... Read more

Hematology

view channel
Image: The low-cost portable device rapidly identifies chemotherapy patients at risk of sepsis (Photo courtesy of 52North Health)

POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy

Neutropenia, a decrease in neutrophils (a type of white blood cell crucial for fighting infections), is a frequent side effect of certain cancer treatments. This condition elevates the risk of infections,... Read more

Pathology

view channel
Image: The OvaCis Rapid Test discriminates benign from malignant epithelial ovarian cysts (Photo courtesy of INEX)

Intra-Operative POC Device Distinguishes Between Benign and Malignant Ovarian Cysts within 15 Minutes

Ovarian cysts represent a significant health issue for women globally, with up to 10% experiencing this condition at some point in their lives. These cysts form when fluid collects within a thin membrane... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.